Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Bandung Althea Medical Journal
Trully D. Sitorus
Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Medicine & Pharmacology

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Green Tea and its Effect on Hemostasis Measured by Thrombelastography Chua, Bryant Alyzandyr Eumhyn; Sitorus, Trully D.; Dalimoenthe, Nadjwa Zamalek
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.611 KB)

Abstract

Background: Increasing health problems may come from changes in lifestyle including stressful lifestyles, high calorie diets, and lack of physical activity. Those may also lead to an increase occurrence of abnormal hemostasis. Green tea has been well known for its many benefits, including its antithrombotic effect. The aim of this study was to determine whether the consumption of green tea actually affects hemostasis and to measure changes in hemostatic parameters after its consumption.Methods: A preliminary explorative study was conducted on 3 healthy female subjects aged between 21 to 22 years old for 8 weeks from October to November 2012 in Jatinangor, Sumedang, Indonesia. The subjects were subjected to initial thrombelastography analysis and started drinking green tea twice a day after meals. The solution was made by steeping a teabag in 250ml water of 70°C for 2 minutes. After 8 weeks, another thrombelastography analysis was performed to the subjects. Results: Pre- and post-intervention results of the analysis were averaged and compared according to the parameters. The results of this study showed prolonged R (Reaction-time) and K (K-time), decreased α (angle) and MA (Maximum Amplitude), and increased LY30 (lysis at 30 minutes), showing an overall reduction in coagulability. Conclusions: The consumption of green tea twice a day for 8 weeks affects hemostasis with hemostatic parameters measured by thrombelastography show differences before and after consumption.Keywords: Green tea, hemostasis, thrombelastographyDOI: 10.15850/amj.v2n1.426
The Teratogenic Effect of The Mindi (Melia azedarach L) Leaves Ethanol Extract on Mice (Mus musculus) Fetus Sutomo, Adisti Erlina; Sitorus, Trully D.; Pribadi, Adhi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.353 KB)

Abstract

Background: Mindi leaves (Melia azeradach L.) were used by Indonesians as a traditional medicine for pregnant women because it was considered to be safe. Mindi leaves contain several active compounds and one of them is suspected as a teratogen and can disrupt fetus growth in gestation. This research aims to know about the teratogenic effect of ethanol extract of Mindi leaves by using mice.Methods: This was a laboratory experimental study using 27 pregnant female mice (Mus musculus) of Swiss Webster strain which were randomly assigned to 3 groups (n=9) controlled (Carboxymethyl cellulose 1% for day 1–18 of pregnancy), group I (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 1–5 of pregnancy), and group II (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 6–18 of pregnancy). Observation was done to see total amount of fetus, live normal fetus count, length and weight of fetus, abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorbed fetus count. This research was done from October to November 2012 in Pharmacological laboratory of Faculty of Medicine Universitas Padjajdjaran. Data analysis utilized unpaired t-test.Results: The result showed a significant difference (p<0.05), seen from live normal fetus count and abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorpted fetus count. Conclusions: Administration of Mindi leaves extract during pregnancy of mices can cause teratogenic effect.[AMJ.2015;2(1):221–25]
Effect of Centella asiatica Leaves on Gastric Ulcer in Rats Mariska, Ester; Sitorus, Trully D.; Rachman, Januarsih A.
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1072.882 KB)

