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All Journal Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kartika Kimia Jurnal Ilmu Kefarmasian Indonesia Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Farmasi Farmasyifa Pharmaceutical Sciences and Research (PSR) Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian
Hestiary Ratih
Fakultas Farmasi Universitas Jenderal Achmad Yani
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Solubility Enhancement of Clozapine Through Co-Crystal Formation with Isonicotinamide Fikri Alatas; Hestiary Ratih; Hesti Kurnia; Sundani Nurono Soewandhi
Indonesian Journal of Pharmaceutics Vol 2, Issue 1, Jan - April 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i1.23957

Abstract

Clozapine (CLO) is an effective atypical antipsychotic to control the symptoms of psychosis and schizophrenia. Clozapine has low solubility and high permeability, so it is classified as a class II in the biopharmaceutical classification system. The aim of this study was to improve the solubility and dissolution rate of clozapine by clozapine-isonicotinamide (CLO-INA) co-crystal formation. CLO-INA co-crystal was prepared by solvent-drop grinding (SDG) method using water as a solvent. Characterization of SDG result was conducted by powder X-ray diffraction (PXRD) and Fourier transform infrared (FTIR).  Solubility test was performed in water at room temperature. The dissolution test was performed in 900 mL of pH 6.8 phosphate buffer solution, 50 rotation per minute of paddle rotation, and at 37±0.5 °C. The PXRD pattern of  SDG result of CLO-INA has many different peaks from its parent components, and this may indicate the co-crystal formation. The solubility of the co-crystal clozapine was fifteen folds higher than pure clozapine. The dissolution rate of CLO-INA co-crystal increased in the first 10 minutes compared to pure clozapine. Percentage of clozapine dissolved after 10 minutes from CLO-INA co-crystal and pure CLO were 10.2 and 2.4%, respectively. CLO and INA can form co-crystal by SDG method that can improve the solubility and dissolution rate of clozapine.Keywords: Clozapine, Isonicotinamide, Co-crystal, Solubility, Dissolution
Pembuatan dan Karakterisasi Ko-kristal Flukonazol-Resorsinol Fikri Alatas Alatas; Hestiary Ratih; Titta Hartyana Sutarna; Yoga Windu Wardhana; Dini Tereslina; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.779

Abstract

Fluconazole (FLU), an oral antifungal widely used in the treatment of vaginitis andcandidiasis, is known to have low bioavailability due to its low solubility. The purpose of this studywas to prepare and characterize co-crystal fl uconazole-resoscinol (FLU-RES). The preparation ofco-crystal was performed by grinding together the equimolar mixture of FLU-RES which is drippedwith a few ethanol. Powder X-ray diff raction, diff erential scanning calorimetry (DSC), and polarizedmicroscopy methods were performed to characterize the formation of FLU-RES co-crystal. Relevantphysicochemical properties include solubility tests in water and dissolution tests in pH 1.2; 4.5 and6.8 buff er solution. The powder X-ray diff ractogram of FLU-RES milled result showed the presenceof new peaks and loss of the main peaks of FLU and RES. The characterization of grinding result byDSC and polarized microscopy methods also showed the co-crystal formation between FLU and RES.The solubility of FLU-RES co-crystal in water is solubility two folds more than pure FLU, while itsdissolution rate is 1.67-1.72 times faster than pure FLU.
Pengaruh Disintegran dan Cara Pencampuran Terhadap Sifat Fisika Kimia Telmisartan Hestiary Ratih; Fikri Alatas; Jessie Sofia Pamudji; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1013

Abstract

Telmisartan (TMS) has a compact structure and is interlocked between crystal units. As a result, the substance has a high electrostatic force, which causes TMS to sintering when compressed into tablets. One method of overcoming sintering on TMS tablets is to add a disintegrant to the compressed tablet. The disintegrants used are derived from starch groups: Starch 1500® (S1500) and sodium starch glycolate (SSG), as well as microcrystalline cellulose (MCC) and croscarmellose sodium (CCS) groups. The purpose of this study was to examine the effects of several disintegrants on the dissolution and physicochemical properties of TMS with various treatments. TMS was varied with each disintegrant at a ratio of 1:9 % b/b. The treatment of TMS binary mixtures with various disintegrants includes physical mixtures, milled mixtures, compressed mixtures, and crushed compressed mixtures. Characterization and evaluation include PXRD and SEM testing as well as dissolution test. The characterization of PXRD and SEM in various treatments showed the effect of physicochemical properties on the TMS binary mixture with various disintegrants. The combination of TMS:CCS with a ratio of (1:9) resulted in the highest dissolution rate in all treatments.The treatment of the milled mixture produced the highest dissolution with DP60 minutes, which was around 55.86±2.47%. The addition of disintegrants to TMS with various treatments may reduce sintering but is not sufficient to meet the requirements for TMS dissolution, which dissolves within 30 minutes in phosphate buffer medium pH 7.5 with Q>75%.
Profil Disolusi Tablet Sustained Release Natrium Diklofenak dengan Menggunakan Matriks Metolose 90 SH 4000 Rini Agustin; Hestiary Ratih
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.244 KB) | DOI: 10.29208/jsfk.2015.1.2.33

