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Hikmah Fitriani
Fakultas Kedokteran Universitas Swadaya Gunung Jati
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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INFLUENCE OF GIVING BREADFRUIT (Artocarpus altilis (Park) Fosberg.) LEAVES EXTRACT TO DECREASE URIC ACID LEVELS IN WISTARS RATS HYPERURICEMIC Wibawa, Hagi; Fitriani, Hikmah; B, Rama Samara; L, Irwan Meidi
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Hyperuricemic is a condition where the uric acid levels in blood more than 7 mg/dl. In 2010, Hyperuricemic was included as one of non-communicable disease with incidence rate up to 30% and can cause the mortality. This study aims to examine the effective dose of breadfruit (Artocarpus altilis (Park) Fosberg.) leaves extract to decrease uric acid levels in Wistar rats Hyperuricemic.Methodology: This study was an experimental with pre-posttest with control group design. 30 Wistar rats aged three months was divided into 2 control groups (K1 and K2) and 3 treatment groups (K3, K4, and K5). Control groups were given purine (K1= standard, K2=high) and aquadest. Differently, treatment groups were given high purine and breadfruit leaf extract (K3=0.25g /KgBW, K4=0.5g /KgBW, K5=0.75g/KgBW). All the treatments were given one time daily in the morning for 7 days. Data were analyzed by the Shapiro-Wilk test followed by the One-Way ANOVA test and then Post-hoc Tamhane test.Result: The control groups revealed negative average reduction of uric acid in mg/dl (K1= -0.05, K2= -0.09) whereas the treatment groups revealed the positive average reduction of uric acid in mg/dl (K3=2.19, K4= 4.26, K5=5.87). The significant differences (p<0.05) of uric acid levels before and after treatment in each treatment groups had meaning that giving the Breadfruit leaf extract could reduce the uric acid level rats. Post-hoc Tamhane test result showed that the mean decrease of each group was significantly different. Particularly, K5 was the most effective treatment compared with others. Conclusion: Breadfruit leaves extract with dose of 0.75g/KgBW was the most effective treatment to reduce the uric acid level in blood. Stakeholders in health field should promote the Breadfruit as the traditional medicine method to reduce the uric acid in blood.
THE EFFECTIVENESS OF LEMON JUICE (Citrus limon) TOWARD PYRAMIDAL NEURON CELLS OF MALE WHITE MICE’SCEREBRAL CORTEX THAT EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Arifiyani, Pepi; Fitriani, Hikmah; Wibisono, Rachmanda Haryo
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The consumption rate of Monosodium Glutamate (MSG) in Indonesia remains high. Lemon is an antioxidant and neutralizer of free radicals which contains vitamin C and phytochemicals to prevent the long-term effects of MSG to pyramida cells. This study aims to test the effect of oral administration of lemon juice (Citrus limon) to the number of pyramidal neuron cells.   Methodology: This experimental study employed 30 male white mice aged 2.5 to 3 months. Those mice were randomly divided into five control-groups: Normal Control (KN), Negative Control (K-) was treated with 4 mg/grBB MSG, Dose Group 1 (KD1) was treated with 3.33 ml/kgBB lemon juice, Dose Group 2 (KD2) was treated with 6.67 ml/kgBB lemon juice, and Dose Group 3 (KD3) was treated with 13.33 ml/kgBB lemon juice. Kruskal Wallis test was used to determine the difference in distribution between groups, followed with Post hoc Mann Whitney test.Results: After 28 days of treatment, the average number of pyramidal neuron cells in dose group 1 (637 cells) was higher than in negative control (589.5 cells) (p=0.078). The average number of pyramidal neuron cells in dose group 3 (482,5 cells) was lower than in the negative control (589.5 cells) (p=0.016). The statistical result shown that there were groups with a significant difference in pyramidal cells number. Mann-Whitney analysis of pyramidal cells number had shown that there was a significant difference between group KD3 and KD1, KD3 and K (-), KD3 and KD2.Conclusion: Lemon juice (Citrus limon) in precise dose has a beneficial effect to reduce the excitotoxic effect of MSG. Further studies is needed to validate the active compound and toxicity effect of lemon juice.
