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All Journal Majalah Kedokteran Bandung Jurnal Biosains Pascasarjana The Indonesian Biomedical Journal
Noer Halimatus Syakdiyah
Fakultas Kedokteran Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PENGARUH EKSTRAK BAYAM MERAH (AMARANTHUS GANGETICUS) TERHADAP MORFOLOGI STRATUM HIPOKAMPUS MODEL ANAK MENCIT PASCASAPIH INDUK YANG TERPAPAR TIMBAL SELAMA MASA KEHAMILAN Kalanjati, Viskasari; Pratiwi, Made Pury; Syakdiyah, Noer Halimatus; Widiasi, Etha Dini; Anggraeni, Mayang Rizki; Pratiwi, Intan Anggun; Argarini, Raden
Majalah Kedokteran Bandung Vol 46, No 3 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1418.333 KB)

Abstract

Kandungan antioksidan ekstrak bayam merah (Amaranthus gangeticus) diduga dapat melawan efek toksik timbal asetat pada sistem saraf pusat. Penelitian ini bertujuan untuk mengamati pengaruh pemberian ekstrak bayam merah terhadap morfologi hipokampus model anak mencit (Mus musculus) pascasapih yang induknya terpapar timbal asetat per oral selama masa kehamilan. Penelitian dilakukan di Laboratorium Hewan Coba Fakultas Kedokteran, Universitas Airlangga (FKUA) pada bulan April?Juni 2013. Dua puluh tujuh ekor anak mencit pascasapih dibagi dalam 3 kelompok: M0 (sodium carboxymethyl cellulose atau CMC Na 0,5%), M1 (CMC Na 0,5%+timbal asetat 1,16 mg/10 g BB/hari) dan M2 (CMC Na 0,5%+timbal asetat 1,16 mg/10 g BB/hari+ekstrak bayam merah 382,2 mg/10 g BB/hari). Sediaan otak diambil untuk dibuat preparat histologi dengan pewarnaan hematoxylin-eosin (HE). Lebar stratum granulare girus dentatus (GD), stratum oriens-piramidale (SOP) CA1, CA2, dan CA3 dianalisis dengan analysis of variance (ANOVA) dan least significant different (p<0,05). SOP CA1 dan CA2 pada kelompok M2 lebih lebar dibandingkan dengan kelompok M1 (p<0,05). SOP CA1 kelompok M2 lebih lebar pula bila dibandingkan dengan M0 (p=0,001). Lebar SG dari GD dan SOP CA3 kelompok M2 menunjukkan nilai yang lebih tinggi (p>0,05). Simpulan, pemberian ekstrak bayam merah dapat mengurangi efek negatif timbal asetat yang merusak struktur hipokampus model anak mencit pascasapih yang induknya terpapar timbal selama kehamilan. Kata kunci: Bayam merah, hipokampus, timbal asetatEffect of Red Spinach (Amaranthus gangeticus) Extract on Hippocampus Morphology of Post-Weaning Mice Infant Model from Lead-Acetate Exposed Pregnant Mice Antioxidants in red spinach (Amaranthus gangeticus) extract are proposed to combat the toxicity of lead acetate in the central nervous system. The effect of red spinach extract to the morphology of post weaning mouse hippocampus model (Mus musculus) in pregnant mice that received oral lead acetate during pregnancy was analyzed. Twenty seven post-weaning mice offsprings were grouped into 3 groups: M0 (sodium carboxymethyl cellulose or CMC Na 0.5%), M1 (CMC Na 0.5%+lead acetate 1.16 mg/10 g of body weight/day) and M2 (CMC Na 0.5%+lead acetate 1.16 mg/10 g of body weight/day+red spinach extract 382.2 mg/10 g of body weight/day). Brains were histologically processed and stained with hematoxylin-eosin (HE). Width of stratum granulare (SG) of the dentate gyrus (GD) and each of stratum oriens-pyramidale (SOP) of CA1, CA2, CA3 from each mouse hippocampus were obtained and analyzed statistically using analysis of variance (ANOVA) and least significant difference (LSD) (p<0.05). The CA1 and CA2 SOPs in M2 were significantly wider compared to those of M1 (p<0.05). Meanwhile, the SOP of CA1 in M2 was significantly wider compared to that of M0 (p=0.001). The SG width of GD and the CA3 SOP in M2 were wider than those of M0 and M1 (p>0.05). In conclusion, red spinach extract might dampen the adverse effects of oral lead acetate in post-weaning mouse hippocampus model from pregnant mice orally exposed to lead acetate during pregnancy. Key words: Hippocampus, lead acetate, red spinach DOI: 10.15395/mkb.v46n3.116
THE ROLE OF PROBIOTICS AS ADJUVANT THERAPY IN INFLAMMATORY CARDIOVASCULAR DISEASES Yosephi, Valensa; Syakdiyah, Noer Halimatus; Atmaja, Peter Yustian; Soegiarto, Gatot
Jurnal Biosains Pascasarjana Vol. 26 No. 2 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i2.2024.152-164

