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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Global Health research
Rosmayanti Syafriani Siregar
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Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Interleukin-6 urin sebagai pemeriksaan cepat pielonefritis pada neonatus Nezman Nuri; Rafita Ramayati; Oke Rina Ramayani; Rosmayanti Syafriani Siregar; Beatrix Siregar
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 46, No 2 (2013): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Pyelonephritis is a common infection to all children in all age groups, including the newborn. The diagnosis of urinary tract infection is established certainly by urine culture. Additional investigations can be done to help confirm the diagnosis, such as urinary interleukin-6. Increased number of urinary interleukin-6 is helpful to quickly confirm the occurrence of pyelonephritis. Keyword : pyelonephritis; neonates; urine culture; interleukin-6
The Relationship Between Lipid Profile and the Incidence of Relapsing Nephrotic Syndrome in Children Utari Olivina Tarigan; Rosmayanti Syafriani Siregar; Syamsidah Lubis; Isti Ilmiati Fujiati; Melda Deliana; Cynthea Prima
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7017

Abstract

Nephrotic syndrome (NS) is one of the most common chronic kidney diseases in children, characterized by massive proteinuria, hypoalbuminemia, edema, and dyslipidemia. Relapse occurs in most cases and contributes to worsening the disease course. Dyslipidemia is suspected to influence relapse risk, but the specific relationship between lipid profile and relapsing NS remains unclear. Objective to analyze the association between total cholesterol, triglycerides, LDL, and HDL levels with relapse incidence in children with nephrotic syndrome. A retrospective study was conducted on 66 children aged 2–18 years with NS treated at H. Adam Malik General Hospital, Medan, in 2024. Subjects were divided into relapsing (n=54) and non-relapsing (n=12) groups. Data were obtained from medical records and analyzed using the Mann-Whitney test and Spearman correlation. Triglyceride (p=0.007), LDL (p=0.013), and HDL (p<0.001) levels differed significantly between the relapsing and non-relapsing groups. Total cholesterol showed no significant difference (p=0.164). The mean albumin level was significantly lower in the relapsing group (2.9 g/dL vs. 4.1 g/dL; p<0.001). A significant negative correlation was found between albumin and triglyceride levels (r=-0.326; p=0.008). Triglyceride, LDL, and HDL levels are significantly associated with relapse in pediatric nephrotic syndrome. Hypoalbuminemia is also an important risk factor. Lipid profile evaluation can serve as a useful indicator in monitoring and managing relapses.
Co-Authors Beatrix Siregar Cynthea Prima Fujiati, Isti Ilmiati Melda Deliana Nezman Nuri Oke Rina Ramayani, Oke Rina Rafita Ramayati Syamsidah Lubis Utari Olivina Tarigan