THE INHIBITION TEST OF FLAVONOID AND TANNIN IN NONI FRUIT (Morinda citrifolia Linn) COMPARED TO CEFTRIAXONE TOWARDS Escherichia coli IN VITRO Islamia, Tessa Swesty; Sutisna, Atik; Fitriani, Hikmah
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Escherichia coli is one of the causatives of infection agents. Noni fruit that contains the antibacterial ingredients was predicted as an alternative medicine to reduce the resistance of antibiotics. Noni fruit extract can inhibit the growth of Escherichia coli. The absence of research on the active substances contained in this fruit which plays a role in inhibiting the growth of Escherichia coli encourages the researcher to conduct this research.Methodology: The research was an experimental laboratory with post-test only control group design. The Escherichia coli grown on Mac conkey agar. Flavonoid and tannin in noni fruit (Morinda citrifolia Linn.) diluted with 3 concentrations, 50%, 70%, 100% and 2 control groups, positive control with ceftriaxone and negative control with Dimethylsulfoxide 10% (DMSO). The treatment group were incubated for 24 hours, then the inhibitory zone formed was measured in mm. Results: The Kruskall-Wallis test showed significant difference in all concentration. The results obtained from this research showed that the average of inhibition towards Escherichia coli on positive control (22.83 mm) had the largest inhibition zone among flavonoid 100% (18.83mm), flavonoid 70% (14.67 mm), flavonoid 50% (6 mm), tannin 100% (17.33 mm), tannin 70% (10.83 mm), tannin 50% (7.50 mm), and negative control (2 mm).Conclusion:  Flavonoid and tannin in noni fruit (Morinda citrifolia Linn) were effective for inhibiting the growth of Escherichia coli. The 100% concentration is the most effective concentration that can be promoted as an alternative medicine.
THE EFFECTIVENESS OF LEMON JUICE (Citrus limon) ON PURKINJE CELL OF WHITE MALE MICE (Mus musculus) CEREBELLAR CORTEX THAT EXPOSED BY MONOSODIUM GLUTAMATE (MSG) Afsari, I Gusti Ayu Novita; Fitriani, Hikmah; Suroso, Triono Adi
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Introduction: A number of studies have indicated that excessive MSG (Monosodium glutamate) consumption can lead to the formation of free radicals that can have a negative effect on purkinje cells in the cerebellar cortex. Lemon fruit is a plant that has benefits as a natural antioxidant because it contains compounds such as flavonoids, vitamin C, citric acid and other substances. This study aims to examine the effect of lemon juice (Citrus limon) to purkinje cells of the cerebellum cortex on male white mice (Mus musculus) which exposed of monosodium glutamate.Method: This research is an experimental laboratory with a post test only control group design. The research  subjects were 30 white male mice divided into 5 groups: normal control given standard  feed, negative control  given MSG dose 4mg / grBW, group of dose I , dose II , and dose III that were each given lemon juice with doses 3.33ml / kgBW, 6.67ml / kgBW, 13.33ml/ kgBW respectively. The number of purkinje cells is calculated in the cerebellar cortex by HE staining. The results of the study were analyzed by One Way ANOVA followed by the Bonferroni Post hoc test.Results: The average number of purkinje cells in administration of lemon juice with dosages of 3.33 ml/kgBW, 6.67 ml/kgBW and 13.33 ml /kgBW were 14.10 cells, 16.73 cells and 17.50 cells respectively. Based on the Post Hoc test, the average number of purkinje cells at the dose of 13.33 ml / kgBW was higher than the negative control (p = 0.021)Conclusion: Lemon juice could be used to reduce negative effect of MSG on purkinje cells of white male mice. Moreover, this finding could be used as reference on further research of benefit of lemon juice.
