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Muzahar dr
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Health Professions Medicine & Pharmacology

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Perbandingan nilai rasio neutrofil-limfosit dan kadar c-reactive protein dengan kultur darah positif dan kultur darah negatif pada penderita systemic inflammatory response syndrome Hilda Sungkar; Muzahar dr; Ricke Loesnihari
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 2 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Introduction : Systemic Inflammatory Response Syndrome (SIRS) is a non specificreaction that could be caused by infection, inflammation, or acombination of both factors.Bacteremia detectionin SIRS patientsis a challenge forclinicians. Neutrophil-lymphocyte count ratio (NLCR) and C-reactive protein (CRP) could rapidly predict bacteremia.Method : Thiscross sectional study was conducted in Emergency Unit RSUPH.Adam Malik Medan from January to March 2016. Patients that met SIRS criteria had their NLCR, CRPand blood culture tested.Result : Of 48 samples, 21 (43.75%) were male and 27 (56.25%) were female.In this study, there was significant difference of NLCR from both groups, where NLCR in SIRS with positive blood culture was higher that SIRS with negative blood culture(38.16 ± 34.97vs9.68 ± 5.26, P=0.001). There wasa significant difference between CRP in both groups. CRP in SIRS with positive blood culture was higher than SIRS with negative blood culture. (5.89 ± 3.09vs 3.15 ± 1.89, p = 0.001).Conclusions : There is significant difference of NLCR and CRP in SIRS patients with positive and negative blood culture. RNL and CRP could be used as a marker for detecting bacteremia in SIRS patients.Keywords : Neutrophil to Lymphocyte Count Ratio, C-Reactive Protein, Systemic Inflammatory Response Syndrome
Pola resistensi antimikroba pada infeksi saluran kemih yang disebabkan oleh bakteri penghasil ESBL dan non-ESBL Lindayanti dr; Muzahar dr; Abdurrahim Rasyid Lubis
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 2 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background : Urinary tract infection (UTI) is the most frequent infectious diseases occur and took second place after respiratory tract infections, where his first-line therapy is an antimicrobial. Many sufferers are not improved after treatment due to the onset of bacterial resistance to antimicrobials specific types and also the discovery of bacteria producing Extended-Spectrum BetaLactamase (ESBL). The aim of study is to determine the differences in patterns of antimicrobial resistance urinary tract infections caused by ESBL-producing bacteria and Non-ESBL.Methods : This study was an observational study with cross-sectional method included 50 outpatients in Departments of Internal Medicine Haji Adam Malik Hospital. Urinalisa examination found nitrites(+) or hematuria(+) or leukocytes> 10/lpb and continued urine cultures, Double Disk Synergy Test (DDST) and sensitivity test.Results : Antimicrobial resistance in ESBL groups were ampicillin (94.7%), and trimethoprim/sulfamethoxazole, ceftriaxon (84.2%), followed by cefotaxime, cefpodoxime and tetracyclin (78.9%) while in Non-ESBL group were ampicillin (88%), and trimethoprim/sulfamethoxazole (84%), and tetracyclin (76%). Differences patterns of antimicrobial resistance in E.coli ESBL producing group and Non-ESBL found cefotaxime significant (P = 0.021) and aztreonam significant (P = 0.031). Conclusion : ESBL-producing bacteria have an increased resistance to several antimicrobial mainly cephalosporin class although not statistically significantly different.Keywords : antimicrobial resistance; urinary tract infection; extended spectrum beta lactamase
Co-Authors Abdurrahim Rasyid Lubis Hilda Sungkar Lindayanti dr Ricke Loesnihari