Abstract

  Background: Gastric ulcer is disruption of gastric mucosal integrity due to lack of smaller defensive factors (e.g. mucus levels) than gastric aggressive factors. Centella asiatica is a traditional medicine that contains triterpenoids and flavonoids. The objective of this study was to analyze the effect of ethanol extract of Centell aasiatica leaves for preventing gastric mucus level reduction of aspirin-induced gastric ulcer model in rats and compared it to misoprostol.Methods: An experimental laboratory study using 24 rats that were divided into 4 groups. Group I (negative control) received carboxymethy cellulose (CMC) solution, group II (positive control) received CMC and aspirin 450mg/kg, group III (tested group) received Centella asiatica 400 mg/kg and aspirin 450 mg/kg, group IV (compared group) received misoprostol 72μg/kg and aspirin 450mg/kg for three days. Then the rats were laparatomied and their gastric mucus levels were measured. The results were statistically analyzed by Independent T-test.Results: The mean levels of gastric mucus of group I, II, III, IV, respectively were 0.112; 0.035; 0.537; 0.455 optical densities per gram of tissue. The statistical test suggested a significant difference between the positive control group and tested group. Moreover there is no significant difference between the tested group and compared group.Conclusions: Centella asiatica leaves can prevent gastric mucus level reduction of aspirin-induced gastric ulcer model in rats and has similar effect in gastric mucus level with misoprostol.Keywords: Centella asiatica, gastric mucus, gastric ulcer, misoprostolDOI: 10.15850/amj.v2n1.444 
Efek Pemberian Niasin terhadap Glukosa Darah pada Tikus Wistar dengan Obesitas Hermawan, Robby; Sitorus, Trully D.; Sastramihardja, Herri S.
Majalah Kedokteran Bandung Vol 43, No 1
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Niasin memiliki kontroversi mengenai efeknya terhadap pengaturan glukosa darah. Penelitian bertujuan untuk mengetahui efek niasin terhadap kadar glukosa darah pada tikus Wistar dengan obesitas yang diinduksi diet. Penelitian ini merupakan penelitian eksperimental laboratorik dengan desain paralel yang menggunakan randomisasi di laboratorium Farmakologi Fakultas Kedokteran Unpad periode Juli 2008–Maret 2009. Penelitian dilakukan pada tikus jantan galur Wistar. Pertama, semua subjek penelitian diinduksi menjadi obesitas dengan diet tinggi lemak selama 10 minggu. Tikus yang memenuhi kriteria dibagi dalam dua kelompok secara acak. Kelompok pertama diberikan plasebo. Kelompok kedua diberikan niasin. Niasin dan plasebo diberikan selama 20 hari. Dosis niasin yang diberikan sebesar 0,135 mg/gBB/hari. Glukosa darah puasa (GDP) dan tes toleransi glukosa oral (TTGO) diukur pada hari ke-21. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan yang bermakna antara kelompok kontrol dan perlakuan baik pada GDP maupun TTGO. GDP kelompok niasin lebih rendah 4,0 mg/dL (IK95% -0,342–8,4) dibandingkan dengan kelompok kontrol, dengan p=0,068, sedangkan hasil TTGO kelompok niasin lebih tinggi 0,8 mg/dL (IK95% -5,6–7,1) dibandingkan dengan kelompok kontrol, dengan p=0,800. Disimpulkan pemberian niasin tidak menyebabkan perbedaan kadar GDP dan TTGO pada tikus jantan galur Wistar dengan obesitas yang diinduksi diet. [MKB. 2011;43(1):16–20].Kata kunci: Glukosa darah puasa, niasin, obesitas, tes toleransi glukosa oralThe Effect of Niacin to the Blood Glucose in Obese Wistar RatsNiacin has many controversies about its effect to the management of the blood glucose. The objective of the research was to know the effect of niacin to the blood glucose in obese wistar rats. This research was an experimental laboratory study with a parallel design using randomization. Male Wistar rats were used in this research. All rats were induced to be obesed with high-fat feeding for 10 weeks. Rats that fulfill the criteria were randomly divided into two groups. The first group was given the placebo. The second group was given the niacin. The niacin and the placebo were given for the next 20 days. The niacin dose was 0.135 mg/g body weight/day. Fasting blood glucose (FBG) and oral glucose tolerance test (OGTT) were taken on the 21st day. The results showed that there were not any significant differences in FBG and OGTT between control and treated group. The FBG of the niacin group was 4.0 mg/dL (95% CI -0.342–8.4) lower than the control group, with p=0.068. The OGTT result of the niacin group was 0.8 mg/dL (95% CI -5.6 –7.1) higher than the control group, with p=0.800. This study concludes that taking niacin does not cause differences in FBG and OGTT results in the male Wistar rats with diet induced obesity. [MKB. 2011;43(1):16–20].Key words: Fasting blood glucose, niacin, obesity, oral glucose tolerance test DOI: http://dx.doi.org/10.15395/mkb.v43n1.39
Co-Authors Adhi Pribadi Adisti Erlina Sutomo, Adisti Erlina Bryant Alyzandyr Eumhyn Chua, Bryant Alyzandyr Eumhyn Ester Mariska, Ester Herri S. Sastramihardja Januarsih A. Rachman, Januarsih A. Nadjwa Zamalek Dalimoenthe Robby Hermawan