Hubungan Pemakaian Alat Kontrasepsi dalam Rahim Terhadap Kejadian Keputihan di Puskesmas Rancabango Subang Hikmah Fitriani; Dany Ramdhani; Triono Adi Suroso
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 5, No 2 (2019): Tunas Medika Jurnal Kedokteran & Kesehatan
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Latar Belakang:Alat kontrasepsi dalam rahim (AKDR) merupakan alat kontrasepsi yang berbentuk huruf T dan biasanya terdiri dari bahan plastik polietilena ada yang dililit oleh tembaga dan ada yang tidak dililit tembaga.Beberapa peneltian menunujukan adanya hubungan antara bakterial vaginosis dengan wanita yang menggunakan AKDR. Pada wanita yang menggunkana AKDR terjadi peningkatan bakteri anaerob di vagina karena adanya benda asing dalam rahim sehingga menimbulkan reaksi terjadinya infeksi.Tujuan: Tujuan penelitian ini adalah untuk mengetahui hubungan antara pemakaian alat kontrasepsi dengan terjadinya flour albus (keputihan).Metode: Jenis penelitian yang digunakan ini adalah dengan menggunakan metode observasional dengan pendekatan cross sectional, cara pengambilan sampel menggunakan tehnik consecutive sampling, sebanyak 50 orang, penelitian ini menggunakan tehnik pembagian kuisioner dan menggunakan uji statistik chi square dan uji kolerasi koefsien kontingensi..Hasil: dari hasil penelitian di dapatkan adanya hubungan antara pemakain AKDR dengan kejadian keputihan dengan nilai signifikan 0,031.Simpulan:ada hubungan pengaruh pemakain alat kontrasepsi dalam rahim (AKDR) terhadap keputihan dengan nilai signifkan 0,031.Kata Kunci : AKDR dan Keputihan Backgound : The uterus contraceptive device (AKDR) has a characteristics shape same as (T) and usually consists of a polyethylene plastic material with or without copper. Several studies have shown a link between bacterial vaginosis and women using an AKDR. In women who use AKDR increase anaerobic bacteria inside of vagina because of foreign objects in the uterus therefore arises infection react.objective: The purpose of the research was to determine the relationship between the use of contraception with the occurrence of leucorrhoeamethod : observational method with cross sectional approach is a method used in this type of research, statistical analysis ( Chi Square) used to analyze the data which are collected by consecutive sampling technique from questionnaires gather from 50 respondent.Result : this result found that there is a relationship between the use of  intrayterine device and the occurens of flour albus, with 0,031 significant value.Conclusion: there is an effect intrauterine device toward the occurrence of flour albus with 0,031 significant value.Keywords : AKDR and flour albus
Pengaruh Pemberian Minyak Ikan Tuna Albakora (Thunnus alalunga) terhadap Kadar Kolesterol Total, HDL, dan LDL Pada Tikus Putih Jantan dengan Hiperkolesterol Hikmah Fitriani; Muhammad Satrio Primaeso; Venty Muliana Sari Soeroso
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 4, No 2 (2018): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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AbstrakHiperkolesterolemia adalah kondisi dimana kadar kolesterol total dalam darah  meningkat (≥130 mg/dl) dan merupakan salah satu faktor risiko terjadinya gangguan pada sistim kardiovaskular. Menurut Survei Kesehatan Rumah Tangga (SKRT) tahun 2004, tingkat hiperkolesterolemia di Indonesia sebesar 9,3% pada rentang usia 25 hingga 34 tahun dan 15,5% pada rentang usia 55 hingga 64 tahun. Sekitar 18% dari populasi Indonesia menderita hiperkolesterolemia, dan 80% diantaranya mengalami kematian mendadak akibat serangan jantung. Penelitian menunjukkan bahwa konsumsi minyak ikan dapat bermanfaat untuk menurunkan hipertensi, aterosklerosis, dan arthritis. Asam lemak omega-3 yang dihasilkan dari minyak ikan terdiri dalam bentuk EPA (Eicosa Pentanoic Acid) dan DHA (Docosa Hexanoic Acid). