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Helmi Arifin
Universitas Andalas
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Faktor - Faktor Yang Mempengaruhi Kepatuhan Pasien HIV/AIDS di Poliklinik Khusus Rawat Jalan Bagian Penyakit Dalam RSUP dr. M. Djamil Padang Periode Desember 2011- Maret 2012 Martoni, Wildra; Arifin, Helmi; Raveinal, Raveinal
Jurnal Farmasi Andalas Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Andalas

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Abstract

AIDS adalah penyakit yang disebabkan oleh infeksi dengan virus yang disebut Human Immunodeviciency Virus (HIV). Salah satu langkah penting menanggulangi HIV/AIDS adalah dengan meningkatkan kepatuhan ODHA yang minum obat ARV. Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor yang mempengaruhi kepatuhan pasien HIV/AIDS terhadap terapi antiretroviral di Rumah Sakit Umum Pusat Dr. M. Djamil Padang pada bulan Desember 2011-Maret 2012. Design penelitian ini adalah cross-sectional dengan 55 orang sampel yang diperoleh secara Propotional Random sampling. Data penelitian diperoleh melalui kuisioner dan wawancara langsung terhadap pasien. Analisis data dilakukan secara bertahap mencakup analisis univariat, analisis bivariat menggunakan uji chi-square, dan analisis multivariat menggunakan uji regresi logistik berganda metode Backward Wald pada pogram SPSS Version 15.0. Hasil penelitian ini menginformasikan bahwa ada tiga variabel yang paling signifikan terhadap kepatuhan pasien HIV/AIDS, dengan faktor pengetahuan pasien menjadi faktor paling dominan (Wald = 6,833 ; OR = 9,003; Cl 95% = 1,733 - 46,770), dibandingkan dua faktor lain yaitu tingkat pendidikan (Wald = 4,369 ; OR = 6,732; Cl 95% = 1,126 – 40,238) dan Beck Deppresion Inventory (BDI) (Wald = 5,491 ; OR = 7,760; Cl 95% = 1,398 – 43,069).
EFEK EKSTRAK ETANOL BIJI PINANG MUDA (Areca catechu L.) TERHADAP AKTIFITAS SISTEM SARAF PUSAT MENCIT PUTIH Arifin, Helmi; Riyono, Heppy; Elka, Elka
Jurnal Sains dan Teknologi Farmasi Vol 15, No 1 (2010)
Publisher : Universitas Andalas

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Abstract

The central nervous system stimulant activity of the ethanol extract of young areca nut (Areca catechu L.) has been studied on mice. The observation was done by assessing the indurance, motor activity, curiousity, sleeping induced time and sleeping time in many variable of doses. Results showed that the ethanolic extract of 500 mg/ Kg bodyweight dose showed significant effect (P<0,05).
UJI PREKLINIS VIRGIN COCONUT OIL TERHADAP PENINGKATAN KADAR KOLESTEROL BAIK HDL, PENURUNAN KADAR TRIGLISERIDA, PROFIL KIMIA ASAM LEMAK (C6-C18) DAN OMEGA-3 PADA SERUM DARAH TIKUS PUTIH (Mus musculus) Syukur, Sumaryati; Dahlyanti, Rina; Sumanti, Titi; Murni, Yulia; Hidayat, Zoni; Arifin, Helmi; Purwati, Endang; -, Risfaheri
Jurnal Riset Kimia Vol 1, No 1 (2007): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v1i1.79

