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ANALISIS KANDUNGAN BORAKS PADA KERUPUK NASI YANG DIJUAL DI PASAR TRADISIONAL KABUPATEN TANGGAMUS SECARA SPEKTROFOTOMETRI UV-Vis Samsuar Samsuar; Akhmad Rokiban; Suparsi Suparsi
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

The use of additional subtance for food is to increase or to maintain nutritional value and quality of storability. Our govermment prohibits the use of borax as an additives subtance for food as appointed in Permenkes No.033, 2012. Borax is a chemical compound in white colorless crystalline with a chemical formula Na2B4O7.10H2O. Rice crackers are crackers made from rice with spices and flavor enhancer. In manufacturing crackers Borax is sometimes added to get savory crackers and to make them swelling. The purpose of this study is to find out the borax content on rice crackers in traditional markets Tanggamus district by using the qualitative method. It uses the flame test, cucurmin reagen test and ammonia steam test. It also applies quantitative test by using spectophotometry UV-Vis. There are 8 samples which were taken in tradisional markets Tanggamus district. The result of determination of the maximum length waves is 543 nm. This method has been validated before being used for the samples. The resulf of the research shows a curve with linear calibration,with the regression equalition y = 0,539x + 0,009 and correlation coefficient (r) = 0,9979. The average recorvery or accuracy value is 104,71 %. The precision or the result of standartd deviation and standard deviation relative or coeffecient of variation (CV) is 0,219%. The LOD acquistion value is 0,069 µg/ml and the LOQ is 0,320 µg/ml. The validation of the test shows that all methods have been done are valid, so it can be used to test the borax assay on the samples. Based on the analysis on 8 samples of rice crackers, quanlitative obtained sample testing shows 6 detected containing borax, then the result of quantitative obtained the level of borax ranged from 46,75 µg/g until 107 µg/g. Keywords : borax, rice crackers, Spectrofometry UV-Vis

FRAKSI AIR EKSTRAK DAUN WUNGU (Graptopphyllumpictum L.) SEBAGAI ANTIINFLAMASI TERHADAP TIKUS PUTIH JANTAN Ramadhan Triyandi; Akhmad Rokiban; Catur Setia Pratiwi MS
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.325

Abstract This study aims to determine the anti-inflammatory effect of the water extract of Daun wungu (Graptophyllum pictum L.) extract which was observed from the decrease in the volume of edema of rat’s feet which was induced by 1 % carrageenan as much as 0,1 ml, was carried out in 25 male white rats divided into 5 groups. Negative controlwas given distilled water given 5 % Na CMC, diclofenac sodium as a positive control with a dose of 0,9 mg/200 g BB and water fraction of wungu leaf extract with a dose 1 (1,125 mg/kg bb), dose 2 (2,25 mg/kg bb) dan dose 3 (4,5 mg/kg bb). The measurement of edema volume is carried out every hour for six hours after induced carrageenan. From the results of testing the water fraction of wungu leaf extract, % inhibition showed that the dose group 3 (4,5 mg/kg bb) had anti-inflammatory activity that was comparable to the positive control group. Of all dosage variatons in this study the effective dose which has the highest percentage of edema is the dose 3 (4,5 mg/kg bb). Based on the results of statistical analysis, the percentage of edema inhibition data on the water fraction of wungu lear extract from all dose variations showed significant differences with negative controls. Keyword : Graptophyllum pictum L Anti-Inflamasi

EVALUATION OF THE USE OF ANTIMALARIA MEDICINES IN HANURA HEALTH CENTRE PESAWARAN DISTRICT PERIOD JANUARY-DECEMBER IN 2018 Akhmad Rokiban; Ramadhan Triyandi; Karnila Sari
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.330

Abstract Malaria is a public health problem in Indonesia, especially those living in isolated areas. This is published in Presidential Regulation No. 5/2010 concerning the National Medium Term Development Plan for malaria endemic areas, which are divided into high, medium and low endemic areas. High endemic if the API is greater than 50 out of 1,000 population in the provinces of Maluku, Papua, North Sumatra and East Nusa Tenggara. Moderate endemic if the API is 1 to less than 50 dari 1,000 population in the provinces of Aceh, Bangka Belitung, Jambi and West Nusa Tenggara. Low endemic if the API is 0-1 per 1,000 population in Kalimantan, Sulawesi, and parts of Java. This study aims to determine the evaluation of the use of antimalarial drugs with the characteristics of age, sex, and type of malaria plasmodium at the Hanura Public Health Centre based on the criteria of the right indication, the right drug, the right dose, the right interval of drug administration (4T). This research is a descriptive research with purposive sampling method. Collection of prescription data and medical records in January-December 2018. The results showed that in cases of Malaria based on age, the most common cases occurred in the age range of 56-65 years, amounting to 99.6%, based on sex experienced in men by 77.41%, based on body weight the most occurred at 41-59 kg at 45.16%, based on the type of plasmodium experienced plasmodium vivax mostly at 84.95%. Based on these data, it was concluded that the evaluation of the use of antimalarial drugs based on 4T criteria was 100% accurate indication, 100% correct drug, 72.04% correct dose, 98.92% correct interval of drug administration. Keywords: Malaria vivax, treatment, Puskesmas, 4T

