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All Journal Indonesian Journal of Pharmaceutical Science and Technology Biota Syntax Literate: Jurnal Ilmiah Indonesia JFL : Jurnal Farmasi Lampung Jurnal Inovasi Pembangunan Jurnal Media Pengabdian Kepada Masyarakat (JM-PKM)

Widodo, Subur

Program Studi Farmasi, Fakultas MIPA, Universitas Tulang Bawang Lampung

Author-ID : 867657

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Antibacterial Activity From Cucumber (Cucumis sativus .L) Ethanol Extract In Deodorant Roll On Dosage Form Susanti, Laila; Widodo, Subur; Aini, Qurrota; Rahmawati, Dyah
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Body odor of human skin usually occur due to excessive production of sweat glands couples with the presence of bacteria. The active ingredient to prevent body odor are chemicals materials from alum or sodium in order to have negative effects such as skin irritation, Alzheimer disease, prostate and breast cancer. Natural materials technology has been development as an active agent by using cucumber (Cucumis sativus .L). The purpose of this research to conduct a deodorant roll on a stable and qualified physical quality and also develop the use of extract cucumber as an antibacterial Staphylococcus epidermidis. Cucumber extraction has been done by maceration with ethanol 70% for 4 days and then divided into three formulation extract (5%, 10%, and 20% (b/v)). All of the formulations has been tested by zone inhibition, organoleptic, homogenity, pH, viscosity and irritation test. The results given that all of the formulations meet the quality requirements of physical and the best formulation extract 20% able to inhibit bacterial by 26 mm as a largest diameter of the inhibitory zone. In addition the stability of deodorant roll on form were performed accelerated stability test for 35 days at room temperature (28Â°C) and 40Â°C. The test results indicate that the stability of the extract 10% quali ed physical quality during storage at room temperature (28Â°C) and high temperature (40Â°C) for 35 days. While in the extract 20% at high temperature (40oC) physical changes characterized by the deposition. Keyword : cucumber, deodorant roll on, antibacteriaÂ

Antibacterial Activity From Cucumber (Cucumis sativus .L) Ethanol Extract In Deodorant Roll On Dosage Form Laila Susanti; Subur Widodo; Qurrota Aini; Dyah Rahmawati
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Body odor of human skin usually occur due to excessive production of sweat glands couples with the presence of bacteria. The active ingredient to prevent body odor are chemicals materials from alum or sodium in order to have negative effects such as skin irritation, Alzheimer disease, prostate and breast cancer. Natural materials technology has been development as an active agent by using cucumber (Cucumis sativus .L). The purpose of this research to conduct a deodorant roll on a stable and qualified physical quality and also develop the use of extract cucumber as an antibacterial Staphylococcus epidermidis. Cucumber extraction has been done by maceration with ethanol 70% for 4 days and then divided into three formulation extract (5%, 10%, and 20% (b/v)). All of the formulations has been tested by zone inhibition, organoleptic, homogenity, pH, viscosity and irritation test. The results given that all of the formulations meet the quality requirements of physical and the best formulation extract 20% able to inhibit bacterial by 26 mm as a largest diameter of the inhibitory zone. In addition the stability of deodorant roll on form were performed accelerated stability test for 35 days at room temperature (28°C) and 40°C. The test results indicate that the stability of the extract 10% quali ed physical quality during storage at room temperature (28°C) and high temperature (40°C) for 35 days. While in the extract 20% at high temperature (40oC) physical changes characterized by the deposition. Keyword : cucumber, deodorant roll on, antibacteria

Formulation Of Ointment From Extract Combination Of Lemongrass (Cymbopogon nardus L. Rendle), Green Betel Leaf (Piper betle L.) And Natural Zeolite As An Antibacterial Agent Laila Susanti; Subur Widodo; Mashuri Yusuf; Retno Fardila Sari
Biota Vol 6 No 2 (2020): Jurnal Biota 2020
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/10.19109/Biota.v6i2.6363

