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Aaltje Manampiring
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Other

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POTENSI PENERAPAN KONSEP HOSPITAL WITHOUT WALLS DALAM RANGKA MENURUNKAN ANGKA COLD CASE Jossy Indriane Nelwan; Gustaaf Ratag; Aaltje Manampiring
Jurnal Kesehatan Medika Saintika Vol 12, No 2 (2021): Desember 2021
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v12i2.1117

Abstract

ABSTRAKHospital without wall menerapkan pelayanan kepada masyarakat untuk mendapatkan kebutuhan medis sehingga masyarakat tidak perlu lagi datang berobat ke rumah sakit. Ini merupakan salah satu strategi untuk penurunan angka cold case. Penelitian ini bertujuan untuk mengetahui potensi penerapan konsep hospital without wall dalam pelayanan kesehatan mata. Desain penelitian ini adalah penelitian kualitatif (grounded research). Penelitian dilaksanakan pada bulan September  2020 sampai Mei 2021 di RSU GMIM Bethesda Tomohon dan salah satu Puskesmas di Kota Tomohon. Penelitian ini menggunakan metode wawancara mendalam kepada 10 informan. Instrumen berupa daftar pertanyaan, alat perekam, dan alat tulis menulis serta pemantauan data observasi. Hasil penelitian didapati potensi penerapan konsep hospital without wall masih dalam level minimalis antara lain dokter spesialis  menjalankan konsep telemedicine ini walaupun hanya sebagian pasien, format rujukan balik ke fasilitas layanan kesehatan primer tentang informasi mengenai diagnosa pasien sudah dijalankan tapi hanya terbatas pasien peserta BPJS. Juga telah dijalankan pelayanan berupa promotif dan preventif kesehatan kepada masyarakat. Kesimpulan dari penelitian ini adalah penerapan konsep hospital without wall di poli mata RSU GMIM Bethesda Tomohon memiliki potensi dan dapat dijalankan. Konsep ini dapat dilakukan dengan memperhatikan tantangan dan hambatan yang ada dan harus diatasi terlebih dahulu seperti dari segi sarana dan prasarana, kesiapan SDM, administrasi serta sistem pembiayaan yang harus disesuaikan agar supaya penerapan konsep hospital without wall dapat berjalan baik dalam level minimal maupun optimal. Saran bagi rumah sakit yang melakukan penerapan konsep hospital without walls dapat bekerjasama dengan pemerintah, dinas kesehatan serta fasilitas layanan kesehatan primer agar supaya mendapatkan solusi untuk pemecahan tantangan dan hambatan yang muncul.Kata Kunci: Hospital without walls; cold case.ABSTRACTHospital without wall implements services to the community to get medical needs so that people no longer need to come for treatment at the hospital. This is one strategy to reduce the number of cold cases. This study aims to determine the potential application of theconcept hospital without wall in eye health services. The design of this research is a qualitative research (grounded research). The study was carried out from September 2020 to May 2021 at GMIM Bethesda Tomohon Hospital and one of the Puskesmas in Tomohon City. This study used in-depth interviews with 10 informants. Instruments in the form of a list of questions, recording equipment, and writing instruments as well as monitoring observation data. The results of the study found that the potential for the application of theconcept was hospital without wall still at a minimalist level, including specialist doctors running theconcept telemedicine even though only some patients, the format for referrals back to primary health care facilities about information about patient diagnoses has been carried out but only limited to BPJS participants. It has also carried out services in the form of promotive and preventive health to the community. The conclusion of this study is that the application of the concept of a hospital without wall in the eye clinic of RSU GMIM Bethesda Tomohon has potential and can be implemented. This concept can be implemented by taking into account the challenges and obstacles that exist and must be overcome first, such as in terms of facilities and infrastructure, readiness of human resources, administration and the financing system that must be adjusted so that the application of theconcept hospital without wall can run both at a minimum and optimal level. Suggestions for hospitals that implement the concept of hospital without walls can cooperate with the government, health services and primary health care facilities in order to get solutions to solve the challenges and obstacles that arise.Keywords: Hospital without walls; cold case.
ANALISIS FAKTOR YANG MEMPENGARUHI STATUS KESEHATAN PEKERJA PEMBANGUNAN MAL PELAYANAN PUBLIK (MPP) PT SAMEROT TRI PUTRA DI MANADO Winny Vionita Rambitan; Billy Kepel; Aaltje Manampiring
Jurnal Kesehatan Medika Saintika Vol 12, No 2 (2021): Desember 2021
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v12i2.993

