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All Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Manajemen
Umar Mansur
Departemen Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Public Health

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Kajian Mutu Produk Tablet Metformin Hidroklorida Extended-Release yang Dipasarkan di Indonesia Yuni Anggraeni; Umniyaty Mufidah; Umar Mansur
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.24755

Abstract

Some metformin hydrochloride extended-release (MetHCl-XR) tablet products have been marketed in Indonesia with varying prices. In general, price is considered to indicates the quality of a product. This research was conducted to review the products quality, especially the dissolution rate of the products, and to find out if the price is an indicator of the product quality. Three brands of MetHCl 500 mg XR tablets were randomly selected, namely Tablet A, B, and C which the price of Tablet B > A > C, then the Tablets were characterized. The results showed that Tablet A, B, and C contain MetHCl with an average of 100.61%, 98.72%, and 101.15% respectively, and met the uniformity of dosage unit requirement. Tablet A met the requirements of dissolution tests 1, 2, 3, and 4, while Tablet B and C met the requirements of dissolution tests 1 and 3. The cumulative percentage of MetHCl release at the 10th hour of Tablet A, B, and C were 94.18%, 97.24%, and 94.59% respectively with the release kinetics of Tablet A and B following Higuchi model, whereas Tablet C following a first-order. Drug release of all tablets occurred in non-Fick diffusion. In conclusion, the three tablets met the standards required by USP 43 and the price is not an indicator of MetHCl-XR tablet products quality.
Analytical Methods Validation of Retinoic Acid and Hydroquinone Using Ultra High Performance Liquid Chromatography in Medicinal Cream Linda Mazroatul; Annisa Ananda Ulya; Supandi Supandi; Umar Mansur
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 1, No 1 (2019)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (706.105 KB) | DOI: 10.15408/pbsj.v1i1.12689

Abstract

Hydroquinone and retinoic acid have been widely used as whitening agents in cosmetic creams and have a negative impact if used without a medical prescription. In this study, development of analytical method of retinoic acid (REA) and hydroquinone (HYQ) were carried out using Ultra High Performance Liquid Chromatography (UHPLC) with a PDA detector, Phenomenex Luna® ODS / C18 column (150 mmx4.6 mm), methanol-acetic acid 0.1% (85:15) as mobile phase, flow rate of 1.0 mL/min and detected at 295 nm for HYQ and 341 nm for REA. The result of the validation method showed a retention time of HYQ at 1.55 minutes and REA at 3.73 minutes. Validation parameters performed are selectivity, range, linearity, LOD, LOQ, accuracy, and precision. Linear detector response in the concentration range of 75-250 ppm with a calibration curve equation. The calibration curve equation for HYQ is y = 0.4607x + 1.9014 (r = 0.999), mean while REA is y = 2.3138x + 21.0429 (r = 0.999). LOD and LOQ values of HYQ are 1.615 ppm; 13.98 ppm respectively and REA 1.02 ppm and 3.11 ppm, respectively. The precision (% RSD) ≤ ± 2% and accuracy (% recovery) in the range of 99.0% - 100.6%. This method is valid to be used to analyze HYQ and REA in commercial cosmetic cream samples.
The Development of Derivative Method analysis 1,4 Benzodiazepines in Biological Matrix using High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Annisa Larasati Putri; supandi supandi; Umar Mansur
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24629

Abstract

1.4 benzodiazepine derivatives are the benzodiazepine class that is used most frequently in clinical as a sedation agent, anxiolytic, and antiepileptic. The high tense of benzodiazepine consumption can causes addiction and misappropriation. That matter causes benzodiazepine and its metabolites often find in toxicology clinical and forensic. This systematic review aimed to identify an efficient sample preparation procedure and an accurate analysis method to determine benzodiazepine existence in various biological matrices. According to the PRISMA flow diagram’s chart, twenty-four reviewed articles systematically pointed that plasma and urine utilization gave good accuracy results and recovery than other biological matrices. SBSE extraction method development using vinylpyrrolidone ethylene glycol dimethacrylate polymer gave efficient results with the amount of recovery 96%, and HPLC instrument utilization was still selective and sensitive with LOD until 12ng/ml and LOQ 36 ng/ml.
The Development of Derivative Method analysis 1,4 Benzodiazepines in Biological Matrix using High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Annisa Larasati Putri; supandi supandi; Umar Mansur
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24629

Abstract

1.4 benzodiazepine derivatives are the benzodiazepine class that is used most frequently in clinical as a sedation agent, anxiolytic, and antiepileptic. The high tense of benzodiazepine consumption can causes addiction and misappropriation. That matter causes benzodiazepine and its metabolites often find in toxicology clinical and forensic. This systematic review aimed to identify an efficient sample preparation procedure and an accurate analysis method to determine benzodiazepine existence in various biological matrices. According to the PRISMA flow diagram’s chart, twenty-four reviewed articles systematically pointed that plasma and urine utilization gave good accuracy results and recovery than other biological matrices. SBSE extraction method development using vinylpyrrolidone ethylene glycol dimethacrylate polymer gave efficient results with the amount of recovery 96%, and HPLC instrument utilization was still selective and sensitive with LOD until 12ng/ml and LOQ 36 ng/ml.
Implementasi Etika Bisnis dalam Praktik Usaha Berkelanjutan pada UMKM Mie Jontor Akiw Umar Mansur; Azura, Putri Fadya; Lestari, Anggie Puji; Jelita, Ita; Panggraina, Galuh
MAMEN: Jurnal Manajemen Vol. 4 No. 4 (2025): Oktober 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/mamen.v4i4.6710

Abstract

This study provides an in-depth examination of the implementation of business ethics in sustainable business practices at Mie Jontor AKIW, a local culinary MSME recognized for its strong commitment to moral, social, and environmental values. Employing a qualitative approach with a case study method, the research highlights the application of ethical business principles such as honesty, transparency, accountability, social responsibility, and environmental stewardship. The findings show that Mie Jontor AKIW practices product information transparency through clear labeling and open communication with customers, maintains consistent food quality without the use of harmful preservatives, treats employees fairly by providing decent wages and a safe work environment, and actively engages in community social initiatives and environmental impact reduction efforts, such as waste management and minimizing single-use plastics. These practices have been proven to foster customer loyalty, build a positive reputation, and strengthen business resilience amid competition and market dynamics. Customer perceptions of the enterprise’s integrity and social responsibility are highly positive, indicating that business ethics is not merely a normative obligation but an effective and value-adding sustainability strategy. The study recommends strengthening the integration between business ethics and sustainability objectives as a strategic foundation for developing MSMEs that are more competitive, adaptive, and resilient in the long term.
Co-Authors Annisa Ananda Ulya Annisa Larasati Putri Azura, Putri Fadya Jelita, Ita Lestari, Anggie Puji Linda Mazroatul Panggraina, Galuh Supandi Supandi Umniyaty Mufidah Yuni Anggraeni