Lemongrass (Cymbopogon nardus L. Rendle) and green betel (Piper betle L.) plants are native to Indonesia. Empirically betel leaf can be used as a wound healer, lemongrass leaves are widely used as medicine for insect bites. On the basis of information obtained from various literatures, in this research has been done formulation of ointment from extract combination of lemongrass, green betel leaf and natural zeolite as antibacterial of Staphylococcus aureus. The use of zeolites based on features has a three-dimensional framework structure that is interconnected so that it has a large surface. Based on these reasons, it is believed that zeolites can increase the activity of active substances in ointments. The formulation of ointment extracts of lemongrass leaves-green betel leaves and zeolites with various dosages are KZ (zeolite control), KE (20% -5%), F1 (10% -6% + zeolite), F2 (20% - 5% + zeolite), F3 (30% -4% + zeolite), F4 (20% -0% + zeolite), F5 (0% -5% + zeolite) with a fixed amount of zeolite (2 gr). Evaluation of ointment preparations including organoleptic test, pH, homogeneity, spreading test and adhesion test showed results that met the requirements. The sample was tested for antibacterial activity with positive control (gentamicin 0.1%) showed that all formulas can provide an inhibition zone against staphylococcus aureus, except KZ. Test results were analyzed using One Way Annova with sig (0,000) <p value (0,050) followed by Tukey's further tests. From this explanation it can be concluded that the formulation of ointment from extract combination of lemongrass leaves, green betel leaves and zeolites has antibacterial agent.

Uji Formulasi Sediaan Salep Ekstrak Batang Brotowali (Tinospora Crispa L. Miers ) Kombinasi Zeolit Terhadap Bakteri Staphylococcus Aureus dan Pseudomonas Aeruginosa Laila Susanti; Subur Widodo; Syaiful Bahri; Wenny Indriasari
Inovasi Pembangunan : Jurnal Kelitbangan Vol 4 No 03 (2016): November 2016
Publisher : Balitbangda Provinsi Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.591 KB)

Treatment of infected wounds on the skin generally use synthetic chemicals, which when used in the long term lead to negative side effects. Development of herbal medicines have been done as an alternative to synthetic chemicals because of cheap and has no side effects and low toxicity. From this background, the test formulation extract ointment preparation brotowali (Tinospora crispa L. Miers) a combination of zeolite against Staphylococcus aureus and Pseudomonas aeruginosa in vitro. This study aims to get the best formulation of the extract ointment preparation brotowali (Tinospora crispa L. Miers) which has an antibacterial effect against Staphylococcus aureus and Pseudomonas aeruginosa. In this study, the method used discs to observe the growth of bacteria by doing two to three treatments. P1 was the treatment group were given a salve on the market, namely the ointment Gentamicin as a positive control, P2 is the treatment group were given an ointment containing extract brotowali combination of zeolite with base oils, P3 is the treatment group were given ointment without extract brotowali oily base as a negative control. From the research results generated extract ointment brotowali with base oils produced are bactericidal and active substance formulations extract brotowali combination of zeolite that is at 9%v/v.

UJI KADAR NITRIT PADA DAGING BURGER DI KOTA BANDAR LAMPUNG MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Laila Susanti; Merinda Setyowati; Subur Widodo; Anita Setiawati
JFL : Jurnal Farmasi Lampung Vol. 7 No. 1 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v7i1.38

