Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

1.633

P-Index

This Author published in this journals

All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Majalah Obat Tradisional Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Media Sains Jurnal Akuntansi, Ekonomi dan Manajemen Bisnis Journal of Global Pharma Technology Jurnal Akuntansi, Ekonomi dan Manajemen Bisnis

I M, Sukadana

Program Studi Kimia FMIPA Universitas Udayana, Bukit Jimbaran, Bali

Author-ID : 389943

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Other

Published : 22 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3

AKTIVITAS ANTIOKSIDAN TOTAL FLAVONOID DAN FENOL KULIT BATANG GAYAM (Inocarpus fagiferus Fosb) Sri Rahayu Santi; I Made Sukadana
Jurnal Kimia (Journal of Chemistry) Vol. 9, No. 2 Juli 2015
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

These researchs aim to know of contain total flavonoid, total phenol and antioxidant activity in vitro of gayam stem bark of each extract (Inocarpus fagiferus Fosb). The result of extraction 1 kg stem bark of gayam with 8500 mL ethanol (5 x 1700 mL) to yield 30 g of concentrated extract its brown red. The partition of 15 g concentrated ethanol extract with chloroform, n-buthanol, and water to yields of 1.5g yellowish concentrated chloroform extract, 5.87 g brown red concentrated n-buthanol extract and 5.63 g concentrated water extract respectively. The result of phytochemical test of fourth extract shown that the ethanol, n-buthanol, and water extracts qualitatively contain of flavonoid and phenol compounds, while the chloroform extract only to contain phenol compound with much total flavonoid in ethanol extract 0.14 % and less at n-buthanol extract is 0.09 %. The result of antioxidant activity with DPPH method shown that water and n-buthanol extract of gayam stem bark have value IC50 was 20 ppm smaller than IC50 of vitamin E was 25 ppm its mean the water and n-buthanol extract of gayam stem bark have the highest potent scavenger of free radical. The result of antioxidant activity with lipid peroxide-ammonium thiocyanate method shown the extract n-buthanol extract have the highest potent inhibition of formed lipid peroxide (63.04%), it is higher than antioxidant activity of vitamin E (50.39%).

AKTIVITAS ANTIBAKTERI SENYAWA FLAVONOID DARI KULIT AKAR AWAR-AWAR (Ficus septica Burm F) I M. Sukadana
Jurnal Kimia (Journal of Chemistry) Vol. 4, No. 1 Januari 2010
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.374 KB)

Isolation of flavonoid antibacterial compounds from Awar-awar root skin (Ficus septica Burm.f) has beencarried out. As much as 120.0 g of concentrated methanol extract was resulted from 3.9 kg dry powder of Awar-awarroot skin. About 60.0 g of this extract was dissolved into 2 N hydrochloride acid and then partitioned withchloroform. Extraction of the acid extract using chloroform resulted in 0.82 g of chloroform concentrated extractwhich contained flavonoids. Further, the separation of this extract using column chromatography resulted in 8fractions namely F1, F2, F3, F4, F5, F6, F7 and F8 fraction. The result of flavonoid test of the eight fractions suggestedthat F2, F5, and F6 fractions contained flavonoid compounds. The purification of F2 fraction using n-hexane obtained 2fraction F2.1 and F2.2 (0.13 g and 0.01 g respectively). Infra red and ultra violet-visible spectroscopy were employed inorder to identify the F2.1 fraction. From infra red spectra, it was identified that the isolate had –OH, C=O, C=C andC-H aromatic and C-H aliphatic. The ultra violet-visible spectra showed 2 peaks at 328.6 nm (band I) and 281.5 nm(band II) which indicated flavonoid class compounds flavanon or dihidroflavonol. By using ”shitting” reagent theisolate was suggested to contain flavanon group with hydroxy groups at C-2’, C-5’ or C-6’ and C-8, and methyl orglycosilacy goups at C-5 and C-7 atom. The isolate flavanon showed antibacterial activity toward Vibrio cholera andEschericia coli.

