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All Journal The Journal of Experimental Life Sciences (JELS) Journal of Indonesian Tourism and Development Studies
Maic Audo Lin Sihombing
Brawijaya University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Environmental Science Immunology & microbiology Medicine & Pharmacology Neuroscience Social Sciences

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Spatial Diversity in Composition and Structure of Nekton in Ngenep Spring and its Channels, Karangploso - Malang Hapsari, Lia; Sihombing, Maic Audo Lin; Rohie, Ade Meylisa Crystel; Retnaningdyah, Catur
Journal of Indonesian Tourism and Development Studies Vol. 2 No. 2 (2014)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitode.2014.002.02.04

Abstract

Water springs and its channel degradation due to anthropogenic pollution may alter the community structure of aquatic organisms. Water spring degradation therefore affect the quality of water as tourism resources. This study aims to investigate the changes in community structure of nekton and determine the relationships between water quality characteristics to the diversity of nekton. The field survey was set up in Ngenep spring and its channels. Results showed that nekton species found in Ngenep spring and its channels consists of 4 classes, 4 orders, 6 families, and 7 species with total 627 nekton samples. It is comprises of fishes, shrimp, frogs and waterstriders. Nekton diversity index (H') in the spring and irrigation channel were in moderate level (1<H'<3) while in settlement channel was low (0,67). Evenness values of nekton ranged 0,24 - 0,53, whereas dominancy index of nekton ranged 0,41 - 0,74. Evenness value in settlement channel was very low (0, 24) with high dominancy index (0, 74); it indicates that nekton species were spread not evenly in the channel, it dominated by fish Rasbora sp. (highest IVI, 184,95). There were spatial variations of physico-chemical water qualitiy parameters in Ngenep springs and its channels (temperature, stream velocity, turbidity, conductivity, pH, DO, BOD and TOM) which affected to nekton diversity and community structure. Clustering analyses and PCA result shows correlation pattern between nekton distribution with physico-chemical water quality parameters. However, physico-chemical water quality parameters in Ngenep springs and its channel were still optimum as nekton habitat (PP No. 82/ 2001). Keywords: Community structure, Nekton, Spatial diversity, Spring, Water channel
EMSA Eritin Blocks Nuclear Factor-Kappa B in Diabetes Mellitus Mice Model Sihombing, Maic Audo Lin; Sumitro, Sutiman B.; Rifa'i, Muhaimin
The Journal of Experimental Life Science Vol. 5 No. 1 (2015)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1025.231 KB) | DOI: 10.21776/ub.jels.2015.005.01.05

Abstract

Diabetes mellitus is one of the common metabolic disorders with increasing prevalence during recent years with hyperglycemia as its characteristic. DM has been shown to be a state of free radicals over production resulted from hyperglycemia that can activate cellular signaling pathways transcription of factor NF-κB which stimulates the production of several inflammatory mediators andl lead to chronic inflammation. Chronic inflammation is implicated in β-cell damage and function and promotes apoptosis. EMSA Eritin is a polyherbal consisting of soy bean extracts, coconut water extract and red rice extract that assumed to be antidiabetic and anti-inflammatory. This study will assess the effectiveness of EMSA Eritin against inflammation in diabetes mellitus by measuring levels of NF-κB produced by immunocompetent cells in DM mice model. Streptozotocin 100 mg.kg-1 BW is used to induce diabetes mellitus in mice. Oral administration of EMSA Eritin was given for 14 days with dose of 0.3125 mg.g-1 BW, 3.125 mg.g-1 BW and 31.25 mg.g-1 BW. Data were analyzed using One-way ANOVA (p<0.05) and Duncan test using SPSS 16.0 for Windows. The results showed that EMSA Eritin can be used as an alternative therapy for the treatment of DM. The level of NF-κB in diabetic mice significantly decreased when the mice received EMSA Eritin. Keywords: Diabetes Mellitus, EMSA Eritin, NF-κB, ROS
Co-Authors Ade Meylisa Crystel Rohie Catur Retnaningdyah Lia Hapsari Rifa'i, Muhaimin Sutiman B. Sumitro