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All Journal The Journal of Pure and Applied Chemistry Research Indonesian Journal of Chemistry Jurnal Farmasi Indonesia Jurnal Farmasi al Kimiya : Jurnal Ilmu Kimia dan Terapan JURNAL REKAYASA KIMIA & LINGKUNGAN

Bambang Purwono

Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO BOX BLS 21, Yogyakarta 55281

Author-ID : 350244

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Energy Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 12 Documents Claim Missing Document

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Synthesis of 1-(2-Methoxybenzyl)-1,10-phenanthrolin-1-ium Bromide from Gandapura Oil Muhammad Idham Darussalam Mardjan; Dhina Fitriastuti; Bambang Purwono; Jumina Jumina
The Journal of Pure and Applied Chemistry Research Vol 8, No 3 (2019): Edition September-December 2019
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2019.008.03.484

This study describes simple synthetic method to prepare 1-(2-methoxybenzyl)-1,10-phenanthrolin-1-ium bromide from gandapura oil. The salt were synthesized in four steps. Initially, commercial gandapura oil was directly subjected to the alkylation reaction under basic condition using dimethyl sulfate to give methyl 2-methxybenzoate in 86% yield. Next, the produced benzoate ester was reduced by LiAlH4 to produce 2-methoxybenzyl alcohol in 67% yield. The treatment of benzyl alcohol with phosphorus tribromide under solvent free condition produced the corresponding benzyl bromide (in 67% yield), which was directly introduced into bimolecular nucleophilic substitution reaction with 1,10-phenantroline monohydrate to finally give the desired product in 63% yield.

Chalcone Based Colorimetric Sensor for Anions: Experimental and TD-DFT Study Adita Silvia Fitriana; Harno Dwi Pranowo; Bambang Purwono
Indonesian Journal of Chemistry Vol 16, No 1 (2016)
Publisher : Universitas Gadjah Mada

The interactions between sensor chalcone of 3-(4-hydroxy-3-methoxyphenyl)-1-phenyl-2-propen-1-one (1) and anions (F–, Cl–, Br–, CN–, CO32–, and SO42–) have been experimentally and TD-DFT theoretically investigated. Sensor (1) showed a naked-eye detectable color change from yellow to red upon addition of F–, CO32–, CN–, and SO42– anions in DMSO, whereas no significant color change was observed upon addition of Cl– and Br– anions. The interaction models were predicted by optimizing (1)-anion complex using DFT/B3LYP method. Optimized (1)-anion complexes showed that sensor (1) was deprotonated by CO32–, CN–, F–, and SO42–. The formation of deprotonated sensor (1)– was responsible for the colorimetric signaling. Absorption spectra of neutral and deprotonated sensor were calculated using TD-DFT method. The calculated spectra were in good agreement with experimental results.

Method Development for the Analysis of Pharmaceuticals with Acethylcholinesterase Activity in Water Using HPLC-DAD and Solid Phase Extraction Samuel Budi Wardhana; Marit Kolb; Müfit Bahadir; Bambang Purwono; Tutik Dwi Wahyuningsih
Indonesian Journal of Chemistry Vol 14, No 1 (2014)
Publisher : Universitas Gadjah Mada

An SPE followed by HPLC-DAD method with ion pair chromatography technique to analyze pharmaceuticals with acethylcholinesterase activity including pyridostigmine (PYR), galathamine (GAL), neostigmine (NEO), eserine (ESE), and donepezil (DON) in water samples was developed. Acetylcholinesterase (AChE) inhibitors have been used to treat less severe dementias such as Alzheimer’s disease. Chromatographic separation was achieved using reversed-phase SymmetryShield column using gradient system with mobile phase consisting of H2O/ACN (99:1, v/v) as mobile phase A with 10 mM sodium 1-hexanesulfonate and 0.1% acetic acid (HAc). The HPLC/DAD method was linear between concentrations of 5 to 100 ng/μL. The IDL and IQL ranged from 0.50 to 1.25 ng/μL and 1.5 to 3.0 ng/μL, respectively. SPE was used to extract and clean up the target substances in spiked pure water, tap water, and wastewater samples. The application of extraction method of 5 target substances in wastewater sample was divided into 2 parts: Oasis WCX (6 mL, 500 mg) for PYR and Oasis HLB (6 mL, 200 mg) for GAL, NEO, ESE and DON. The developed SPE and HPLC/DAD method is applicable for quantification of the 5 target substances in water samples in a concentration range > 50 µg/L and assumable lower for DON (> 25 µg/L).

