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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Farmasi Higea

Auzal Halim

Fakultas Farmasi Universitas Andalas

Author-ID : 3768770

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Articles

Profil Disolusi Parasetamol Mukoadhesif Menggunakan Kombinasi Polimer Natrium Karboksimetilselulosa dan Gom Arab Auzal Halim; Riri Hariyani; Maria Dona Octavia
Jurnal Farmasi Higea Vol 2, No 1 (2010)
Publisher : STIFARM Padang

Dissolution profiles of 4 formulas of paracetamol mucoadeshif formulas has been done. The test done by using pH 5,8 phosphate buffer as dissolution medium with rowing method, as stated in the Indonesian Pharmacopoeia IV edition. Paracetamol concentrations were measured by UV spectrophotometer at 243 nm. The average dissolution from each formula at 60 minutes are 10.1641%, 15.015%, 11.0631% and 11.8493% respectively. Adhesion test of some mucoadhesive granule adhesion test formulated by using Na-CMC single polymer and a combination of Na-CMC and gum arabic done bioadhesif in vitro assay using rabbit intestinal tissue. The result showed that the combination of Na-CMC polymer and gum Arabic can be used as a polymer bioadhesif because it shows results that meet the requirements of the test bioadhesif.

Profil Disolusi Parasetamol Mukoadhesif Menggunakan Kombinasi Polimer Hydroxy Propyl Metyl Celluloce (HPMC) dan Natrium Alginat Maria Dona Octavia; Novi Rini Novita; Auzal Halim
Jurnal Farmasi Higea Vol 2, No 2 (2010)
Publisher : STIFARM Padang

Research on the dissolution profile of paracetamol by using a combination of polymer mucoadhesive hydroxypropyl methylcelulloce (HPMC) and sodium alginate has been done. This study aimed to see the effect of the combination of polymer HPMC and Sodium Alginate on the dissolution profile of paracetamol mucoadhesive. in this study were made four formula granule containing 100 grams of acetaminophen as an active ingredient and combination of HPMC with sodium alginate with various concentrations: 50 grams of sodium alginate (F1), 40 grams of sodium alginate and 10 grams of HPMC (F2), 30 grams of sodium alginate and 20 grams of HPMC (F3) and 50 grams of HPMC (F4), where Avicel PH 102 is used as a filler. The resulting granules are evaluated which include : content level, dissolution profile and test bioadhesif granules. Dissolution profiles performed by the method of rowing in the 900 mL medium of pH 5.8 buffer fosphat, 37±0.5°C and a speed of 50 rotation/min. The measurement results at minute 60 shows that the average granule dissolution F1, F2, F3 and F4 are 8.8341%, 9.2838%, 12.9828% and 17.2589% respectively. The Conclusion is the combination of paracetamol mucoadhesive polymers HPMC with sodium alginate showed an influence on the dissolution profile of paracetamol, where F1 formula shows the best dissolution profiles among the other four formulas.

Uji Disolusi Beberapa Tablet Parasetamol yang Ada di Perdagangan Maria Dona Octavia; Resita Sandra; Auzal Halim
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

The dissolution test four generic tablets and one branded name of parasetamol tablets has been undertaken. Method applied was in the paddle method as required by Pharmacopea of Indonesian ed. IV. Paracetamol concentration measured spectrophotometrically at maximum wave length of 243 nm in dissolution medium pH 5.8 phosphate buffer solution. The result dissolution test to comply with tolerance is not less than 80% of the labeled amount of paracetamol is dissolved in tweenty minutes. The dissolution about drown from the plot between percentage of paracetamol dissolved versus time.The percentage of paracetamol dissolved at T30 analyzed by using ANOVA test. Result showed in the dissolution rates between generic 1,2,3,4 and branded name were significant different take. Then continued to DUNNET test , only generic 2 tablets was not significantly difference whereas the other generic tablets were significant differences.