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian minyak ikan tuna albakora terhadap kadar kolesterol total, HDL, dan LDL pada tikus putih jantan hiperkolesterol. Penelitian ini merupakan penelitian eksperimental dengan Pre and Post test control group design menggunakan 25 ekor tikus galur Sprague Dawley yang dibagi kedalam 5 kelompok. Kelompok kontrol positif, kelompok kontrol negatif, kelompok perlakuan 1, 2, dan 3 diberikan perlakuan minyak ikan masing-masing 61mg, 122mg, dan 183mg. Ada pengaruh yang signifikan pemberian minyak ikan tuna albakora terhadap kadar kolesterol total, HDL, dan LDL dengan nilai P<0,05. Minyak ikan tuna albakora memiliki pengaruh terhadap kadar kolesterol total, HDL, dan LDL. Dosis 183mg/200g BB dapat menurunkan kadar kolesterol total, meningkatkan kadar HDL, dan menurunkan kadar LDL plasma tikus putih jantan galur Sprague Dawley.  Kata Kunci: Minyak Ikan, Kolesterol Total, HDL, LDL AbstractHypercholesterolemia is a condition where the level of total cholesterol in blood has increased (≥130 mg/dl) and is one of the most common risk factor of cardiovascular disease. Based on Household Health Survey in 2004, there are 9.3% of hypercholesterolemia at the age of 25 – 34 years old, and about 15,5% at the age 55 – 64 years in Indonesia population. Of the 18% people with hypercholesterolemia in Indonesia, 80% has suffered from sudden death due to a heart attack. Previous studies had revealed that routine fish oil consumption was help to decrease blood hypertension, risk of atherosclerosis and arthritis. Omega-3 fatty acid from fish oil consists of EPA (Eicosa Pentanoic Acid) and DHA (Docosa Hexanoic Acid). This study is aims to find out the effect of albacore tuna fish oil on total cholesterol, HDL, and LDL in hypercholesterolemia white male rat. This research is an experimental study with pretest and posttest control group design using 25 of white male rat strain Sprague Dawley which divided into 5 group. Negative control group, positive control group and three experimental group that have been fed by albacore tuna fish oil in dose of 61 mg, 122 mg and 183 mg. There is a significant effect of albacore tuna fish oil onlevel of total cholesterol, HDL, and LDL with P value <0,005, which the dose of 183 mg/dl has the highest effect. Albacore tuna fish oil with dose of 61 mg, 122 mg and 183mg has effect for lowering the total cholesterol and LDL levels, also significantly increased HDL level in hypercholesterolemia male white rat.  Keywords: Fish Oil, Total Cholesterol, HDL, LDL
Hubungan antara Jumlah Faktor Risiko Konvensional dengan Fraksi Ejeksi Ventrikel Kiri pada Pasien Penyakit Arteri Koroner di Rumah Sakit Jantung Hasna Medika Cirebon Hikmah Fitriani; Irwan Meidi Lubis; Muhammad Taufikqul Hakim
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 4, No 1 (2018): Tunas Medika Jurnal Kedokteran & kesehatan
