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All Journal Jurnal Farmasi Udayana Jurnal Kedokteran Brawijaya Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional Jurnal Farmasi Sains dan Komunitas Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JURNAL PENGABDI Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Ilmu Kefarmasian Indonesia Rengganis Jurnal Pengabdian Masyarakat Jurnal Locus Penelitian dan Pengabdian Makara Journal of Science
Phebe Hendra, Phebe
Faculty of Pharmacy, Universitas Sanata Dharma
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Health Professions Mathematics Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences

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EFEK HEPATOPROTEKTIF DAN NEFROPROTEKTIF BIJI ALPUKAT PADA TIKUS TERINDUKSI KARBON TETRAKLORIDA Hendra, Phebe; Krisnadi, Gidion; Perwita, Ni Luh Putu Dian; Kumalasari, Ike; Quraisyin, Yuditha Anggarhani
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (491.145 KB) | DOI: 10.14499/mot-TradMedJ19iss3pp133-137

Abstract

Penelitian ini bertujuan untuk mengetahui efek hepatoprotektif dan nefroprotektif dari biji alpukat pada tikus terinduksi karbon tetraklorida. Sejumlah tikus diberikan infusa dan dekokta biji alpukat dengan dosis berturut-turut 360,7; 642,1 dan 1142,9 mg/kg sekali sehari selama 6 hari berturut-turut kemudian pada hari ke-7 diberi karbon tetraklorida dosis hepatotoksin. Pengambilan darah tikus dilakukan setelah 24 jam melalui sinus orbitalis mata, lalu diukur aktivitas enzim transaminase dan kadar kreatinin. Kenaikan serum transaminase dan kreatinin pada tikus terinduksi karbon tetraklorida dapat diturunkan secara signifikan (p<0,05) baik dengan perlakuan ekstrak infusa dan dekokta. Berdasarkan hasil penelitian dapat disimpulakn bahwa infusa dan dekokta biji alpukat mempunyai efek protektif pada hepar dan ginjal tikus jantan terinduksi karbon tetraklorida. 
Korelasi Antropometri terhadap Profil Lipid pada Masyarakat Pedesaan Cangkringan, Kabupaten Sleman, Daerah Istimewa Yogyakarta Hendra, Phebe; Virginia, Dita Maria; Fenty, Fenty; Widayati, Aris
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (612.501 KB) | DOI: 10.15416/ijcp.2017.6.2.107

Abstract

Prevalensi abnormalitas profil lipid cukup besar pada masyarakat pedesaan. Pengukuran profil lipid (kolesterol total (KT), low density lipoprotein (LDL), high density lipoprotein (HDL), dan trigliserida (TG)) di laboratorium membutuhkan implementasi teknologi kesehatan sedangkan di daerah pedesaan kurang tenaga medis dan permasalahan ekonomi. Pengukuran antropometri yang mudah, tidak invasif, ekonomis, dan dapat dilakukan oleh tiap individu diharapkan dapat memprediksi abnormalitas profil lipid bagi masyarakat pedesaan. Penelitian ini bertujuan untuk mengobservasi korelasi pengukuran antropometri dengan abnormalitas profil lipid di daerah pedesaan. Penelitian ini merupakan penelitian observasional dengan desain potong lintang. Pengukuran antropometri meliputi Body Mass Index (BMI), lingkar pinggang (LP), dan rasio lingkar pinggang panggul (RLPP). Kriteria inklusi adalah penduduk Kecamatan Cangkringan, Sleman, DI Yogyakarta berumur 40–60 tahun, tidak ada riwayat penyakit kardiometabolik, tidak edema, dan konsumsi obat-obatan terkait kardiometabolik. Lokasi penelitian dipilih menggunakan klaster random sampling. Sampel penelitian dipilih secara purposive sampling dan diperoleh besar sampel 100 responden. Analisis data menggunakan Kolmogorov-Smirnov, Mann-Whitney, dan Spearman. Hasil penelitian ini menunjukkan korelasi antara BMI (r= –0,286; p=0,044), LP (r= –0,410; p=0,003), dan RLPP (r= –0,365; p=0,009) terhadap HDL pada kelompok wanita. Terdapat juga korelasi antara BMI (r=0,325; p=0,021), LP (r=0,394; p=0,005), dan RLPP (r=0,368; p=0,009) terhadap trigliserida pada kelompok wanita. Terdapat korelasi antara BMI terhadap KT (r=0,285;p=0,045), LDL (r=0,344;p=0,014), dan TG (r=0,446; p=0,001). Parameter LP pria memiliki korelasi terhadap HDL (r= –0,355; p=0,011) dan TG (r=0,488; p=0,000). Parameter RLPP pria memiliki korelasi terhadap seluruh profil lipid; terhadap KT (r=0,287; p=0,043), LDL (r=0,338; p=0,016), HDL (r=0,316; p=0,025), dan TG (r=0,359; p=0,011). Kesimpulan, pada kelompok wanita pengukuran anthropometri memiliki korelasi terhadap HDL dan TG, sedangkan parameter RLPP lebih sensitif pada kelompok pria.
Sayur Bukan Menjadi Preferensi Makanan Remaja di Indonesia Hendra, Phebe; Suhadi, Rita; Virginia, Dita Maria; Setiawan, Christianus Heru
Jurnal Kedokteran Brawijaya Vol 30, No 4 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (739.975 KB) | DOI: 10.21776/ub.jkb.2019.030.04.18

