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All Journal Medical Journal of Indonesia Eksakta : Berkala Ilmiah Bidang MIPA JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
TJAHJANI MIRAWATI SUDIRO
Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health

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Journal : Eksakta : Berkala Ilmiah Bidang MIPA

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SARS-CoV-2 Proteases: Role and Potential as Drug Target Swestikaputri, Chrecentia Hanna; Sudiro, Tjahjani Mirawati
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 03 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss03/437

Abstract

The coronavirus disease of 2019 (COVID-19) has become a long global pandemic caused by a transmitted and pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Even though WHO has retracted the global emergency status of COVID-19, it remains a threat. Various antiviral treatments are being devised and developed due to the coronavirus's high rate of mutation and need to create more effective treatments for infections. Protease is an important part of the life cycle of SARS CoV-2 hence it is intended as an antiviral target. Several protease inhibitor candidates have been identified, but there is still much to learn, including the structure and mechanism by which these inhibitors inhibit protease. This article investigates the function of proteases in the SARS CoV-2 life cycle and the mechanism of protease inhibition. Past and present research on the protease inhibitor mechanism of action was evaluated in order to generate this literature review. Here we found that the main protease (Mpro), one of SARS-CoV's proteases, is highly conserved among coronaviruses and has no human homolog. As a result, numerous Mpro inhibitors have been developed in an effort to treat COVID-19. PAXLOVID, an Mpro inhibitor, is already approved by FDA for emergency use.
Co-Authors Agus Sjahrurachman Beti Ernawati Dewi Betty Ernawati Fera lbrahim Fithriyah Kartika, Aisya Alma Asmiranti Leonard Nainggolan Mardiastuti Mardiastuti Nugraheni, Enny Pratiwi Pujilestari Sudarmono Swestikaputri, Chrecentia Hanna