ANALISIS KADAR NITRIT PADA SOSIS SAPI KEMASAN YANG BEREDAR DI PASAR TRADISIONAL KOTA BANDAR LAMPUNG SECARA SPEKTROFOTOMETRI UV-VIS Samsuar Samsuar; Akhmad Rokiban; Dodo Hardoyo
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.331

Abstract The use of nitrite as a preservative and provider of the stable red color, aroma as well as taste for the meat is allowed within processed meat products, such as beef sausage. However, it should be noted that its use does not exceed the maximum permitted limit so as not to negatively impact human health. Excess nitrite in the human body can cause acute poisoning, namely methemoglobinemia and chronic poisoning as a result of the formation of carcinogenic nitrosamine derivatives. This research aims to determine whether the levels of nitrite contained in the packaged beef sausage distributed in the traditional market of Bandar Lampung is in accordance with the regulations of The Indonesia Food and Drug Authority or Indonesia FDA No. 36 of 2013 which is not more than 30 mg/kg. The analysis of nitrite levels in the sample was carried out using with UV-Vis Spectrophotometry method based on diazotation reaction between nitric acid and sulfanilamide forming diazonium salts. The products were then reacted again with naphthyl ethylenediamine to form a purplish red compound whose absorbance was measured at a wavelength 0f 543,8 nm. From the results of the analytical methods validation, it was obtained that the value of the correlation coefficient was 0,9997, the coefficient of determination 0,9994, the coefficient of variation 1,2121%, the range of percent recovery between 98,630-101,240%, and the detection and the quantitation limit respectively at 0,0187 ppm and 0,0623 ppm. This indicates that all test parameters meet the requirements for their use. The result of determining the average levels of nitrite in the samples show that there were two samples that had levels exceeding the maximum allowed limit, i.e sampel C=40,407 mg/kg and sample D=33,181mg/kg while sample A=18,963 mg/kg, sample B=9,427 mg/kg, sample E=9,423 mg/kg and sample F=8,689 mg/kg did not exceed the maximum allowed limit. Keywords: Beef Sausage, Nitrite, UV-Vis Spectrophotometry, Method AnalysisValidation

EVALUASI PENGGUNAAN OBAT PADA PASIEN HIPERTENSI RAWAT JALAN DI RUMAH SAKIT UMUM WISMA RINI PRINGSEWU TAHUN 2019 Ramadhan Triyadi; Akhmad Rokiban; Anggun Carima
JFL : Jurnal Farmasi Lampung Vol. 9 No. 2 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i2.336

Abstract Hypertension is a non-communicable disease characterized by the increase of systolic blood pressure is >140 mmHg and diastolic blood pressure is >90 mmHg. Hypertension is also the major risk factor of other cardiovascular disease. The incidence rate of hypertension with or without complications increases every year, so the potential for inaccurate use of drugs is increasing. The purpose of this research is to determine the characteristics of hypertension outpatients and the proper hypertension drug use in hypertension outpatients at Wisma Rini General Hospital Pringsewu in 2019 based on the proper patient, the proper indication, the proper drug, and the proper dose using the standard reference of Guidelines JNC VIII. This research is descriptive research, the data was collected retrospectively based on medical records. The sample collection technique in this research is using a purposive sampling technique. The results in this study obtained from 110 patient samples diagnosed with the hypertension showed that most of hypertension patients are women (55,46%), mostly aged 56-65 years old (40%), and the most taken hypertension drug is CCB group amlodipine with 78 patients (71%). The evaluation of antihypertensive drug use obtained is proper patient with 110 patients (100%), proper indication with 110 patients (100%), proper drug with 92 patients (75,6%), and proper dose with 110 patients (100%). Keywords: Antihypertensive, Hypertension, Accuracy drug use.