Abstract

Workers with prime health determine the level of work productivity. When the worker’s health condition are declining and eventually became ill, the ability to think and doing tasks in workplace will also declining. The purpose of this research, is to find what factors that effecting the health status dan to understand which factor has the most influence to the worker’s of the development of public service mall (PSM) of PT Samerot Tri Putra in Manado health condition. There are 40 respondets. The research activity starts by signing the agreement paper, filling in the questioneaire, measuring body weight, height, and measuring the pulse. The research method are using quantitative data, in form of analytical surveys with Cross sectional approach. Data analysis are using univariat analitic, bivariat analitic with the Chi-square tests, dan multivariat with the regretion logistic analysis. The chi square test results of each independent variables are found with the p value of nutrition status (p=0,505) and health service accsess (p=0,005). The test result of logistic regression shows that variable with the high OR which is physical working load (OR=10,102). The conclusion of this research is, the variable that has the most effect to the health is the physical and mental working load and the health service accsess . The variable that has no effect in health status is the nutrition status. The company can consider to provide expert of K3 and health clinic as the form of Company’s primary health service to deal with the worker health’s needs.Keywords: Nutrition status, working load, health service accsess, health status.
Uji Aktivitas Sitotoksik Ekstrak Etanol Buah Sirih (Piper betle L.) dengan Metode Brine Shrimp Lethality Test (BSLT) Angelique C. M. Tanan; Fona Budiarso; Widdhi Bodhi; Fatimawali Fatimawali; Billy J. Kepel; Aaltje Manampiring
eBiomedik Vol. 10 No. 1 (2022): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v10i1.37659

Abstract

Abstract: Cancer is one of the causes of high mortality rate in the world. Side effects and the high cost of treatment are a problem for cancer sufferers. The use of herbal medicine is increasingly chosen as an alternative cancer treatment because of the fewer side effects and affordable price. Betel (Piper betle L) is one of the plants of Piper genus that is often used as a medicinal plant. This study was aimed to determine the cytotoxic activity test of the ethanol extract of betel fruit against the Artemia salina Leach. The cytotoxic test using the Brine Shrimp Lethality Test (BSLT) method. The concentrations given are 1000 ppm, 500 ppm, 250 ppm, 100 ppm, 10 ppm, 0 ppm. Observations on Artemia salina larvae were carried out for 24 hours after administration of the extract. The results showed that the ethanolic extract of betel fruit has a high toxic value, is the LC50 value of 60.05 ppm. In conclusion, the ethanol extract of betel fruit is cytotoxic and has the potential as an anticancer.Keywords: Cytotoxic test; Betel Fruit (Piper betle L.); Brine Shrimp Lethality Test (BSLT)  Abstrak: Kanker merupakan salah satu penyebab tingginya angka kematian di dunia. Efek samping dan biaya yang mahal dari pengobatan menjadi masalah bagi para penderita kanker. Penggunaan obat herbal semakin banyak dipilih sebagai pengobatan alternatif kanker dikarenakan efek samping yang lebih sedikit dan harga yang terjangkau. Sirih (Piper betle L) adalah salah satu tanaman dari genus Piper yang sering dimanfaatkan sebagai tanaman obat. Penelitian ini bertujuan untuk mengetahui aktivitas sitotoksik dari ekstrak etanol buah sirih terhadap  Artemia salina Leach. Penelitian uji sitotoksik menggunakan metode Brine Shrimp Lethality Test (BSLT). Konsentrasi yang diberikan yaitu 1000 ppm, 500 ppm, 250 ppm, 100 ppm, 10 ppm, 0 ppm. Pengataman pada Artemia salina dilakukan selama 24 jam setelah pemberian ekstrak. Hasil penelitian menunjukan bahwa ekstrak etanol buah sirih memiliki nilai toksik yang tinggi, yaitu nilai LC50 sebesar 60,05 ppm. Sebagai simpulan, ekstrak etanol buah sirih bersifat sitotoksik dan berpotensi sebagai antikanker.Kata Kunci: Uji sitotoksik; Buah Sirih (Piper betle L.); Brine Shrimp Lethality Test (BSLT)
Analisis Antioksidan Senyawa Bioaktif Ekstrak Lidah Buaya Secara Insilico Dos D. L. E. Br Siagian; Billy J. Kepel; Aaltje Manampiring; Widdhi Bodhi; Fatimawali Fatimawali; Fona D.H. Budiarso
eBiomedik Vol. 10 No. 2 (2022): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v10i2.46334

