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All Journal Jurnal Gizi dan Pangan Buletin Farmatera Muhammadiyah Medical Journal eJournal Kedokteran Indonesia
Lailan Safina Nasution
Department Of Nutrition, Faculty Of Medicine And Health, Universitas Muhammadiyah Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Mitochondrial Adaptations of Obese Adult Rat Visceral Adipocytes which Differ in Nutritional Status during Childhood Lailan Safina Nasution; Ahmad Aulia; Sri Widia A. Jusman; Mohamad Sadikin
eJournal Kedokteran Indonesia Vol 9, No. 3 - Desember 2021
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.296 KB) | DOI: 10.23886/ejki.9.48.197-202

Abstract

Mitochondria are highly dynamic organelles that can adapt to different environmental stimuli. This study aims to analyze differences in the function and biogenesis of mitochondria and anaerobic glycolysis activity between obese adult rats that were undernourished in childhood (LCD28) and those which were normal (SD28) or already fat (HFD28). Sprague-dawley rats were assigned groups and given diet treatments from December 2017 until August 2018 in the Laboratory Animal Management Unit, Faculty of Veterinary Medicine, Bogor Agricultural Institute. To observe mitochondrial function and biogenesis, MnSOD activity and PGC1α levels were analyzed using ELISA. To investigate the existence of anaerobic glycolysis, LDH activity was analyzed using a spectrophotometry method. The results showed that MnSOD activity and PGC1α levels of LCD28 increased compared to the other groups, signifying higher mitochondrial function and biogenesis. Meanwhile, no significant difference in LDH activity was found, signifying similar levels of anaerobic glycolysis.
The Effects of High Fat Diets on Body Weight and Lipid Profile Changes of Sprague-Dawley Rats Nasution, Lailan Safina; Mustika, Aulia Andi; Andriyanto, Andriyanto
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.9336

Abstract

Background: Lipids come in from many different sources in ones diet. In this experiment, we intend to find out the kind of lipids that causes the highest increase in rat body weight and the most influence in the lipid profiles. Method: We compared three kinds of lipid: beef fats, egg yolk and palm oil which were added to the rats standard diet. Twenty-eight 20-24 week-old male Sprague-Dawley rats weighing 250300 g were randomly divided into 4 treatment groups given a high beef fat diet (BF), a high egg yolk (EY), a high vegetable fat (VF), and a standard chow diet (SD) as control for 30 days. The body weight of each rat was monitored weekly and the lipid profiles were measured enzymatically at the end of the experiment. Result: The EY and VF body weights increased significantly compared to the SD (p0.05). The total cholesterol level of BF, EY and VF increased significantly compared to the SD groups (p0.001). The triglycerides level of BF, EY, and VF increased significantly compared to SD (p0.001). The HDL-cholesterol levels were significantly lower in BF, EY and VF compared to SD (p0.05). The LDL-cholesterol in BF, EY and VF were significantly increased compared to SD (p0.05). Conclusion: High egg yolk diet causes a bigger increase in rat body weight, LDL levels, cholesterol levels, and triglycerides than the high beef fat diet and high vegetable fat diet compared to control. It also causes lower HDL levels than the other diet groups compared to control.
Correlation Between Diet History and Nutritional Status of Children Aged 24–59 Months in Tarumajaya, Bekasi in 2019 Nasution, Lailan Safina; Karim, Nursakinah A.
Jurnal Gizi dan Pangan Vol. 19 No. Supp.2 (2024)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2024.19.Supp.2.298-303

Abstract

This study aimed to analyze the correlation between diet history and the nutritional status of pre-school children. This was an analytical observational study using a cross-sectional design. Sam-ples were 96 children aged 24‒59 months in Tarumajaya, Bekasi, West Java. Diet history was obtained from questionnaires containing history of breastfeeding and diet since the infancy period. The children’s heights were measured using a microtoise stature meter. Subjects were considered stunted if their Height-for-Age Z-score was minus 2 or lower according to WHO Child Growth Standard. Data was analyzed using Fisher’s exact test. Out of the 96 children, 16 (16.7%) were stunted. There were 80 (83.3%) children who received exclusive breastfeeding, 51 (53.1%) who received an appropriate frequency of meals, 78 (81.3%) who met the minimum dietary diversity, and 29 (30.2%) who had a minimum acceptable diet. Fisher’s exact test showed that dietary diversity was a significant factor for stunted children (p<0.001).
Level of Knowledge of Hypertension Patients and Compliance with Treatment at Sirnajaya Health Center Ramadhani, Alya; Nasution, Lailan Safina
Muhammadiyah Medical Journal Vol 4, No 2 (2023): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.4.2.86-94

Abstract

Background: Uncontrolled hypertension is the most common and important risk factor for cardiovascular diseases, which can lead to complications or even death. Uncontrolled hypertension can be caused by noncompliance with hypertension medication instructions. One factor contributing to the disobedience of hypertension medication instructions is the level of knowledge on hypertension. Purposes: This study analyzed the correlation between patients’ hypertension knowledge and hypertension medication compliance in Sirnajaya Health Center, Bekasi, West Java, Indonesia. Methods: A cross-sectional study was conducted among 62 hypertension patients in Sirnajaya Health Center in December 2022. They were asked to answer the Hypertension Knowledge-Level Scale (HK-LS) questionnaire and the Morisky Medication Adherence Scale-8 (MMAS-8) to assess their hypertension knowledge and compliance with the hypertension medication. The chi-squared test was used to determine the correlations between the variables. Results: There were 36 respondents (58.1%) with low knowledge and 39 respondents (62.9%) with low medication compliance. Analysis through the chi-squared test reveals a correlation between knowledge level and medication compliance (p 0.001). Conclusion: There was a correlation between hypertension knowledge and compliance in consuming hypertension medication among the hypertension patients of Sirnajaya Health Center, Bekasi, West Java, Indonesia.
Co-Authors Ahmad Aulia Andriyanto Andriyanto Aulia Andi Mustika Jusman, Sri Widia Azraki Karim, Nursakinah A. Mohamad Sadikin Ramadhani, Alya