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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Menara Ilmu
Hilmarni Hilmarni
Akademi Farmasi Imam Bonjol Bukittinggi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Kajian Toksisitas Serbuk Biji Mahoni terhadap Perkembangan Tingkah Laku, Histologi Hati serta Hematologi Anak Mencit Hilmarni Hilmarni; Almahdy Almahdy; Helmi Arifin
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1172.138 KB) | DOI: 10.29208/jsfk.2015.2.1.49

Abstract

This study aims to determine the effect of seed powder mahogany (Swietenia macrophylla King) on the development of behavior, liver histology and hematology of pups mice. Experimental animals used were 45 female mice were divided randomly into 5 groups. Group 1 as a control group. Groups 2, 3, 4, and 5, respectively mahogany seed powder given at a dose of 5, 10, 15, and 20 mg/20g/day from fetal life until lactation is completed. Developmental toxicity test carried out by behavioral test battery, observation of histology and hematology profile. The results showed that the provision of mahogany seed powder causes abnormal in the conduct reflex test and motor test on post natal day of 8 and 10, as well as the vision test on post natal day of 14-18. While the observation of liver histology and hematology profile did not show any effect.
Formulasi Sediaan Gel Ekstrak Etanol Daun Torbangun (Plectranthus Amboinicus (Lour. Spreng) Dengan Penambahan Minyak Zaitun (Olea Europaea) Hilmarni Hilmarni; Irma Rizkita Azzahra; Mega Yulia
Menara Ilmu : Jurnal Penelitian dan Kajian Ilmiah Vol 17, No 2 (2023): Vol 17 No. 02 JULI 2023
Publisher : LPPM Universitas Muhammadiyah Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/mi.v17i2.3927

Abstract

Daun torbangun (Plectranthus amboinicus (Lour. Spreng) merupakan salah satu tanaman yang memiliki banyak manfaat dan khasiat, salah satunya memiliki aktivitas antibakteri dan antiinflamasi. Kandungan senyawa dalam daun Torbangun yaitu flavonoid, saponin, fenolik, terpenoid dan minyak atsiri. Penelitian ini bertujuan untuk membuat formula gel ekstrak etanol daun Torbangun dengan penambahan minyak zaitun (Olea europaea). Ekstrak diformulasikan dalam bentuk gel dengan variasi konsentrasi basis Carbopol-940 0,5%, 0,75%, 1%. Evaluasi sediaan meliputi pemeriksaan organoleptis seperti bau, warna, bentuk, pemeriksaan homogenitas, pengujian daya sebar, pengukuran pH dan uji iritasi. Hasil penelitian menunjukkan bahwa sediaan gel ekstrak etanol daun Torbangun dengan basis carbopol-940 dengan konsentrasi 0,75% memenuhi evaluasi karakteristik fisik sediaan gel meliputi pemeriksaan organoleptis, pemeriksaan homogenitas, pengujian daya sebar, pengukuran pH dan uji iritasi.
Co-Authors Almahdy Almahdy Helmi Arifin Irma Rizkita Azzahra Mega Yulia