Syntheses of Azo-Imine Derivatives from Vanillin as an Acid Base Indicator Bambang Purwono; Chairil Anwar; Ahmad Hanapi
Indonesian Journal of Chemistry Vol 13, No 1 (2013)
Publisher : Universitas Gadjah Mada

Preparations of azo, imine and azo-imine derivatives from vanillin as an indicator of acid-base titration have been carried out. The azo derivative of 4-hydroxy-3-methoxy-5-(phenylazo)benzaldehyde 2 was produced by diazotitation reaction of vanillin in 37.04% yield. The azo product was then refluxed with aniline in ethanol to yield azo-imine derivatives, 2-methoxy-6-(phenylazo)-4-((phenylimino)methyl)phenol 1 in 82.21% yield. The imine derivative, 2-methoxy-4-((phenylimino)methyl)-phenol 3 was obtained by refluxing of vanillin and aniline mixture in ethanol solvent and produced 82.17% yield. The imine product was then reacted with benzenediazonium chloride salt. However, the products indicated hydrolyzed product of 4-hydroxy-3-methoxy-5-(phenylazo)benzaldehyde 2 in 22.15% yield. The 2-methoxy-4-((phenylimino)methyl)phenol 2 could be used as an indicator for titration of NaOH by H2C2O4 with maximum concentration of H2C2O4 0.1 M while the target compound 1 could be used as titration indicator for titration of NaOH with H2C2O4 with same result using phenolphthalein indicator.

SYNTHESIS OF 2-METHOXY-4,6-DI(PROP-1-ENYL)PHENOL FROM EUGENOL AND ITS ACTIVITY AS AN ANTIOXIDANT Hernawan Hernawan; Bambang Purwono; Tutik Dwi Wahyuningsih
Indonesian Journal of Chemistry Vol 12, No 2 (2012)
Publisher : Universitas Gadjah Mada

Synthesis and antioxidant activity of 2-methoxy-4,6-di(prop-1-enyl) phenol from eugenol have been investigated. Synthesis was conducted through three stages of reaction. The first step was CTAB micellar catalytic O-allylation reaction at room temperature, to give 4-allyl-1-(allyloxy)-2-methoxybenzene (2). Compound (2) was subsequently heated for Claisen rearrangement and produced 2,4-diallyl-6- methoxyphenol (3). The final steps was isomerization of compound (3) in alkaline conditions in ethylene glycol, to yield 2-methoxy-4,6-di(prop-1-enyl) phenol (4). Antioxidant activity test was conducted by TBARS and DPPH methods. TBARS test showed that the compound (4) at a concentration of 50 μM could inhibit the oxidation of linoleic acid shown by the increasing of time lag phase (96 ± 2.94 min), reducing the rate of propagation (± 54.54%) and reducing of malonal dialdehyde (MDA) formation (68.04 ± 0.84%). The DPPH test revealed that compound (4) indicated DPPH free radical scavenging activity with IC50 107.66 μM and comparable with IC50 for BHT 107.37 μM.

STUDIES ON LEWIS ACID REACTION OF ISOEUGENOL AND ISOEUGENYL ACETATE Bambang Purwono; Retno Dwi Soelistyowati; Mudasir Mudasir
Indonesian Journal of Chemistry Vol 3, No 1 (2003)
Publisher : Universitas Gadjah Mada

Studies of the Lewis Acid (AlCl3 and BF3-methanol) to isoeugenol and isoeugenyl acetate have been conducted. Reactions were carried out by stirring of isoeugenol and isoeugenyl acetate for 4 days at room temperature.Structure analysis of the products using IR, MS, 1H NMR and 13C NMR spectrophotometer showed that cyclic dimer product has been obtained white crystal, 175 oC, as a 1-ethyl-5-hydroxy-3-(4-hydroxy-3-methyl phenyl)-6-methoxy-2-methyl indane.

QSAR STUDY OF FLAVONE / FLAVONOL ANALOGUES AS THE ANTIRADICAL COMPOUNDS BASED ON HANSCH ANALYSIS Iqmal Tahir; Karna Wijaya; Bambang Purwono; Dinni Widianingsih
Indonesian Journal of Chemistry Vol 3, No 1 (2003)
Publisher : Universitas Gadjah Mada

Quantitative Structure-Activity Relationship (QSAR) analysis of substituted flavone / flavonol compounds has been carried out by applying Hansch Analysis using their physicochemical properties as the predictors. The properties i.e. log P, (log P)2, core-core interaction energy (Eint), volume (V), molecular mass (M), dipole moment (μ), heat of formation (ΔHof), binding energy (Ei), total energy (ET), surface area (L), polarizability (α), molar refractivity (RM), hidration energy (EH), electronic energy (Eel) and isolated atomic energy (Eat,is), were obtained on the basis of geometry optimization using PM3 semiempirical method. The QSAR analysis used antiradical activities (% A) as the dependent variable and has been done by applying multilinear regression technique. The result showed that QSAR equations i.e.% A = 77.426 - 67.343 [log P] + 3.160 [(log P)2 + 67.884 [α] + 6.63x10-4 [ Eint] - 5.280 [L] + 1.179 [V] + 0.447 [M] - 11.000 [μ] + 0.093 [Ei] + 3.433 [EH] - 3.44x10-3 [ET](n = 16 ; r2 = 0.987 ; SD = 9.205; Fcal/Ftable = 4.797)