Abstract

 ABSTRACT The Virgin Coconut Oil (VCO) products have different qualities and controversy effects of lipids metabolism. This research has been used one of VCO product that was produced by fermentation method using Lactobacillus sp. It has high amount of lauric acid (C12) up to 51 %, caprilic acid (C8) 8.9 %, capric acid (C10) 7 % include Omega-3, 6 and 9, vitamins A, D, E, K and three kinds of phytohormone. The ratio of Omega-3 and 6 was very proportional, therefore it is important to investigate the Pre Clinic Test of animal experiment. Pre Clinic Test of dietary VCO as food supplement has been determined by using 40 mice’s, which divided into 4 groups. Feeding on egg yolk to Group I (negative control), Group II (positive control) increased cholesterol level. The others were Group III (egg yolk and VCO 2 %) and group IV (egg yolk and VCO 4 %). It was determined the total of cholesterol, HDL at 10th, 20th and 30th day treated by using the enzymatic methods. The dietary of VCO 2-4 % resulted in significant increases in HDL levels from 32 % to 69 %. The dietary of VCO 4 % for four weeks did not toxic to mice metabolism. Triglycerides level decreased 50 % from 177 to 85 and similar resulted to cholesterol ratio. Feeding on VCO for 4 weeks, the SCFA and MCFA not detected in serum of mice. The LCFA (C16) palmitate in significant decreased from 0.96 to 0.1%. The significant level of Omega-3 increased more than three times in serum of mice dietary VCO 2-4 %.  Keywords: Coconut Oil, Lactobacillus
Pengaruh Air Perasan Bengkuang (Pachyrhizus Erosus (L.) Urb.) Terhadap Kadar Gula Darah Mencit Putih Jantan Diabetes Arifin, Helmi; Merry C, Ann; Ahmad, Asram
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Telah dilakukan penelitian tentang air perasan umbi bengkuang (Pachyrhizus erosus (L.) Urb.) terhadap kadar gula darah mencit putih jantan diabetes yang diinduksi dengan aloksan dosis 200 mg/kg BB. Air perasan umbi bengkuang diberikan secara oral dengan dosis 10, 20 dan 30 ml/kg BB selama 21 hari. Parameter yang diukur adalah kadar glukosa darah, berat badan, volume air minum, dan volume urin. Hasil penelitian menunjukkan bahwa air perasan umbi bengkuang dengan dosis 30 ml/kg BB mampu menurunkan kadar glukosa darah mencit diabetes secara bermakna (P<0.05). Air perasan umbi bengkuang juga dapat memperbaiki konsumsi air minum, tetapi tidak dapat memperbaiki berat badan dan volume urin mencit diabetes.
Analisa Drug Related Problems pada Pasien Hiperurisemia di Bangsal Rawat Inap dan Rawat Jalan Penyakit dalam RSUP Dr. M. Djamil Padang Anjelin, Ririn; Arifin, Helmi; Raveinal, Raveinal; Darwin, Deswinar
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

