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All Journal Jurnal e-Biomedik Indonesian Journal of Tropical and Infectious Disease Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Jurnal Prima Medika Sains Journal of Telenursing (JOTING) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE)
Ricke Loesnihari
Departemen Patologi Klinik Fakultas Kedokteran Universitas Sumatera Utara, Rumah Sakit Umum Pusat Haji Adam Malik Medan
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Effect of Ethanol Extract of Chayote (Sechiumedule.Jacq.Swartz) on the Activity of Glutathione Peroxide (GPx) in House Mice (Musmusculus L) Strain DD Webster Hyperglycemia Induced by Streptozotocin (STZ) Siahaan, Jekson Martiar; Harahap, Urip; Loesnihari, Ricke
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Streptozotocin can cause hyperglycemia in guinea pig through the mechanism of oxidative stress which damages pancreatic b cells. Ethanol extract of chayote can decrease oxidative stress.  This study aimed to determine the effect of Ethanol Extract of Chayote ((EEBLS) Ekstrak Etanol Buah Labu Siam) on decreasing blood sugar content and increasing the activity of glutathione peroxide enzyme. Subjects and Method: This was an experimental study. The samples were using random sampling technique. The control group was using male white mice (Musmusculus L.) Strain DD Webster which randomized into four groups: negative control group, positive control group, group which got EEBLS of 100 mg/kgBB, and group which got EEBLS of 200 mg/kgBB.Results: The result of the research showed that there was significant decrease in blood sugar, compared with the control group. There was insignificant decrease in the activity of glutathione peroxide enzyme, compared with the control group.Conclusion: The conclusion of the research was that EEBLS of 200 mg/kgBB decreased blood sugar content of mice significantly, but there was no significant change in the activity of glutathione peroxide enzyme when EEBLS was given to the mice.   Keywords: streptozotocin, oxidative stress, antioxidant, flavonoidCorrespondence: Jekson Martiar Siahaan. Biomedical Science, Faculty of Medicine, North Sumatera University.Indonesian Journal of Medicine (2016), 1(1): 44-49https://doi.org/10.26911/theijmed.2016.01.01.06
Profil Resistensi Antimikroba dari Flora Normal dalam Kavum Nasi Petugas Kamar Operasi Bedah Jantung dan Petugas Pasca Operasi Intensive Coronary Care Unit RSUP H. Adam Malik Medan Irma, Fani A.; Loesnihari, Ricke; Akbar, Nizam
eBiomedik Vol 7, No 1 (2019): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.7.1.2019.23535

Abstract

Abstract: Nosocomial infection often occurs in hospitalized patients due to microbial contamination. This study was aimed to obtain the profile of microbes in nasal cavities of hospital personnel by identification the microbial pattern, therefore, the microbial resistance to several antimicrobial groups could be determined. This was an observational analytical study with a cross sectional design. Subjects were hospital personnel at the Cardiac Surgery room and at the Intensive Coronary Care Unit (ICCU) room of H. Adam Malik General Hospital, Medan. Specimens of nasal cavity swabs were taken from all subjects, and then were cultured and tested for antimicrobial sensitivity. From 37 subjects, the most common bacteria found were S. epidermidis (40%), S. saprophyticus (21%), and S. aureus (12%). The antimicrobial susceptibility test showed that sufamethoxsazole had the highest resistance while erythomycin still had good sensitivity. At the ICCU room, amikacin showed better sensitivity than doxycyclin. Amoxiclav had the highest sensitivity, meanwhile from the floroquinolone class, norfloxacin had better sensitivity than ciprofloxacin. The microbes were still sensitive to cephalosporin class but were resistant to vancomycin. Conclusion: S. epidermidis, S. saprothyticus, and S. aureus were the most commonly found microbes in the nasal cavities of hospital personnel. The nasal cavity microbes were still sensitive to erythromycin, amikacin, amoxiclav, norfloxacin, and cephalosporin group.Keywords: nosocomial infection, nasal cavity, antimicrobial resistance, antimicrobial sensitivity Abstrak: Infeksi nosokomial sering terjadi pada saat pasien dirawat di rumah sakit akibat adanya kontaminasi mikroba yang berada di rumah sakit. Penelitian ini bertujuan untuk mendapatkan pola mikroba kavum nasi dari petugas rumah sakit melalui identifikasi mikroba sehingga dapat ditentukan pola resistensi mikroba terhadap berbagai macam golongan antimikroba. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Subyek penelitian ialah petugas di kamar operasi bedah jantung dan ruang pasca operasi ICCU di RSUP H. Adam Malik Medan. Pengambilan spesimen swab kavum nasi dilakukan pada semua subyek, dilanjutkan dengan pembiakan serta uji resistensi antimikroba. Dari 37 subyek didapatkan bakteri terbanyak yaitu S. epidermidis (40%), diikuti oleh S. saprothyticus (21%), dan S. aureus (12%). Uji sensitivitas terhadap antimikroba lini pertama mendapatkan sulfametoksasol merupakan antimikroba yang paling tinggi resistensinya sedangkan eritromisin merupakan antimikroba yang masih baik sensitivitasnya. Untuk ruang ICCU, sensitivitas terhadap amikasin masih lebih baik dibandingkan doksisiklin. Amoksiklav merupakan antimikroba yang sensitivitasnya sangat baik, sedangkan dari golongan florokuinolon, norfloksasin memiliki sensitivitas yang lebih baik dibanding siprofloksasin. Golongan sefalosporin masih memiliki sensitifitas yang baik, sedangkan vankomisin sudah resisten. Simpulan: Bakteri terbanyak didapatkan dalam kavum nasi ialah S. epidermidis, S. saprothyticus, dan S. aureus. Antimikroba yang masih sensitif yaitu eritromisin, amikasin, amoksiklav, norfloksasin, dan golongan sefalosporin.Kata kunci: infeksi nosokomial, kavum nasi, resistensi antimikroba, sensitivitas antimikroba
Relationship of HbA1c to Diabetic Retinopathy in Type 2 DM Patients at Haji Adam Malik General Hospital 2017-2018 Silalahi, Yuni; Ricke Loesnihari
Sumatera Medical Journal Vol. 3 No. 3 (2020): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v3i3.3626