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Latar belakang: Gagal jantung dengan fraksi ejeksi yang menurun, dimana penyebab yang mendasarinya adalah penyakit arteri koroner (PAK), memiliki prognosis yang lebih buruk dibandingkan dengan gagal jantung dengan fraksi ejeksi yang normal. Pasien PAK dengan multiple risk factor cenderung memiliki angka kematian yang tinggi. Tujuan: Untuk mengetahui ada tidaknya hubungan antara jumlah faktor risiko konvensional dengan fraksi ejeksi ventrikel kiri pada pasien PAK. Metode: Desain penelitian ini adalah observasional analitik, yaitu dengan mengumpulkan data rekam medik pasien PAK untuk mengetahui data fraksi ejeksi ventrikel kiri hasil pemeriksaan ekokardiografi dan melakukan wawancara singkat kepada pasien PAK tersebut. Data yang terkumpul di sajikan secara deskriptif, dan analisis  menggunakan uji korelasi Spearman. Hasil: Penelitian ini didapatkan 180 responden yang telah memenuhi kriteria inklusi untuk dianalisis. Rerata usia responden 56,45 ± 10,61 tahun. Hasil analisis hubungan antara jumlah faktor risiko dengan fraksi ejeksi ventrikel kiri pasien PAK didapatkan hubungan yang tidak bermakna dengan korelasi yang sangat lemah (p = 0,381; r = 0,066). Simpulan: Tidak terdapat hubungan antara jumlah faktor risiko konvensional dengan fraksi ejeksi ventrikel kiriKata Kunci: faktor risiko konvensional, fraksi ejeksi ventrikel kiri ABSTRACTBackground: Heart failure with reduced ejection fraction in patient with coronary heart disease has poor prognosis. Patient with coronary artery disease who has multiple risk factor tend to have increase mortality rate. This study aims to find the correlation between number of conventional risk factor with left ventricular ejection fraction in patient with coronary artery disease. Objective: To study the correlation between the number of conventional risk factor with left ventricular ejection fraction in patient with coronary artery disease (CAD). Methods: This was an analytic observational study, by collecting data from medical record patient with CAD to assess left ventricular ejection fraction from echocardiografi assessment and collect data from patient directly. Collected data is presented by descriptive, and analize with correlation of Spearman analysis.. Results: 180 participant has collected met with inclution criteria for analize. The mean of age is 56,45 ± 10,614 years. Analysis reveals there was no significant correlation between number of conventional risk factor with left ventricular ejection fraction in patient with CAD with very weak correlation (p = 0,381; 0,066). Conclusion: There was no relationship between number of conventional risk factor with left ventricular ejection fraction in patient with Coronary Artery DiseaseKey Word: conventional risk factor, left ventricular ejection fraction
PENGUKURAN KADAR SGOT DAN SGPT PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ISONIAZID SETELAH PEMBERIAN DAUN KERSEN (Muntingia Calabura L.) Hikmah Fitriani; Adam Aljabar Sugiarto; Isti Noviani
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 7, No 1 (2021): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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ABSTRAKLatar Belakang: Gangguan hati oleh karena obat-obatan dapat memberikan efek samping yang toksik pada organ , terutama hati yang dipengaruhi oleh dosis atau lama pemberian obat. Isoniazid merupakan inhibitor enzim yang kuat, yang dapat meningkatkan kadar SGOT dan SGPT di dalam hati. Salah satu tumbuhan yang dapat memberikan efek hepatoprotektif adalah daun kersenTujuan: Untuk mengetahui efektifitas pemberian ekstrak daun kersen terhadap kadar SGOT dan SGPT pada tikus putih jantan yang diinduksi INH.Metode: Penelitian ini adalah penelitian eksperimental dengan rancangan pre, post test control group design dengan menggunakan hewan tikus sebagai subjek penelitian. Dengan menggunakan tikus