This research was a prospective observational study using descriptive cross sectional approach and performed at all patients of hyperuricemia with or without accompanying diseases at Interne Ward and Polyclinic DR. M. Djamil Hospital Padang during Maret to May 2011, by census. The data obtained were analyzed using descriptive analysis method. Results showed that type of DRPs frequently occured at 110 patients with hyperuricemia with/without  accompanying diseases at Interne polyclinic was drug interactions of pharmacokinetic and pharmacodynamic at 36 patients. Adverse drug reaction 9 patients, non-compliance of patients 5 patients. Drug terapy without medical indication, lower and higher dose, inappropriate drug selection, inappropriate drug administration interval were had no problems. At the Interne Ward from 7 patients, the DRPs frequentlyy occured were drug interactions (3 patients), higher drug dose (2 patients), adverse drug reactions (2 patients), patient non-compliance (2 patients), inappropriate drug administration interval (1 patient), drug therapy without medical indication (1 patient), and other DRPs had no problems. There was non toxic drug interactions or adverse drug reactions was found during this study.
Kajian Toksisitas Ekstrak Tumbuhan Talinum triangulare (Jacq) Willd. Rustam, Erlina; Masri, Machdawaty; Arifin, Helmi
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Toxicity studies have been conducted from plant extracts of Talinum triangulare (Jacq) Willd. on male white mice. Toxic effects were observed in the form of liver dysfunction and renal dysfunction of experimental animals that were given orally by the variation extract dose of 150, 300 and 600 mg / kg once daily for 15, 30 and 45 days. As a control group used male white mice which were given only 2.5% Tween 80. Parameters to be measured are the activity of SGPT and SGOT, creatinine clearance, renal function and percentage ratio of kidney weight. From the results of studies it appears that administration of plant extract Talinum triangulare (Jacq) Willd. with a given dose affects liver function and kidney function were significantly (P <0.05)
Pengaruh Hasil Fraksinasi Ekstrak Etanol Daun Lado-lado (Litsea cubeba,Pers) Terhadap Kadar Asam Urat Serum Darah Mencit Putih Jantan Tinggi Asam Urat P, Rizky Yulion; Suhatri, Suhatri; Arifin, Helmi
Jurnal Sains dan Teknologi Farmasi Vol 19 No Supl1 (2017): Vol 19 Supplement 1, December 2017
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Asam urat merupakan produk akhir metabolisme purin pada manusia dan ketidakseimbangan kadar asam urat di dalam darah menjadi pencetus hiperurisemia. Insiden dan prevalensinya cukup tinggi di Indonesia. Dalam penelitian ini sudah dilakukan untuk mengkaji pengaruh pemberian hasil fraksinasi daun lado-lado (Litsea cubeba,Pers) terhadap kadar asam urat dalam serum darah mencit putih jantan hiperurisemia. Penyarian simplisia dilakukan dengan etanol 70% dan fraksinasi ekstrak dilakukan dengan menggunakan pelarut heksan, etil asetat dan air. Peningkatan kadar asam urat pada hewan diinduksi dengan Potasium oksonat 250 mg/kgBB dan jus kacang panjang 0,5 mL/20gramBB. Pada uji pendahuluan, hasil fraksinasi diberikan secara oral selama seminggu dengan dosis 25 mg/kgBB. Kelompok yang memberikan penurunan kadar asam urat tertinggi diuji lagi dengan memvariasikan dosis fraksi terpilih 12,5 mg/kgBB, 25 mg/kgBB dan 50 mg/kgBB yang diberikan secara oral selama 7, 14 dan 21 hari. Hasil penelitian menunjukan bahwa kelompok yang memberikan penurunan kadar asam urat serum tertinggi adalah fraksi etil asetat. Terlihat peningkatan yang nyata (P ≤0.05). Pemberian dosis 50 mg/kgBB dengan lama pemberian 7 hari memberikan hasil terbaik (P ≤0.05) pada kelompok mencit hiperurisemia.
Pengaruh Pemberian Jus Buah Naga Hylocereus Undatus (Haw.) Britt&Rose Terhadap Jumlah Hemoglobin, Eritrosit dan Hematokrit pada Mencit Putih Betina Arifin, Helmi; Nofiza, Welli; Elisma, Elisma
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Sub-acute toxicity test of dragon fruit juice has been research Hylocereus undatus (Haw.) Britt. & Rose of with  hematological  parameters to female white mice. Juice given orally by 0,5 mL/20 g of  weight dose with variation are 100%, 50% and 25%, once a day along 7, 14 and 21 days. A female white mice were only given food and water used as comparison. Calculated and measured parameters are levels of hemoglobin, erythrocytes and hematocrit, using tools haemometer Sahli, haemositometer and centrifuge. Results  that given dose of dragon fruit juice Hylocereus undatus (Haw.) Britt. & Rose has been provided the effect to increased hemoglobin and erythrocytes level (p < 0,05), but did not raised the hematocrit level (p > 0,05).