Abstract

Diabetic retinopathy is a microvascular complication of diabetes mellitus. This complication can occur due to hyperglycemia that occurs in blood vessels for a long period of time. To determine whether there is a relationship between HbA1c levels on the incidence of diabetic retinopathy on pationts with type 2 diabetes mellitus in Haji Adam Malik General Hospital Medan period of 2017 until 2018. This research is an analitical study with retrospective method (case control) and conducted at the General Hospital of Haji Adam Malik Medan. Data collection was performed on medical records of diabetic retinopathy patients at Haji Adam Malik General Hospital Medan in the period January 2017 to December 2018. Data were collected by using medial records of patients with simple random sampling technique with a total sample is 46 samples, 23 samples of diabetic retinopathy, and 23 samples that were not diabetic retinopathy. The results of this study indicate that of 23 diabetic retinopathy samples, 2 of them had controlled HbA1c and the other 21 are not controlled. As well as of the 23 samples were not diabetic retinopathy, 5 of them had HbA1c controlled HbA1c and 18 were uncontrolled. The result of the analysis with chi square test showed no relationship between HbA1c levels to the incidemce of diabetic retinopathy in Type 2 DM patients with a p value of 0,06. From this study it was found that there was no relationship between HbA1c levels and the incidence of diabetic retinopathy for Haji Adam Malik General Hospital in the 2017-2018 period.
Peran analisa urin pada penanganan penyakit ginjal dan traktus urinarius Ricke Loesnihari
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Renal and urinary tract diseases can caused severe problem if its diagnose late. That is because Renal organs have ability to compensate and human can live normally with one renal organ. Urinalysis test as a screening test can be performed without any indication and there are parameters which are represent so many condition that are affected by renal function. Abnormal urinalysis may indicate renal and urinary tract disease or renal damage caused by other disease. The source of uncertain component in urine specimen were estimated on biological variation or influenced by end product of metabolism and the question is whether or not this approach represents good laboratory practice should be identified. In conclusion, urinalysis could detect chronic renal disease in its early stage and also good laboratory practice could give reliable result. Keywords: renal; urinalysis; proteinuria; urine sediment
Perbandingan nilai rasio neutrofil-limfosit dan kadar c-reactive protein dengan kultur darah positif dan kultur darah negatif pada penderita systemic inflammatory response syndrome Hilda Sungkar; Muzahar dr; Ricke Loesnihari
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 2 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Introduction : Systemic Inflammatory Response Syndrome (SIRS) is a non specificreaction that could be caused by infection, inflammation, or acombination of both factors.Bacteremia detectionin SIRS patientsis a challenge forclinicians. Neutrophil-lymphocyte count ratio (NLCR) and C-reactive protein (CRP) could rapidly predict bacteremia.Method : Thiscross sectional study was conducted in Emergency Unit RSUPH.Adam Malik Medan from January to March 2016. Patients that met SIRS criteria had their NLCR, CRPand blood culture tested.Result : Of 48 samples, 21 (43.75%) were male and 27 (56.25%) were female.In this study, there was significant difference of NLCR from both groups, where NLCR in SIRS with positive blood culture was higher that SIRS with negative blood culture(38.16 ± 34.97vs9.68 ± 5.26, P=0.001). There wasa significant difference between CRP in both groups. CRP in SIRS with positive blood culture was higher than SIRS with negative blood culture. (5.89 ± 3.09vs 3.15 ± 1.89, p = 0.001).Conclusions : There is significant difference of NLCR and CRP in SIRS patients with positive and negative blood culture. RNL and CRP could be used as a marker for detecting bacteremia in SIRS patients.Keywords : Neutrophil to Lymphocyte Count Ratio, C-Reactive Protein, Systemic Inflammatory Response Syndrome
SOIL-TRANSMITTED HELMINTH INFECTION AND EOSINOPHIL LEVELS AMONG WASTE COLLECTORS IN BANDA ACEH Imansyah Putra, Teuku Romi; Loesnihari, Ricke; Panggabean, Merina
Indonesian Journal of Tropical and Infectious Disease Vol. 7 No. 2 (2018)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (771.047 KB) | DOI: 10.20473/ijtid.v7i2.7259

