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All Journal PHARMACON J-KESMAS: Jurnal Kesehatan Masyarakat Science Get Journal
STENLY KOMANSILAN
Universitas Trinita
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Mathematics Medicine & Pharmacology Physics Public Health

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UJI EFEKTIVITAS ANTILITHIASIS EKSTRAK ETANOL ALANG-ALANG (IMPERATA CYLINDRICA (L.) BEAUV) PADA TIKUS PUTIH (RATTUS NOVERGICUS) Stenly - Komansilan; Rolef Rumondor
J-KESMAS: Jurnal Kesehatan Masyarakat Vol 8, No 1 (2022): J-KESMAS Volume 8, Nomor 1, Mei 2022
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Al Asyariah Mandar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35329/jkesmas.v8i1.2843

Abstract

Background: Kidneys in the body function as filters to clean blood or other fluids. This function is intended so that the chemicals contained in the blood or other body fluids are not carried back by the blood and circulated throughout the body. Some of this filtered dirt will be excreted through the kidneys with urine and some may be left behind and settles into kidney stones Purpose: The aim of this study was to determine the antilithiation effectiveness of Imperata extracts) Methods: In white rats by looking at the histological picture of the rats' kidneys The study design, the treatment group was divided into 5 groups: Control group (P0), ethylene glycol group (P1), Hydrochlorothiazide treatment group (P2), Imperata extract group with a dose of 100 mg / kgBW ( P3), and the alang-lang extract group at a dose of 200 mg / kgBW (P4) Results: The results showed that Imperata extract had activity in repairing the kidneys of rats with urolithiasis. Conclusion: And the dose of Imperata extract 200 mg / kgBB has better effectiveness
ANALISIS FITOKIMIA EKSTRAK DAGING BUAH PISANG GOROHO MERAH ( Musa acuminata Colla L) SEBAGAI KANDIDAT OBAT HERBAL FEBRINDAH ESTER TAMBALEAN; ROLEF RUMONDOR; STENLY KOMANSILAN; HENDRA PRATAMA MALIANGKAY
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.47591

Abstract

Pisang goroho merupakan jenis tanaman endemik Sulawesi Utara. Pisang goroho sering digunakan masyarakat secara empiris sebagai bahan makanan tambahan / pokok bagi orang yang menderita penyakit diabetes mellitus. Penelitian ini bertujuan untuk menganalisis kandungan fitokimia dan menentukan gugus fungsi senyawa dari ekstrak etanol 96% pisang goroho merah. Preparasi sampel dipotong dari bagian sisir pisangnya, kemudian dipotong kedua ujung pangkal kulit buah pisang goroho dan di potong-potong buah dan dikeringkan. Ekstraksi dilakukan secara maserasi dengan menggunakan pelarut etanol 96%. Penapisan fitokimia dilakukan dengan analisis alkaloid, flavonoid, tanin, saponin, steroid, dan terpenoid. Berdasarkan hasil dari penapisan fitokimia bahwa ekstrak etanol pisang goroho merah mengandung alkaloid, flavonoid, dan tanin.. Hasil penelitian ini menyimpulkan bahwa ekstrak etanol 96% pisang goroho merah memiliki kemampuan baik sebagai kandidat obat herbal
SKRINING FITOKIMIA EKSTRAK KULIT BUAH ALPUKAT (Persea americana MILL) SEBAGAI OBAT TRADISIONAL HINDANG SANCE KAEMPE; STENLY KOMANSILAN; ROLEF MALIANGKAY; ROLEF RUMONDOR
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.47593

Abstract

Kulit buah alpukat saat ini masih menjadi limbah yang belum banyak digunakan oleh masyarakat. Kulit buah alpukat memiliki kandungan senyawa flavonoid dan quersetin yang tinggi sehingga kulit buah alpukat bersifat sebagai obat tradisional, oleh karena itu diperlukan informasi ilmiah tentang kandungan kimia dan efek samping yang ditimbulkan. Penelitian ini bertujuan untuk mengetahui senyawa fitokimia dari ekstrak etanol kulit buah alpukat. Ekstrasi dilakukan secara maserasi dengan menggunakan pelarut etanol 96%. Tahapan penelitian ini meliputi pengujian fitokima yaitu alkaloid, flavonoid, tanin dan saponin. Berdasarkan hasil penelitian skrining fitokimia, kulit buah alpukat diketahui mengandung beberapa senyawa metabolit sekunder, yaitu alkaloid, triterpenoid, tanin, flavonoid dan saponin sebagai kandidat obat tradisional.
Self-Healing Hydrogels Based on Chitosan and Banana Sap for Sustainable Wound Dressing Applications Stenly Komansilan; Tiara Nisa Fauziah
Science Journal Get Press Vol 3 No 2 (2026): April, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i2.604

Abstract

Wound dressings with self-healing properties represent a significant advancement in modern wound management. This study reports the development of self-healing hydrogels fabricated from chitosan and Musa acuminata (Cavendish banana) stem sap, reinforced with genipin as a natural crosslinker a green chemistry alternative to cytotoxic synthetic crosslinkers. Five formulations (F1–F5) were prepared by varying chitosan (1.0–2.0% w/v) and banana sap (5–20% v/v) concentrations. The optimized formulation (F5) achieved a self-healing time of 22 ± 1.2 minutes, swelling ratio of 423 ± 12.0%, tensile strength of 36.8 ± 2.3 kPa, and water vapor transmission rate (WVTR) of 968 ± 19 g/m²/day. FTIR spectroscopy confirmed dynamic Schiff base bond formation responsible for self-healing, and SEM revealed a porous three-dimensional network conducive to moisture retention. F5 demonstrated broad-spectrum antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa (zones of inhibition up to 19.2 mm), and confirmed biocompatibility with L929 fibroblast cell viability exceeding 91%. In vivo studies in Sprague-Dawley rats demonstrated 94.8% wound closure by day 14, compared to 81.2% for untreated controls. These results establish chitosan banana sap hydrogels as promising, sustainable biomaterials for next-generation wound dressing applications.
Co-Authors FEBRINDAH ESTER TAMBALEAN HENDRA PRATAMA MALIANGKAY HINDANG SANCE KAEMPE ROLEF MALIANGKAY Rolef Rumondor Tiara Nisa Fauziah