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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science)
Afid Brilliana Putra
Faculty of Medicine Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Kombinasi Tetrahidrokurkumin dan Cyanidine-3-O-β-glucoside sebagai Terapi Fitokimia Asma Anak melalui Penghambatan IL-4Rα-STAT6 dan Sitokin Proinflamasi Afid Brilliana Putra; Muhammad Ilham Dhiya Rakasiwi; Ihya Fakhrurizal Amin
Jurnal Ilmu Kedokteran Vol 16, No 1 (2022): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v16i1.2022.9-15

Abstract

Asthma is chronic inflammatory disease experienced mostly by children with prevalence of 4.5% in Indonesia. Asthma puts burden on sufferers because of the long duration of treatment. However, prolonged inhaled corticosteroids use in certain doses can cause side effects. Tetrahydrocurcumin (THC) is metabolite of curcumin and has higher bioavailability than its precursor molecules. THC has been shown to significantly reduce leukocyte infiltration, as well as inhibit inflammation through IL-4Rα pathway and decrease GATA3 expression. The same effect is obtained from Cyanidine-3-O-β-glucoside (Cy-3-g). The anti-inflammatory effect of those combination can be used as alternative phytochemical therapy to treat asthma in children.
Exercise During Work Hours Improves Fitness: An Evidence-Based Case Report Afid Brilliana Putra; Rara Maasnika Adham; Febrina Alivia Wantania; Amy Grace Yulita; Listya Tresnanti Mirtha
Jurnal Ilmu Kedokteran Vol 18, No 1 (2024): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v18i1.2024.17-24

Abstract

Relatively tight working hours are problems for employees in urban areas, affecting less time for physical activities. About 59% of office workers in Jakarta are classified as sedentary. The high number of sedentary workers can cause productivity problems due to low fitness. Appropriate interventions are needed to overcome it. We have done literature searches from 7 journal databases in the last 20 years, including ScienceDirect, EBSCOhost, PubMed, ProQuest, Scopus, ClinicalKey, and Cochrane. Inclusion criteria include research design in the form of systematic review/meta-analysis/randomized controlled trials, outcomes in the form of physical fitness or work performance, and interventions in the form of workplace exercise or stretching. Three selected articles showed a significant relationship (p-value <0.05) between programmed physical exercise at work and several fitness factors, such as decreased body fat and fat mass, increased lean mass, and increased sit-up and push-up fitness test results. Physical activity at work decreased cardiovascular risk as assessed by VO2max. In conclusion, physical activity during working hours effectively improves health-related fitness. The minimal intervention types needed are aerobics, strength training, and muscle endurance. We recommend providing interventions for workplace fitness and education programs (WFEP).
Co-Authors Amy Grace Yulita Febrina Alivia Wantania Ihya Fakhrurizal Amin Listya Tresnanti Mirtha Muhammad Ilham Dhiya Rakasiwi Rara Maasnika Adham