Abstract

Cardiovascular diseases are the leading cause of death worldwide. Probiotics are live microorganisms that can provide health benefits to the host when administered in adequate amounts. The anti-inflammatory effects of probiotics were initially studied in Crohn's disease (CD) and ulcerative colitis (UC). This research aim to provide scientific evidence and explanation on the effects of probiotic administration as adjuvant therapy for inflammatory diseases in cardiovascular health. The study employed a descriptive approach using the systematic literature review method on PubMed, Scopus, SAGE, and Web of Science. A total of 13 articles were included in this study. The probiotics used included Bifidobacterium in one clinical trial, Lactobacillus in eight clinical trials, Enterococcus in one clinical trial, a combination of Bifidobacterium and Lactobacillus in one clinical trial, and a combination of Lactobacillus and Propionibacterium in one clinical trial.
Elevated D-dimer is Associated with Anemia, Immune Dysregulation, and Hepatic–Renal Dysfunction in Acute Burn Patients Paramita, Anindya; Hariani, Lynda; Zarasade, Lobredia; Syakdiyah, Noer Halimatus; Dewi, Nurrani Mustika; Sandra, Ferry
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3925

Abstract

BACKGROUND: Burn injury induced increased risk of venous thromboembolism (VTE) due to hypercoagulability, immobilization, and endothelial injury. Despite this risk, VTE in burn patients often remains clinically undetected. Although D-dimer is widely used as a VTE marker, its utility in burn patients is inconsistent, particularly in the early post-burn period. Therefore, this study was conducted to evaluate the correlation between D-dimer levels and factors related to VTE, including hematologic, coagulation, immunologic, organ function parameters, and burn characteristics.METHODS: An analytical observational study was conducted involving adult patients with acute burn injuries enrolled in Dr. Soetomo General Hospital from March to June 2025. Demographic, anthropometric, burn characteristic, and existing comorbid were documented from subjects’ medical records. Blood samples from subjects were collected immediately via venipuncture. D-dimer was analyzed with Enzyme-Linked Fluorescent Assay (ELFA) method, hematology and coagulation profiles were also assessed using hematology analyzer and automated coagulation system, respectively. Meanwhile, hepatic and renal function were analyzed with chemistry analyzers.RESULTS: Most burn subjects (18 of 20) demonstrated elevated D-dimer levels. Higher D-dimer levels were associated with increased leukocyte counts and upward trend of RDW-CV and RDW-SD. Further analysis among the subjects with elevated D-dimer level showed significant negative correlations were observed between D-dimer levels and anemia-related parameters, including hemoglobin, erythrocyte count, and hematocrit (all p<0.05). Elevated D-dimer was also associated with immune dysregulation, reflected by increased basophil percentages and decreased immunoglobulin (Ig) levels. Additionally, D-dimer levels showed significant positive correlations with aspartate aminotransferase (AST), alanine aminotransferase (ALT), and blood urea nitrogen (BUN), suggesting a link between hypercoagulability and kidney as well as renal dysfunction following burn injury.CONCLUSION: Leukocyte count, RDW-CV, and RDW-SD are higher in burn patient with elevated D-dimer levels, suggesting that high D-dimer might be correlated with VTE. Elevated D-dimer in burn patients correlates with several VTE risks including anemia, immune dysregulation, and hepatic–renal dysfunction, indicating early coagulation activation and systemic injury following burn injury. KEYWORDS: burn injury, D-dimer, hypercoagulability, VTE, anemia, immune dysregulation, organ dysregulation
Co-Authors Atmaja, Peter Yustian Etha Dini Widiasi Ferry Sandra Gatot Soegiarto Hariani, Lynda Intan Anggun Pratiwi Made Pury Pratiwi Mayang Rizki Anggraeni Nurrani Mustika Dewi, Nurrani Mustika Paramita, Anindya Raden Argarini Viskasari P. Kalanjati Yosephi, Valensa Zarasade, Lobredia