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Wiryatun Lestariana
Bagian Biokimia, Fakultas Kedokteran Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Nursing Public Health

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Efek ekstrak teh hijau (Camellia sinensis (L.) O. Kuntze var. assamica) terhadap berat badan dan kadar malondialdehid wanita overweight Alpha Olivia Hidayati; Wiryatun Lestariana; Emy Huriyati
Jurnal Gizi Klinik Indonesia Vol 9, No 1 (2012): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.15377

Abstract

Background: Overweight and obesity were risk factors of various degenerative diseases. Green tea extract contains polyphenol compounds, particularly catechins which act as antioxidants, fat dissolvent and aid lipolysis. Thus, it is necessary to study the use of green tea as an alternative treatment to overcome overweight.Objective: To identify the effect of green tea extract supplementation on body weight and malondialdehide (MDA) level of overweight women in Yogyakarta District Health Office.Method: This was an experimental study with double-blind randomized controlled trial design. Subject of the study were divided into two groups; one group consumed green tea extract capsules and the other consumed placebo. Weight, 6 times 24 hours recall, and level of MDA were measured on every subject.Results: The results revealed that green tea extract has a weight-reducing effect and decrease MDA level of overweight women, though the reduction of weight and MDA level was not significant (p>0,05). Weight loss of 1.3% was observed in the treatment group, whereas the control group has an increase of 0.6% body weight, but the weight change was not significant (p=0.501, p=0.620). Changes in body weight after 12 weeks of treatment showed a significant disparity between the two groups (p=0.000). MDA level decreased by 10% in the treatment group compared to 8.3% in the control group. MDA levels pre and post intervention was significantly different in the treatment group (p=0.006), whereas in the control group there was no significant discrepancy observed (p=0.123). However, changes in MDA levels after 12 weeks of treatment showed no significant differences among groups (p=0.278). The mean nutrient intakes of subjects were still below the recommended dietary allowance (RDA), except for protein.Conclusion: Green tea extract had a weight-reducing effect and decrease MDA level of overweight women in Yogyakarta District Health Office, though the reduction was not statistically significant.
Keefektifan ekstra putih telur terhadap peningkatan albumin dan penurunan IL-1β pada pasien tuberkulosis dengan hipoalbuminemia Agus Prastowo; Wiryatun Lestariana; Siti Nurdjanah; Retno Sutomo
Jurnal Gizi Klinik Indonesia Vol 10, No 3 (2014): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18857

Abstract

Background: Tuberculosis (TB) is world health problem which still needs attention. Recently, Indonesia ranks the third in TB prevalence after India and China. Research revealed that albumin decreases significantly in TB patients, due to lack of nutritious intakes such as low-calorie intake, anorexia, increased catabolism, enteropathy and acute protein reaction. Low albumin was associated with increased IL-1β and cytokines inflammation in TB patient. Albumin had a very important role in the body and white egg known as a good quality source of protein.Objective: To assess the effect of white egg supplementation in TB patient towards the level of albumin and the level of IL-1β.Method: A single-blind randomized controlled trial was conducted with 75 patient selected for the study and divided to 37 patient as the study group and 38 as a control group. Both groups received high energy high protein diet, while the study group received, additionally, an oral egg white-based on formula calculation Baxter for 14 days. Control group received, additionally, an extra soybean curd and mungbean powder. Albumin and IL-1β were checked before and after the intervention. Data is analyzed by using Mann-Whitney.Results: Research results show that average albumin pre-intervention in the study group was 2.82 g/dL and control group was 2.85 g/dL. Average albumin difference in the study group was 3.47 g/dL and control group was 2.81 g/dL. Bivariate analysis results show significant of increasing albumin between study group and control group (p<0.05). Research results show average IL-1β pre-intervention difference in study group (0.9 pg/mL) and control group (0.67 pg/mL). The average IL-1β difference in the study group was -0.39 pg/mL and control group was 0.76 pg/mL. Bivariate analysis results show a significant difference of IL-1β depletion between study group and control group (p<0.05).Conclusion: Egg white increase albumin level and IL-1β depletion in tuberculosis patients effectively.
Efek pemberian ekstrak teh hijau (Camellia sinesis (L) O. Kuntze) var. Assamica terhadap total lemak tubuh dan profil lipid wanita dewasa overweight dan obesitas Ernawati Hardani; Wiryatun Lestariana; Susetyowati Susetyowati
Jurnal Gizi Klinik Indonesia Vol 10, No 4 (2014): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18874

Abstract

Background: Overweight and obesity can cause high body fat total and lipid profile in the blood that brings risk for diseases to the bearer. Some studies on green tea extract supplementation have been undertaken to find out its effect on the fat reduction in children, men, and mice and the result showed a reduction in body fat, weight, appetite, and triglyceride level. This study uses green tea extract supplemented to overweight and obese women. Objective: To find out the reduction of body fat total and lipid profile (total cholesterol, triglyceride, LDL, HDL) in the blood of overweight and obese women personnel of Yogyakarta Municipal Health Office supplemented with green tea extract.Method: The study was randomized double-blinded control trial. The subject of the study was overweight and obese women of 35-55 years old personnel of Yogyakarta Municipal Health Office. Samples were 86 women randomly taken, comprising experiment group and control group, each of which consisting of 43 women. Each group had diet according to individual appetite. Both groups were given capsules of similar form and color but different ingredients: placebo and green tea extract. The experiment took three months. Blood was taken before and after the experiment to identify lipid profile (total cholesterol, triglyceride, LDL, HDL). Body fat total was examined using body fat analyzer. Data analysis used paired t-test.Results: Green tea extract supplementation could significantly reduce body fat total and insignificantly reduce cholesterol level, triglyceride, and LDL, significantly increase HDL in overweight and obese women.Conclusion: Green tea extract supplementation could reduce body fat total and increase HDL (p<0.005).
Co-Authors Agus Prastowo Alpha Olivia Hidayati Emy Huriyati Ernawati Hardani Retno Sutomo Siti Nurdjanah Susetyowati