Pengaruh Bahan Pelincir terhadap Sifat-Sifat Tablet Parasetamol Sistem Dispersi Padat dengan PEG 6000 Maria Dona Octavia; Yuliana Yuliana; Auzal Halim
Jurnal Farmasi Higea Vol 1, No 2 (2009)
Publisher : STIFARM Padang

A research has been performed on the effect of lubricant to a solid dispersion system of paracetamol tablet with polyetilenglicol 6000, the solid dispersion system of paracetamol-polyetilenglicol 6000 is prepared through the dissolution method with 7 : 3 comparison. Then physiochemical characteristics and dissolution profile evalution is ferformed to three lubricant materials, which is aerosol, stearate magnesium, and talcum.

Tingkat Kepatuhan Penggunaan Obat pada Pasien Tuberkulosis di Rumah Sakit Mayjen H. A Thalib Kabupaten Kerinci. Puspa Pameswari; Auzal Halim; Lisa Yustika
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Kepatuhan pasien dalam mengkonsumsi obat secara teratur sampai tuntas merupakan salah satu faktor yang menentukan keberhasilan dalam pengobatan tuberkulosis paru. Penelitian ini bertujuan untuk mengetahui Tingkat Kepatuhan Pemakaian Obat pada Pasien Penderita TB paru di Rumah Sakit Mayjen H.A Thalib Kabupaten Kerinci, pada bulan April–Juni 2015. Penelitian ini termasuk penelitian observasional (non eksperimental). Pengambilan data menggunakan kuisioner yang dibuat berdasarkan MMAS (Morisky Medication Adherence Scale) dan CSA (Continous Single-Interval Medication Avaibility). Hasil penelitian menunjukkan sebanyak 55,56% responden patuh; 33,33% responden cukup patuh dan 11,11% responden tidak patuh dalam pengunaan obat.

Karakterisasi Fisikokimia Sistem Biner Siprofloksasin HCl – PEG 4000 Resva Meinisasti; Auzal Halim; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

"Physicochemical Characterization of Binary Systems Ciprofloxacin HCl - PEG 4000" has been reseach. This study aimed to characterize ciprofloxacin HCl formula that was developed to 9, with a comparison between ciprofloxacin - PEG 4000 following formula I (1: 9), formula II (2: 8), formula III (3: 7), formula IV (4: 6), formula V (5: 5), formula VI (6: 4), formula VII (7: 3), formula VIII (8: 2) and formula IX (9: 1). Binary system made by the manufacture of solid dispersion by melting method. The results of the binary System were characterized by analysis Differential Thermal Analysis (DTA), X-ray diffraction, IR spectrophotometry, and Scanning Electron Microscope (SEM). The results of this analysis have results of the binary solid dispersion systems a good formula this VII.

Efektivitas Sistem Penghantaran Liposom pada Katekin Sebagai Antioksidan Verawaty Verawaty; Auzal Halim; Febriyenti Febriyenti
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

A study on the effectiveness of liposome delivery system of catechin as an antioxidant has been done. Liposome was derived from phosphatidylcholine of egg and cholesterol. The method used to prepared liposome in this research was thin layer hydration method by using rotary evaporator. Liposome was made in 3 formulas with different comparison between phosphatidylcholine and cholesterol. The first formula with ratio of 1:1; second formula with ratio of 1:2 and third formula with a ratio of 2:1. The result found that the observation with SEM seen sperical liposome and some oval liposomes. The level of entrapment efficiency (%EP) obtained on Formula I, II, and III were 24.49%, 24.67%, and 20.06%, respectively. We can conclude that the increase of cholesterol will increase the efficiency of drug entrapment. Test of the effectiveness of antioxidant found formula II was better than formula I and formula III. It can be concluded that the increase of cholesterol was able to improve the formulation and stability of liposome.

Co-Authors Erizal Zaini Lisa Yustika Maria Dona Octavia Novi Rini Novita Pameswari, Puspa Resita Sandra Resva Meinisasti Riri Hariyani Verawaty Verawaty Yuliana Yuliana

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