Abstract

Remaja dan perilaku akan makanan dan kesehatannya perlu mendapat perhatian utama. Perilaku tersebut akan berlanjut hingga usia dewasa. Penelitian ini bertujuan untuk melihat preferensi makanan pada remaja di Indonesia. Penelitian dengan desain potong lintang menggunakan kuesioner untuk melihat preferensi makanan remaja siswa sekolah menengah atas. Informasi yang diperoleh adalah preferensi makanan utama, minuman dan perilaku snack serta karateristik responden. Responden yang terlibat dalam penelitian sejumlah 774 orang. Ayam merupakan makanan utama yang disebutkan remaja di Indonesia dari 3 jenis makanan utama. Air putih dan biskuit merupakan preferensi minum dan dan snack yang dikonsumsi remaja di Indonesia, sedangkan sayur hanya dipilih oleh sebagian kecil remaja.
Lemongrass (Cymbopogon citratus) Ethanolic Extract Exhibited Activities That Inhibit -glucosidase Enzymes and Postprandial Blood Glucose Elevation Gunawan Puteri, Maria Dewi Puspitasari Tirtaningtyas; Tjiptadi, Felicia Melissa; Hendra, Phebe; Santoso, Filiana; Udin, Zalinar; Artanti, Nina; Florence Ignatia, Florence Ignatia
Makara Journal of Science Vol. 24, No. 4
Publisher : UI Scholars Hub