Daging merupakan salah satu sumber makanan yang berasal dari hewani dan memiliki cita rasa yang khas serta kandungan gizi yang tinggi. Dari berbagai cara pengolahan daging, daging burger merupakan salah satu produk olahan yang banyak dikonsumsi masyarakat. Sebagai bahan pengawet pada daging burger digunakan nitrit, untuk memperpanjang waktu simpan. Tujuan dari penelitian ini adalah untuk mengetahui kadar nitrit pada daging burger dengan menggunakan Spektrofotometri Uv-Vis. Sebagai pelarut digunakan asam sulfanilat bereaksi dengan asam nitrit membentuk garam diazonium kemudian ditambah pelarut naftilamin membentuk senyawa azo yang berwarna ungu, lalu diukur absorbansinya pada panjang gelombang 531 nm. Hasil penelitian menunjukan kadar rata-rata nitrit pada masing- masing sampel A ,B, C, D, E, F secara berurutan adalah 123,95 mg/kg, 30,14 mg/kg, 195,25 mg/kg, 105,74 mg/kg, 20,85 mg/kg dan 16,14 mg/kg. Dari ke enam sampel, ada 4 sampel yang memiliki kandungan nitrit melebihi ambang batas maksimum penggunaan bahan pengawet pada makanan menurut Peraturan Kepala BPOM RI Nomor 36 Tahun 2013 yaitu sebesar 30 mg/kg untuk produk daging olahan. Hanya sampel C yang memiliki kadar nitrit melebihi batas maksimum persyaratan berdasarkan Permenkes Nomor 1168/Menkes/Per/X/1999, yaitu 125 mg/kg. Kata Kunci : Daging burger, Nitrit, Spektrofotometri UV-Vis

FRAKSI ETANOL EKSTRAK KULIT DURIAN (Durio zibethinus L.) SEBAGAI ANTIFUNGI TERHADAP Trichophyton mentagrophytes DAN Candida albicans Yuli Wahyu Tri Mulyani; Subur Widodo; Lisa Selviani
JFL : Jurnal Farmasi Lampung Vol. 8 No. 1 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Durian is a fruit that is in demand by the community, but during durian season environmental problems arise due to waste from skin of durian. The aimed of the study was to prove the antifungal activity of the ethanol fraction of durian skin against Trichophyton mentagrophytes and Candida albicans and to determine the active active compounds inhibiting T. mentagrophytes and C. albicans fungi. Durian skin was extracted by maceration method, then fractionated used ethanol, chloroform, and n-hexane solvents. Ethanol fraction was tested on T. mentagrophytes and C. albicans fungi used the disc method with a concentration of 10%, 20%, 40%, 60%, 80%, 100%, distilled water as a negative control, ketoconazole as a positive control. The best inhibition zone is fungi T. mentagrophytes concentration 100% ( 9.23 mm) negative control (0 mm), positive control (32.96 mm), fungi C. albicans the best inhibition zone is concentration of 100% (8.30 mm), positive control (17.17 mm) negative controls (0 mm).The ethanol fraction was screened by the Thin Layer Chromatography method and positively contained flavonoids (rf 0.7), tannins (rf 0.58), saponins (rf 0.76) and alkaloids (rf 0.64). Minimum Inhibitory Concentrations of T. mentagrophytes were 7% and C. albicans were 8%. The most effective active compound growht of T. mentagrophytes is tannins (rf 0.7) and for C. albicans is flavonoid (rf 0.6). The ethanol fraction of durian bark extract has antifungal activity against T. mentagrophytes and C. albicans. Keywords: Antifungi, Candida albicans, ethanol fraction skin of durian, Trichophytonmentagrophytes

RASIONALITAS PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI RAWAT INAP DI RS DAERAH Dr. A. DADI TJOKRODIPO BANDAR LAMPUNG Mashuri Yusuf; Subur Widodo; Diah Pitaloka
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.329

