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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Oea Khairsyaf
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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High Altitude Pulmonary Physiology Erika Putri Rozita; Oea Khairsyaf; Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.552

Abstract

High altitude is defined as regions above 2400 meters above sea level. Almost 2% of the world’s population dwells in high-altitude regions of the world. The respiratory system plays an important role in determining survival and undergoes a series of adaptive changes to compensate for hypobaric hypoxic states (decreased barometric pressure with increasing altitude) including increased alveolar ventilation, diffusion capacity, pulmonary vascular vasoconstriction, increased cardiac output, shifted of oxyhemoglobin dissociation curve and polycythemia. Being at a high altitude suddenly without compensation can be bad and cause medical problems that will arise when at an altitude due to a decrease in PaO2 caused by a drop in barometric pressure.
High Altitude Pulmonary Physiology Erika Putri Rozita; Oea Khairsyaf; Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.552

Abstract

High altitude is defined as regions above 2400 meters above sea level. Almost 2% of the world’s population dwells in high-altitude regions of the world. The respiratory system plays an important role in determining survival and undergoes a series of adaptive changes to compensate for hypobaric hypoxic states (decreased barometric pressure with increasing altitude) including increased alveolar ventilation, diffusion capacity, pulmonary vascular vasoconstriction, increased cardiac output, shifted of oxyhemoglobin dissociation curve and polycythemia. Being at a high altitude suddenly without compensation can be bad and cause medical problems that will arise when at an altitude due to a decrease in PaO2 caused by a drop in barometric pressure.
Airway Stent in Lung Cancer: A Narrative Literature Review Jeffri Sofian Leksana; Oea Khairsyaf; Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.665

Abstract

Lung cancer complications are the leading cause of death in lung cancer patients. This study aimed to describe the prevalence of stent placement, indications for stent placement, success and complication rates, and prognosis of airway stent placement in patients with lung cancer. Malignant central airway obstruction (MCAO) is one of the significant complications. Insertion of airway stent can restore airway patency in more than 90% of patients with MCAO. Airway stent placement is indicated in patients with extrinsic lesions, obstruction of ≥ 50%, have patent airway below the obstruction, and are not in the terminal state. The technical success was reported to be very high and consistent with the range of 95-100%. Early complications were relatively rare; however, up to 87% of long-term complications were reported. Stent placement is a risk factor for lower respiratory tract infection, an adverse prognostic factor in lung cancer survival. Airway stents should be indicated and used with caution and discretion. With the advancement and development of technology, various materials and types of airway stents are being developed to minimize adverse outcomes.
Airway Stent in Lung Cancer: A Narrative Literature Review Jeffri Sofian Leksana; Oea Khairsyaf; Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.665

Abstract

Lung cancer complications are the leading cause of death in lung cancer patients. This study aimed to describe the prevalence of stent placement, indications for stent placement, success and complication rates, and prognosis of airway stent placement in patients with lung cancer. Malignant central airway obstruction (MCAO) is one of the significant complications. Insertion of airway stent can restore airway patency in more than 90% of patients with MCAO. Airway stent placement is indicated in patients with extrinsic lesions, obstruction of ≥ 50%, have patent airway below the obstruction, and are not in the terminal state. The technical success was reported to be very high and consistent with the range of 95-100%. Early complications were relatively rare; however, up to 87% of long-term complications were reported. Stent placement is a risk factor for lower respiratory tract infection, an adverse prognostic factor in lung cancer survival. Airway stents should be indicated and used with caution and discretion. With the advancement and development of technology, various materials and types of airway stents are being developed to minimize adverse outcomes.
Pulmonary Embolism: A Narrative Literature Review Bobby Hasibuan; Oea Khairsyaf; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.705

Abstract

Pulmonary embolism (PE) is a pulmonary emergency that is quite common with various clinical manifestations, from asymptomatic to life-threatening. The incidence of pulmonary embolism is reported to be 1 per 1000 population, with 50,000 deaths per year. Making the diagnosis is difficult because the symptoms vary widely in each patient. Management of acute pulmonary embolism is carried out with a systematic approach involving early intervention, patient risk stratification, selection of therapy, and determination of the length of treatment.
Pulmonary Embolism: A Narrative Literature Review Bobby Hasibuan; Oea Khairsyaf; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.705