ANALISIS DRUG RELATED PROBLEMS (DRPs) PADA PASIEN RAWAT JALAN DIABETES MELITUS TIPE 2 DI UPT PUSKESMAS RAWAT INAP GEDONG AIR BANDAR LAMPUNG Akhmad Rokiban; Dwiauliaramdini Dwiauliaramdini; Sitijuwariyah Sitijuwariyah
JFL : Jurnal Farmasi Lampung Vol. 9 No. 2 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i2.342

Abtract Diabetes mellitus (DM) is a serious chronic disease that occurs because the pancreas does not produce enough insulin or when insulin is not use effectively in the body. This study aims to analyze the incidence of Drug Related Problems (DRPs) and find out the category of DRPs in outpatients with a diagnosis of type 2 diabetes mellitus at UPT Puskesmas Gedong Air Inpatient for the Bandar Lampung. This research is a nonexperimental research with a descriptive design taken retrospectively. The sampling technique used in this study is total sampling based on the patient's medical record data. Data were analyzed using the classification of DRPs according to Cipolle 2004, then using Medscape Tools as a tool to check potential drug interactions. The results of this study were 61 patients including 29 patients (46%) with DRPs and 33 patients (54%) without DRPs. The number of male patients is 25 patients and the number of female patients is 36 patients with age range 25-45 and 46-65. A total 52 patien Type 2 Diabetes Mellitus have cormobid and 9 patients without comorbid. DRP categories that occur include drugs without indication as much (8%), indications without drugs as much as (15%), and potential drug interactions (48%). The conclusion in this study is that Drug Related Problems (DRPs) have occurred in outpatients diagnosed with type 2 diabetes mellitus in UPT Puskesmas Gedong Air Inpatient with the highest DRPs category is the potential for drug interactions (48%). Key words: Diabetes Mellitus Type 2, Drug Related Problems

FRAKSI ETANOL EKSTRAK KULIT PISANG KEPOK KUNING ( Musa balbisiana) TERHADAP BAKTERI Staphylococcus epidermidis, Staphylococcus aureus, dan Propionibacterium acnes Yuli Wahyu Tri Mulyani; Akhmad Rokiban; Galih Cipto Mahendra
JFL : Jurnal Farmasi Lampung Vol. 10 No. 1 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i1.492

Yellow kepok banana peel (Musa balbisiana) contains antibacterial compounds against S. epidermidis, S. aureus and P.acne. This study aims to proved the antibacterial activity of the yellow kepok banana peel extract fractionated using ethanol as a solvent against S.epidermidis, S.aureus and P.acne. The yellow kepok banana peel extraction process was carried out by maceration method with 70% ethanol followed by fractionation to obtain ethanol fraction. Antibacterial activity testing using nutrient agar (NA) media with wells method with a concentration of 25,000 ppm, 50,000 ppm, 100,000 ppm, aquadest as a negative control and clindamycin as a positive control. The phytochemical test of the ethanol fraction showed the content of alkaloids, flavonoids, saponins, tannins and quinones. The results of the inhibition zone diameter of the ethanol fraction at a concentration of 100,000 ppm against S. epidermidis (11.87 mm), S. aureus (12.04 mm) and P. acne (11.35 mm). The test is to determined the minimum inhibitory concentration (MIC) the minimum inhibitory concentration value of the ethanol fraction of S. epidermidis, S. aureus is 20,000 ppm and for P. acne is 17,500 ppm. The conclusion of this studied was that the ethanol fraction of kepok yellow banana peel extract has inhibitory and bacteriostatic properties against S. epidermidis, S. aureus and P.acne bacteria.Keywords: alkaloids,Ant ibacter ial , flavonoids , Fractionated, Musa balbisiana

UJI AKTIVITAS ANTIBAKTERI ISOLAT SENYAWA GOLONGAN TERPENOID DARI BIJI PEPAYA (Carica papaya L.) TERHADAP Staphylococcus aureus SECARA IN VIVO PADA KELINCI JANTAN Samsuar Samsuar; Akhmad Rokiban; Adityo Hartono; Ratna Setianingsih
JFL : Jurnal Farmasi Lampung Vol. 10 No. 1 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i1.497

