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Maria Ludya Pulung
Jurusan Kimia FMIPA UNIPA
Agriculture, Biological Sciences & Forestry Chemistry Mathematics Physics

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Uji Aktivitas Antidiabetes Dengan Metode Penghambatan Enzim α-Glukosidase dan Karakterisasi Kandungan Senyawa Aktif pada Fraksi Metanol dan Kloroform Daun Lavetar (Wedelia biflora (L).DC) Asal Biak Bertha Mangallo; Adrianus Banu Pradana Putra; Maria Ludya Pulung
Jurnal Natural Vol. 15 No. 1 (2019): Jurnal Natural
Publisher : FMIPA Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30862/jn.v15i1.28

Abstract

Salah satu jenis tanaman yang dijadikan sebagai obat tradisional adalah tumbuhan Lavetar (W. biflora) yang di manfaatkan oleh masyarakat Biak sebagai obat untuk mengobati penyakit diabetes. Penemuan sumber penghambat α-glukosidase sangat bermanfaat dalam upaya pengembangan obat herbal yang lebih efektif bagi penderita diabetes. Penelitian ini bertujuan untuk menentukan aktivitas antidiabetes fraksi metanol dan fraksi kloroform daun Lavetar dengan metode aktivitas penghambatan enzim α-glukosidase serta menentukan kandungan senyawa aktif dengan menggunakan GCMS. Hasil skrining fitokimia menunjukkan bahwa senyawa aktif pada fraksi metanol adalah flavonoid dan tannin sedangkan fraksi kloroform mengandung senyawa flavonoid, tannin, dan saponin. Uji aktivitas penghambatan enzim α-glukosidase fraksi kloroform tergolong lemah sedangkan fraksi metanol tergolong sangat lemah dengan nilai nilai IC50 masing – masing sebesar 112,562 µg/mL dan 211,151 µg/mL. Hasil Interpretasi spektra FTIR dan skrining fitokimia menunjukkan bahwa gugus fungsi utama adalah flavanoid. Hasil analisis dengan GC-MS menunjukkan bahwa pada fraksi metanol terdapat 84 puncak senyawa dengan senyawa dominan yaitu 1-Heptatriacotanol (m/z = 190) dan fraksi kloroform terdapat 102 puncak senyawa dengan senyawa dominan yaitu cyclopropanebutanoic acid,2-[[2-[[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]metyl]-,metyl ester (m/z = 270).
UJI AKTIVITAS ANTIBAKTERI DAN SKRINING FITOKIMIA EKSTRAK HEKSANA, ETIL ASETAT DAN METANOL TUMBUHAN SURUHAN (Peperomia pellucida L. Kunth) Restianti Restianti; Bimo Budi Santoso; Maria Ludya Pulung
Jurnal Natural Vol. 16 No. 2 (2020): Jurnal Natural
Publisher : FMIPA Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30862/jn.v16i2.114

Abstract

Antibacterial activity test and screening of phytochemical of extract hexane, ethyl acetate and methanol have been carried out. The extraction of the P.pellucida plants was carried out by the maceration method in stages based on the polarity of the solvent. Analysis of chemical compounds done with phytochemical screening test. Based on the identification of chemical compounds by phytochemical screening, hexane and ethyl acetate extract has been detected only in the presence of flavonoid compounds with moderate categories. Methanol extract contains high-grade alkaloids and moderate flavonoid and tannin compounds. Antibacterial test using disffusion methods suggest that ethyl acetate and methanol extract have categorically strong antibacterial activity againts the S. aureus of 14 mm and 16 mm respectively. Hexane extract and acetate ethyl have a strong inhibition to E. coli of 11 mm and 12 mm respectively. Methanol extract has a weak inhibition to bacteria E. coli and a hexane extract has a weak inhibition to bacteria S. aureus.
ANALISIS KADAR BIOETANOL HASIL FERMENTASI DARI NIRA NIPAH (Nypa fruticans wurmb) ASAL PAPUA Sefnat Sopater Runtuboi; Maria Ludya Pulung; Evelina Somar
Jurnal Natural Vol. 15 No. 2 (2019): Jurnal Natural
Publisher : FMIPA Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30862/jn.v15i2.127

Abstract

This study aims to analyze the ethanol content in fermented palm juice.This research includes the preparation of raw materials, fermentation, distillation and distillation products analyzed by gas chromatography method. Fermentation is carried out for 2, 5, 7 days, the highest level of bioethanol produced is then selected for distillation. Levels the highest fermentation process is on the 5th day with a level of 18%. Got results the final distillation is 117 mL with a level of 94% of the initial volume of 4.2 L fermentation based on measurements using an alcoholmeter while the analysis by gas chromatography yielded 93.9% levels. The density of bioethanol is 0.8232 gr / mL. The results of the retention time measurement show the sample has a retention time which is almost the same as standard ethanol, namely 3,761 standard ethanol samples 3,764. From retention time data can be concluded that the sample is ethanol. Ethanol content in sample based on analysis by gas chromatography is 93.9%
Co-Authors Adrianus Banu Pradana Putra Bertha Mangallo Bimo Budi Santoso Evelina Somar Restianti Restianti Sefnat Sopater Runtuboi