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Abstract

Lemongrass is a common ingredient in Indonesian traditional herbal medicine that potently inhibits carbohydrate hydrolysis. In this study, the in vitro α-glucosidase inhibitory (AGI) activity of lemongrass was compared with its in vivo activity to retard postprandial blood glucose elevation, and the bioactive compounds responsible for these activities were observed. Both water and ethanolic extracts of lemongrass (WLG and ELG, respectively) were tested in vitro for its inhibition of the sucrose and maltose hydrolyzing activities of rat intestinal glucosidase. ELG was observed to exert higher inhibitory activities (Sucrase IC50 = 8.74 mg/mL; Maltase IC50 = 18.93 mg/mL) than WLG. ELG was evaluated for its in vivo activity to retard blood glucose elevation in mice after sucrose, maltose, and glucose consumption. ELG was also fractionated using activity-guided chromatography, followed by liquid chromatography–mass spectrometry and high-performance liquid chromatography (HPLC). In vivo sugar tolerance test confirmed the AGI activity in a non-dose-dependent manner and showed potential additional mechanisms that may prevent postprandial hyperglycemia. The active principles were acquired in methanol-soluble fraction and purified using preparative thin-layer chromatography. HPLC analysis with commercial standards identified caffeic acid and kaempferol as the compounds responsible for the bioactivity of ELG. Results showed that lemongrass has the potential as herbal medicine ingredient in the management of diabetes.
Hubungan Kepatuhan Terapi Antihiperglikemia Terhadap Terkontrolnya HbA1c pada Pasien Terdiagnosa Diabetes Melitus Tipe 2 di RSU Prima Medika, Denpasar Ariyanti, Ni Kadek Nining; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Diabetes mellitus is a disease caused by chronic metabolic disorders accompanied by increased blood glucose levels. Adherence to treatment is very important to achieve therapeutic success in type 2 diabetes mellitus (T2DM) patients and prevent complications. HbA1c value is one of the parameters used to see the success of T2DM therapy. This study was conducted to determine the relationship between compliance with antihyperglycemic therapy for T2DM patients and the patient's HbA1c value. This study used a cross-sectional research design and data collection was carried out by non-random sampling with purposive sampling technique. The research subjects were 100 T2DM patients at RSU Prima Medika Denpasar, Bali with the age of 40-70 years. The level of patient compliance in taking medication was measured by the Medication Possession Ratio (MPR) method based on patient treatment records. The results showed 78% aged 40-59 years, 53% female, 86% T2DM with comorbidities 62% received combination therapy, 87% were compliant with taking medication. There was no significant relationship between the characteristics of T2DM patients and compliance (p-value > 0.05). There was a significant association between medication adherence and controlled HbA1c values in patients with T2DM (p-value < 0.05; OR (95%CI) : 4,902 (1,026 - 23,430)).
The Analysis of Cardiovascular Disease Risk in Type 2-Diabetes Mellitus and Hypertension Patients Consuming Metformin Sari, Theresia Maria Fioretty Ine; Gollumawo, Serly Sofia D.; Co’o, Maria Dolorosa; Virginia, Dita Maria; Hendra, Phebe; Pramono, Zita Dhirani
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 1 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i1.13057

Abstract

Increased blood sugar levels indicate a metabolic disease known as diabetes mellitus (DM). DM is often accompanied by hypertension. Antidiabetic therapy that can be used is metformin, either monotherapy or combined with other drugs such as glimepiride. This study aimed to analyze the risk of heart disease based on creatine phosphokinase (CPK) in patients with type 2 DM and hypertension who are taking metformin and a combination of metformin and glimepiride. We conducted an analytic observational using a cross-sectional design and applied a purposive sampling technique. The study subjects were type 2 DM patients with hypertension who met the inclusion criteria. The data analysis used univariate analysis, Mann-Whitney, and Fisher’s. The results showed that women aged 60-75 years old with uncontrolled FBS, duration of DM < 5 years, and high CPL level were dominated by our respondents. We found that there was no difference in CPK values (p=0.916), and there was no relationship between the use of metformin monotherapy or the combination of metformin and glimepiride on the risk of heart disease in type 2 DM patients with hypertension (p=0.693). In conclusion, metformin consumption in type 2 DM patients has no significant association with heart disease risk.
Ketaatan Terapi Antihipertensi dengan Terkontrolnya Tekanan Darah pada Pasien Hipertensi Komorbid DM Tipe2 di Puskesmas Kabupaten Sleman Pratiwi, Vera Dwi; Hendra, Phebe; Virginia, Dita Maria
Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Vol 10, No 1 (2024): JMK Yayasan RS.Dr.Soetomo, Pertama 2024
Publisher : STIKES Yayasan RS.Dr.Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29241/jmk.v10i1.1909

