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All Journal Jurnal Penelitian Farmasi Indonesia JOPS (Journal Of Pharmacy and Science) Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE Jurnal Farmasi Indonesia
Nofriyanti
Sekolah Tinggi Ilmu Farmasi Riau
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GAMBARAN PENGGUNAAN OBAT GASTRITIS PADA PASIEN RAWAT JALAN DI SALAH SATU RUMAH SAKIT DI PROVINSI RIAU Nofriyanti Nofriyanti
Jurnal Penelitian Farmasi Indonesia Vol. 3 No. 2 (2014): jpfi
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.065 KB)

Abstract

Indonesia ranks fourth with the highest number of patients with gastritis after USA, England and Banglasdesh which totaled to 430 million people.Gastritis become one of the top ten most prevalent disease in outpatient in Indonesia which totaled to 30.154 cases (4,9%). The purposes of this studyto provide an overview of the usage of gastritis drugs quantitatively on outpatient at Departement of Internal Disease at one hospital in RiauProvince, according the proportions of gender, age range, type of gastritis, patent or generic, classes of drugs, type of gastritis drug and combinationsand interactions among the gastritis drug. The type of this study is observational with descriptive method using retrospective data. The selected data isgastritis patient medical record outpatient. The population of this study are the gastritis patient who outpatient at Departement of Internal Disease atone hospital in Riau Province totaled to 124 patients. The highest proportion based on gender totaled 67 persons (54,03%) are women, based on agerange totaled 99 persons (79,84%) are adult (18-55 years), based on type of gastritis totaled 48 cases (38,71%) are limfositic gastritis, based on patentand generic totaled 173 items ( 62,91%) are generics, based on classes of the drug totaled 115 items (41,82%) are proton pump inhibitor, based ontype drug of gastritis totaled90 items (32,73%) are Dexanta [A l(OH)3, Mg(OH)2, DMPS] and Lansoprazol, based on combinations and interactionsamong the gastritis drug totaled 65 items (30,66%) are combination of [Al(OH)3, Mg(OH)2, DMPS] and Lansoprazol.
Optimasi Formula Nanoemulsi Antioksidan Minyak Nilam (Pogostemon cablin Benth.) dengan Metode Box Behnken Design Ferdy Firmansyah; Widia Wulandari; Wildan Khairi Muhtadi; Nofriyanti Nofriyanti
Jurnal Mandala Pharmacon Indonesia Vol. 8 No. 2 (2022): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v8i2.259

Abstract

Minyak nilam (Pogostemon cablin Benth.) yang memiliki konstituen utama patchouli alcohol menunjukkan aktivitas antioksidan. Karakteristik khusus dari minyak nilam yaitu memiliki sifat volatilitas yang tinggi sehingga perlu untuk diformulasi menjadi bentuk sediaan yang lebih stabil seperti nanoemulsi. Tujuan penelitian ini yaitu untuk mendapatkan konsentrasi optimum dari masing-masing komponen penyusun nanoemulsi yang melibatkan proses yaitu waktu pengadukan yang menghasilkan sediaan nanoemulsi dengan karakteristik yang baik   menggunakan Box Behnken Design (BBD) serta melakukan uji aktivitas antioksidan nanoemulsi minyak nilam. Konsentrasi Smix (surfaktan dan kosurfaktan), air, dan waktu pengadukan merupakan faktor yang diamati dalam optimasi formula dan sebagai respon digunakan persen transmitan. Karakteristik yang diamati antara lain rata-rata ukuran partikel, indeks polidispersitas, dan zeta potensial. Berdasarkan data diagram fase digunakan minyak nilam 5%. Data hasil optimasi diperoleh nilai konsentrasi Smix 24%, air 35,511%, dan waktu pengadukan 5,516 menit, memberikan nilai rata-rata ukuran partikel 12,76 nm, indeks polidispersitas 0,162, dan zeta potensial -26,1 mV. Aktivitas antioksidan nanoemulsi minyak nilam menunjukkan nilai IC50 >1000 ppm. Sehingga dapat disimpulkan bahwa Box Behnken Design (BBD) dapat digunakan untuk optimasi nanoemulsi minyak nilam yang menghasilkan nanoemulsi dengan karakteristik yang baik. Penelitian lebih lanjut diperlukan untuk menentukan konsentrasi minyak nilam yang diformulasikan sebagai nanoemulsi untuk penggunaan sebagai antioksidan.
Formulasi Dan Uji Aktivitas Antibakteri Facial Foam Minyak Biji Jintan Hitam (Nigella Sativa Oil) Nesa Agistia; Gressy Novita; Nofriyanti Nofriyanti
Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta Vol 2 No 1 (2023): Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jppie.v2i1.800

