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All Journal Biotika: Jurnal Ilmiah Biologi Indonesian Journal of Chemistry Jambura Journal of Chemistry JKPK (Jurnal Kimia dan Pendidikan Kimia) Fullerene Journal of Chemistry Oxygenius Journal Of Chemistry Education Jurnal Dedikasi Seminar Nasional Pengabdian Kepada Masyarakat Jurna Beta Kimia JIPI (Jurnal IPA dan Pembelajaran IPA)
Rymond Jusuf Rumampuk
Universitas Negeri Manado
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Physics Other

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PENERAPAN PEMBELAJARAN KIMIA BERBASIS CHEMO-ENTREPRENEURSHIP PADA MATERI LARUTAN PENYANGGA KELAS XI SISWA SMA CITRA KASIH MANADO Runtuwene, Christiana Paula; Rumampuk, Rymond; Tengker, Soenandar; Kaeng, Meilanie; Pongoh, Emma
Oxygenius: Journal Of Chemistry Education Vol 7 No 1 (2025): Oxygenius : Journal Of Chemistry Education
Publisher : Chemistry Department, Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/ojce.v7i1.722

Abstract

This study aims to determine the effect of applying Chemo-Entrepreneurship (CEP)-based chemistry learning on students' engagement and learning outcomes in the buffer solution material for Grade XI students at SMA Citra Kasih Manado. This research employed a Classroom Action Research (CAR) method conducted in two cycles, each consisting of planning, implementation, observation, and reflection stages. The research instruments included student activity observation sheets and learning outcome tests. The results showed that the application of CEP-based learning significantly increased students' engagement and learning outcomes. The average learning activity score increased from 42.5% (categorized as low) in the first cycle to 90% (categorized as very good) in the second cycle. The average learning outcome score also rose from 56 in the first cycle to 89 in the second cycle, achieving a 100% mastery level. The implementation of Chemo-Entrepreneurship through a research-based learning model proved effective in enhancing student engagement, creativity, and understanding of buffer solution concepts. Therefore, this approach is recommended for use in other chemistry learning topics to foster entrepreneurial potential and 21st-century skills among students.
Isolation and Identificationof Octadecane-3-on Compound From Ethyl Acetate Fraction of Momordica balsamina L. Leaves Pongoh*, Emma Julien; Rumampuk, Rymond Jusuf; Paat, Vlagia Indira; Rumengan, Stefan Marco; Soputan, Julieta
Jurnal IPA & Pembelajaran IPA Vol 8, No 1 (2024): March 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jipi.v8i1.37717

Abstract

Momordica balsamina L. is a wild plant that generally grows in moist soil and gets a lot of sunlight. The leaves and fruit are reported to have various medicinal and nutritional properties. This study aimed to isolate and identify the compounds contained in the ethyl acetate fraction in Momordica balsamina L The isolation stage was carried out by the maceration method and the separation and purification of the compounds using gravity column chromatography methods to obtain isolate fraction F1.6.2 with a sample weight of 2.4 mg. Identification of compounds using proton nuclear magnetic resonance (1H-NMR) and carbon nuclear magnetic resonance (13C-NMR) spectroscopy techniques. The proposed identified compound is octadecan-3-one or 3-octadecanone with the molecular formula C18H36O
In Silico Study of the YAKRCFR Peptide Structure and Its Interaction with Human Peroxiredoxin-5 Najoan, Jessika Maya Jovanka; Rumampuk, Rymond Jusuf; Paat, Vlagia Indira; Aloanis, Anderson Arnold
Jurnal Beta Kimia Vol 5 No 2 (2025): Volume 5 Issue 2, November 2025
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jbk.v5i2.22710

Abstract

The identification of bioactive peptides with therapeutic potential is an emerging focus in drug discovery. In this study, we evaluated the structural stability and binding affinity of the oyster-derived peptide YAKRCFR through molecular modeling and docking simulations against the human peroxiredoxin receptor. Structural prediction using the PEP-FOLD4 server revealed a consistent α-helical conformation across all models, stabilized by key intramolecular hydrogen bonds and favorable sOPEP energy values. Molecular docking was validated with a root mean square deviation (RMSD) of 0.273 Å, confirming the reliability of the docking protocol. The YAKRCFR peptide exhibited a strong binding affinity with the 1HD2 receptor (ΔG = –8.1 kcal/mol), outperforming both ascorbic acid (–6.1 kcal/mol) and the native ligand (–4.862 kcal/mol). Detailed interaction analysis indicated that YAKRCFR forms stable hydrogen bonds and van der Waals interactions with critical residues such as ILE A119 and PHE A120, contributing to its thermodynamic stability and binding specificity. These findings suggest that YAKRCFR holds promise as a lead compound for further development in peptide-based therapeutic strategies, particularly for targets involving the human peroxiredoxin receptor.
Total Synthesis and Molecular Docking study of Peptide AWVDY as an Anti-inflamation Agent Aloanis, Anderson Arnold; Najoan, Jessika Maya Jovanka; Paat, Vlagia Indira; Rumengan, Stefan Marco; Rumampuk, Rymond Jusuf
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 10, No 2 (2025): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v10i2.103623

Abstract

Bioactive peptides are known for their diverse biological functions, many of which support health and well-being. In this study, we synthesized and evaluated the anti-inflammatory potential of the peptide AWVDY, derived from oyster (Crassostrea rivularis). The synthesis was performed using the solid-phase peptide synthesis (SPPS) method, applying the Fmoc strategy on 2-chlorotrityl chloride (2-CTC) resin, and achieved a high yield of 95.83%. The resulting peptide was characterized using Time-of-Flight Mass Spectrometry (TOF-MS), which detected a peak at m/z [M+H⁺] 653.1418, consistent with the expected molecular formula C₃₂H₄₀N₆O₉. This was further validated by analytical HPLC, showing a retention time of 22.596 minutes. Molecular docking studies indicated that AWVDY binds favorably to the pro-inflammatory cytokines TNF-α and Interleukin-6, with binding affinities of -10.360, -10.430, and -8.960 kcal/mol, respectively. These findings suggest that AWVDY may act as a dual-target peptide capable of modulating inflammatory pathways, highlighting its potential as a promising candidate for the development of new anti-inflammatory therapeutics. 
Co-Authors Ade Wiwit Tahulending Anderson Arnold Aloanis Anthony J Herlt Ardi Kapahang Arfiani Rizki Paramata Astin Lukum claudia christy senduk Dewi Indriyany Manangkoda Dian Howan Djefry Tani E. M. Soekartadiredja Emma Julin Pongoh Febby Hauwita Gabriel Reinhard Kahiking Hotma Rotua Br. Simbolon Husein Hernadi Bahti Hutri C. Werfete Istiani Astari Nanangkong Justitia Mifthania Bulotio Kaeng, Meilanie Laode Rijai Lewis N Mander Mokosuli Yermia Samuel Najoan, Jessika Maya Jovanka Ni Wayan Suriani Nonny Manampiring Paat, Vlagia Indira Pongoh*, Emma Julien Ponis Tarigan Ponis Tarigan Ponis Tarigan Ponis Tarigan Ratu Safitri Revolson Mege Runtuwene, Christiana Paula Soetijoso Soemitro Soetijoso Soemitro Sofia Satriani Krisen Sofyan M Nur SOFYAN M.NUR, SOFYAN Soputan, Julieta Stefan Marco Rumengan Supriyatna Sutardjo Tengker, Soenandar Millian Tompunu Theresia N. R. Boce Unang Supratman Veyta Tamunu W.C. Taylor Wilson Alexander Raymond Rombang Yue Mao Shen