POTENSI EKSTRAK KULIT BATANG BUNI (Antidesma bunius L. Spreng) UNTUK MENURUNKAN KADAR GLUKOSA DARAH TIKUS WISTAR HIPERGLIKEMIA S. R. Santi; I. M. Sukadana; N. W. I. Paramitha
Jurnal Kimia (Journal of Chemistry) Vol.14 No.1 Januari 2020
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Buni (Antidesma bunius L. Spreng) is one of the traditional medicinal plants whose stem bark has been proven in vitro as an antidiabetic by inhibiting the activity of the ? glucosidase enzyme. This study aims to determine the potential of ethanol extract of buni bark to reduce blood glucose levels in wistar rats in vivo induced by alloxan. Two groups of control rats K (+) and K (-), and three groups of treated rats (P1, P2, and P3) which were given the extract with a dose of 50, 100, and 200 mg/ kg BW respectively, were induced with 150 mg / kg BW alloxan monohydrate to make the rats hyperglycemic. On the 14th day of the trial (posttest) the average blood glucose level was tested using ANOVA with a = 0.05 and Tamhane's. It was concluded that the 200 mg / kg BW ethanol extract of buni bark was able to reduce blood glucose levels to closer to the normal condition when compared to negative control K(-). Keywords: antidiabetic, Antidesma bunius L. Spreng., GC-MS, stem barks

POTENSI EKSTRAK ETANOL BAWANG MERAH (Allium ascolonicum L.) DAN GARAM NaCl MENURUNKAN LUAS AREA SERTA MENINGKATKAN KONTRAKSI JARINGAN LUKA BAKAR RINGAN I M. Sukadana; S. Rahayu; Melli Melli
Jurnal Kimia (Journal of Chemistry) Vol.13 No.1 Januari 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Burns is a skin response and subcutaneous tissue to temperature or thermal trauma that affects skin damage. The weight or severity of tissue damage from burns is influenced by several factors including deep burns, burns area, burn location, general body health, injury mechanism and age. The area of ??burns and the percentage of wound contractions is an indicator of the healing process of minor burns. This study used 25 wistar rats divided into 5 treatment groups with randomized posttest only control group design as follows; K: given vaseline treatment (negative control), Kp: given bioplacenton treatment (positive control), P1: given salt treatment at 7.5% concentration in vaseline, P2: given onion extract treatment at 40% concentration in vaseline, and P3: given a mixture of onion extract 40% and kitchen salt at a concentration of 7,5% in vaseline. The result of One-Way ANOVA and Post Hoc Test LSD using SPSS for Windows version 19 shows P2 treatment group is onion extract of 40% give the best result concentration of onion extract so it is very potential to be developed further as light burning agent compared to P1 and P3 treatment group because of its ability to decrease the area of ??340,79 mm2 on the first day to 11,75 mm2 and increased wound contraction by 81,59% at the end of treatment

PELATIHAN MEMBUAT SABUN MANDI ANTI BAKTERI ALAMI DARI DAUN MIMBA (Azadirachta indica A.Juss) DI DESA PENARUKAN KERAMBITAN TABANAN Sri Rahayu Santi; I M, Sukadana; W. Bogoriani
Buletin Udayana Mengabdi Vol 10 No 2 (2011): Volume 10 No.2 – September 2011
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (512.343 KB)

The activity of the community service about the manner of making nature antibacterial soap from Neem leaf (Azadirachta indica A Juss) was conducted on the 24st of October 2010 to the PKK members of Penarukan village, Kerambitan subdistrict, Tabanan Regency. Making nature antibacterial soap has very simple formulaic techniquee. The soap was made by using many chemicals, among others : coconut oil, 32% sodium hydroxide, dextrin, surfactant, dyes, parfume, as well as antibacterial agent from Nemm leaf (Azadirachta indica A Juss). The result of this activity and evaluation showed that the antimicrobial soap product is as good as ordinary soap, having full of foam, not hot without iritation, because it is properly laboratory tested. All of participants showed their enthusiasm during activity and they will try to make soap. This was showed by the evaluation report saying that all participants understand about making soap and they want to try at home. This public service made people interested to improve their knowledge, skill, and possibility to open of new entrepreneur in village so that it can be vacancy and increase income to community.

