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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Sriwijaya Journal of Internal Medicine
Masrul Basyar
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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Delayed SARS-COV-2 Viral Clearance in a Newly Diagnosed HIV Patient: A Case Series Dimas Bayu Firdaus; Oea Khairsyaf; Dewi Wahyu; Irvan Medison; Deddy Herman; Masrul Basyar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.836

Abstract

Background: SARS-CoV-2 can infect anyone, but people with HIV have underlying conditions or comorbidities that can make them seriously ill if infected with SARS-CoV-2. HIV attacks and destroys the immune system delays the response of specific antibodies, and even causes failure to thrive, resulting in a long course of the disease. This case report aimed to describe 2 cases of HIV patients co-infected with SARS-CoV-2 with delayed viral clearance. Case presentation: There are two HIV patients with co-infection with SARS-CoV-2. The first patient, a 32-year-old man with COVID-19 and HIV-AIDS, was referred from a regional hospital after being treated for 10 days due to clinical deterioration. Physical examination showed that the patient's general condition was moderately ill, and other vital signs were within normal limits. Oral candidiasis was seen in the patient's mouth, crackles were found in both lung fields, and epigastric tenderness was found on abdominal examination. The patient tested positive for COVID-19 based on the results of an antigen swab examination from the previous hospital. The second patient, a 26-year-old man, came with complaints of intermittent fever 1 week before entering the hospital. Complaints began with the body feeling weak and coughing without phlegm 2 weeks ago. The patient tested positive for COVID-19 based on the results of an antigen swab examination. The delayed viral clearance of SARS-CoV-2 in the two patients was possibly caused by the impaired immune response due to HIV infection, as shown by the presence of lymphopenia and decreased CD4+. Conclusion: ARV use can suppress HIV viral load and increase immunity so that can help viral clearance of SARS-CoV-2.
Delayed SARS-COV-2 Viral Clearance in a Newly Diagnosed HIV Patient: A Case Series Dimas Bayu Firdaus; Oea Khairsyaf; Dewi Wahyu; Irvan Medison; Deddy Herman; Masrul Basyar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.836

Abstract

Background: SARS-CoV-2 can infect anyone, but people with HIV have underlying conditions or comorbidities that can make them seriously ill if infected with SARS-CoV-2. HIV attacks and destroys the immune system delays the response of specific antibodies, and even causes failure to thrive, resulting in a long course of the disease. This case report aimed to describe 2 cases of HIV patients co-infected with SARS-CoV-2 with delayed viral clearance. Case presentation: There are two HIV patients with co-infection with SARS-CoV-2. The first patient, a 32-year-old man with COVID-19 and HIV-AIDS, was referred from a regional hospital after being treated for 10 days due to clinical deterioration. Physical examination showed that the patient's general condition was moderately ill, and other vital signs were within normal limits. Oral candidiasis was seen in the patient's mouth, crackles were found in both lung fields, and epigastric tenderness was found on abdominal examination. The patient tested positive for COVID-19 based on the results of an antigen swab examination from the previous hospital. The second patient, a 26-year-old man, came with complaints of intermittent fever 1 week before entering the hospital. Complaints began with the body feeling weak and coughing without phlegm 2 weeks ago. The patient tested positive for COVID-19 based on the results of an antigen swab examination. The delayed viral clearance of SARS-CoV-2 in the two patients was possibly caused by the impaired immune response due to HIV infection, as shown by the presence of lymphopenia and decreased CD4+. Conclusion: ARV use can suppress HIV viral load and increase immunity so that can help viral clearance of SARS-CoV-2.
Platelet-to-Lymphocyte Ratio as a Predictor of Exacerbation Severity and Hospital Length of Stay in Acute Exacerbation of COPD: A Dual-Center Study in West Sumatra, Indonesia Herry Saputra Yunior; Masrul Basyar; Deddy Herman
Sriwijaya Journal of Internal Medicine Vol. 4 No. 1 (2026): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v4i1.271

Abstract

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a leading driver of morbidity, mortality and health-care expenditure, and simple admission biomarkers that grade severity are needed in resource-limited settings. The platelet–lymphocyte ratio (PLR) integrates thrombo-inflammation and relative lymphopenia, yet Indonesian evidence linking it to exacerbation severity and length of stay (LOS) remains limited. Objective: To evaluate admission PLR as a predictor of exacerbation severity and prolonged length of stay in hospitalised patients with AECOPD. Methods: In this dual-center analytical cross-sectional study, 141 hospitalised AECOPD patients at Dr. M. Djamil General Hospital, Padang and RS Madina Bukittinggi (January–December 2024) were analysed. Admission PLR was related to Anthonisen severity and LOS (>7 days) using Kruskal–Wallis and Mann–Whitney tests, Spearman correlation, ROC analysis and multivariable logistic regression (adjusted odds ratios, aOR). Results: Most patients were male (86.5%) and heavy smokers (87.5%). Mean PLR rose across severity strata (mild 126.8, moderate 192.3, severe 444.9; p<0.001) and correlated moderately with severity (ρ=0.534) but weakly with LOS (ρ=0.295). PLR discriminated severe exacerbation with excellent accuracy (AUC 0.929; cut-off ≥216.3, sensitivity 100%, specificity 73.2%). After adjustment, PLR independently predicted severe exacerbation (aOR 3.73 per 50 units, 95% CI 1.87–7.42), whereas prolonged stay was driven by pneumonia (aOR 6.40) rather than PLR. Conclusion: Admission PLR is an inexpensive, widely available biomarker that accurately identifies severe AECOPD and may support early risk stratification, although it should not be used alone to predict length of stay, which is governed chiefly by comorbidity.
Co-Authors Dewi Wahyu Dimas Bayu Firdaus Herman, Deddy Herry Saputra Yunior Irvan Medison Oea Khairsyaf