Abstract

Acne is a disease that most people suffer especially among adolescent, one of the causes of acne is usually caused by the growth of acne-causing bacteria that is Staphylococcus epidermidis. One of the ingredients that can be used as an antibacterial product is black cumin seed oil (Nigella sativa oil), it is known that black cumin seed oil contains Thymoquinone and α-pinen which are efficacious as antibacterial. This research aims to produce a cosmetic preparation in the form of a face wash that effectively cleans the skin from dust and dirt from makeup, as well as preparations that have antibacterial activity against Staphylococcus epidermidis by using the well diffusion method. Black cumin seed oil is formulated into facial foam in several concentrations, namely 3% (FI), 5% (FII) and 7% (FIII). Evaluation of fa cial foam preparations includes examination of organoleptic, pH, foam power, skin irritation, homogeneity, wetting power, alcohol insoluble portion, freeze and thaw, examination of mineral oil, washability and antibacterial activity. Data analysis using One Way ANOVA statistical test and descriptive. The result showed that the physical stability test, the three facial foam formulas have good physical stability and meet the pH requirements of topical cosmetic preparation. In the antibacterial activity test, it was found that the facial foam preparation of black cumin seed oil give inhibition of 15.37 mm (FI), 16.52 mm (FII) and 17.25 mm (FIII). Based on the one way ANOVA statistical data, the p value <0,05 which means that three is a significant difference in inhibition diameter between FI, FII and FIII which negative control and positive control. It is concluded that the facial foam preparations of black cumin seed oil was physically stable and based on antibacterial activity tests, it is known that FIII has the most bacterial resistance of 17.25 mm with medium resistance category.
Formulasi dan Uji Aktivitas Antioksidan Serum Spray Gel Minyak Rosemary (Rosmarinus officinalis L.) Nesa Agistia; Nofriyanti Nofriyanti; Suci Nurhafizah
Jurnal Farmasi Indonesia Vol 21 No 2 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i2.2079

Abstract

Free radicals can trigger premature aging which can affect the skin structure. Therefore, we need antioxidants that can stabilize reactive free radicals so that they inhibit the free radical oxidation process. One of the plants that can be used as an antioxidant is rosemary (Rosmarinus officinalis L.) in the form of essential oil which contains compounds 1,8-cineole, α-pinene and β-pinene. This study aims to produce a topical preparation of rosemary oil in the form of a serum spray gel and has antioxidant activity. The concentrations of rosemary oil used at F1, F2, F3 and F4 were 0%, 5%, 10%, and 15%, respectively. Evaluation of rosemary oil serum spray gel formulation which includes organoleptic, pH, homogeneity, stickiness, viscosity, stability and spraying pattern. The evaluation results meet the requirements. The conclusion of this study is that rosemary oil serum gel spray preparation is physically stable and the best antioxidant activity is F4 with a rosemary oil concentration of 15% and an IC50 value of 152.6274 µg/mL.
Formulasi dan Uji Aktifitas Antikutu Kepala (Pediculus humanus capitis) Sediaan Sampo Minyak Sereh Wangi (Citronella oil): Formulation and Test of Anti-Head Lice Activity (Pediculus humanus capitis) Citronella Oil Shampoo Preparation (Citronella oil) nesa agistia; Nofriyanti Nofriyanti; Ratna Sari Dewi
JURNAL FARMASI DAN MAKANAN Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3578

Abstract

One of the problems that reduce a person's confidence is pediculosis. Natural ingredients used as anti-lice are citronella oil (Citronella oil), citronella oil contains citronellal compounds. This study aims to obtain a shampoo preparation that has anti-head lice activity. Citronella oil is formulated in several concentrations, namely 5% (FI), 7.5% (FII) and 10% (FIII). Evaluation of shampoo preparations included organoleptic examination, pH, homogeneity, foam height, irritation, cleaning power, freeze and thaw and anti-lice activity. Data analysis used the One Way ANOVA statistical test to see the comparison formula against the time of tick death. Based on the evaluation of the preparations, it was found that the shampoo had a thick liquid consistency, white in color, had a distinctive smell of citronella oil and no phase separation, pH 5.62-5.69, homogeneous, good cleaning power test, non-irritating, stable, anti-lice activity test FI = 6.24 minutes, FII = 5.38 minutes, FIII = 3.68 minutes, there was a significant difference (p<0.05) between the formulas on the time of tick death.
Microemulsion-Based Delivery of Celery (Apium graveolens L.) Extract as a Hair Growth Promoter: Penghantaran Ekstrak Seledri (Apium graveolens L.) Berbasis Mikroemulsi sebagai Promotor Pertumbuhan Rambut Wira Noviana Suhery; Nofriyanti; Nurul Latifah; Mustika Furi; Haiyul Fadhli; Rahayu Utami
JURNAL FARMASI DAN MAKANAN Vol 9 No 1 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i1.6831