PELATIHAN MERAMU CAIRAN PEMBASMI JENTIK NYAMUK DARI DAUN SIRIH (Piper betle L.) DI DESA TIBUBIU KECAMATAN KERAMBITAN TABANAN I M. Sukadana; Sri Rahayu Santi; N. W. Bogoriani
Buletin Udayana Mengabdi Vol 11 No 1 (2012): Volume 11 No.1 – April 2012
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (542.213 KB)

The Community Service activity about the manner of making natural mosquito antilarvae liquids from Piper betle L leaf was conducted on the 24st of October 2010 to the mothers of PKK of Tibubiu village, Kerambitan subdistrict, Tabanan district. Making natural mosquito antilarvae liquids from Piper betle L leaf used the simple formulation technique. The liquids were made by using petroleum as a solvent and Piper betle L leaf as a antilarvae agent. The result of this activity and evaluation showed that the mosquito antilarvae liquids product is as good as chemical agent like “abate”. All participants showed enthusiastic during the activity and they will try to make these liquids. All participants, moreover understand about making liquids and they want to try at home. Such public service is interesting to because the peoples have improved knowledge, skill, and possibility to open of new entrepreneur in village so that it can be vacancy and increase income to community.

POTENSI EKSTRAK n-BUTANOL DAUN TENGGULUN (Protium javanicum Burm. F.) DALAM MENGHAMBAT PERTUMBUHAN BAKTERI Staphylococcus aureus N. M. Puspawati; G. A. G. Indukirana; I M. Sukadana
Jurnal Kimia (Journal of Chemistry) Vol. 17, No.1, Januari 2023
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JCHEM.2023.v17.i01.p13

Staphyloccocus aureus merupakan salah satu bakteri penyebab penyakit menular di Indonesia. Penelitian ini bertujuan untuk mengidentifikasi komponen senyawa yang terdapat pada ekstrak n-butanol daun tenggulun (Protium javanicum Burm. F.) dan mengidentifikasi konsentrasi hambat minimum yang menghambat pertumbuhan bakteri S.aureus. Metode ekstraksi yang digunakan adalah maserasi. Uji aktivitas antibakteri menggunakan metode sumur difusi dan dentifikasi senyawanya menggunakan LC-MS/MS (Liquid Mass Spectrometry-Tandem Mass Spectrometry). Serbuk daun tenggulun sebanyak 1 kg dimaserasi dengan metanol, menghasilkan 90,58 g ekstrak kental metanol yang dipartisi dengan n-butanol. Ekstrak n-butanol pekat pada konsentrasi 20% mampu menghambat pertumbuhan S.aureus secara kuat dengan dengan diameter zona hambat sebesar 16,66 mm dan memiliki konsentrasi hambat minimum (KHM) sebesar 8,75 mm pada konsentrasi 1%. Pemisahan komponen senyawa pada ekstrak n-butanol dilakukan dengan metode kromatografi kolom dengan silika gel sebagai fase diam dan fase gerak etil asetat : asam asetat : asam formiat : air dengan perbandingan 10 : 1 : 1 : 2,6 , dimana hasil pemisahannya diperoleh 5 fraksi gabungan (FA, FB, FC, FD, FE). Dalam penelitian ini hanya Fraksi A dan E yang relatif murni secara kromatografi lapis tipis. Hasil identifikasi fraksi A dengan LC-MS/MS, diduga mengandung senyawa Kokamidropropil betain, 2-feniletanol dan Morin. Sementara itu pada fraksi E diduga mengandung senyawa Rutin. Kata Kunci: antibakteri, daun tenggulun (Protium javanicum Burm. F), LC MS/MS, Staphylococcus aureus. ABSTRACT One of the microorganisms that causes infectious disorders in Indonesia is Staphyloccocus aureus (S.aureus). According to preliminary research Tenggulun leaves can prevent the growth of S.aureus. In order to stop the growth of S.aureus, this study was set out to estimate the minimum inhibitory concentration of an n-butanol extract from tenggulun leaves (Protium javanicum Burm. F.) and to characterize its components. Maceration was utilized to extract the tenggulun leaves, agar well diffusion method was used to test for antibacterial activity, and Liquid Mass Spectrometry-Tandem Mass Spectrometry (LC-MS/MS) was applied to identify the chemicals. One kilogram of tenggulun leaf powder was macerated in metanol to produce 90.58 grams of thick methanol extract divided among with n-hexane, ethyl acetate, and n-butanol to be partitioned. The growth of S.aureus bacteria could be inhibited by the concentrated n-butanol extract at a concentration of 20% with an inhibition diameter of 16.66 mm and the minimum inhibitory concentration of 1% was 8.5 mm. By using column chromatography based on silica gel as the stationary phase and ethyl acetate : acetic acid : formic acid : water in the ratio of 10 : 1 : 1 : 2.6 as the mobile phases, the component of chemicals in the n-butanol extract were separated into 5 mixed fractions (FA, FB , FC, FD, FE). Only relatively pure fractions A used in this study to be identified using a thin layer chromatography. According to the results of the LC-MS/MS, identification of fraction A, it was assumed that this fraction comprised the substances of Cocamidropropyl betaine, 2-phenylethanol, and 2-(2,4-Morin. Meanwhile, the fraction E contained the substance of Rutin. Keywords: antibacterial, LC MS/MS, tenggulun (Protium javanicum Burm. F), Staphylococcus aureus.