putih jantan 24 ekor sebagai objek penelitian. Peneliti ini menggunakan 4 kelompok, yaitu 1 kelompok kontrol dan 3 kelompok perlakuan dan setiap kelompok terdiri dari 6 ekor tikus putih jantan, kelompok kontrol dengan dosis INH 80 mg/200gBB, perlakuan 1 ekstrak daun kersen dengan dosis 600 mg/200gBB, perlakuan 2 ekstrak daun kersen dengan dosis 1200 mg/200gBB, perlakuan 3 ekstrak daun kersen dengan dosis 1800 mg/200gBB. Penelitian dilakukan selama 14 hari.Hasil: Penelitian ini menunjukkan bahwa terdapat peningkatan yang bermakna pada nilai SGPT dan SGOT tikus putih yang diinduksi isoniazid, sebelum dan sesudah mendapatkan intervensi berupa ekstrak daun kersen dengan dosis 600, 1.200, dan 1.800 mg/200gBB, namun peningkatan SGOT dan SGPT pada penelitian ini dapat ditekan dengan ekstrak daun kersen dengan dosis 1800mg/200gBB.Kesimpulan: peningkatan SGOT dan SGPT pada penelitian ini dapat ditekan dengan pemberian ekstrak daun kersen dengan dosis 1800mg/200gBBKata Kunci: INH, ekstrak daun kersen, SGPT, SGOT.ABSTRACTBackground: Liver disorders due to drugs can have toxic side effects on organs, especially the liver which is affected by the dose or duration of drug administration. Isoniazid is a powerful enzyme inhibitor, which can increase levels of SGOT and SGPT in the liver. One of the plants that can give hepatoprotective effect is cherry leaf (Muntingia Calabura L).Objective: To determine the effectiveness of administration of cherry leaf extract on SGOT and SGPT levels in INH-induced male white rats.Method: This study was an experimental study with a pre, post test control group design using rat animals as research subjects. By using 24 male white rats as research objects. This researcher used 4 groups, namely 1 control group and 3 treatment groups and each group consisted of 6 male white rats, a control group with a dose of INH 80 mg / 200gBB, treatment of 1 extract of cherry leaf at a dose of 600 mg / 200gBB, treatment of 2 extracts Cherry leaves with a dose of 1200 mg / 200gBB, treatment 3 extracts of cherry leaves with a dose of 1800 mg / 200gBB. The study was conducted for 14 days.Results: This study showed that there was a significant increase in the SGPT and SGOT values of isoniazid-induced white mice, before and after the intervention in the form of cherry leaf extract at doses of 600, 1,200 and 1,800 mg / 200gBB, but the increase in SGOT and SGPT in this study can be pressed with cherry leaf extract at a dose of 1800mg / 200gBB.Conclusion: The increase in SGOT and SGPT in this study can be suppressed by administering cherry leaf extract at a dose of 1800mg / 200gBB.Keywords: INH, cherry leaf extract, SGPT, SGOT.
PERBANDINGAN EFEKTIFITAS JUS JAMBU BIJI MERAH (Psidium guajava L.) DENGAN JUS BUAH BIT (Beta vulgaris L.) SERTA KOMBINASINYA TERHADAP HEMOGLOBIN TIKUS PUTIH JANTAN GALUR WISTAR Hikmah Fitriani; Erlangga Permadi Yudha; Atik Sutisna
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 7, No 1 (2021): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
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ABSTRAKLatar Belakang: Anemia adalah suatu kondisi di mana hemoglobin dalam sel yang terlalu sedikit atau jumlah sel darah merah. prevalensi anemia pada tahun 2011 tertinggi pada balita 42,6%. Pengobatan anemia dapat dilakukan dengan mengkonsumsi obat-obatan tetapi obat-obatan ini memiliki efek samping. Salah satu alternatif dalam meningkatkan kadar hemogobin darah dengan memanfaatkan potensi dari buah jambu biji merah dan buah bit.Tujuan: Untuk membandingkan efektifitas jus buah jambu