Styrene and Azo-Styrene Based Colorimetric Sensors for Highly Selective Detection of Cyanide Agustina Eka Prestiani; Bambang Purwono
Indonesian Journal of Chemistry Vol 17, No 2 (2017)
Publisher : Universitas Gadjah Mada

A novel styrene (1) and azo-styrene (2) based chemosensor from vanillin has been successfully synthesized. Sensor 1 was obtained by one step Knoevenagel condensation of Ultrasound method and sensor 2 by coupling diazo and Knoevenagel condensation reaction. Both of sensors showed high sensitivity and selectivity to detect CN- in aqueous media, even the presence of other anions, such as F-, Cl-, Br-, I-, CO32-, SO42-, H2PO4-, and AcO-. Colorimetric sensing of sensor 1 is inclined to be deprotonating of sensor binding site in the presence of cyanide and consequently improve the selectivity and sensitivity in sensing cyanide which displayed color change of sensor from yellowness to red-purple and then purple in 1 min. Sensor 2 exhibited chemodosimeter phenomenon which is caused by the nucleophilic addition of cyanide with a colour change from green to greenish-blue. The results enable to do an anion detection by a naked eye.

COMPARISON OF ESSENTIAL OILS QUALITY FROM PARTS OF NUTMEG BASED ON MYRISTICINE LEVELS Hery Muhamad Ansory; Hardjono Sastrohamidjojo; Bambang Purwono; Nurrohmah Dwi Mahesti
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Telah dilakukan isolasi minyak atsiri dari daging buah, fuli dan biji buah pala denganmenggunakan metode distilasi uap. Analisis kadar senyawa miristisin sebagai indikator darikualitas minyak pala dilakukan dengan menggunakan kromatografi gas dan spektrometer massa.Isolasi senyawa miristisin dilakukan dengan metode distilasi fraksinasi pengurangan tekanan.Analisis kemurnian miristisin dari hasil isolasi dilakukan dengan menggunakan kromatografi gas.Analisis struktur miristisin hasil isolasi dilakukan dengan menggunakan spektrofotometer inframerah dan 1H NMR.Hasil isolasi minyak pala dengan metode distilasi uap dari daging buah pala didapatkan0,75% dengan kadar miristisin 10,54%, fuli pala didapatkan 4,77% dengan kadar miristisin 38,45%dan biji pala didapatkan 6,62% dengan kadar miristisin 9,24%. Hasil isolasi senyawa miristisin dariminyak pala dengan metode distilasi fraksinasi pengurangan tekanan didapatkan dengan kadar92,13%.Kualitas minyak atsiri dari bagian fuli pala memiliki kualitas yang lebih baik dengankandungan miristisin sebesar 38,45%.

Metode Ekstraksi Sarang Semut (Myrmecodia Pendans) dengan Teknik Maserasi untuk Menghasilkan Obat Alternatif Kanker Paru Suharyanto; Purwono, Bambang
Jurnal Farmasi (Journal of Pharmacy) Vol. 4 No. 1 (2015): Jurnal Farmasi (Journal of Pharmacy), October 2015
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Cancer is a growing cells of any type of cell and tissue in the body anywhere, a large number of diseases are characterized by tissue and cell type of origin. Each year found nearly 6 million new patients known to have cancer, and more than 4 million of them died. Until now cancer treatment is done by 3 ways: surgery, radiation, and drug delivery of anti -neoplastic or anti- cancer. However, all three treatments over a lot of side effects to the patient. This study aims to conduct a series of pre-clinical trials to determine the optimal dose of Sarangsemut plant ( Myrmecodia pendens ) can be used as a drug to cure lung cancer. The specific objective of this research is to extract Sarangsemut plant ( Myrmecodia pendens ) and soursop leaves to produce drugs alterlatif cancer disease. Benefits of this research can be used.

Co-Authors Adita Silvia Fitriana Agustina Eka Prestiani Ahmad Hanapi Arfiani Nur Chairil Anwar Dhina Fitriastuti Dinni Widianingsih Hardjono Sastrohamidjojo Harno Dwi Pranowo Hernawan Hernawan Iqmal Tahir Jumina Jumina Karna Wijaya Marit Kolb Mudasir Mudasir Müfit Bahadir Muhamad Ansory, Hery Muhammad Idham Darussalam Mardjan Nurrohmah Dwi Mahesti NURUL HIDAYAH Retno Dwi Soelistyowati Samuel Budi Wardhana Suharyanto Tutik Dwi Wahyuningsih

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