Abstract

Abstract: Aloe vera (Aloe vera L.) is a functional plant that is often found and has a wide range of health advantages. Antioxidants are chemical molecules that inhibit free radicals in the body, which can cause disease by generating oxidation events that destroy cell structure and function. The goal of this research is to see how bioactive chemicals from the aloe vera plant (Aloe vera L.) interact with antioxidant activity. The molecular docking method is combined with insilico analysis in this study, which employs four key applications: autodock tools, autodock vina, biovia discovery studio, and open babel. All amino acid residues in the bioactive compound Aloe vera (Aloe vera L.) act on the active site of the Human endothelial nitric oxide synthase (4D1O) receptor, according to the findings of this study. The binding energi of bioactive substances from aloe vera skin extract (Aloe vera L.) to the 4D1O receptor yielded promising results. Conclusion: Aloe vera (Aloe vera L.) extract bioactive component possesses antioxidant activity, which can particularly reduce or prevent free radical generation in the body. Keywords: Aloe vera (Aloe vera L.); Antioxidant; Human endothelial nitric oxide synthase (4D1O) receptor; Insilico. Abstrak: Lidah Buaya (Aloe vera L.) merupakan tanaman fungsional yang umum ditemui dan memiliki banyak manfaat bagi kesehatan. Antioksidan adalah senyawa kimia penghambat radikal bebas di dalam tubuh yang dapat menghambat terjadinya reaksi oksidasi dalam tubuh yang dapat merusak struktur dan fungsi sel sehingga menimbulkan penyakit. Penelitian ini bertujuan untuk mengetahui interaksi antara senyawa bioaktif dari tanaman lidah buaya (Aloe vera L.) terhadap aktivitas antioksidan. Penelitian ini menggunakan metode molecular docking dengan analisis secara insilico yang menggunakan 4 aplikasi utama: autodock tools, autodock vina, biovia discovery studio, dan open babel. Hasil penelitian ini menunjukkan bahwa semua residu asam amino pada senyawa bioaktif Lidah buaya (Aloe vera L.) bekerja pada sisi aktif reseptor Human endothelial nitric oxide synthase (4D1O). Hasil binding energi senyawa bioaktif ekstrak kulit lidah buaya (Aloe vera L.) terhadap reseptor 4D1O menunjukkan nilai yang bagus. Simpulan: Senyawa bioaktif ekstrak Lidah buaya (Aloe vera L.) memiliki aktivitas antioksidan yaitu secara spesifik dapat menekan atau menghambat aktivitas pembentukan radikal bebas di dalam tubuh. Kata kunci: Lidah buaya (Aloe vera L.); Antioksidan; reseptor Human endothelial nitric oxide synthase (4D1O); Insilico.
Hubungan Antara Obesitas, Perilaku Merokok dan Konsumsi Alkohol dengan Kualitas Hidup Kesehatan Remaja Toar L. Runtuwene; Aaltje Manampiring; Gustaf Ratag
Jurnal Biomedik:JBM Vol. 14 No. 2 (2022): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.v14i2.46343

