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Studi Kestabilan Fisika Dan Kimia Dispersi Padat Ketoprofen – Polivinil Pirolidon K-30 Salman Umar; Nella Vista Sari; Rieke Azhar
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

The study of physical and chemical stability of solid dispersion ketoprofen-PVP K-30 has been studied. The solid dispersions system were prepared by solvent method with several variation amount. Ketoprofen-PVP K-30 was evaluated by its physicochemical properties using the Differential Thermal Gravimetric (DTG), FT-IR spectroscopy and dissolution profiles. This study used an accelerated stability test at temperature (40±2)˚C for 3 months. The test include organoleptic test and ketoprofen content. Ketoprofen content were measured by UV spectrophotometer at 255.5 nm, respectively, after were stored for 1, 2 and 3 months at a temperature (40±2)˚C. The analysis of DTG showed endothermic peak friction ketoprofen is significant. FT-IR spectra indicated no chemical interaction between ketoprofen-PVP K-30 in the solid dispersion. The result showed that solid dispersion of ketoprofen with PVP K-30 gave a good physicochemical characterization of ketoprofen and could improve the dissolution rate of ketoprofen. Formula 3 of solid dispersion shown the highest dissolution rate at 30 minute (82.657%) ( not less than 80%). The chemical and physical stability of solid dispersion of ketoprofen-PVP K-30, indicating change in the physics and chemistry of solid dispersions. The organoleptic test also showed discoloration of the three formulas and third assay formula showed that increasing the concentration of PVP-K-30 in the solid dispersion will lead to decreased content of ketoprofen. In addition, the most stable formula is a formula 1 with a ratio of 1:1 which resulted usage of 29 months.

Pengaruh Polivinilpirolidon K-30 terhadap Disolusi Ketoprofen dalam Sistem Dispersi Padat Rieke Azhar; Muslim Suardi; Salman Umar
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

Effects of polyvinylpyrrolidone K-30 on dissolution characteristics of solid dispersion systems have been studied. Solid dispersions were prepared by solvent method using several ratios of ketoprofen-polyvinylpyrrolidone K-30 as follows 1:9, 3:7, 5:5, 7:3, 9:1. Physical mixtures of ketoprofen-polyvinylpyrrolidone K-30 were used as a comparison. The solid dispersion systems and physical mixtures were evaluated for physicochemical properties and dissolution characteristics. Dissolution tests were measure with modified basket method using pH 7.2 phosphate buffer as dissolution medium. Samples were taken up after 5, 10, 15, 20, 30, 45, and 60 minutes. Results generally showed that solid dispersion system of ketoprofenpolyvinylpyrrolidone K-30 have a different physicochemical properties compared to physical mixtures and pure ketoprofen and exhibited better dissolution rate and dissolution efficiency of ketoprofen. Dissolution efficiency and dissolution rate constant of the solid dispersion system were 59.41%, and 1.66 mg/s, respectively.

Penggunaan Kombinasi Pati Bengkuang – Avicel PH101 Sebagai Bahan Pengisi Co-Process Tablet Isoniazid Cetak Langsung Syofyan Syofyan; Ezi Afri Yelni; Rieke Azhar
Jurnal Farmasi Higea Vol 5, No 1 (2013)
Publisher : STIFARM Padang

Starch yam bean (Pachyrrhizus erosus Urban) is tablet excipient with poor of both flowability and compressibility which can not be used as diluents of direct tablet compression. The purpose of this research is to know the influence of the combination avicel PH101-starch as a filler material co-process. Tablet made with direct compression method with isoniazid as a model drug. Results of the study show that the formula 4 (Avicel PH101 concentration with 4%) can produce co-process with mechanical and physical properties of compresibilitas-the most good, as for the evaluation of isoniazid tablets do not meet the requirements of violence and friabilytas on all formula. In summary, use of Co-Process yam bean starch-Avicel PH101 with 0-4% Avicel PH101 concentration was not produced a tablet that meet the requirements.

Mikroenkapsulasi Parasetamol Dengan Polimer Hidroxy Prophyl Methyl Celluloce (HPMC) Menggunakan Metoda Penguapan Pelarut Rieke Azhar; Elva Yunengsih; Auzal Halim
Jurnal Farmasi Higea Vol 2, No 2 (2010)
Publisher : STIFARM Padang

The study on paracetamol microencapsulation by solvent evaporation method using hidroxy prophyl methil celluloce (HPMC) as a polimer has been done. The paracetamol Quantitation by UV spectrofotometer at 243 nm, using phosphate buffer pH 5,8 as the dissolution medium. The result showed that 1st formula’s dissolution rate is higher than 2nd and 3nd formulas, because the HPMC content of those formula are higher than the 1st formula, so paracetamol as a core are coored thicker, so that lower in drug rate releasing. The kinetic releasing mechanism of active ingredient from the microcapsule following the zero order, first order and Higuchi equation.

