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Pengaruh Penggunaan Kombinasi Maltodekstrin De 5-10 dari Pati Beras (Oryza sativa) dengan Laktosa sebagai Pengisi Terhadap Kompresibilitas dan Komprimabilitas Tablet Ibuprofen Syofyan, Syofyan; Rosanih, Rosanih; Arsyadi, Arsyadi
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Has conducted research on the effect of the combined use of maltodextrin DE 5-10 of starch rice (Oryza sativa) with lactose as a filler to the compressibility and comprimability ibuprofen tablets. Mass properties of compressibility and comprimability examined and evaluated according to the quality of the tablet Indonesian pharmacopoeia. The results showed that the analysis using one-way ANOVA F calculation obtained 1,130 less than the value of 3.48 which means the F table did not show any difference between the formulas. It can be concluded that the difference in the levels of the combination of lactose-maltodextrin DE 5-10 of rice starch did not affect the value of compressibility and tablet dosage ibuprofen komprimabilitas.
Pengaruh Kombinasi Surfaktan Natrium Lauryl Sulfat dan Benzalkonium Klorida Terhadap Kelarutan Ibuprofen Syofyan, Syofyan; Safari, Tuti Agustia; Azhar, Rieke
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

A study on the influence of sodium lauryl sulfate and benzalkonium chloride combination on the solubility of ibuprofen has been done. The solubility of ibuprofen with sodium lauryl sulfate, benzalkonium chloride and it’s combination was determined by surface tension method with Du Nouy Tensiometer and by refractive index method with Refractometer ABBE. The solubility was determined at surfactant concentration above the CMC value. Results showed that formula 4 gave the highest solubility of ibuprofen (96,25 %). Combination of the surfactants caused precipitation.
Penggunaan Kombinasi Pati Bengkuang Avicel Ph101 sebagai Bahan Pengisi Co-Process Tablet Isoniazid Cetak Langsung Syofyan, Syofyan; Yelni, Ezi Afri; Azhar, Rieke
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Starch yam bean (Pachyrrhizus erosus Urban) is tablet excipient with poor of both flowability and compressibility which can not be used as diluents of direct tablet compression. The purpose of this research is to know the influence of the combination avicel PH101 – starch as a filler material co-process. Tablet made with direct compression method with isoniazid as a model drug. Results of the study show that the formula 4 (Avicel PH101 concentration with 4%) can produce co-process with mechanical and physical properties of compresibilitas-the most good, as for the evaluation of isoniazid tablets do not meet the requirements of violence and friabilytas on all formula. In summary, use of Co-Process yam bean starch – Avicel PH101 with 0-4% Avicel PH101 concentration was not produced a tablet that meet the requirements.
Edukasi Obat pada Masyarakat Bebasis Ibu Rumah Tangga Menggunakan Model Permainan Pintar dengan Obat (Piano) Syofyan Syofyan; Dachriyanus Dachriyanus; Masrul Masrul; Rosfita Rasyid; Erizal Erizal; Hadi Ihsan; Agung Tri Sasongko
Warta Pengabdian Andalas Vol 26 No 3 (2019)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

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Abstract

Many people's behavior in using medicines is still incorrect. The intended behavior is starting from how to get, use, store and dispose of drugs. This is inseparable from the factor of low knowledge about medicines. Community service activities aim to provide appropriate education to the community related to the above drug problems. As partners are the PKK Team of Talago Sariak Village, Pariaman City is a housewife. Selection of housewives as targets because housewives are usually the most responsible community groups in terms of managing medicines in the household or family. The activity method is in the form of using a game model that is Smart with medicines (PIANO) and questionnaires in the form of pre-test and post-test. The results showed that there was an increase in people's knowledge and attitudes about medicine, where the percentage of the average score of knowledge increased from 50.6% to 69.4%. Likewise with attitudes from 67.36% to 73.46%. From these results, it can be concluded that education about medicines using the PIANO game model can be a pretty good educational model in helping to improve people's knowledge and attitudes about medicine.
Pemberdayaan Siswa SMA di Kota Pariaman Melalui Aksi Promotif Kefarmasian (Apotek-R) sebagai Upaya Pencegahan terhadap Kejahatan Narkoba Syofyan Syofyan; Erizal Erizal; Suryati Suryati
Warta Pengabdian Andalas Vol 26 No 1 (2019)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.26.1.52-61.2019

Abstract

Drug abuse has been so alarming that victims of both young and adult children always fall every day and tend to increase from year to year. Various strategies have been carried out by the government to eradicate this drug crime, including preventive efforts to schools. Pariaman City as a crossing area in West Sumatra is a place that is prone to this drug crime. To that end, in an effort to prevent the occurrence of drug crimes, especially for high school students in Pariaman City, activities have been carried out in the form of pharmaceutical promotive actions (Apotek-R). The purpose of this activity is to know the description of the knowledge of high school students in Pariaman City, about Drugs and the influence of the Apotek-R activities on the prevention of drug abuse. The method used in the form of Communication, Information and Education (CIE) uses a pharmacy promotion action (Apotek-R). From this activity information was obtained that the knowledge of high school students in Pariaman City about drug problems is quite good. Promotional action activities of pharmacy (Apotek-R) can be used as a model in providing positive activities in efforts to prevent drug abuse among high school students.
Penggunaan Kombinasi Pati Bengkuang – Avicel PH101 Sebagai Bahan Pengisi Co-Process Tablet Isoniazid Cetak Langsung Syofyan Syofyan; Ezi Afri Yelni; Rieke Azhar
Jurnal Farmasi Higea Vol 5, No 1 (2013)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.602 KB) | DOI: 10.52689/higea.v5i1.75

