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E. Tjitra
National Institute of Health Research and Development, Ministry of Health, Jakarta.
Medicine & Pharmacology

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Clinical comparison of arthemeter and quinine treatment of severe and complicated falciparum malaria patients in Indonesia: A preliminary report Pribadi, W.; Arbani, P. R.; Oey, T. S.; Harianto, P. N.; Soemohardjo, S.; Marwoto, H. A.; Syahrudji, N.; Sudiarso, Sudiarso; Gunawan, S.; Tjitra, E.; Oemijati, S.; Sulaksono, S.
Medical Journal of Indonesia Vol 4, No 4 (1995): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1454.008 KB) | DOI: 10.13181/mji.v4i4.922

Abstract

[no abstract available]
Efficacy of existing antimalarial drugs for uncomplicated malaria in Timika, Papua, Indonesia Siswantoro, H.; Ratclif, A.; Kenangalem, E.; Wuwung, M.; Maristela, R.; Rumaseuw, R.; Laihad, F.; Ebsworth, P.; Anstey, N. M.; Price, R. N.; Tjitra, E.
Medical Journal of Indonesia Vol 15, No 4 (2006): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.408 KB) | DOI: 10.13181/mji.v15i4.243

Abstract

Chloroquine resistant malaria is a serious problem in Indonesia particularly in Papua. A trial of the existing antimalarial drugs was conducted in Timika, Papua. The objective of the study was to determine the efficacy of cloroquine (CQ) + sulfadoxine-pyrimethamine (SP). Patients with uncomplicated malaria due to Plasmodium falciparum, P. vivax, P. ovale or P. malariae were enrolled and treated with supervised CQ+SP (P. falciparum) or CQ (non-P. falciparum). Patients were followed for 28-42 days. Patients failing therapy were retreated with unsupervised quinine±doxycycline. 207 patients were enrolled in the study (88 P. falciparum, 40 P. vivax, 15 mixed infections, 50 P. malariae and 14 P. ovale). Early treatment failures occurred in 4 of 86 (5%) patients with falciparum malaria, 6 of 37 (16%) patients with vivax malaria and none of those with P. ovale or P. malariae infections. The failure rate by day 28 for P. vivax was 22 of 30 (73%) patients, with all recurrences occurring in the presence of plasma chloroquine concentration above the minimum effective concentration (MEC>15ng/ml). After correcting for reinfections the day 42 recrudescence rate for falciparum malaria was 48% [95%CI:31-65] and in 61% of cases this was in the presence of chloroquine levels above 30 ng/ml. Retreatment with unsupervised quinine±doxycycline resulted in further recurrence of malaria in 48% [95%CI:31-65] of P. falciparum infections and 70% [95%CI:37-100] of P. vivax infections. None of the patients with P. ovale or P. malariae had treatment failures within 28 days. There is a high prevalence of antimalarial drug resistance of P. falciparum and P. vivax to the existing antimalarial drugs. However chloroquine retains adequate efficacy against P. ovale and P. malariae in Papua. (Med J Indones 2006; 15:251-8) Keywords: Malaria, P. falciparum, P. vivax, P. ovale, P. malariae, Chloroquine, Sulfadoxine-pyrimethamine, Papua
Comparative study of artemether and quinine treatment in severe and complicated falciparum malaria at Balikpapan General Hospital Pribadi, W.; Tjiptaningsih, B.; Leman, Y.; Mamesah, H.; Arbani, P. R.; Darwoto, Darwoto; Syahrudji, N.; Sudiarso, Sudiarso; Gunawan, S.; Tjitra, E.; Oemijati, S.; Oey, T. S.
Medical Journal of Indonesia Vol 5, No 4 (1996): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1103.244 KB) | DOI: 10.13181/mji.v5i4.876

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[no abstract available]
Treatment of uncomplicated in vitro chloroquine resistant falciparum malaria with artemether in Irian Jaya Tjitra, E.; Pribadi, W.; Raharjo, K.; Budiono, W.; Arbani, P. R.; Naibaho, P.; Supriyanto, S.; Romzan, A.; Dewi, R. M.; Gunawan, S.
Medical Journal of Indonesia Vol 5, No 1 (1996): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1051.87 KB) | DOI: 10.13181/mji.v5i1.843

Abstract

[no abstract available]
Co-Authors A. Ratclif A. Romzan B. Tjiptaningsih Darwoto Darwoto E. Kenangalem F. Laihad H. A. Marwoto H. Mamesah H. Siswantoro K. Raharjo M. Wuwung N. M. Anstey N. Syahrudji P. Ebsworth P. N. Harianto P. Naibaho P. R. Arbani R. M. Dewi R. Maristela R. N. Price R. Rumaseuw S. Gunawan S. Oemijati S. Soemohardjo S. Sulaksono S. Supriyanto Sudiarso Sudiarso T. S. Oey W. Budiono W. Pribadi Y. Leman