Garuda - Garba Rujukan Digital

Audrey Wahani

Universitas Sam Ratulangi

Author-ID : 410520

Biochemistry, Genetics & Molecular Biology Health Professions

Published : 5 Documents Claim Missing Document

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HUBUNGAN ANTARA KADAR KALSIUM DENGAN SERANGAN ASMA PADA ANAK Rompies, Ronald; Sumampow, Christine; Wahani, Audrey
JURNAL BIOMEDIK : JBM Vol 8, No 3 (2016): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.8.3.2016.14153

Abstract: Asthma is a chronic inflammatory disorder of the respiratory tract that can cause an increased response and activity within the airway which is characterized by the recurrent episodes of wheezing, shortness of breath, and cough accompanied by airway obstruction in varying degrees. Vitamin D plays a role in the pathogenesis of asthma. Many studies suggest a relation between vitamin D and calcium, which can be seen as a possible link between calcium levels and asthma. This study aimed to determine the correlation between the level of calcium and asthma attacks in children. This was a case-control study that gathered 21 asthmatic children and 19 non-asthmatic children with acute respiratory infections who did not use corticosteroids for the treatment at outpatient services Prof. Dr. R. D. Kandou Hospital Manado from January to June 2015. Calcium levels of asthmatic patients and non-asthmatic were noted. Statistical analysis using logistic regression with a P value < 0.05 were considered significant. The results of logistic regression analysis showed a significant association between calcium level and asthma attack (P = 0.04 with OR = 2.75). The average level of calcium in the asthmatic group was 9.2 mg/dL (0.81, 95% CI 8.91 to 9.64) and the non-asthmatic group was 8.7 mg/dL (0.72, 95% CI 8.38-9.07). Conclusion: There was a correlation between calcium level and asthma attack in children. The lower the level of calcium, the higher the chance of asthma attack.Keywords: children, asthma, calciumAbstrak: Asma adalah kelainan inflamasi kronis saluran pernapasan yang dapat menyebabkan peningkatan respon dan aktivitas jalan napas, ditandai dengan episode mengi berulang, sesak napas, dan batuk yang disertai obstruksi jalan napas dalam derajat bervariasi. Vitamin D berperan dalam patogenesis asma. Banyak penelitian mengatakan bahwa terdapat hubungan antara vitamin D dan kalsium, sehingga diduga adanya hubungan antara kadar kalsium dan asma. Penelitian ini bertujuan untuk mengetahui hubungan kadar kalsium dengan serangan asma pada anak. Jenis penelitian ialah kasus kontrol dimana dikumpulkan 21 anak dengan asma dan 19 anak non-asma dengan infeksi saluran napas akut dan tidak menggunakan kortikosteroid yang datang berobat di pelayanan rawat jalan RSUP Prof. Dr. R. D. Kandou Manado dari Januari sampai Juni 2015. Kadar kalsium pasien asma dan non-asma dicatat. Analisis statistik menggunakan regresi logistik dengan nilai P < 0,05 dianggap bermakna. Hasil analisis regresi logistik menunjukkan hubungan bermakna antara kadar kalsium dengan serangan asma (P = 0,04 dengan OR = 2,75). Rerata kadar kalsium pada kelompok asma 9,2 mg/dL (0,81, 95% CI 8,91-9,64) dan kelompok non asma 8,7 mg/dL (0,72, 95% CI 8,38-9,07). Simpulan: Terdapat hubungan antara kadar kalsium dan serangan asma pada anak. Makin rendah kadar kalsium, makin tinggi peluang terjadinya serangan asma.Kata kunci: anak, asma, kalsium

HIPERBILIRUBINEMIA PADA NEONATUS Mathindas, Stevry; Wilar, Rocky; Wahani, Audrey
JURNAL BIOMEDIK : JBM Vol 5, No 1 (2013): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.5.1.2013.2599

Abstract: Hyperbilirubinemia is an increase of the blood bilirubin level due to physiological or non-physiologic factors, which is clinically characterized by jaundice. Bilirubin is produced in the reticuloendothelial system as the end product of heme catabolism through an oxidation-reduction reaction. Due to its hydrophobic nature, unconjugated bilirubin is carried in the plasma, tightly bound to albumin. In the liver, bilirubin is transported into hepatocytes, bound to ligandin. After being excreted to the small intestine through the bile ducts, bilirubin undergoes a reduction to become colorless tetrapyrole due to the action of intestinal microbes.This unconjugated bilirubin can be reabsorbed into the circulation; therefore, it increases total plasma bilirubin. The treatments of hyperbilirubinemia in neonati are phototherapy, intravenous immunoglobulin (IVIG), replacement transfusion, temporary breastfeeding cessation, and medical therapy. Keywords: hyperbilirubinemia, bilirubin, biliverdin, enterohepatic cycle. Abstrak: Hiperbilirubinemia ialah terjadinya peningkatan kadar bilirubin dalam darah, baik oleh faktor fisiologik maupun non-fisiologik, yang secara klinis ditandai dengan ikterus. Bilirubin diproduksi dalam sistem retikuloendotelial sebagai produk akhir dari katabolisme heme dan terbentuk melalui reaksi oksidasi reduksi. Karena sifat hidrofobiknya, bilirubin tak terkonjugasi diangkut dalam plasma, terikat erat pada albumin. Ketika mencapai hati, bilirubin diangkut ke dalam hepatosit, terikat dengan ligandin. Setelah diekskresikan ke dalam usus melalui empedu, bilirubin direduksi menjadi tetrapirol tak berwarna oleh mikroba di usus besar. Bilirubin tak terkonjugasi ini dapat diserap kembali ke dalam sirkulasi, sehingga meningkatkan bilirubin plasma total. Pengobatan pada kasus hiperbilirubinemia dapat berupa fototerapi, intravena immunoglobulin (IVIG), transfusi pengganti, penghentian ASI sementara, dan terapi medikamentosa. Kata kunci: hiperbilirubinemia, bilirubin, biliverdin, siklus enterohepatik.

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