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All Journal Jurnal Indah Sains dan Klinis Mejuajua
Muhammad Gunawan
Program Studi Farmasi, Sekolah Tinggi Ilmu Kesehatan Indah Medan, Indonesia
Humanities Chemistry Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Indah Sains dan Klinis

 1 
Pembuatan Hidrogel Berbasis Mikrokristal Selulosa Daun Nanas (Ananas comosus L. Merr) dengan Variasi Volume Glutaraldehid Muhammad Gunawan; Nanda Lestari
Journal of Indah Science and Clinic Vol. 1 No. 1 (2020)
Publisher : LPPM STIKes Indah Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v1i1.3

Abstract

Pineapple leaves natural fibers contain lignin, hemicellulose, and cellulose. The cellulose content of pineapple leaves is around 69.5% -71.5%. Cellulose-derived microcrystals can be used in the pharmaceutical field as binders in tableting formulations. The research objective was to determine whether pineapple leaves can produce microcrystals, microcrystals can be used in the manufacture of hydrogels and to determine variations in the volume of glutaraldehyde that can affect hydrogels. Experimetal research began with delignification with 4% NaOH, immersed for 1 hour and heated, washed with distilled water until neutral pH and blended with 2.7% NaOH, 7.9% acetic acid, NaOCl until white, heated, the residue was taken and drained. , soaked in 1 N HCl, reheated for 2 hours, re-stirred and blended until smooth. Cellulose hydrogel was dissolved in 8.5% NaOH and added with glutaraldehyde in various volume variations. Cellulose and hydrogel microcrystals were characterized by visual, swelling ratio test, FTIR, SEM and XRD. The yield of microcrystalline cellulose was 22%, white, homogeneous. Cellulose and hydrogel microcrystals contain O-H (3800-2700 cm-1), C-H (3000-2850 cm-1) and C-O (1300-800 cm-1) groups. Microcrystalline cellulose can be made from pineapple leaves, hydrogel formation is influenced by variations in the volume of glutaradehyde and the highest and lowest swelling ratios are 400% and 12.5%, respectively.
Penetapan Kadar Zink dalam Ikan Tongkol yang Beredar di Pasar Sei Sikambing secara Spektrofotometri Sinar Tampak Muhammad Gunawan; Ucha Gustamayanti
Journal of Indah Science and Clinic Vol. 1 No. 1 (2020)
Publisher : LPPM STIKes Indah Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v1i1.4

Abstract

Tuna as a seafood product that is often consumed by the public, has a high protein content and omega-3 fatty acids. The micro zinc mineral is needed, both for the synthesis and degradation of biomolecules as well as the role of enhancing the immune system. Zinc reacts with ditizone in a red base. Research to determine zinc content in raw, fried, steamed, and grilled tuna. Samples were taken purposively at the Sei Sikambing Medan traditional market, determination of levels using visible spectrophotometry, digestion with a solution of ditizone in alkaline. Method validation parameters include accuracy, precision, and sensitivity. Percent recovery of 100.50% and RSD 0.95%, LOD 0.620 ?g/ml and LOQ 2.066 ?g/ml. The zinc levels of raw, steamed, fried, and grilled tuna were 22.214 mg, 22.063 mg, 22.3384 mg, and 22.234 mg per 100g, respectively. ANOVA test, there is a significant difference in the acquisition of zinc levels in raw tuna, steamed tuna, grilled tuna, fried tuna. The method used is quite accurate. The zinc content of raw, fried, grilled tuna was higher than that of steamed, but there was no real difference.
Penetapan Kadar Zink Ikan Lele (Clarias batrachus) dari Pasar Sei Sikambing secara Spektrofotometri Sinar Tampak Muhammad Gunawan; Rahmad Hidayat
Journal of Indah Science and Clinic Vol. 2 No. 2 (2021)
Publisher : LPPM STIKes Indah Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v2i2.22

