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All Journal Jurnal Kedokteran Brawijaya Jurnal Farmasi Klinik Indonesia INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Berkala Ilmiah Kedokteran Duta Wacana JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)
Rita Suhadi
Fakultas Farmasi, Universitas Sanata Darma
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

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Evaluation of using Antihipertensi of Angiotensin Renin system to kidney protection on Diabetic patient in X hospital of Yogyakarta Suhadi, Rita; Donatus, Imono Argo; Sidarto, B.
INDONESIAN JOURNAL OF PHARMACY Vol 15 No 4, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (381.811 KB) | DOI: 10.14499/indonesianjpharm0iss0pp177-184

Abstract

The renin-angiotensin-system antihypertensive drugs (RAS), i.e. Angiotensin Converting Enzyme Inhibitors (ACEIs) and Angiotensin II Receptor Antagonists (AIIRAs) are prescribed for diabetes patients to slow the nephropathy progression. There are only limited clinical evidence of the RAS for Indonesian patients. This study aimed at assessing the antihypertensive drug selection and the renoprotective effect on Indonesian patients.The study was done with retrospective survey and descriptiveevaluative design. A total of 116 diabetic patients were participated in the drug selection assessment and the renoprotective effect among 52 patients was analyzed by Kruskal-Wallis non-parametric statistics. The results showed that the antihypertensive drug selection consisted of RAS (ACEIs 48% and AIIRAs 11%), non-RAS 22%, and without antihypertensive drugs 19%. The RAS antihypertensive drugs were administered at 53%; 56%; 92%; and 71% by normal; mild; moderate; and severe kidney dysfuntion patients respectively.The annual clearance creatinine (Clcr) reduction were 3.93; 9.95; 0.85ml/min and the Clcr reduction in 23 months were 9.27; 8.66; 7.76% for non-RAS; without; and RAS antihypertension respectively, but the effects were not significantly different (p>0.05). In conclusion, renoprotection on diabetic patients by RAS was not more superior than that by non-RASantihypertensive drugs. Key words: Diabetic Nephropathy, Renoprotection, ACE-Inhibitors (ACEI), Angiotensin II Receptor Antagonists (AIIRA).
Co-Authors A.A. Ketut Agung Cahyawan W Antonia Adeleide Anutopi B. Sidarto, B. Bambang Irawan Budianto Budianto Budianto Budianto Chatarina Danik Wijayanti Christianus H Setiawan, Christianus H Christianus Heru Setiawan Clarentia Dwivani Damasari, Puspa Raras Dita M Virginia, Dita M Dita Maria Virginia Dwivani, Clarentia Fenty Fenty Fenty Fenty Fenty Fenty Fenty Fenty, Fenty Fransisca Tielman Gregorius Bhaskara Wikanendra Gregorius Bhaskara Wikanendra Greta Paulina Harijadi, Karina Hasrat, Kresensia T. Herlina Herlina Herlina Herlina Imono Argo Donatus, Imono Argo Iwan Dwiprahasto Iwan Dwiprahasto Iwan Dwiprahasto Jarir At Thobari Jasmine, Millatina Karina Harijadi Lusia Dewi Maemonah, Maemonah Melani, Fransisca Oktawati, Nurjati Dwi Phebe Hendra Phebe Hendra Phebe Hendra, Phebe Widyasti, Bonifasia A. C. Yunita Linawati