Abstract

Hipertensi dan diabetes melitus (DM) tipe2 seringkali terjadi secara bersamaan dan merupakan penyakit degeneratif, namun perburukan prognosis dapat dikendalikan dengan perubahan gaya hidup dan pengobatan. Ketaatan pasien terhadap terapi antihipertensi mempunyai peranan penting dalam manajemen terapi tekanan darah. Tingkat ketaatan terapi dihitung menggunakan metode MPR (Medication Possession Ratio) berdasarkan catatan pengobatan pasien. Penelitian ini bertujuan untuk menganalisis pengaruh ketaatan terapi antihipertensi dengan terkontrolnya tekanan darah pada pasien hipertensi dengan komorbid DM tipe2 di Puskesmas Kabupaten Sleman. Penelitian ini menggunakan desain cross-sectional dan pengambilan data menggunakan teknik non-probability dengan jenis purposive sampling. Sebanyak 116 pasien rawat jalan telah memenuhi kriteria inklusi dan eksklusi. Hasil penelitian menunjukkan responden didominasi oleh pasien perempuan, usia 60-70 tahun, tekanan darah terkontrol, overweight, tidak polifarmasi, dan menggunakkan BPJS PBI. Ketaatan berhubungan signifikan terhadap terkontrolnya tekanan darah (p-value <0,001, OR (95%CI) = 4,526 (2,071-9,899)). Jenis kelamin, usia, IMT, polifarmasi, status jaminan kesehatan tidak mempengaruhi ketaatan secara signifikan (p-value >0,05). Penelitian ini menyimpulkan bahwa ketaatan terapi berpengaruh signifikan terhadap terkontrolnya tekanan darah pada pasien hipertensi dengan komorbid DM tipe2 di Puskesmas Kabupaten Sleman. Kata kunci : Ketaatan, MPR, Antihipertensi, Komorbid
In vitro and in vivo anti-hyperglycemia effects of extract of Faloak (Sterculia quadrifida R.Br.) leaves Andrestia Dias, Velia; Celine Dinanda, Laurenza; Conrad Rambung, Charles; Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Maria; Julianus, Jeffry; Hendra, Phebe
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.28263

Abstract

Despite the availability of various conventional treatments, diabetes mellitus remains a serious global health concern with an increasing prevalence. This trend underscores the need to explore potential natural alternatives. Faloak, an indigenous plant of Indonesia, has been traditionally used for various health conditions, yet its potential as an anti-hyperglycemic agent has not been comprehensively investigated. This research focused on identifying the ingredients of Faloak leaves that could lower blood sugar levels and confirm these effects in laboratory and animal models. At various concentrations, the in vitro evaluation assessed the inhibitory effect of α-amylase and α-glucosidase enzymes. For in vivo evaluation, male mice were administered glucose, sucrose, and starch after being pretreated with Faloak leaf extract, and their blood glucose levels were monitored for 120 min. Faloak leaf extract demonstrated significant inhibitory activity against α-amylase and α-glucosidase enzymes. The IC50 values for sucrose and maltose inhibition were 30.37 and 65.36 mg/mL, respectively, while α-amylase inhibition showed an IC50 of 27.02 mg/mL. In the in vivo test, mice pretreated with the extract exhibited significantly decreased blood glucose levels at 120 min compared to the control group. These findings indicate that the ethanolic extract of Faloak leaves possesses promising anti-hyperglycemic activities, positioning it as a potential candidate for developing plant-based blood glucose management. Our results demonstrate that Faloak leaf extract exhibits substantial anti-hyperglycemic properties, inhibiting vital digestive enzymes and effectively reducing postprandial glucose levels. Identifying active ingredients paves the way for further research to elucidate specific bioactive compounds and their mechanisms of action
Edukasi Hipertensi pada Pasien PROLANIS Puskesmas Wonosari II Hendra, Phebe; Pramono, Zita Dhirani; Julianus, Jeffry; Riswanto, Florentinus Dika Octa
Jurnal Pengabdi Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jplp2km.v7i2.85251