Abstract Hypertension is one of non contagious diseases marked by the increase of systolic blood pressure > 140 mmHg and diastolic blood pressure > 90 mmHg. Hypertension becomes the main risk factor of other cardiovascular diseases. The number of hypertension occurance with or without companion increases every year. The purpose of this research is to know the rationality of anti - hypertension medicine usage on hypertension inpatients at RSUD of Dr. A. Dadi Tjokrodipo Bandar Lampung year of 2019 based on precise patient, precise indication, precise medicine, and precise dosage using reference standard of Guidelines JNCVIII. This research was a descriptive research with data collection of medical record retrospectively. The technique of sample selection used purposive sampling technique. The research results obtained from 82 samples based on the patients’ characteristics of genders such as 50 female patients (60,98%) and 42 male patients (39,02%). The patients’ characteristics based on age obtain mostly the patients are at age of 46-55 years old in the amount of 39 patients (47,6%). The patients’ characteristics based on the pattern of medicine usage obtain the most anti-hypertension used is amlodipin CCB class in the amount of 54 patients (45%). Rationality evaluation of anti-hypertension medicine usage obtains precise patient in the amount of 81 patients (99,8%), precise indication in the amount of 82 patients (100%), precise medicine in the amount of 61 patients (74,4%), and precise dosage in the amount of 82 patients (100%). The conclusion of this research is the usage of hypertension on the hypertension inpatients at Public Hospital of Dr. A. Dadi Tjokrodipo Bandar Lampung is already rational. Keywords: Anti-hypertension, Hypertension, Rationality of Medicine Usage

EVALUASI PENGGUNAAN OBAT PADA PENDERITA DIARE AKUT PASIEN PEDIATRI DI INSTALASI RAWAT INAP RUMAH SAKIT ADVENT BANDAR LAMPUNG PERIODE JULI – DESEMBER 2019 Subur Widodo; Novita Tri Wahyuni; Lea Yekti Utami
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.333

Abstract Acute diarrhea is diarrhea that lasts less than 14 days. Regarding its severity, acute diarrhea is classified as mild, moderate or severe. Mild when signs of dehydration are not observed, moderate when there are mild or moderate signs of dehydration and rehydration can be done orally and severely when it results in more intense dehydration with or without electrolyte disturbances, and requires intravenous therapy. Diarrhea disease in the Inpatient Installation Bandar Lampung Adventist Hospital is the 10 biggest diseases and has never been evaluated on the use of drugs in pediatric patients. This study aims to evaluate the use of drugs in patients with acute diarrhea inpatients installation at the Bandar Lampung Adventist Hospital calculated from July to December 2019 data. This research is a descriptive study with retrospective data collection. The data collection process begins by tracing medical records of acute diarrhea patients. The population of acute diarrhea cases was 152 patients and then the number of samples obtained was then selected according to the inclusion criteria as a sample of 60 patients. From the research results it is known that the use of drugs in patients with acute diarrhea in pediatric patients includes antibiotics, electrolyte solutions, analgesic/antipyretics, antidiarrheals and other drugs (antihistamines, supplements and probiotics). The validation of drug use on the right indicators, the right patient and the right dose has reached 100%, the right indicator is 37% and the drug is 63% incorrect, this is due to the use of antibiotics without laboratory results that show acute diarrhea due to infection. Keywords: acute diarrhea, evaluation of drug use, pediatric

ANALISIS WAKTU TUNGGU PELAYANAN RESEP PADA PASIEN RAWAT JALAN DI RSUD DR. H. ABDUL MOELOEK PROVINSI LAMPUNG Subur Widodo; Masyuri Yusuf; M. Desirwan Dinata
JFL : Jurnal Farmasi Lampung Vol. 9 No. 2 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i2.339