Abstract

Starch yam bean (Pachyrrhizus erosus Urban) is tablet excipient with poor of both flowability and compressibility which can not be used as diluents of direct tablet compression. The purpose of this research is to know the influence of the combination avicel PH101-starch as a filler material co-process. Tablet made with direct compression method with isoniazid as a model drug. Results of the study show that the formula 4 (Avicel PH101 concentration with 4%) can produce co-process with mechanical and physical properties of compresibilitas-the most good, as for the evaluation of isoniazid tablets do not meet the requirements of violence and friabilytas on all formula. In summary, use of Co-Process yam bean starch-Avicel PH101 with 0-4% Avicel PH101 concentration was not produced a tablet that meet the requirements.
Formulasi Dan Evaluasi Stabilitas Fisik Suspensi Ibuprofen Menggunakan Kombinasi Polimer Serbuk Gom Arab Dan Natrium Karboksimetilselulosa Rina Wahyuni; Syofyan Syofyan; Septa Yunalti
Jurnal Farmasi Higea Vol 9, No 1 (2017)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.133 KB) | DOI: 10.52689/higea.v9i1.158

Abstract

The research about formulation and evaluation of physical stability of ibuprofen suspension using arabic gom and  natrium carboxymethylcelulose as suspending agent had been done. Concentration of arabic gom and  natrium carboxymethylcelulose were 2.5 : 0.25, 5 : 0.5, 2.5 : 0.75 and 5 : 1 % for F1, F2, F3 and F4 respectinely. Evaluation of physical stability had been done  for 8 weeks, ie organoleptic, density, viscosity, volume of sedimentation, redispresion, pH, freeze thaw cycling, crystal growth and particle size distribution. Concentration of arabic gom and natrium carboxymethylcelulose had been influenced the physical stability of suspension.
Pengaruh Penggunaan Aerosil Terhadap Disolusi Tablet Isoniazid (Inh) Cetak Langsung Syofyan Syofyan; Thika Dwi Lestari; Rieke Azhar
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (754.118 KB) | DOI: 10.52689/higea.v6i1.99

Abstract

The research about the effect of aerosil to the dissolution rate of isoniazid tablet with direct compression method has been done. Isoniazid tablets were made with different aerosil consentration in each formulas, that is 0.5%; 1%; 1.5%. Tablet evaluation were done by measuring drug loading assay and dissolution test using HCl 0.1 N. The assay was measured using spectrophotometer UV at 266.5nm; where obtained levels of isoniazid tablets in each formulas is 95.779% - 103.776%. The results of disolution test showed that every formulas reached the 80% of cumulatif persentage as follows, 98.671%; 98.441%; 98.327% at 45th minutes. The result concluded that the addition of execessive aerosil as lubricant can decreased tablet disintegration rate and dissolution rate.
Karakterisasi Kompleks Inklusi Ketokonazol-Β-Siklodekstrin Menggunakan Metode Co-Grinding Berdasarkan Variasi Mol Yeni Novita Sari; Syofyan Syofyan; Yella Matagi
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (609.286 KB) | DOI: 10.52689/higea.v7i2.122

Abstract

The research about characterization inclusion complex of ketoconazole-β-cyclodextrin with co-grinding method, with variations 1:1, 1:2,5 and 1:3 has been done. The formed inclusion complexes characterized by x-ray diffraction, IR spectrofotometer, scanning electron microscope and dissolution test. Dissolution test done based on Indonesian Pharmacopeia V Edition using apparatus type 2. The result of research showed that x-ray diphractogram was decreased the peak intensity and change crystalline form to amorphous form, while from IR spectrofotometer was a bit stretch compare with pure ketoconazole which indicate the formation of complex. Based on the results, concluded that the form of inclusion complex can increased dissolution rate from ketoconazole.
Pengetahuan dan Sikap tentang Obat pada Orangtua Siswa SD di Kota Padang Syofyan Syofyan; Hivzil Indra; Suryati Suryati; Almahdy Almahdy
Jurnal Sains Farmasi & Klinis Vol 5, No 3 (2018): J Sains Farm Klin 5(3), Desember 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.807 KB) | DOI: 10.25077/jsfk.5.3.212-217.2018

Abstract

Masalah keamanan obat pada anak seringkali diabaikan oleh orang tua. Anak masih dianggap sebagai pengguna pasif padahal anak sesuai dengan perkembangannya telah memiliki otonomi dalam penggunaan obat-obatannya sendiri. Untuk itu, anak perlu diberdayakan sesuai dengan pengetahuannya dibawah pengawasan orang tua. Penelitian ini bertujuan untuk melihat gambaran pengetahuan dan sikap orangtua tentang obat pada anak. Disain penelitian yang digunakan menggunakan disain studi kuantitatif dengan pendekatan cross sectional. Dari peneitian ini didapatkan bahwa pengetahuan orang tua siswa SD di kota Padang tentang obat dikategorikan sedang(69,20 %). Sedangkan sikap orang tua menunjukan sikap positif dengan persentase sikap positif (97,4%). Tidak adanya hubungan yang bermakna antara tingkat pengetahuan dan sikap  orang tua siswa SD di kota Padang. (P>0,05). Faktor yang mempengaruhi pengetahuan yaitu uhuamur, tempat tinggal, pekerjaan, pendidikan terakhir, dan tempat penyimpanan obat responden. Tidak adanya hubungan yang bermakna antara semua karakteristik terhadap sikap responden. Dapat disimpulkan bahwa perlu edukasi kepada orangtua agar dapat memberikan informasi tentang keamanan obat pada anak.