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All Journal Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Ahmad Dahlan Medical Journal
Dyah Mustika Nugraheni
Universitas Muhammadiyah Semarang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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C-REACTIVE PROTEIN BERKORELASI TERHADAP KADAR D-DIMER PASIEN COVID-19 Lida Wati; Dyah Mustika Nugraheni; Kanti Ratnaningrum; Andra Novitasari
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 5, No 1 (2022): ILMU KEDOKTERAN
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v5i1.7166

Abstract

Latar belakang: Coronavirus Disease 2019 (COVID-19) merupakan penyakit menular yang ditimbulkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).Pada penderita COVID-19 berat sering dijumpai adanya gangguan koagulasi (koagulopati). Salah satu pemeriksaan penunjang untuk menilai keberlangsungan proses koagulasi pada penderita COVID-19 dengan mengadakan pemeriksaan D-dimer. Aktivasi trombosit dan proses inflamasi pada penderita COVID-19 sering dihubungkan dengan gangguan koagulasi. Salah satu pemeriksaan untuk mengetahui aktivasi trombosit dan proses inflamasi adalah jumlah trombosit dan C-reactive protein. Penelitian ini bertujuan membuktikan korelasi antara jumlah trombosit dan C-reactive protein dengan kadar D-dimer pada penderita COVID-19. Metode: Penelitian dilaksanakan di Rumah Sakit Roemani Muhammadiyah Semarang pada bulan Januari 2022. Desain penelitian cross sectional dan pengambilan sampel mengaplikasikan teknik consecutive sampling. Sampel merupakan penderita rawat inap terkonfirmasi positif COVID-19 melalui tes RT-PCR berusia 30-45 tahun. Data yang digunakan adalah jumlah trombosit, C-reactive protein, dan kadar D-dimer. Analisis bivariat menggunakan uji normalitas dilanjutkan dengan uji Rank Spearman.Hasil: Dari 56 sampel terdapat korelasi C-reactive protein dengan kadar D-dimer pada penderita COVID-19 (p=0,000; r=0,517) sedangkan tidak terdapat korelasi jumlah trombosit dengan kadar D-dimer pada penderita COVID-19 (p=0,59; r=0,145).Kesimpulan: Terdapat korelasi antara C-reactive Protein dengan kadar D-dimer pada penderita COVID-19 dan tidak terdapat korelasi antara jumlah trombosit dengan kadar D-dimer pada penderita COVID-19
Effects of Giving Kaffir Kaffir Extract ( Citrus hystrix ) on Blood Glucose Levels in Wistar Rats Ika Dyah Kurniati; Dyah Mustika Nugraheni; Mutiara Aura Kusuma
Ahmad Dahlan Medical Journal Vol. 3 No. 2 (2022): November 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dyslipidemia is associated with cardiovascular disease as well as hyperglycemia and insulin resistance. One of the natural ingredients for controlling dyslipidemia is kaffir lime peel ( Citrus hystrix ), which contains flavonoids and polyphenols that act as antioxidants and regulate blood glucose. This study aims to prove the effect of kaffir lime peel in lowering blood glucose levels. Methods : Post-test only controlled group design study , using 25 wistar rats divided into 5 groups, namely group (K-) without high-fat diet and extract (K+) was given a high-fat diet alone, (P1) was given kaffir lime peel extract at a dose of 35 mg/kg BW rats/day, (P2) was given extract at a dose of 70 mg/kg BW rats/day and (P3) was given extract at a dose of 140 mg. /kgBW rats/day. The intervention was given for 3 weeks and then blood glucose levels were measured using the GOD-PAP method. The data were analyzed using the Kruskal Wallis test and continued with the Mann-Whitney test. Results : The results showed a significant difference in the mean GDS levels between groups p=0.011 (p<0.05), Mann-Whitney test showed K(-) against P1 (ρ=0.009), K(-) against P2 (ρ=0.016) , K(-) to P3 (ρ=0.028), and P1 to P2 (ρ=0.028).
Co-Authors Andra Novitasari Ika Dyah Kurniati Kanti Ratnaningrum Lida Wati Mutiara Aura Kusuma