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All Journal INDONESIAN JOURNAL OF PHARMACY CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL PELS (Procedia of Engineering and Life Science)
Aditiawardana Aditiawardana, Aditiawardana
Department Of Nephrology, Faculty Of Medicine, Dr. Soetomo Hospital, Jl. Mayjen Prof. Dr. Moestopo No.6-8, Airlangga, 60286, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Paricalcitol For CKD-MBD Associated With Secondary Hyperparathyroidism: A Case Series Focus On TRAP5b, b-ALP, and DKK-1 Suprapti, Budi; Hartono, Frenky; Iqbal, Muhammad; Zuhri, Muhammad Isnaini; Aditiawardana, Aditiawardana
Indonesian Journal of Pharmacy Vol 30 No 1, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (884.22 KB) | DOI: 10.14499/indonesianjpharm30iss1pp66

Abstract

Chronic kidney disease (CKD) lead to secondary hyperparathyroidism (sHPT) that caused by phosphate retention and hypocalcemia. This condition known as mineral and bone disorder (CKD-MBD). The increase in parathyroid hormone would increase bone turnover that result in an increased risk of bone fractures, and vascular calcification. These will increase the levels of tartrate-resistant acid phosphatase 5b (TRAP5b), and bone-specific alkaline phosphatase (b-ALP), which is a marker of bone turnover, and also dickkopf-related protein 1 (DKK-1), which is an inhibitor of the Wnt pathway. Secondary hyperparathyroidism in CKD also caused by calcitriol deficiency. Paricalcitol is a synthetic calcitrol analogue used to reduce parathyroid hormone (iPTH) with minimal calcemic and phosphatemic activity. Vitamin D receptor activation by paricalcitol will decrease TRAP5b, b-ALP, and DKK-1. In this study we reported 9 cases of CKD-MBD with Hemodialysis (HD) and associated with sHPT. Four of nine cases received 5μg paricalcitol every HD (twice a week) while the others five is not. Level of iPTH, phosphate, calcium, TRAP5b, b-ALP, and DKK-1 were measured before initiation of study and after three months treatment. According to this study, the paricalcol administration suppresses the increase in iPTH level, bone turnover and vascular calcification showed by decreasing or supresses the increase b-ALP, TRAP5b, DKK-1  leves without increasing calcium and phosphate levels.
Development of a Machine Learning-Based Web Application for Quality Justification in Dialysis Healthcare Nisak, Umi Khoirun; Kautsar, Irwan Alnarus; Ilmi, Laili Rahmatyul; Natasya, Nabila Insyira; Cholifah, Cholifah; Aditiawardana, Aditiawardana
Procedia of Engineering and Life Science Vol 6 (2024): The 3rd International Scientific Meeting on Health Information Management (3rd ISMoHIM
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/pels.v6i0.1962

Abstract

The quality of healthcare services, especially for chronic conditions like kidney failure requiring dialysis, is critical. This study aims to develop a machine learning-based web application to evaluate and justify dialysis healthcare quality. Conducted at Siti Khodijah Hospital from January to June 2024, the research employed a developmental and experimental design involving 123 medical professionals. The methodology included needs assessment, system design, algorithm selection, data collection, model training, system integration, and validation. The web application, named Renal Data Processor, features user-friendly navigation, robust data visualization, and machine learning algorithms. It provides real-time analysis and predictive insights, allowing healthcare providers to make data-driven decisions. Results showed significant improvements, including a 20% reduction in data entry time and a 15% enhancement in nurse certification tracking efficiency. User feedback indicated high satisfaction with the application's functionality and its impact on workflow efficiency. In conclusion, the Renal Data Processor has enhanced dialysis healthcare quality by streamlining data management and providing actionable insights. This study demonstrates the potential of machine learning to transform healthcare delivery and outcomes, suggesting further research to expand its capabilities and applicability in other healthcare settings.
Causes and Profiles Pertaining to the Emergency Room Admission of Stage V Chronic Kidney Disease Patients Undergoing Regular Hemodialysis at a Tertiary Hospital in Surabaya, Indonesia Hani, Farahdhila; Aditiawardana; Atika
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.66432

Abstract

Introduction: Chronic kidney disease (CKD) is characterized by decreased kidney function, with a glomerular filtration rate below 60 mL/min/1.73 m² persisting for at least three months. Hemodialysis is a common therapy for stage V CKD, yet complications may arise requiring emergency treatment. This study aimed to elucidate the causes and profiles of stage V CKD patients on regular hemodialysis who were admitted to the Emergency Department of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: A retrospective cross-sectional design and purposive sampling were used in this descriptive observational study. A univariate analysis was conducted on data collected from 72 stage V CKD patients who underwent regular hemodialysis and were admitted to the emergency room between January and March 2023. The inclusion criteria comprised stage V CKD patients undergoing regular hemodialysis in the emergency room. Patients with incomplete medical records were excluded. The collected data encompassed patients' age, sex, hemodialysis duration, interdialytic weight gain (IDWG), comorbidities, and complications. Results: Among the 72 patients, the predominant demographic was male (51.4%), primarily aged 56–65 years (30.6%), with a hemodialysis duration of ≤12 months (65.3%), an IDWG of 1–2 kg (16.7%), and hypertension (54.2%). The complications leading to patient admission in the emergency room mostly included anemia (77.8%), metabolic acidosis (54.2%), urinary tract infection (23.6%), hyperkalemia (19.4%), pulmonary edema (18.1%), and pneumonia (18.1%). Conclusion: Stage V CKD patients on regular hemodialysis are primarily admitted to the emergency room due to complications, including anemia, metabolic acidosis, urinary tract infections, hyperkalemia, pulmonary edema, and pneumonia.   Highlights: 1. Since almost all patients with stage V chronic kidney disease (CKD) undergo routine hemodialysis, it is important to assess its associated complications to help improve patient outcomes. 2. This study reports the prevalence of comorbid diseases and the diagnostic outcomes of patients experiencing complications in the Emergency Department of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. 3. The findings of this study provide valuable insights to patients, researchers, and future medical personnel regarding the characteristics of stage V CKD patients who regularly undergo hemodialysis and present to the emergency room.
Co-Authors Ardityo R Ardhany, Ardityo R Artaria Tjempakasari, Artaria atika Budi Darma Siahaan Budi Suprapti Chandra Irwanadi Chandra Irwanadi Chandra Irwanadi, Chandra Cholifah, Cholifah Dana Pramudya Dicky Pendi Alaudin Sangadji Djoko Santoso Fauzia N Liani Hani, Farahdhila Hartono, Frenky Ilmi, Laili Rahmatyul Irwan Alnarus Kautsar Lindawati Alimsardjono M Thaha, M Natasya, Nabila Insyira Nunuk Mardiana, Nunuk P Pranawa Pranawa Pranawa pranawa pranawa, pranawa Tri P Asmarawati, Tri P Umi Khoirun Nisak Widodo Widodo Widodo Widodo Widodo Widodo Zuhri, Muhammad Isnaini