Abstract

Pulmonary embolism (PE) is a pulmonary emergency that is quite common with various clinical manifestations, from asymptomatic to life-threatening. The incidence of pulmonary embolism is reported to be 1 per 1000 population, with 50,000 deaths per year. Making the diagnosis is difficult because the symptoms vary widely in each patient. Management of acute pulmonary embolism is carried out with a systematic approach involving early intervention, patient risk stratification, selection of therapy, and determination of the length of treatment.
Delayed SARS-COV-2 Viral Clearance in a Newly Diagnosed HIV Patient: A Case Series Dimas Bayu Firdaus; Oea Khairsyaf; Dewi Wahyu; Irvan Medison; Deddy Herman; Masrul Basyar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.836

Abstract

Background: SARS-CoV-2 can infect anyone, but people with HIV have underlying conditions or comorbidities that can make them seriously ill if infected with SARS-CoV-2. HIV attacks and destroys the immune system delays the response of specific antibodies, and even causes failure to thrive, resulting in a long course of the disease. This case report aimed to describe 2 cases of HIV patients co-infected with SARS-CoV-2 with delayed viral clearance. Case presentation: There are two HIV patients with co-infection with SARS-CoV-2. The first patient, a 32-year-old man with COVID-19 and HIV-AIDS, was referred from a regional hospital after being treated for 10 days due to clinical deterioration. Physical examination showed that the patient's general condition was moderately ill, and other vital signs were within normal limits. Oral candidiasis was seen in the patient's mouth, crackles were found in both lung fields, and epigastric tenderness was found on abdominal examination. The patient tested positive for COVID-19 based on the results of an antigen swab examination from the previous hospital. The second patient, a 26-year-old man, came with complaints of intermittent fever 1 week before entering the hospital. Complaints began with the body feeling weak and coughing without phlegm 2 weeks ago. The patient tested positive for COVID-19 based on the results of an antigen swab examination. The delayed viral clearance of SARS-CoV-2 in the two patients was possibly caused by the impaired immune response due to HIV infection, as shown by the presence of lymphopenia and decreased CD4+. Conclusion: ARV use can suppress HIV viral load and increase immunity so that can help viral clearance of SARS-CoV-2.
Delayed SARS-COV-2 Viral Clearance in a Newly Diagnosed HIV Patient: A Case Series Dimas Bayu Firdaus; Oea Khairsyaf; Dewi Wahyu; Irvan Medison; Deddy Herman; Masrul Basyar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.836

Abstract

Background: SARS-CoV-2 can infect anyone, but people with HIV have underlying conditions or comorbidities that can make them seriously ill if infected with SARS-CoV-2. HIV attacks and destroys the immune system delays the response of specific antibodies, and even causes failure to thrive, resulting in a long course of the disease. This case report aimed to describe 2 cases of HIV patients co-infected with SARS-CoV-2 with delayed viral clearance. Case presentation: There are two HIV patients with co-infection with SARS-CoV-2. The first patient, a 32-year-old man with COVID-19 and HIV-AIDS, was referred from a regional hospital after being treated for 10 days due to clinical deterioration. Physical examination showed that the patient's general condition was moderately ill, and other vital signs were within normal limits. Oral candidiasis was seen in the patient's mouth, crackles were found in both lung fields, and epigastric tenderness was found on abdominal examination. The patient tested positive for COVID-19 based on the results of an antigen swab examination from the previous hospital. The second patient, a 26-year-old man, came with complaints of intermittent fever 1 week before entering the hospital. Complaints began with the body feeling weak and coughing without phlegm 2 weeks ago. The patient tested positive for COVID-19 based on the results of an antigen swab examination. The delayed viral clearance of SARS-CoV-2 in the two patients was possibly caused by the impaired immune response due to HIV infection, as shown by the presence of lymphopenia and decreased CD4+. Conclusion: ARV use can suppress HIV viral load and increase immunity so that can help viral clearance of SARS-CoV-2.
Co-Authors Afriani Bobby Hasibuan Dewi Wahyu Dimas Bayu Firdaus Erika Putri Rozita Fenty Anggrainy Herman, Deddy Irvan Medison Jeffri Sofian Leksana Masrul Basyar