A research on the isolation of terpenoid class of compounds from the seeds of papaya (Carica papaya L.) and test its activity against Staphylococcus aureus in vivo in male rabbits. This research aims to prove that the terpenoid compounds isolated from the seeds of papaya (Carica papaya L.) can inhibit the growth of Staphylococcus aureus in vivo. Separation of terpenoid compounds by column chromatography ((eluent n-hexane: ethyl acetate: ethanol)) resulted in 25 eluates, and then merged based on the results of identification by TLC ((nhexane: ethyl acetate (8: 2)) and the color test reagent Lieburmann -Burchard produce 5 fraction groups. fraction D showed positive terpenoids with Rf 0.75 and the color purple with Lieburmann-Burchard reagent. study using 15 rabbits were divided into 5 groups: P1 (negative control), P2 (positive control) , P3 (5% of the test group), P4 (10% of the test group), P5 (test group 15%). each group was given the intracutaneous Staphylococcus aureus as 0,2ml on the backs of rabbits. Having symptoms of infection each group was given the test substance 3 times a day topically, the observed parameter is the diameter of the wound, and histopathological observations performed on days 3,6 and 9 Analysis of the results of research conducted using ANSIRA showed highly significant differences between groups (p <0.05). Then proceed with the analysis of the results of the analysis HSD test showed highly significant differences in the test group 5% to 10% of the test group and the test group 15%. Isolates terpenoid class of compounds from the seeds of papaya (Carica Papaya L.) with a concentration of 10% and 15% can inhibit the growth of Staphylococcus aureus. Keywords: Antibacterial, Staphylococcus aureus, male rabbits

PENETAPAN NILAI SPF (SUN PROTECTION FACTOR) SEDIAAN KRIM TABIR SURYA DI KOTA BANDAR LAMPUNG DENGAN METODE SPEKTROFOTOMETRI UV-VIS Subur Widodo; Akhmad Rokiban; Lilik Koernia Wahidah; Ikhrami Nurjannah
JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i1.978

Nowadays people awareness of the healthy skin importance is increasing, this is evident by the increasing cosmetic brands and there are many beauty clinics. Cosmetic products marketed should have the same efficacy as those listed on the packaging. Therefore, determining the efficacy of sunscreen preparations is very important to see the compliance of cosmetics manufacturers. The purpose of this study was to determine the suitability of the SPF product efficacy. The samples are the products which have SPF 30, the sample was tested by in vitro method using UV-Vis spectrophotometer, every 5 nm with the wavelength range 290 nm - 320 nm absorbance was measured, then analyzed with the mansur equation. Also did antioxidant activity tested with vitamin C as a control positive using the DPPH method. The principle of the DPPH method is the measurement of absorbance of DPPH radicals which are degraded due to the presence of antioxidant compounds using a UV-Vis spectrophotometer. The decrease in DPPH absorbance intensity is proportional to the increase in the concentration of antioxidant compounds expressed in IC50 (Inhibition Concentration 50). Sample 4 has an SPF value close to the value written on the packaging. Samples 2, 5, 1, 3, 6, 7 and 8 have SPF values smaller than those listed on the packaging. The antioxidant activity obtained is rateable to the SPF value, sample 4 has the highest antioxidant activity followed by sample 2, sample 5, sample 1, sample 3, sample 6, and sample 7 and sample 8 have the lowest antioxidant activity. Keywords: Antioxidant , DPPH, UV-Vis spectrophotometry, SPF, Sunscreen

HUBUNGAN PENGETAHUAN DAN PERILAKU IBU DENGAN KEJADIAN ISPA PADA BALITA DI PUSKESMAS KALIREJO KECAMATAN NEGERI KATON KABUPATEN PESAWARAN Akhmad Rokiban; Novita Tri Wahyuni; Anita Purnama Sari
JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i1.980

Acute Respiratory Infection (ARI) is an upper or lower respiratory tract disease, where an acute infection process that lasts for 14 days, is caused by microorganisms that attack one or more parts of the respiratory tract, from the nose to the alveoli. This study aims to determine the relationship between knowledge and behavior of mothers with the incidence of ARI in children under five at the Kalirejo Public Health Center Negeri Katon District Pesawaran Regency. This type of research is descriptive observational. This research was conducted in June. The sample in this study was 100 respondents, the sampling technique in this study was accidental sampling, in this study the validity and reliabilitas Based on the chi-square results between knowledge and maternal behavior, a value (p value = 0.020) was obtained, maternal knowledge with the incidence of ARI was obtained (p value = 0.000), maternal behavior with ARI incidence was obtained (p value = 0.041). From this study, it can be concluded that the significance value < 0.05 indicates that there is a relationship between knowledge and maternal behavior, knowledge relationship with the incidence of ARI, and behavior with the incidence of ARI. Keywords: Incidence of ARI, Knowledge, Behavior

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