Abstract

Clarias batrachus is one of the commercially cultivated freshwater fish species in Indonesia, especially in North Sumatra. Nutrinya content of protein, fat, minerals, carbohydrates, and water. Minerals play an important role in metabolic processes that ensure the maintenance of body functions at the cellular, tissue and organ levels. The research was aimed at determining the zinc content of raw, steamed, grilled, and fried catfish by using visible light spectrophotometry method after destruction and adding alkaline dithizone solution. Clarias batrachus samples were taken purposively from the traditional market of Sei Sikambing Medan. Method validation includes accuracy, precision, and sensitivity. The results show that it is accurate with accuracy, precision, limit of detection and quantitation of 99.95% each; 1.06%; 0.620 g/ml; 2.066 g/ml. ANOVA test showed no significant difference in zinc content of raw, steamed, grilled, and fried catfish.
Evaluasi Konsentrasi Karboksimetilselulosa-Alginat Formula Pasta Gigi Antiseptik Ekstrak Etanol Daun Seledri (Apium graveolens L.) Suprianto Suprianto; Samran Samran; Muhammad Gunawan; Melati Yulia Kusumastuti
Journal of Indah Science and Clinic Vol. 3 No. 1 (2022)
Publisher : LPPM STIKes Indah Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i1.45

Abstract

Maceration of Celery leaves using 96% ethanol solvent was used to make the extract. Toothpaste is formulated with carboxymethylcellulose and alginate binders. The active ingredient in the form of ethanol extract of Celery leaves has the potential for antibacterial. This study was to evaluate the concentration of carboxymethylcellulose-alginate in the preparation of antiseptic toothpaste of ethanol extract of Celery leaves. Evaluation of production results consisted of organoleptic, homogeneity, spreadability, foam formation, acidity and viscosity. The higher the concentration of carboxymethylcellulose, the lower the foam and spreadability and the higher the viscosity, while the alginate concentration is the opposite. Carboxymethylcellulose-alginate affects the evaluation parameters of antiseptic toothpaste preparations ethanol extract of Celery leaves
Analisis Biaya Efektif Terapi Diare Pasien Rawat Inap RS Putri Hijau Medan Suprianto Suprianto; Muhammad Gunawan; Melati Yulia Kusumastuti; Sumardi Sumardi; Debi Meilani
Journal of Indah Science and Clinic Vol. 3 No. 1 (2022)
Publisher : LPPM STIKes Indah Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i1.46

Abstract

Diare ditandai ekskresi tinja cair dengan ulangan tiga kali atau lebih per hari, akibat infeksi saluran cerna karena makanan dan air terkontaminasi mikroorganisme, ataupun langsung dari manusia akibat rendahnya sanitasi. Penelitian ditujukan untuk mengetahui karakteristik pasien diare, pengobatan dan efektivitas biaya pengobatan di Rumah Sakit Putri Hijau Medan. Penelitian non eksperimental bersifat deskriptif dan retrospektif rekam medik pasien bagian keuangan sejak Juli-Desember 2018. Cost Effectiveness Analysis sebagai metode analisis biaya. Karakteristik pasien diperoleh perempuan 14 (46,670%) dan laki-laki 16 (53,33%). Efektivitas New Diatabs (92,30%) dan New Diatabs-Metronidazole (94,11%). Biaya terapi dengan New Diatabs Rp 1.547,771/pasien dan New Diatabs-Metronidazole Rp 1.562,590/pasien. Average cost effectiveness New Diatabs Rp. 190.345 dan New Diatabs-Metronidazole Rp 183.060, sehingga disimpulkan terapi cost effective adalah penggunaan kombinasi New Diatabs-Metronidazole dibandingkan New Diatabs
Co-Authors Alam Suhada Ancel Mus Silaban Cut Fatimah Debi Meilani Edi Ananta Tarigan Elvy Oktima Fitriani, Enny Herliana Melati Yulia Kusumastuti Nanda Lestari Rahmad Hidayat Rama Asiah Siregar Safriana Safriana Samran, Samran Sindy Andriani Suhendra Tawarnate Sumardi Suprianto Suprianto Ucha Gustamayanti