Abstract

Diclofenac sodium (Na-diclofenac) is a non-steroidal anti-inflammatory drug that is commonly used for arthritis patients. However, its short half-life time which is about 1-2 hours causes the drug should be administered repeatedly over a short time interval for oral administration. Therefore, the purpose of this study was to formulate a sustained release tablet of diclofenac sodium with metolose 90 SH 4000 as the matrix. In order to see the influence metolose 90 SH 4000 to the dissolution profile of diclofenac sodium tablet, metolose 90 SH 4000 was added with a ratio of 0% (F0), 5% (F1), 10% (F2), 15% (F3), 25% (F4). The tablets was prepared by wet granulation method. The dissolution results showed the formula F0, F1, F2, and F3 can be reached within 120, 240, 300, and 480 minutes, respectively. Meanwhile, F4 did not reach the dissolution for 480 minutes. According to the USP 26, only F3 qualified the dissolution of sustained release tablet.
Kemampuan Pati Pregelatinasi Buah Sukun (Artocarpus altilis (Parkinson ex F.A.Zorn) Fosberg) sebagai Bahan Penghancur pada Tablet Eritromisin Stearat Wulan Anggraeni; Hestiary Ratih; Nabila Anis; Abilyo Ramadan
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.9125

Abstract

Pati merupakan salah satu disintegran sediaan tablet yang berfungsi menghancurkan tablet sehingga zat aktif dapat dilepaskan. Tujuan penelitian ini untuk memanfaatkan pati hasil pregelatinasi dari buah sukun (Artocarpus altilis (Parkinson ex F.A.Zorn) Fosberg) sebagai bahan penghancur pada tablet eritromisin stearat (ERS). Penelitian diawali dengan mengidentifikasi kemampuan pati pregelatinasi buah sukun (PPBS) dengan melakukan uji swelling power dari pregelatinasi pati pada suhu 0, 60, 70, 80 dan 90oC. Pati yang memiliki swelling power yang paling baik dipilih sebagai bahan penghancur pada tablet ERS. Dalam penelitian ini dibuat 4 formula, yaitu F1 (ERS tunggal), F2 (ERS-PPBS, 9:1), F3 (ERS-PPBS, 7:3) dan F4 (ERS-PPBS, 1:1). Tablet dikempa langsung dengan alat kompaktibilitas (hydrolic press), selanjutnya tablet dievaluasi kekerasan, kerapuhan, kompaktibilitas dan waktu hancur tablet serta dikarakterisasi dengan scanning electron microscopy (SEM). Hasil penelitian menunjukkan bahwa penambahan pati pregelatinasi buah sukun dapat menurunkan nilai kekuatan tarik (tensile strength) campuran massa kempa. Fotomikrograf SEM menunjukkan penambahan pati pregelatinasi buah sukun dapat mencegah terjadinya sintering pada tablet ERS. Tablet campuran ERS-PPBS dapat meningkatkan waktu hancur dari pada tablet ERS tunggal. Waktu hancur paling cepat terjadi pada F4 yaitu pada 0,45±0,06 menit. Hasil ini mengindikasikan bahwa pati pregelatinasi buah sukun dapat mencegah terjadinya fenomena sintering dan meningkatkan waktu hancur tablet eritromisin stearat.
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP- 55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36678

Abstract

The combination formulation of tuberculosis drugs may cause interactions if these drugs are givensimultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid(INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to makeINH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. Theprocess of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solventevaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21%and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules metthe requirements of the Indonesian Pharmacopoeia Edition V. The FTIR results showed that there wasno change either in the chemical composition of isoniazid or in the coating of the microencapsulation.Scanning Electron Microscopy (SEM) showed the active substance was well coated. This studyproduces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCPHP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.Keywords: HPMCP HP 50, HPMCP HP-55, isoniazid, microcapsules, solvent evaporation method
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP-55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36513