biji merah dan jus buah bit serta kombinasinya dalam peningkatan kadar hemoglobin darah tikus putih jantan.Metode: Penelitian yang dilakukan bersifat eksperimental dengan rancangan penelitian pre and post test with control group design dengan menggunakan tikus putih (Rattus novegicus) jantan galur Wistar sebagai objek penelitian. Penelitian ini menggunakan 20 ekor tikus yang dibagi secara acak ke dalam 4 kelompok, yaitu 1 kelompok kontrol dan 3 kelompok perlakuan. Kelompok kontrol (KK) kontrol kontrol, Kelompok perlakuan (KP) adalah kelompok yang mendapatkan jus jambu biji merah dan jus buah bit, (KP2) jus jambu biji merah dengan dosis 3 ml,(KP3) jus bit dengan dosis 4,5ml,(KP4) kombinasi jus jambu biji merah dan jus bit. Data diuji menggunakan uji one way annova dengan uji Post hoc.Hasil: Terdapat peningkatan kadar hemoglobin pada (KP2) sebesar 11.81g/dl, (KP3) sebesar 13.18 g/dl, (KP4) sebesar 13.94 g/dl.Simpulan: jus jambu biji merah (Psidium guajava L.) dan jus bit (Beta vulgaris L.) serta kombinasinya memiliki efek meningkatkan kadar hemoglobin pada tikus putih anemia.Kata Kunci: Hemoglobin, (Psidium guajava L.), (Beta vulgaris L.), Jus buah jambu biji merah, Jus buah bit.ABSTRACTBackground: Anemia is a condition in which hemoglobin concentration below normal limits. The prevalence of anemia in 2011 in infants was 42.6%. Treatment modalities of anemia mostly consist of drugs but these drugs have side effects. One of treatment alternative is to utilize ing the potential traditional herbs of red guava and beet.Aim: To compare the effectiveness of red guava fruit juice and beet juice and its combination in increasing the blood hemoglobin levels of male white rats.Methods: The study was experimental in nature with a pre and post test design with control group design using white rats (Rattus novegicus) male Wistar strain as research objects. This study used 20 rats which were randomly divided into 4 groups, namely 1 control group and 3 treatment groups. Control group (KK) control control, treatment group (KP) is a group that gets red guava juice and beet juice, (KP2) red guava juice at a dose of 3 ml, (KP3) beet juice at a dose of 4.5 ml, ( KP4) a combination of red guava juice and beet juice. Data were tested using one way annova test with Post hoc test.Results: There is an increase in hemoglobin levels in (KP2) of 11.81g / dl, (KP3) of 13.18 g / dl, (KP4) of 13.94 g / dl.Conclusions: red guava juice (Psidium guajava L.) and beet juice (Beta vulgaris L.) and their combination have the effect of increasing hemoglobin levels in anemic white rats.Keywords: Hemoglobin, (Psidium guajava L.), (Beta vulgaris L.), Guava juice, Beet juice
PENGARUH PEMBERIAN EKSTRAK BUAH BIT (Beta vulgaris L.) TERHADAP GAMBARAN HEPATOSIT PADA HARI TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR SPRAGUE-DAWLEY YANG DIINDUKSI SOFT DRINK Hikmah Fitriani; Uftifah Aulina Selvira; Nurbaiti Nurbaiti
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 7, No 2 (2021): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
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Abstract