Abstract

Abstract: Teenagers as a quarter of world population, is one of human development index’s indicator. Behaviors such as sedentary life style can leads to obesity, while smoking and alcohol consumption can lead to decrease of life quality. This study aims to analyze the relationship between obesity, smoking, and alcohol consumption with quality of life of teenagers in Minahasa Selatan. This is an analytic study with cross-sectional design, with total samples of 443 teenager students of secondary and high schools in Minahasa Selatan during October-December 2021. The instrument used is questionnaire, and data are analyzed using Chi Square. This study concluded there is no relationship between obesity with health life quality of teenagers, although we found relationship between smoking and alcohol consumption with health life quality of teenagers in Minahasa Selatan. Keywords: Alcohol; Smoking; Obesity; Teenager Abstrak: Remaja adalah salah satu penentu indeks pembangunan manusia, dimana seperempat penduduk dunia berada dalam segmen remaja. Perilaku remaja tidak selalu mendukung untuk memiliki kesehatan optimal. Perilaku beresiko seperti gaya hidup sedentari yang berakibat terjadi obesitas, perilaku merokok dan konsumsi alkohol dapat mengakibatkan penurunan kualitas hidup kesehatan remaja. Tujuan Penelitian ini yaitu untuk menganalisis hubungan antara obesitas, perilaku merokok dan konsumsi alkohol dengan kualitas hidup kesehatan remaja di kabupaten Minahasa Selatan.Penelitian ini merupakan penelitian analitik dengan pendekatan potong lintang, total sampel 443 remaja yang bersekolah di SMP dan SMA di Kabupaten Minahasa Selatan, selama bulan Oktober-Desember 2021. Variabel penelitian yaitu; obesitas, perilaku merokok, konsumsi alkohol dan kualitas hidup kesehatan. Instrumen penelitian yaitu kuesioner, dan data dianalisis menggunakan uji Chi Square. Penelitian ini menunjukkan tidak ada hubungan antara obesitas dengan kualitas hidup kesehatan remaja. Ada hubungan antara perilaku merokok dan konsumsi alkohol dengan kualitas hidup kesehatan remaja pada domain lingkungan di kabupaten Minahasa Selatan. Kata Kunci: Alkohol; Merokok; Obesitas; Remaja
Molecular Docking Senyawa Vitexin, Ursolic Acid dan Flavonol dalam Tumbuhan Binahong (Andredera Cordifolia (Ten.) Steenis) yang Berpotensi sebagai Penghambat Pertumbuhan COVID-19 Sensea R. Rambitan; Aaltje Manampiring; . Fatimawali; Billy J. Kepel; Fona Budiarso; Widdhi Bodhi
eBiomedik Vol. 9 No. 2 (2021): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v9i2.31825

Abstract

Abstract: Currently, there is no specific treatment for all the COVID-19 patients the procedures that can be done are just a symptomatic and oxygen therapy, Therefore all the people around the world have try to avoid this infection by consuming the potensial plants that can boost our body immunity like Binahong.  This study was an in silico experimental. The finale result is the binding affinity score from each compound, for vitexin’s binding affinity score is – 8.0 kcal/mol, ursolic acid – 7.6 kcal/mol and flavonol – 7.8 kcal/mol. The finale result of this procedure also obtained all the amino acid residues that works on the active site of receptor 6LU7 as a main protase of COVID-19, namely THR24, LEU27, HIS41, THR45, SER46, MET49, PHE140, LEU141, ASN142, GLY143, SER144, CYS145, HIS163, MET165, GLU166 and HIS172. In conclusion, the binding affinity of vitexin, ursolic acid and flavonol are higher than remdesivir. Vitexin, ursolic acid and flavonol have a several similar bonds, particularly the van der waals bond and hydrogen bond.Keywords: Molecular docking, COVID-19, binahong, flavonoid Abstrak: Saat ini belum tersedia rekomendasi tatalaksana khusus bagi pasien COVID-19, termasuk antivirus atau vaksin dan tata laksana yang dapat dilakukan adalah terapi simtomatik dan karena itulah, masyarakat dunia mencoba banyak cara agar menghindari infeksi virus ini dengan mengolah dan mengonsumsi tumbuhan yang dinilai berpotensi dalam meningkatkan imunitas tubuh seperti tumbuhan Binahong. Penelitian ini menggunakan metode penelitian in silico. Pada hasil akhir penelitian diperoleh nilai binding affinity dari ketiga senyawa yaitu senyawa vitexin - 8.0 kcal/mol, Ursolic Acid -7.6 kcal/mol dan Flavonol -7.8 kcal/mol. Diperoleh data mengenai residu asam amino yang bekerja pada sisi aktif reseptor 6LU7 sebagai main protase COVID-19 yaitu THR24, LEU27, HIS41, THR45, SER46, MET49, PHE140, LEU141, ASN142, GLY143, SER144, CYS145, HIS163, MET165, GLU166, dan HIS172. Sebagai simpulan, binding affinity dari senyawa vitexin, ursolic acid dari flavonol lebih tinggi dari nilai binding affinity remdesivir. Senyawa vitexin, ursolic acid dan flavonol memiliki beberapa jenis ikatan yang sama termasuk ikatan van der Waals dan ikatan hydrogen.Kata Kunci: Molecular docking, COVID-19, binahong, flavonoid
Molecular Docking Senyawa Asam Askorbat dan Kuersetin pada Tumbuhan Jambu Biji Merah (Psidium guajava L.) Sebagai Pencegah COVID-19 Inggrid V. Gandu; Fona D. H. Budiarso; Billy J. Kepel; . Fatimawali; Aaltje Manampiring; Widdhi Bodhi
eBiomedik Vol. 9 No. 2 (2021): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v9i2.31846

