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Pengaruh Ekstrak Daun Annona muricata L. Terhadap Ekspresi Caspase 3 Pada Adenokarsinoma Mamma Mencit C3H Hikmah Fitriani; Ruri Eka Maryam; Tissa Octavira Permatasari
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 2, No 1 (2015): Tunas Medika Jurnal Kedokteran & Kesehatan
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Background :Treatment of breast cancer such as surgery, radiotherapy and chemotherapy still has a lot of sideeffects. This can be minimized by using herbal medicine such as Annona muricata L. which works selectively attacking cancer cells.Objective :The aim for this research was to determine effect of Annona muricata L. leaves extract on the caspase 3 expression on adenocarcinoma mammae in C3H mice.Methods : Animalexperiment using Post Test Only Control Group design was done. Twelve C3H mice were inoculted with tumour and were devided into two groups : Control (C) group and the other group was Treatment (T) group with Annona muricata L. leaves extract of dose 1 mg/day. All of the groups were treated for three weeks and then measuring caspase 3 expressi on. Mann Whitney test was conducted to analyze the data.Result : There were significant differences on the caspase 3 expression between control group compared with one group administrated with Annona muricata L. leaves extract of dose 1 mg/day respectively ( p = 0,004) between control group compared with one group administrated with Annona muricata L. leaves extract of dose 1 mg/day( p = 0,004). From the result, median of caspase 3 expression were increased with Control = 0,4 and Treatment = 1,36.Conclution :Annona muricata L. leaves extract can increase caspase 3 expressionKeywords:Annona muricata L. leaves extract, caspase 3, adenocarcinoma mammae
ANTENATAL CARE (ANC) VISIT FREQUENCY IN THE THIRD TRIMESTER AND PRETERM EVENTS IN PUSKESMAS PONDOH AND JUNTINYUAT IN INDRAMAYU REGENCY BETWEEN 2014-2016 Elinda Ameliana; Donny Nauphar; Ruri Eka Maryam
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: World Health Organization (WHO) estimates that 15 million babies are born preterm every year and this number continues to increase. Several risk factors for preterm are identified as mother’s lifestyle such as smoking, malnutrition, weight gain during pregnancy, and drug use or other factors such as socioeconomic status. In 2015, WHO reported more than 300.000 women died from pregnancy-related causes and 2.6 million babies were still born worldwide with half occurring during the third trimester. Antenatal Care (ANC) in the third semester aims to identify fetal position and identify complication during pregnancy and screen for pre-eclampsia, infection of the reproductive organs and urinary tract, and plan for delivery. The ANC in the third semester is crucial in keeping pregnant mother healthy throught pregnancy and delivery. Aim: To find out the relationship between third trimester Antenatal Care (ANC) visit frequency and preterm birth event at Puskesmas Pondoh and Juntinyuat in Indramayu regency between 2014-2016. Methods: This was observational analytic study with cross-sectional approach. The sampling technique in this research was done by total sampling with 100 respondens. Data were collected from maternal cohort book and control card of pregnant women. The data were analyzed using Chi-square test and Prevalence Ratio. Results: This study found that the proportion of pregnant mothers with insufficient third trimester ANC was 38% and the number of mothers delivering preterm baby was 32%. Statistical analysis showed that there was a statistical significance between third trimester ANC visit frequency and preterm labor with p=0,000 (p<0,05) and women with insufficient ANC visit have 40 times higher risk of preterm baby compared to mothers who has sufficient ANC visit (PR=40,60; CI95%=11.699-140.8862) in Puskesmas Pondoh and Juntinyuat Indramayu District 2014-2016. Conclusion: Having less than 4 ANC visit in the third trimester may increase the risk of delivering preterm babies. Pregnant women are advised to do ante natal care monthly of a minimum 4 times during the third trimester.