Red Piper Crocatum Leaves Extract Ethanol Lowering Malondialdehyde (MDA) and Blood Glucose Level In Hyperglycemic Wistar Rat Sri Wahjuni; I Made Sukadana; dan Luh Putu Arisanti
Journal of Global Pharma Technology Volume 09 Issue 05
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Changes in fast-food behavior became one cause of diabetes. Potential of the red betel leaf (Piper crocatum) can lower blood sugar levels allegedly because it contains antioxidant-potent compounds inductively induce certain organs to produce insulin hormones that play a role in lowering glucose levels in the blood.The aim of the study is to determine the effectiveness of Piper crocatum leaf ethanol extract in fixing the pancreas β-cell damage rate in alloxan induced hyperglycemic Wistar Rat. Methods: This study used randomized pre-and posttest control group design. Twenty-four (24) male Wistar rats divided into 6 groups namely P0 positive control (P0), P1 as a negative control (allowance 125 mg Kg -1BW), P2 (alloxan and extract dose 50 mgKg-1 BW), P3 (alloxan and extract dose 100 mg Kg -1 BW), P4 (alloxan and extract dose 150 mg Kg - 1 BW), P5 (alloxan and glibenclamide 0.18 mg/day 200g -1BW). Blood glucose measurement was taken through a vein tail performed by the glucose test method. Measurement of MDA levels, blood was taken from the jugular vein and analyzed by the TBARS method. The yield of Piper crocatum extraction with ethanol solvent was 13,1%. The most significant results were shown by dosing of 150 mg Kg -1BW and extract of 50 mg Kg -1 BW gave a comparable effect to glibenclamide as a blood sugar-lowering drug. The results of phytochemical tests showed that Piper crocatum contains phenolic, alkaloid, and steroid. The results of GC-MS analysis of extracts active Piper crocatum were suspected to contain 29 compounds of 13 compounds known as phytol, neophytadiene, β-bisabolene, germacrene-D, α-humulene, sulfamethoxazole, caryophyllene, nandrolone phenylpropionate, thiamin, linalool, β-ocimene, Anthocyanin, and β-myrcene.Keyword: Red Piper crocatum leaf, Blood glucose, MDA (Malondialdehyde).

ANALISIS OPTIMASI PERSEDIAAN BAHAN BAKU DENGAN MENGGUNAKAN METODE JUST IN TIME PADA UD. KARIA JAYA I Made Weda Adnyana; I Made Sukadana
Jurnal Akuntansi, Ekonomi dan Manajemen Bisnis Vol. 2 No. 3 (2022): November : Jurnal Akuntansi, Ekonomi dan Manajemen Bisnis
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jaem.v2i3.348

The purpose of this study is to analyze how to optimize raw material inventory using the just in time method at UD Karia Jaya. The subjects in this study were the owners and employees of the production department who worked at UD Karia Jaya. This research was conducted using qualitative research methods. Based on the results of the study showing that through interviews with related sources, it can be concluded that the existing problems are: 1. Company a. Lack of policy, b. Uncertainty, c. The turnover of money is less clear, d. Cash is not helped, e. Insecurity of transactions. as for the efforts made to facing problems that exist in the company by improving the operational management system in the company from the aspects of the company and employees, namely: 1. Company, a. Fixing the policy, b. Seeking certainty The turnover of money is less clear, c. Cash is not helped, d. Transaction insecurity and 2. Employees, 1.Strive for smooth performance and freedom from uncertainty.

