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Manal Mohamed Talaat El-Saidi
Photochemistry Department, Chemical Research Division, National Research Center, Dokki, Giza, 12622, Egypt
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Synthesis, Characterization and Docking Study of Novel Pyrimidine Derivatives as Anticancer Agents Manal Mohamed Talaat El-Saidi; Ahmed Ali El-Sayed; Erik Bjerregaard Pedersen; Mohamed Abdelhamid Tantawy; Nadia Ragab Mohamed; Wafaa Ahmed Gad
Indonesian Journal of Chemistry Vol 20, No 5 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (761.535 KB) | DOI: 10.22146/ijc.50582

Abstract

New compounds 5 and 9 using DNA bases e.g. Adenine 1 and Guanine 6 derivatives have been synthesized. The use of simple methods to synthesize compounds 5 and 9 were done using pyrimidine as an alternative DNA base ring. Another design to synthesize new simple pyrimidine rings utilizing thiourea and ethylcyano acetate to afford 6-amino-2-thiouracil was adopted. The reaction of thiouracil 10 with chloro cyano or chloro ester and ketone, resulted in the formation of adduct compounds 18-21, rather than the formation of compound 17. All the synthesized compounds were subjected to docking study, in order to gain insights into their binding modes against cyclin-dependent protein kinase 2 (CDK-2) that is involved heavily in cell cycle regulation and receptor protein B-cell lymphoma 2 (BCL-2) which is involved in cell apoptosis. These targets were selected based on their key roles in cancer progression via the regulation of the cell cycle and DNA replication. Molecular-docking analyses showed that compound 14e was the best docked ligand against both targets, as it displayed the lowest binding energy, critical hydrogen bonds and hydrophobic interactions with the targets.
Polyvinyl Alcohol Food Packaging System Comprising Green Synthesized Silver Nanoparticles Ahmed Elsayed Abdelhamid; Eman AboBakr Ali Yousif; Manal Mohamed Talaat El-Saidi; Ahmed Ali El-Sayed
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.55483

Abstract

Green synthesis of silver nanoparticles (AgNPs) using aqueous Moringa extract and their incorporation in polyvinyl alcohol (PVA) as food packaging materials have been performed. The prepared nanoparticles were characterized via Ultraviolet-visible spectra and transmission electron microscope, and the results revealed the formation of silver nanoparticles in a semi-spherical shape with an average size ranged from 2 to 5 nm. The addition of different ratios of the nanoparticles onto the PVA matrix and their crosslinking via citric acid to obtain nanocomposite sheets were performed. The nanocomposite sheets were characterized using FT-IR, UV-Vis, and TGA. In addition, their mechanical properties were evaluated. Water vapor permeability rate and water content were also determined. The composite sheets showed good thermal and optical performance. Antibacterial activities of the prepared nanocomposite sheets were evaluated, and the results exhibited good resistance to bacterial growth.
Co-Authors Ahmed Ali El-Sayed Ahmed Elsayed Abdelhamid Eman AboBakr Ali Yousif Erik Bjerregaard Pedersen Mohamed Abdelhamid Tantawy Nadia Ragab Mohamed Wafaa Ahmed Gad