Latar Belakang: Konsumsi soft drink berlebihan dalam jangka panjang dapat menyebabkan perlemakan hati bukan karena alkohol. Buah bit (Beta vulgaris L.) yang mengandung banyak antioksidan sebagai hepatoprotektor. Tujuan: Mengetahui pengaruh pemberian ekstrak buat bit (Beta vulgaris L.) dalam mengurangi kerusakan hepatosit pada hati tikus putih jantan (Rattus norvegicus) galur Sprague-Dawley yang diinduksi soft drink. Metode: Dilakukan di Laboratorium PAU UGM, Laboratorium PA RSUD Gunung Jati dan Laboratorium Biomedis FK UGJ. Rancangan penelitian post test only group design. Terdiri dari 4 kelompok dengan K1 pakan minum standar, K2 soft drink 6 ml/hari, K3-K4 soft drink 6 ml dengan 4,5 mg/200 gBB (K3) dan 9 mg/200 gBB (K4). Data penelitian dianalisis secara statistik menggunakan uji Shapiro Wilk dilanjutkan dengan Kruskal-Wallis dan Mann Whitney. Hasil: Pemeriksaan histopatologi menunjukkan hepatosit K1 dalam keadaan normal, K2 nekrosis zona 3, K3 degenerasi parenkimatosan dan K4 degenerasi hidropik. Tingkat kerusakan pada K1, K2, K3 dan K4 p=0,000. Perbedaan bermakna pada K1 dengan K2, K3, K4 (p=0,001), K2 dengan K3, K4 (p=0,001), K3 dan K4 tidak memiliki perbedaan bermakna (p=0,209). Simpulan: Ekstrak buah bit dosis 4,5 mg/200 gBB dan 9 mg/200 gBB memiliki efek hepatoprotektif yang sama dalam mencegah kerusakan hepatosit. Kata kunci: bit, Beta vulgaris, soft drink, hepatoprotektif.ABSTRACTBackground: Excessive consumption of soft drinks in the long term can cause fatty liver not due to alcohol. Beetroot (Beta vulgaris L.) which contains many antioxidants as hepatoprotectors. Objective: To determine the effect of beetroot extract (Beta vulgaris L.) in reducing hepatocyte damage in the liver of male white rats (Rattus norvegicus) Sprague-Dawley strain induced by soft drink. Methods: Conducted at the Laboratory of PAU UGM, Laboratory of PA at Gunung Jati Hospital and Biomedical Laboratory of FK UGJ. The research design is post test only group design. Consisting of 4 groups with K1 standard drinking feed, K2 soft drink 6 ml/day, K3-K4 soft drink 6 ml with 4.5 mg/200 gBW (K3) and 9 mg/200 gBW (K4). The research data were statistically analyzed using the Shapiro Wilk test followed by Kruskal-Wallis and Mann Whitney. Results: Histopathological examination showed normal K1 hepatocytes, zone 3 necrosis K2, K3 parenchymatous degeneration and K4 hydropic degeneration. Damage level at K1, K2, K3 and K4 p=0.000. There was a significant difference between K1 and K2, K3, K4 (p=0.001), K2 and K3, K4 (p=0.001), K3 and K4 had no significant difference (p=0.209). Conclusion: Beetroot extract doses of 4.5 mg/200 gBW and 9 mg/200 gBW had the same hepatoprotective effect in preventing hepatocyte damage. Keywords: beetroot, Beta vulgaris, soft drink, hepatoprotective.
Co-Authors Adam Aljabar Sugiarto Afsari, I Gusti Ayu Novita Alfi Meitasari Ari Fajar Ramdani Arifiyani, Pepi Atik Sutisna Atik Sutisna Atik Sutisna B, Rama Samara Dany Ramdhani Edial Sanif Erlangga Permadi Yudha Fajar Islamy, Ilham Fathunnisa, Firda Hagi Wibawa Hagi Wibawa I Gusti Ayu Novita Afsari I Gusti Ayu Novita Afsari Indrakusuma, Mohammad Erwin Irwan Meidi L Irwan Meidi L Irwan Meidi Lubis Islamia, Tessa Swesty Isti Noviani L, Irwan Meidi Marfuati, Sri Marnisah, Luis Maulinda Nur Pramudyas Primia Setyaningrum Muhammad Muhammad Satrio Primaeso Muhammad Taufikqul Hakim Nurbaiti Nurbaiti Nurdina , Annisa Fadhilah Pepi Arifiyani Pepi Arifiyani Putri Amelia Rachmanda Haryo Wibisono Rahmalisa Hafifah Rama Samara Rama Samara B Rama Samara Brajawikalpa Raudatul Patimah Riawan, Firanda Putri Roswaty, Roswaty Ruri Eka Maryam Shonia, Ana Naela Siti Mursyidah Soraya Aldeina Sriwiyati, Kati Surfa, Muhammad Bintang Abdi Suroso, Triono Adi Sutisna, Atik Tessa Swesty Islamia Tessa Swesty Islamia Tissa Octavira Permatasari Triono Adi Suroso Triono Adi Suroso Triono Adi Suroso Uftifah Aulina Selvira Venty Muliana Sari Soeroso Weni, Mustika Wibawa, Hagi Wibisono, Rachmanda Haryo Yulianita Pratiwi Indah Lestari Yuspa