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All Journal Jurnal Ilmiah Farmasi MPI (Media Pharmaceutica Indonesiana) Majalah Farmasetika
Siti Zahliyatul Munawiroh
Jurusan Farmasi, Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta
Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Optimasi Formulasi Nanoemulsi Minyak Biji Anggur Energi Tinggi dengan Box Behnken Design (BBD) Siti Zahliyatul Munawiroh; Fatimah Siyam Handayani; Bambang H Nugroh
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25864

Abstract

Pembuatan emulsi dengan energi rendah membutuhkan surfaktan dalam jumlah besar. Pembuatan nanoemulsi dengan energi tinggi dapat mengurangi jumlah surfaktan dalam pembuatan nanoemulsi yang stabil. Penelitian ini bertujuan untuk melakukan optimasi formulasi  nanoemulsi minyak bijij anggur dengan energi tinggi menggunakan Box Behnken Design (BBD). Variabel bebas yang digunakan adalah persentase Smix (X1), waktu sonikasi (X2), dan pulsar rate (X3). Variabel respon (dependen) adalah ukuran partikel (Y1), indeks polidispersitas (PDI) (Y2) dan potensial zeta (Y3). Eksperimen data yang diperoleh dianalisis dengan analisis ANOVA menunjukkan model yang signifikan untuk respon ukuran partikel mengikuti model kuadratik. Verifikasi antara prediksi dan pengamatan pada 3 respon (Y1, Y2 dan Y3) di 3 formula optimal yang diperoleh, menunjukkan nilai bias (%) kurang dari 10%. Formula optimal terpilih mempunyai karakteristik ukuran partikel yang kecil < 100 nm (77,8±11,4 nm), nilai PDI yang kecil <0,7 (0,474±0,14) dan memiliki nilai zeta potensial yang besar >±30mV (-54,7±2,31 mV). Sehingga dapat disimpulkan bahwa Box Behnken Design (BBD) dapat digunakan untuk optimasi nanoemulsi minyak biji anggur dengan energi tinggi.
PENGARUH PEMBERIAN PENTAGAMAVUNON-0 PADA AKTIVITAS GLUTATION-S-TRANSFERASE PADA HATI TIKUS SECARA IN VIVO Sudibyo Martono; Supardjan Amin M; Siti Zahliyatul Munawiroh
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTGlutathione S-transferase is amount of enzymes catalyze conjugation reac-tion of glutathione(GSH) with electrofilic endogen compound or electrofilic xenobiotic. At the particular cancer there isincreasing GST, especially on mu and phi class that it cause therapy on cancer cell by citostaticdrug (commonly as electrofilic compound) not effectively. Pentagamavunon-0 (PGV-0) is antiinflammationcompound. Base on in vivo research denoted this compound has five timesstrengthened than curcumin to inhibit GST enzyme activity. But using PGV-0 by in vivo to GSTactivity never report or publish yet.This research was done by measuring isolated GST enzyme activity from rat liver was given invivo PGV-0, with nine groups treatment. Each group consist of control group without treatment,control group CMC-Na 0.5 % per oral and intraperitoneal DMSO, group with doses treatment ofPGV-0 20, 40, 80 and 160 mg/Kg BB per oral, rat group was given benzo(a)pirene (BP) 1 mg/KgBB i.p. and group was given BP 1 mg/Kg BB i. p. and PGV-0 80 mg/Kg BB per oral. GST enzymeactivity is measured from reaction of conjugate GSH and DCNB that it’s absorption/minute. Base onrate (absorption/minute) GST enzyme activity can be accounted. Then inhibition percentage can beaccounted from each rat treatment compared with control without treatment and solvent control.Analyze use statistic test (Kruskal-Wallis then continued by Mann-Whitney test), to know specificdifferent of GST class mu enzyme activity in rat liver at each treatments group.Result research denoted that PGV-0 give inhibition effect to GST class mu activity of rat liver byin vivo. Doses level did not give proportional result to GST class mu activity of rat liver. Doses levelof PGV-0 give optimum result to GST class mu activity of rat liver inhibition at 80 mg/Kg BB withinhibition value 19,99 % compared with CMC-Na as solvent.Key word: pentagamavunon-0, in vivo, glutathione S-transferase, inhibition
Optimasi formulasi nanoemulsi minyak biji anggur energi rendah dengan d-optimal mixture design (DMD) Fatimah Siyam Handayani; Bambang H. Nugroho; Siti Zahliyatul Munawiroh
Jurnal Ilmiah Farmasi Vol. 14 No. 1 (2018): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol14.iss1.art03

Abstract

IntisariPembuatan nanoemulsi dengan  energi rendah adalah metode yang efektif dalam pembentukan tetesan emulsi yang berukuran nano. Komposisi dan rasio setiap fase memainkan peran penting dalam pembentukan nanoemulsi dengan energi rendah. Penelitian ini bertujuan untuk mengoptimalkan, merumuskan dan mengevaluasi nanoemulsi energi rendah menggunakan D-Optimal Mixture Design (DMD). Variabel bebas yang digunakan adalah minyak biji anggur sebagai fasa minyak (X1) dan Tween 80: PEG (X2) sebagai surfaktan-cosurfaktan (campuran S) dan air sebagai fasa air (X3). Variabel respon (dependen) adalah ukuran partikel (Y1), indeks polidispersitas (PDI) (Y2) dan potensial zeta (Y3). Nanemulsi berenergi rendah disiapkan menggunakan teknik Phase Inversion Composition (PIC). Eksperimen data yang diperoleh dianalisis dengan analisis ANOVA menunjukkan model yang signifikan untuk respon ukuran partikel mengikuti model kuadratik. Tiga formula optimal diperoleh dan dilakukan verifikasi antara prediksi dan pengamatan pada 3 respon (Y1, Y2 dan Y3) menunjukkan nilai bias (%) kurang dari 10%. Nanemulsi energi rendah dari minyak biji anggur dapat dioptimalkan menggunakan D-Optimal Design (DMD) dan disiapkan menggunakan teknik Phase Inversion Composition (PIC).
Pengembangan Formula Nanoemulsi Air dalam Minyak Biji Anggur (Vitis vinifera L.) sebagai Basis Lipstik Siti Zahliyatul Munawiroh; Agenilia Permatasari; Lutfi Chabib
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.1780

Abstract

The objective of this research is to develop water in grape seed oil nanoemulsions which prepared by low energy method to be used in lipstick base formulation. Water in grape seed oil nanoemulsions were prepared by low energy methods which was employed a Phase Inversion Composition (PIC) technique in elevated temperature at 80°C using mixed-surfactants (tween 20/span 80). In ternary phase diagram (oil:water:mixed-surfactants), the largest area of nanoemulsions was occurred in equal ratio tween 20:span 80 (1:1). The maximum water content of water in grape seed oil nanoemulsions was reached at 20% water with 60% mixed-surfactants (1:1). An unimodal size distribution of water in grape seed oil nanoemulsions with varied water content at 6, 10, and 14% were found with droplet size at 29.33 ± 5.30, 30.23 ± 7.33, and 29.83 ± 11.47 nm. Water content of water in grape seed oil nanoemulsions insignificantly affected to melting profile and hardness properties of lipstick. Water in grape seed oil nanoemulsions which was prepared by low energy can be developed as lipstick base formulation.
Co-Authors Agenilia Permatasari Bambang H Nugroh Bambang H. Nugroho Fatimah Siyam Handayani Fatimah Siyam Handayani Lutfi Chabib, Lutfi Sudibyo Martono Supardjan Amin M