Abstract

This study aimed to formulate a microemulsion of celery ethanol extract (Apium graveolens L.) and evaluate its physical properties and effects on rabbit hair growth. Four formulations were prepared: three containing celery extract at concentrations of 5% (FI), 7.5% (FII), and 10% (FIII), and one blank formula (F0). The microemulsions were assessed for organoleptic properties, percent transmittance, pH, density, viscosity, rheology, stability (including heating–cooling cycles and centrifugation), skin irritation, and globule size. Hair growth activity was tested in rabbits, and data were analyzed using two-way ANOVA. All formulations demonstrated good physical stability and caused no skin irritation. The results showed that the microemulsions significantly promoted hair growth, with the 10% extract formulation (FIII) showing the most pronounced effect, enhancing hair length by 2.7 times compared to the blank. These findings suggest that celery extract microemulsions, particularly at higher concentrations, are effective in stimulating hair growth.
Aktivitas Antibakteri Isolat Jamur Endofit Kulit Batang Rimbang (Solanum torvum Swartz) terhadap Beberapa Bakteri Melzi Octaviani; Salsabila Putri; Sri Lidya Rasihe; Kolista Sisilawati; Nofriyanti Nofriyanti; Rahmayati Rusnedy
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.557

Abstract

Endophytic fungi are known as a promising alternative source of antibacterials due to their ability to synthesize secondary metabolites like their host plants. Although the presence of endophytic fungi associated with Solanum torvum has been reported in previous studies, no studies have focused on fungi isolated from the bark of Solanum torvum and the correlation between the phytochemical content of its fractions and antibacterial activity. The aim of this study was to isolate endophytic fungi from the bark of Solanum torvum and test the antibacterial activity and phytochemical profiles of the fractions from the isolates against pathogenic bacteria. Endophytic fungi were isolated using direct cultivation techniques after surface sterilization. The antibacterial activity test was evaluated using the disc diffusion method against Bacillus cereus ATCC 11778, Staphylococcus aureus ATCC 12600, Escherichia coli ATCC 11775, and Salmonella typhi ATCC 14028 bacteria. Five endophytic fungal isolates were obtained and identified, namely FEST-K1 (Artrographis), FEST-K2 (Acremonium sp.), FEST-K3 (Paecilomyces sp.), FEST-K4 (Lichtheimia), and FEST-K5 (Alternaria sp.). The supernatant was then extracted and fractionated using ethyl acetate, chloroform, and n-butanol. Phytochemical analysis showed that the fungal fraction contained alkaloids, terpenoids, and saponins. FEST-K1 showed the strongest inhibitory activity against S. aureus and B. cereus, with inhibition zone diameters of 15.09 mm and 13.69 mm, respectively. In contrast, the highest activity against E. coli and S. typhi was observed in FEST-K4 (13.78 mm) and FEST-K5 (15.45 mm). One-way ANOVA statistical analysis showed that the antibacterial activity of the fungal extracts was significantly different from the positive control (p < 0.05). These results indicate that endophytic fungi derived from the bark of S. torvum are a potential source of antibacterial compounds.
Formulasi dan Uji Aktivitas Serum Spray Gel Minyak Adas (Feoniculum Vulgare Mill.) terhadap Bakteri Propionibacterium Acnes Nesa Agistia; Nofriyanti .; Erniza Pratiwi; Mifza Azizah
Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta Vol 5 No 1 (2026): Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jppie.v5i1.2449

Abstract

Acne is a prevalent dermatological condition primarily caused by the bacterium Propionibacterium acnes. Antibiotics are used in acne therapy; however, increasing bacterial resistance has been reported in numerous studies. Fennel (Foeniculum vulgare Mill.) essential oil is known to exhibit antibacterial properties, mainly due to its active constituents, anethole and fenchone. This study aimed to develop a pharmaceutically stable serum spray gel formulation containing fennel essential oil and to evaluate its anti-acne activity. Fennel essential oil was formulated into serum spray gel preparations at concentrations of 10%, 15%, and 20%. The formulations were evaluated for organoleptic characteristics, pH, homogeneity, viscosity, flow behavior, adhesiveness, physical stability, spray pattern, and antibacterial activity.The results demonstrated that all serum spray gel formulations exhibited good physical stability, as indicated by acceptable organoleptic properties, homogeneity, pH values, viscosity, flow behavior, adhesiveness, stability, and spray patterns. One-way analysis of variance (ANOVA) revealed a statistically significant difference (p < 0.05) among the formulations in terms of antibacterial activity, as measured by the diameter of the inhibition zones. Post hoc Tukey analysis showed that the 10% fennel essential oil formulation exhibited the highest antibacterial activity, with an inhibition zone diameter of 23.6 mm, which was classified as strong antibacterial activity.
Co-Authors agistia, nesa Ferdy Firmansyah Gressy Novita Haiyul Fadhli Kolista Sisilawati Melzi Octaviani Mifza Azizah Muhtadi, Wildan Khairi Mustika Furi nesa agistia Nurul Latifah Pratiwi, Erniza Rahayu Utami Ratna Sari Dewi Rusnedy, Rahmayati Salsabila Putri Sri Lidya Rasihe Suci Nurhafizah Widia Wulandari Wira Noviana, Wira Noviana