Analisa Drug Related Problems pada Pasien Dislipidemia di Bangsal Rawat Inap dan Rawat Jalan Penyakit dalam RSUP Dr. M. Djamil Padang Arsil, Yuliana; Arifin, Helmi; Darwin, Deswinar; Raveinal, Raveinal
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Dyslipidemia is an abnormality of lipid metabolism, which is characterized by elevated or reduced plasma lipid fractions. Dyslipidemia is a major risk factor of cardiovascular disease. An Improve of lipid profile may reduce the risk of cardiovascular disease. This research was conducted to determine the Drug Related Problems (DRPs) occured in patients with dyslipidemia. This research was a prospective observational study using descriptive cross sectional approach, performed on dyslipidemia patients with or without comorbidities in outpatient and inpatient of Internal Medicine DR. M. Djamil Padang from March to May 2011. Evaluation of the data was carried outdescriptively. Results showed that type of DRPs occurred from 11 dyslipidemia patients with or without comorbidities on inpatient of Internal Medicine were drug interactions in 4 patients, adverse drug reactions in 2 patients, noncompliance in 2 patients, dosage too high in 1 patient, inappropriate drug administration interval in 1 patient while other components of DRPs had no problem. In the outpatient of Internal Medicine, DRPs occured at 98 patients of dyslipidemia with or without accompanying diseases were drug interactions in 26 patients, patient noncompliance in 22 patients, adverse drug reactions in 13 patients, dosage too low in 5 patients, drug therapy without medical indications in 4 patients, inappropriate drug administration interval in 3 patients while other components DRPs had no problem. Drug interactions consisted of pharmacokinetic and pharmacodynamic interactions. In practice, those can be accommodates by separating their administration and monitoring of drug interaction. Meanwhile, toxic drug interactions were not found.
Pengaruh Pemberian Jus Jambu Biji Merah (Psidiumguajava L.) Terhadap Jumlah Sel Eritrosit, Hemoglobin, Trombosit dan Hematokrit pada Mencit Putih Arifin, Helmi; Agustina, Agustina; Rizal, Zet
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Evaluation of the effect of red guava juice (Psidiumguajava, L.) on hematology parameters (red blood cell, hemoglobin, thrombocyts, and hematocrit) to female white mice has been done. The juice was administered orally with variation of doses at 25, 50 and 100 % one times a day for 7, 14, and 21 days respectively. As a control group was female white mice administered aquadest.  Results showed that administration of guava juice with a variation of dose did not influence red blood cell counts, hemoglobin and hematocrit, but increased thrombocytes  levels.
Co-Authors -, Risfaheri ., Nirwanto Agustini, Tiara Tri Akmal M. Hanif Almahdy Almahdy Ariadi, Aried Aried Ariadi Aried Eriadi Arina Widya Murni Asram Ahmad Barmitoni Barmitoni Benny Benny Bobbi Hemriyantton Candra Syuryani Dahlyanti, Rina Delladari Mayefis Deni Kurniati Deswinar Darwin Dewi Eka Putri Dian Ayu Juwita Diana Idrifa Dwisari Dillasamola Eddy Duarto Elisma Elisma Elisma Elisma Elka Elka Ella Handalia Endang Purwati RN Erlina Rustam Fajrian Aulia Putra Fathul Jannah Feni Efrianti Fitri Maya Sari Gina Sonia Harto H. Havizur Rahman Havizur Rahman Hengki Afdhal Henny Lucida Heppy Riyono Hesti Effendi Hidayat, Zoni Hidayati Hidayati Hilmarni Hilmarni Ifora Ifora Ira Oktaviani Rz Jaka Perdana Leli Sriyani Machdawaty Masri Masitah Masitah Menkher Manjas Meri Andani Meri Susilawati Merry C, Ann Murni, Yulia Nasrul Zubir Nela Andriani Nelfa Yulianti Nelwati, Nelwati Netty Suharti Nirwanto . Nirwanto Nirwanto Nofiza, Welli Novi Priyoka Putra Novika Maulina Octy Aisyahharma Rahimatul Uthia Rahimatul Uthia Rahman, Havizur Rahmi Yosmar Rahmi Yulia Nesia Randika Fransiska RAVEINAL RAVEINAL Raveinal Raveinal Raveinal Raveinal Rella Silvia Reni Trevia Ria Irawati Rina Dahlyanti Ririn Anjelin Risfaheri - Rizky Yulion Rosa Julia Wijaya Rostin Rostin Rusdi Rusdi Rusdi Saputra, Harry Saputra, Harry Satrina Chania Sinata, Novia Solly Aryza Sri Ana Setianingsih Sri Oktavia Sri Oktavia Suci Ahda Novitri Suhatri Suhatri Sumanti, Titi Sumaryati Syukur Surya Dharma Susi Handayani Tesa Inmerka Alwi Titi Sumanti Vivi Resviana Wesnawati, Wesnawati Widya Kardela Wildra Martoni Yulia Murni Yuliana Arsil Yuni Andriani Zet Rizal Zet Rizal ZK Abdurahman Baizal Zoni Hidayat