Abstract

Abstract: Coronavirus Disease 2019 or COVID-19 is an infectious disease first identified in Wuhan, China in December 2019. Prevention of COVID-19 infection is an important thing to do in reducing the spread of this virus. Boosting the body's immune system can be done as a preventive measure, one of which is by consuming natural plants such as red guava. This study aims to determine the molecular docking of red guava (Psidium guajava L.) as a plant to prevent COVID-19. This was an in silico with computerized methods. The samples in this study were ascorbic acid and quercetin compounds in red guava plants obtained from the PubChem website. The results showed that the binding affinity of ascorbic acid is -5.4 and the binding affinity of quercetin is -7.6. Remdesivir which was used as a positive control had a binding affinity of -7.3. In conclusion, quercetin compounds have better results than ascorbic acid compounds and remdesivir.Keywords: COVID-19, red guava, molecular docking  Abstrak: Coronavirus Disease 2019 atau COVID-19 merupakan suatu penyakit menular yang pertama kali ditemukan di Wuhan, Tiongkok pada Desember 2019. Pencegahan infeksi COVID-19 merupakan hal yang penting untuk dilakukan dalam mengurangi penyebaran dari virus ini. Meningkatkan sistem imun tubuh dapat dilakukan sebagai tindakan pencegahan salah satunya dengan mengonsumsi tumbuhan-tumbuhan alami seperti jambu biji merah. Penelitian ini bertujuan untuk mengetahui molecular docking jambu biji merah (Psidium guajava L.) sebagai tanaman pencegah COVID-19. Jenis penelitian ialah in silico dengan metode komputerisasi. Sampel penelitian yaitu senyawa asam askorbat dan kuersetin pada tumbuhan jambu biji merah yang diperoleh dari website pubchem. Hasil penelitian mendapatkan binding affinity dari senyawa asam askorbat yaitu -5.4 dan binding affinity dari senyawa kuersetin yaitu -7.6. Remdesivir yang dijadikan sebagai kontrol positif mendapatkan hasil binding affinity yaitu -7.3. Simpulan penelitian ini ialah senyawa kuersetin memiliki hasil yang lebih baik daripada senyawa asam askorbat dan juga obat remdesivir.Kata kunci: COVID-19, jambu biji merah, molecular docking
Co-Authors . Fatimawali Angelique C. M. Tanan Billy J. Kepel Billy Kepel Dos D. L. E. Br Siagian Fatimawali . Fona Budiarso Gustaaf Ratag Gustaf Ratag Inggrid V. Gandu Jossy Indriane Nelwan Sensea R. Rambitan Toar L. Runtuwene widdhi Bodhi Winny Vionita Rambitan