Pemeriksaan Kualitatif Hidrokuinon dan Merkuri dalam Krim Pemutih Roslinda Rasyid; Eva Susanti; Rieke Azhar
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

Studies have been conducted to analyse the hydroquinone and mercury content in beauty whitening creams from parlor and on the market in Padang city. Beauty whitening cream samples were A, B, C, D,E and F, then were observed using FeCl3, Ag-ammoniacal, Sodium Hydroxide, Potassium Iodide, and amalgam reagents. Hydroquinon was determined using Thin Layer Cromatography (TLC) and UV spectrophotometer. The results showed that six samples from three samples whitening cream B, D and F identified containing hydroquinone and two samples B and F contain mercury. So from the six samples of beauty whitening cream, three samples of the products do not contain hydroquinone and mercury.

Studi Kestabilan Fisika Dan Kimia Dispersi Padat Ketoprofen -Urea Salman Umar; Monica Selfia; Rieke Azhar
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

A research on the study of physical and chemical stability of ketoprofen-urea solid dispersions. Solid dispersions prepared through dissolution method with ketoprofen-urea ratio is 1:1, 1:3, 1:5. Powder solid dispersion system was evaluated physicochemical properties include analysis Differential Thermal Analysis (DTA), FT-IR spectroscopy, and dissolution profiles. Accelerated stability test for 3 months at a temperature (40±2)°C. The parameters tested include organoleptic test and ketoprofen levels. Ketoprofen levels were measured by UV spectrophotometer at a wavelength of 255.5 nm after being stored for 1, 2, and 3 months at a temperature (40±2)°C. DTA analysis results showed endothermic peak shift ketoprofen meaningful. FT-IR spectra showed no chemical interaction between ketoprofen-urea solid dispersion powder. The results showed that solid dispersions of ketoprofen-urea can improve the physicochemical properties and can enhance the dissolution profile of solid dispersion compared to pure ketoprofen with the highest dissolution results indicated by solid dispersion formula 3 (1:5) is 105.674%. Test chemical and physical stability of solid dispersions of ketoprofen-urea showed a change in the physics and chemistry of solid dispersions. Organoleptic test the change in color the three formulas. While the test by the chemical assay, the three formulas while showed that increasing the concentration of urea in the solid dispersion of a decrease in the levels of ketoprofen. The most stable formula is the formula 1 (1:1) to 24.748 months of age.

Pengaruh Penggunaan Aerosil Terhadap Disolusi Tablet Isoniazid (Inh) Cetak Langsung Syofyan Syofyan; Thika Dwi Lestari; Rieke Azhar
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

The research about the effect of aerosil to the dissolution rate of isoniazid tablet with direct compression method has been done. Isoniazid tablets were made with different aerosil consentration in each formulas, that is 0.5%; 1%; 1.5%. Tablet evaluation were done by measuring drug loading assay and dissolution test using HCl 0.1 N. The assay was measured using spectrophotometer UV at 266.5nm; where obtained levels of isoniazid tablets in each formulas is 95.779% - 103.776%. The results of disolution test showed that every formulas reached the 80% of cumulatif persentage as follows, 98.671%; 98.441%; 98.327% at 45th minutes. The result concluded that the addition of execessive aerosil as lubricant can decreased tablet disintegration rate and dissolution rate.

Penentuan Parameter Fisika Dan Kimia Bromelin Kasar Dari Batang Nanas (Ananas comosus Merr.) Rieke Azhar; Budi Ariyanto; Salman Umar
Jurnal Farmasi Higea Vol 4, No 1 (2012)
Publisher : STIFARM Padang

Isolation of crude bromelain from pineapple stem has been done using phosphate buffer pH 7.0 as solvent,nthen it was centrifuged at 3,500 rpm for 15 minutes. It’s physicochemical properties then evaluated by it’s organoleptic, solubility, lost of drying, ash content, pH value, microscopic photo, particle size distribution, water absorbtion, protein qualitative and quantitative test. It’s total protein analysis done by using Mikro Kjeldahl method than gave result 8.0384% proteins.

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