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All Journal Jurnal Respirasi (JR)
Wira Winardi
Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Health Professions Medicine & Pharmacology Public Health

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Detection of SARS-CoV-2 Delta Variant of Concern AY.57 and Clinical Characteristics of Imported Cases on a Vietnamese Coal Carrier Vessel in East Kalimantan, Indonesia: A Case Report Marwan Marwan; Wira Winardi; Abdul Mu'ti; Sri Wahyuni; Ridmawan Wahyu Jatmiko; Donni Irfandi Alfian; Muhammad Ikhwan Nur; Satria Sewu
Jurnal Respirasi Vol. 8 No. 2 (2022): May 2022
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (352.759 KB) | DOI: 10.20473/jr.v8-I.2.2022.99-105

Abstract

Introduction: The 2019 Coronavirus Diseases (COVID-19) continues to be a severe public health issue throughout the world. Disease transmission channels exist across all modes of transportation, including land, air, and water. The presence of this disease has been demonstrated by a study conducted in South Korea, which discovered that 90% of ship passengers have also been tested with SARS-CoV-2 virus. Case: At the port of Samarinda, real-time polymerase chain reaction (RT-PCR) testing was performed on 20 Vietnamese coal carrier vessel crew members. According to the findings obtained from the RT-PCR test, every single member of the team had been infected with the virus. Since they exhibited symptoms of an infection caused by SARS-CoV-2 virus (such as coughing, fever, and shortness of breath), a total of 6 members had to be taken to the hospital. According to the results of genomic sequencing, the crew members were found to be infected with SARS-CoV-2 virus and variant of concern (VOC) of Delta AY.57, Vietnam lineage. Conclusion: COVID-19 can be transmitted via public transportation, including land, air, and sea travel. Controlling the spread of the virus requires RT-PCR testing at terminals, stations, and ports. SARS-CoV-2 Delta variant is still dominating Southeast Asia region, particulary Delta VOC AY.57.
Hematologic Paraneoplastic Syndrome in Newly Diagnosed Patients with Lung Cancer Andika Chandra Putra; Steven Jonathan; Wira Winardi; Elisna Syahruddin
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.18-29

Abstract

Introduction: Lung cancer could have signs and symptoms generated by paraneoplastic syndromes. This study aimed to describe and analyze hematologic paraneoplastic syndrome in patients with lung cancer in Indonesia. Methods: This was a cross-sectional analytic study conducted in Persahabatan National Respiratory Referral Hospital, Jakarta, between September 2018 and February 2019, on all newly diagnosed patients with lung cancer whose diagnosis was established and who fulfilled the inclusion and exclusion criteria. Results: The mean age of subjects was 56.7 ± 11.4 years old. Most subjects were male, had normal nutritional status (42.6%), had a smoking history (75%), and had a moderate Brinkman Index (BI) value (52%). The most common type of histology was squamous cell carcinoma (SCC) (39.7%), with advanced stage (83.8%) and performance status <2 (94.1%). Paraneoplastic anemia was 40.4%, associated with poor nutritional status and commonly normocytic normochromic anemia. The proportion of paraneoplastic leukocytosis was 39%, associated with males and smoking history. The proportion of paraneoplastic neutrophilia was 51.5%, and it was related to males, smoking history, and SCC histology type. Paraneoplastic hypereosinophilia and thrombocytosis proportions were 2.9% and 18.4%, respectively. The proportion of paraneoplastic hypercoagulability was 91.2%, which was caused by the elevated D-dimer level. Conclusion: The most common hematologic paraneoplastic syndromes in patients with lung cancer were hypercoagulability, neutrophilia, and anemia. The low hemoglobin (Hb) level of paraneoplastic anemia was associated with low body mass index (BMI). Male and smoking history in lung cancer patients were associated with paraneoplastic leukocytosis and/or neutrophilia.
Co-Authors Abdul Mu'ti Donni Irfandi Alfian Elisna Syahruddin Marwan Marwan Muhammad Ikhwan Nur Putra, Andika Chandra Ridmawan Wahyu Jatmiko Satria Sewu Sri Wahyuni Steven Jonathan