Abstract

Hipertensi merupakan salah satu penyakit yang menjadi penyebab kematian terbanyak di dunia. Pengendalian hipertensi dapat dilakukan dengan berbagai cara. BPJS Kesehatan telah menetapkan PROLANIS (Program Pengelolaan Penyakit Kronis) sebagai salah satu program yang ditujukan untuk pasien dengan penyakit kronis. Puskesmas Wonosari II merupakan salah satu layanan primer yang mengadakan program PROLANIS secara rutin. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukasi kepada peserta PROLANIS terkait penyakit hipertensi melalui media booklet. Kegiatan ini diselenggarakan atas kerjasama dari tim dari Fakultas Farmasi Universitas Sanata Dharma dan Puskesmas Wonosari II. Sebanyak 26 peserta menghadiri kegiatan edukasi yang bersamaan dengan kegiatan rutin yakni senam PROLANIS. Adanya edukasi melalui media booklet ini diharapkan dapat meningkatkan kualitas hidup dan mengontrol tekanan darah pasien.
The impact of medication adherence on health outcomes for patients with metabolic syndrome Setiawan, Christianus Heru; Virginia, Dita Maria; Pinaryanto, Kartono; Sari, Lisa Kurnia; Hendra, Phebe
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1378

Abstract

Cardiovascular disease is a non-communicable disease that is often associated with metabolic syndrome (MetS). MetS is a group of abnormal conditions that include hypertension, obesity, and diabetes. Patients with MetS often require multiple drugs to achieve therapeutic targets, but poor medication adherence can lead to complications. Poor medication adherence can worsen the disease and increase hospitalizations. The purpose of this study was to investigate whether medication adherence affects metabolic syndrome outcomes. This study was conducted using a cross-sectional design and purposive sampling. Our respondents were focused on patients with hypertension, diabetes mellitus, or dyslipidemia. Patients' adherence was measured using a self-made questionnaire. The study obtained data on the patient's lipid profile, HbA1c, and blood pressure (hypertension, diabetes, or dyslipidemia). The study used Spearman analysis to investigate adherence scores to lipid profile levels, HbA1c, and blood pressure. Therapeutic coverage was analyzed using a T-test. Confounding variables, such as age, HbA1c level, and blood pressure, were considered when analyzing the correlation between adherence scores and lipid profiles. The majority of patients were women or elderly, and more than 90% reported that their therapeutic needs were met. Total cholesterol and LDL-c significantly negatively correlated with adherence for patients' factor category, therapeutic regimen factor, and overall factor (p<.05). Triglyceride levels correlated significantly with adherence only to category interaction factors between patients and family/health workers. Regression analysis shows that all correlations are negative to total cholesterol, LDL, HDL, and triglyceride levels (p<.05).
Co-Authors Andrestia Dias, Velia Aris Widayati Ariyanti, Ni Kadek Nining Arwinda, Prili Bramantyo , Dominicus Adyatma Celine Dinanda, Laurenza Christianus Heru Setiawan Conrad Rambung, Charles Co’o, Maria Dolorosa Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Maria Dewita, Aquina Nino Rama Dhanti Dita Maria Virginia Fenty Fenty, Fenty Filiana Santoso Florence Ignatia, Florence Ignatia Florentinus Dika Octa Riswanto Gidion Krisnadi, Gidion Gollumawo, Serly Sofia D. Gunawan Puteri, Maria Dewi Puspitasari Tirtaningtyas Hane, Angelina Rosari Ike Kumalasari, Ike Jeffry Julianus Lisa Kurnia Sari, Lisa Kurnia Ni Luh Putu Dian Perwita, Ni Luh Putu Dian Nina Artanti Pinaryanto, Kartono Pramono, Zita Dhirani Pratiwi, Vera Dwi Putri , Elsha Tiany Rajagukguk, ⁠Greysianita Rita Suhadi Santi , Nyoman Pradnya Yoni Meytri Sari, Theresia Maria Fioretty Ine Siallagan , Angela Meirella Tjiptadi, Felicia Melissa Wahyuning Setyani Yuditha Anggarhani Quraisyin, Yuditha Anggarhani Zalinar Udin