Abstract

Soil-Transmitted Helminth (STH) has infected more than one billion people worldwide. Waste collectors are at risk for STH infection because their work mostly in contact with soil and waste. Eosinophilia is a sign of human immune response to STH infection in addition to increased IgE and cytokine production. This cross sectional study aims to examine the association between STH infection and eosinophil levels among waste collectors in Banda Aceh. The study sample were 60 waste collectors working for the Sanitation department of Banda Aceh. Examination of stool samples using Kato-Katz technique revealed the prevalence of STH infection among waste collectors was 23.3% (14/60), consisting of T.trichiura infection (21.7%) and mixed infection (1.6%). There were no single infections of A. lumbricoides nor the hookworm infection was found. Blood tests to count eosinophil showed the prevalence of eosinophilia at 21.7%. There was no significant correlation between the intensity of STH infection and eosinophil levels (p value = 1.00). This study does not recommend the use of eosinophilia to indicate STH infection.
The difference in IL-17 level between mild and severe COVID-19 inpatients of H. Adam Malik General Hospital Sembiring, Alemmina; Loesnihari, Ricke; Rahmaini, Ade
Jurnal Prima Medika Sains Vol. 6 No. 1 (2024): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i1.4549

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a new coronavirus, Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). Pro-inflammatory cytokines play a central role in many viral respiratory infections by coordinating and activating adaptive immune responses. Higher serum levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-2, IL-6 and IL-17) and chemokines (IL-8) have been observed in many patients with severe COVID-19 compared with individuals with a mild degree. This research is an observational study with cross sectional data collection method. This study took blood samples from mild and severe COVID-19 patients who were treated at the HAM Hospital as many as 34 patients. Samples were examined only once for IL-17 in mild and severe COVID-19 patients. The research was conducted after obtaining ethical approval and informed consent. This study was followed by 18 female subjects (52.9%). The mean age of the subjects was 47.52 years with the youngest age being 23 years old and the oldest being 81 years old. By using the Mann Whitney test, it showed that there was a significant difference in interleukin 17 levels between Covid-19 patients with severe and mild degrees (p = 0.049). IL-17 examination can be used as an alternative diagnostic marker and assess the severity in COVID 19 patients. Further studies are needed that involve a larger number of subjects, and are associated with other inflammatory markers such as CRP or with coagulation status such as D- dimer.
Kolesterol Total dan Kolesterol LDL terhadap hsCRP pada Pasien COVID-19 Berat Irawaty, Noni; Syafril, Santi; Loesnihari, Ricke
Journal of Telenursing (JOTING) Vol 5 No 2 (2023): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v5i2.7251

