Article Per Year (5 Year)
p-Index From 2020 - 2025
0.61
P-Index
This Author published in this journals
All Journal Indonesian Journal of Pharmaceutical Science and Technology JURNAL ILMIAH EKONOMI, MANAJEMEN, BISNIS DAN AKUNTANSI
Mia Agustin
Unknown Affiliation
Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP- 55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36678

Abstract

The combination formulation of tuberculosis drugs may cause interactions if these drugs are givensimultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid(INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to makeINH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. Theprocess of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solventevaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21%and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules metthe requirements of the Indonesian Pharmacopoeia Edition V. The FTIR results showed that there wasno change either in the chemical composition of isoniazid or in the coating of the microencapsulation.Scanning Electron Microscopy (SEM) showed the active substance was well coated. This studyproduces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCPHP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.Keywords: HPMCP HP 50, HPMCP HP-55, isoniazid, microcapsules, solvent evaporation method
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP-55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36513

Abstract

The combination formulation of TB drugs may cause interactions if these drugs are given simultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid (INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to make INH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. The process of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solvent evaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21% and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules met the requirements of the Indonesian Pharmacopoeia Edition V. The FTIR test showed that the microcapsules didn’t change the chemical composition of isoniazid or the coating on the microencapsulation so that it was concluded that no chemical reaction or decomposition occurred before and after the formation of the microcapsules. Scanning Electron Microscopy (SEM) showed a spherical microcapsule surface morphology and the active substance was well coated for INH: HPMCP HP-50 (2:3), while for INH: HPMCP HP-55 (2:3) the surface of the microcapsules was round but hollow. This study produces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCP HP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.
PENGARUH RETURN ON EQUITY DAN TOTAL ASSETS TURNOVER TERHADAP FINANCIAL DISTRESS PADA PERUSAHAAN FOOD AND BEVERAGE YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2019-2023 Mia Agustin; Nugroho, Riski Dwi
JURNAL ILMIAH EKONOMI, MANAJEMEN, BISNIS DAN AKUNTANSI Vol. 2 No. 5 (2025): September
Publisher : CV. KAMPUSA AKADEMIK PUBLISING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/jemba.v2i5.1385

Abstract

This study aims to determine the effect of Return On Equity and Total Asset Turnover on financial distress using the Altman Z-Score bankruptcy prediction approach. The research method used is a descriptive associative method with a quantitative approach. The population in this study were 83 food and beverage companies listed on the Indonesia Stock Exchange in 2019–2023. The sample in this study was determined using a purposive sampling technique and obtained 8 food and beverage companies with a five-year observation period so that the data obtained were 40 sample data. Hypothesis testing was carried out using panel data regression analysis with the help of the EViews 12 program and the significance level used was 5%. The results of this study indicate that simultaneously Return On Equity and Total Asset Turnover have a significant effect on financial distress with a significance value of 0.000000 <0.05 and an f-count of 24.09815> f-table (3.24). The determination coefficient obtained using Adjusted R-Squared is 0.542234 or 54.22%, while the remaining 45.78% is influenced by other variables outside this research model. Partially, Return On Equity has a positive and significant effect on financial distress with a significance of 0.0000 <0.05 and a t-count value of 6.018630> t-table (2.02107), while Total Asset Turnover does not have a significant effect on financial distress with a significance value of 0.0825> 0.05 and a t-count of −1.781015 <t-table 2.02107.
Co-Authors Bella Dewinta Saraswati Fikri Alatas Gladdis Kamilah Pratiwi Hestiary Ratih Nugroho, Riski Dwi