SEARCH FOR TOXIC EXTRACT COMPOUNDS IN TARO LEAF ETHANOL (Colocasia esculenta L) BY BRINE SHRIMP LETHALITY TEST METHOD Simalango, N. T. H.; Puspawati, N. M.; Sukadana, I M.
Jurnal Kimia (Journal of Chemistry) Vol. 18, No.2, Juli 2024
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Colocasia esculenta L yang dikenal sebagai Talas merupakan tanaman herba menahun yang secara tradisional seluruh bagian tanaman dimanfaatkan sebagai bahan obat. Pada peneltian ini, toksisitas ekstrak etanol daun talas dan hasil partisinya diuji dan kandungan senyawa aktif pada ekstrak yang paling toksik diidentifikasi. Pengujian toksisitas dilakukan dengan metode Brine Shrimp Lethality Test (BSLT) dan identifikasi senyawa aktif dengan Liquid Chromatography Mass Spectrometry Tandem Mass Spectrometry (LC-MS/MS). Sampel daun talas sebanyak 1 kg dimaserasi dengan etanol 96% menghasilkan 60,01 g ekstrak kental etanol yang bersifat toksik dengan nilai LC50 sebesar 89,52 ppm. Toksisitas hasil partisi ekstrak etanol dengan pelarut n- heksana, etil asetat, n-butanol, dan air memberikan nilai LC50 berturut-turut 68,13; 191,69; 425,80; dan 678,36 ppm sehingga ekstrak n-heksana dapat dikatakan bersifat paling toksik dibandingkan ekstrak lainnya. Pemisahan senyawa aktif pada ekstrak n-heksana dilakukan dengan metode kromatografi kolom dengan silica gel sebagai fase diam dan dielusi secara gradien dengan fase gerak n-heksana dan kloroform menghasilkan 12 fraksi gabungan dengan toksisitas yang relatif tinggi terdapat pada fraksi C dan D dengan nilai LC50 berturut-turut 23,88 dan 106,18 ppm. Fraksi aktif C diduga mengandung senyawa N,N-dimetil-2- [6- metil-2-(4-metilphenil) imidazol [1,2-a] piridin-3-il] asetamide (zolpidem) dan pada fraksi D diduga mengandung senyawa asam (9Z,12Z,15Z)- oktadeka-9,12,15-trienoat (asam linolenat). Kata Kunci: Artemia salina Leach, Brine Shrimp Lethality Test (BSLT), Colocasia esculenta L, daun talas, toksisitas ABSTRACT Colocasia esculenta L, known as taro, is a perennial herb traditionally used in its entirety for medicinal purposes. This study tested the toxicity of taro leaf ethanol extract and its fractions, and identified the active compounds in the most toxic extract. Brine Shrimp Lethality Test (BSLT) was used to test for toxicity, and LC-MS/MS was used to identify active compounds. A sample of 1 kg of taro leaves was macerated with 96% ethanol, yielding 60.01 g of toxic ethanol extract with an LC50 value of 89.52 ppm. Toxicity partitioning of the ethanol extracts using n-hexane, ethyl acetate, n-butanol and water as solvents gave LC50 values of 68.13, 191.69, 425.80 and 678.36 ppm, respectively, indicating that the n-hexane extract was the most toxic. Separation of the active compounds in the n-hexane extract was performed using column chromatography with silica gel as the stationary phase and gradient elution with n-hexane and chloroform as the mobile phases, resulting in 12 combined fractions. The fractions with relatively high toxicity were fractions C and D with LC50 values of 23.88 and 106.18 ppm respectively. The active fraction C may contain the compound N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazole [1,2-a]pyridin-3-yl]acetamide (zolpidem) and the fraction D probably contains compounds (9Z,12Z,15Z)-octadeca-9,12,15- trienoic acid (linolenic acid). Keywords: Artemia salina Leach, Brine Shrimp Lethality Test (BSLT), Colocasia esculenta L, taro leaves, toxicity

Co-Authors Ali Djamhuri Anak Agung Istri Sri Wiadnyani dan Luh Putu Arisanti Frida R. Koreh G. A. G. Indukirana Guna, I Kadek Diantara Adi I Made Dira Swantara I Made Weda Adnyana I Nyoman Setiawan Ida Ayu Putu Sri Adnyasari Irvansyah Habibi Resaputra Janardana, I Gusti Ngurah Melisa Anggraini Melli Melli Monikayani, Ni Wayan N. K. Juliarti N. W. Bogoriani N. W. I. Paramitha Ni Made Puspawati Pemayun, Anak Agung Gede Maharta S. R. Santi S. Rahayu Simalango, N. T. H. Sri Rahayu Santi Sri Wahjuni Wibawa, I Komang Ari Satya WIWIK SUSANAH RITA

Title

Found 22 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 22 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 22 Documents
Search