Abstract Pharmaceutical services are health services in hospitals that are expected to meet minimum service standards (SPM) in an effort to improve the quality of services to patients. One of the pharmaceutical service categories in the minimum service standard (SPM) in hospitals is the waiting time for prescription services in the form of nonconcoction drugs is the grace period from the time the patient submits a prescription to receiving non-concoction drugs with a minimum standard set by the Ministry of Health that is ≤ 30 minutes, whereas the waiting time for prescription concoction services is the grace period from the time the patient submits the prescription until receiving the concoction drug that is ≤ 60 minutes. This research was conducted to analyze the waiting time for outpatient prescription services in Dr. H. Abdul Moeloek based on hospital minimum service standards (SPM) as an overview of prescription services, evaluation materials and pilots in an effort to improve the quality of pharmaceutical services. This research will be conducted at the pharmacy outpatients Dr. H. Abdul Moeloek in August - September 2019 with a sample of 172 recipes, consisting of 98 non-concoction recipes and 74 recipe concoctions. Based on the research that has been done, the results of waiting time for non-concoction prescription services in the Outpatient Installation of Dr. H. Abdul Moeloek is in accordance with the SPM at the Hospital with an average waiting time of 11 minutes. Waiting time for prescription concoction services in Dr. Outpatient Hospital Installation H. Abdul Moeloek is in accordance with the SPM at the Hospital with an average waiting time of 19.4 minutes. Keywords: Pharmaceutical services, waiting time, pharmaceutical service standards.

PENGARUH TINGKAT PENGETAHUAN OBAT DAN PENYAKIT HIPERTENSI TERHADAP KEPATUHAN PENGAMBILAN OBAT PENDERITA HIPERTENSI DI PUSKESMAS ROWOREJO KABUPATEN PESAWARAN LAMPUNG Dwi Efayanti; Subur Widodo; Ade Kristanto
JFL : Jurnal Farmasi Lampung Vol. 9 No. 2 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i2.340

ABSTRACT Hypertension is a disease that contributes to death by 29.8%, factors that cause an increase in the prevalence of hypertension include patient compliance, compliance itself is influenced by one's behavior factors, one of which is knowledge. This study aims to look at the effect of the level of knowledge on the compliance of taking drugs with hypertension in Roworejo Public Health Center, Pesawaran Regency, Lampung. This research is a descriptive analysis research, conducted by giving a questionnaire that has been tested for validity and reliability and has obtained ethical permission from the ethics committee of Malahayati University, Bandar Lampung with No.485 / EC / Kep-UNMAL / VII / 2019. The level of compliance with drug taking can be seen from the recap of prescriptions for hypertension in April-June 2019. The category of adherence level uses the formula MPR (Medication Possession Ratio) which is <80% categorized as non-compliant and> 80% categorized as compliant. The data is then analyzed using linear regression, if the significant value <0.05 means that there is an influence between the variable X on the Y variable, if the significant value> 0.05 means that there is no influence between the variable X on the Y variable. The results showed that the most hypertensive patients aged> 60 years 81%, female sex 59%. The level of knowledge of the respondents mostly had medium knowledge 98% and high knowledge 2%. The level of compliance with respondent's drug taking was only 3% of respondents who were compliant and 97% of respondents were not compliant From the results of linear regression analysis in this study showed that the value of Significant value 0.000> 0.05, which can be concluded that there is an influence between the variable level of knowledge of the level of compliance with drug taking. Keywords: Hypertension, Compliance with drug uptake, Knowledge, MPR, Roworejo.

Co-Authors Ade Kristanto Anita Setiawati Anny Victor Purba Aqbar Raka Irwansyah Dhearani , Chairunnisa Diah Pitaloka Dwi Efayanti Dyah Rahmawati Hartono, Adityo Ikhrami Nurjannah Isbiyantoro Lea Yekti Utami Lilik Koernia Wahidah Lisa Selviani Luthfiyah, Yosi M. Desirwan Dinata M. Wahyu Ariawan Mashuri Yusuf Masyuri Yusuf Mega Intan Yulianti Merinda Setyowati Novita Tri Wahyuni Pratiwi, Inda qurrota aini Rahmawati, Dyah Retno Fardila Sari Riyanti, Deski Rokiban, Akhmad Rokiban, Akhmad Safitri, Andika Samsuar Samsuar, Samsuar Siti Nurjanah Sivitha, Sivitha Suri, Nurma Susanti, Laila Syaiful Bahri Wenny Indriasari Widiyastuti, Asih Yuli Wahyu Tri Mulyani

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