Abstract

This study aims to examine the relationship between total LDL cholesterol and hsCRP in severe COVID-19 patients at the H. Adam Malik Hospital, Medan. The research method used was a cross-sectional retrospective study. The research results showed a negative correlation between Total Cholesterol and LDL Cholesterol and hsCRP in severe COVID-19 patients. In conclusion, a decrease in Total Cholesterol and LDL Cholesterol levels was found in severe COVID-19 patients. Increased hsCRP levels were found in severe COVID-19 patients. The demographic characteristics of the research subjects were dominated by male patients. The most common comorbidity found is Diabetes Mellitus Type 2, followed by hypertension. Keywords: Severe COVID-19, hsCRP, LDL Cholesterol, Total Cholesterol
Perbedaan Kadar Pentraxin 3 pada Penderita Hepatitis B Kronis dengan Cirrosis dan Tanpa Cirrosis Sasmita, Afrianda Wira; Sungkar, Taufik; Loesnihari, Ricke
Journal of Telenursing (JOTING) Vol 5 No 2 (2023): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v5i2.7252

Abstract

This study aims to see differences in pentraxin 3 levels in chronic hepatitis B sufferers with cirrosis and without cirrosis. The method uses cross sectional consecutive sampling. The results of this study found a significant difference between the average value of Pentraxin 3 in chronic Hepatitis B patients with liver cirrhosis group compared to the group without liver cirrhosis (p<0.001). There was a significant difference between the Pentraxin 3 levels in the group of Chronic Hepatitis B sufferers with liver cirrhosis compared to the group of Chronic Hepatitis B sufferers without liver cirrhosis (p<0.001) where the Pentraxin 3 levels in the Chronic Hepatitis B group with liver cirrhosis were higher compared to the group without liver cirrhosis. In conclusion, Pentraxin 3 levels can be used as an alternative marker to assess the development of liver cirrhosis in Chronic Hepatitis B patients. Keywords: Chronic Hepatitis B, Liver cirrhosis, Pentraxin 3
Correlation between Troponin I and Serum Sodium and Potassium Levels in Acute Coronary Syndrome Rahma, Hadiyatur; Loesnihari, Ricke; Siregar, Dewi Indah Sari
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.794

Abstract

Background: Acute Coronary Syndrome covers a spectrum of conditions that include patients who have recently changed symptoms or clinical signs, with or without changes in the 12-lead electro­cardiogram, and with or without acute elevations in cardiac troponin (Tn) concentrations. Advances in technology have refined troponin testing and increased its accuracy in detecting and measuring cardiomyocyte injury, high sensitivity, and can detect small myocardial necrosis that is not detected on an electrocardiogram or CKMB examination. This study aims to analyze the correlation between troponin I and sodium and potassium levels in acute coronary syndrome. Subjects and Method: This study was an analytical observational research with a cross-sectional design, involving 40 patients with acute coronary syndrome who visited the Integrated Heart Center Emergency Department. The independent variable is acute coronary syndrome, while the dependent variables are troponin I, sodium, and potassium. The study was conducted at H.Adam Malik Hospital in Medan from February to March 2024. Patients were interviewed for medical history, and then blood samples were taken for troponin I examination and serum electrolyte (sodium and potassium) examination. Data were analyzed using the Spearman correlation test. Results: 40 study subjects, most of the study subjects over 55 years, mostly male (72.5%), with a smoking history of 67.5%, and a family history of hypertension of 52.5%. The median troponin I level was 6.09 ng/ml (range 0.12-15), the median sodium level was 143.5 mmol/L (range 130-155), and the mean potassium level was 4.19 mmol/L (SD= 0.52). There was a weak and non-significant positive correla­tion between troponin I and sodium (r= 0.129, p= 0.429), as well as a weak and non-significant positive correlation between troponin I and potassium (r= 0.059, p= 0.717). Conclusion: There was no correlation between troponin I and sodium, as well as troponin I and potassium.
Co-Authors Akbar, Nizam Ester Maduma Napitupulu Hilda Sungkar Indah Afriwanty Simatupang Irawaty, Noni Irma, Fani A. Malayana Rahmita Nasution Merina Panggabean Muzahar dr Nico Dana Saputra Rahma, Hadiyatur Rahmaini, Ade Santi Syafril, Santi Sasmita, Afrianda Wira Sembiring, Alemmina Siahaan, Jekson Martiar Silalahi, Yuni Siregar, Dewi Indah Sari Tasrif Hamdi Taufik Sungkar, Taufik Teuku Romi Imansyah Putra, Teuku Romi Urip Harahap Wan Tysa Muhaira