Abstract

The combination formulation of TB drugs may cause interactions if these drugs are given simultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid (INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to make INH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. The process of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solvent evaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21% and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules met the requirements of the Indonesian Pharmacopoeia Edition V. The FTIR test showed that the microcapsules didn’t change the chemical composition of isoniazid or the coating on the microencapsulation so that it was concluded that no chemical reaction or decomposition occurred before and after the formation of the microcapsules. Scanning Electron Microscopy (SEM) showed a spherical microcapsule surface morphology and the active substance was well coated for INH: HPMCP HP-50 (2:3), while for INH: HPMCP HP-55 (2:3) the surface of the microcapsules was round but hollow. This study produces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCP HP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.
POTENSI KRIM ANTIOKSIDAN GETAH JARAK TINTIR (Jatropha mulfida L.) DALAM MENGHAMBAT ENZIM TIROSINASE SECARA IN SILICO SEBAGAI ALTERNATIF AGEN PEMUTIH Farah Salsabilla Saidah Azhar; Sheila Nur Hasanah; Renata Ananda Marthasedana; Meyra Pratami Dewilestari; Sri Restu Andriyani; Wulan Anggraeni; Dadan Suryasaputra; Akhirul Kahfi Syam; Hestiary Ratih
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 1 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i1.10700

Abstract

Getah Jarak Tintir (Jatropha multifida Linn.) yang berasal dari famili Euphorbiaceae diketahui memiliki kandungan fenolik dan flavonoid yang berpotensi sebagai antioksidan alami. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sebagai antioksidan, interaksi senyawa metabolit sekunder dalam getah jarak tintir dengan enzim tirosinase, dan mengaplikasikannya dalam bentuk sediaan. Metode pengujian antioksidan dilakukan dengan metode DPPH dan pengujian aktivitas inhibitor enzim tirosinase dilakukan dengan in silico metode molekular docking. Formulasi hand and body cream getah jarak tintir dibuat dalam tiga formula yaitu F0 (basis krim sebagai kontrol), F1 (basis krim dengan 100×IC50 serbuk getah jarak tintir), F2 (basis krim dengan 200×IC50 serbuk getah jarak tintir). Hasil penelitian menunjukkan bahwa senyawa yang mempunyai afinitas kuat dalam menghambat enzim tirosinase yaitu Multifidol dengan nilai ∆G sebesar -6,01 kkal/mol dan KI sebesar 39,37 nM. Hasil pengujian antioksidan dari hasil freeze drying serbuk getah jarak tintir menunjukkan nilai IC50 sebesar 8,33 µg/mL yang termasuk kategori sangat kuat. Persen inhibisi pada krim F1 (konsentrasi zat aktif 8,33 µg/mL) dan F2 (konsentrasi zat aktif 16,4 µg/mL) berturut-turut adalah 25,08% dan 50,57% yang termasuk kategori sangat kuat dan berpotensi sebagai alternatif krim pemutih. Kata kunci: Getah jarak tintir, molecular docking, krim, antioksidan, DPPH  The sap of Jarak Tintir (Jatropha multifida Linn.) from the family Euphorbiaceae was known to contain phenolic and flavonoid compounds that have the potential as natural antioxidants. This study aimed to determine the content of metabolites as antioxidants, the interaction of secondary metabolites in Jatropha sap with tyrosinase enzymes, and to apply them in a dosage form. The antioxidant test method was carried out using the DPPH method and the tyrosinase enzyme inhibitory activity was tested using the molecular docking in silico method. The hand and body cream formulation of the sap was made in three formulas, namely F0 (cream base as control), F1 (cream base + 100×IC50 of the sap powder), F2 (cream base + 200×IC50 of the sap powder). The results showed that the compound that has a strong affinity to inhibit the tyrosinase enzyme is Multifidol with a ∆G value of -6.01 kcal/mol and a KI of 39.37 nM. The freeze-drying of the sap powder had the potential as an antioxidant with an IC50 value of 8.32 g/mL which was categorized as very strong activity. The percentage of inhibition in F1 cream (active substance concentration 8.32 g/mL) and F2 (active substance concentration 16.4 g/mL) were 25.08% and 50.57%, respectively, included in the very strong category and have potential to be alternative whitening cream. Keywords:  the sap of Jarak tintir, molecular docking, cream, antioxidant, DPPH
Identification of Candesartan Cilexetil-L-Arginine Co-amorphous Formation and Its Solubility Test Fikri Alatas; Erina Sifa Mutmainah; Hestiary Ratih; Titta Hartyana Sutarna; Sundani Nurono Soewandhi
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2942

Abstract

The formation of co-amorphous is one alternative that can be attempted to enhance the solubility of drugs. The study aimed to identify the co-amorphous formation between candesartan cilexetil (CAN) and l-arginine (ARG) and to know its effect on the solubility and dissolution rate of candesartan cilexetil. Initial prediction of co-crystal formation was undertaken by observing differences in crystal morphology between the candesartan cilexetil-l-arginine (CAN-ARG) mixture and each of its initial components due to crystallization in ethanol. The CAN-ARG co-amorphous was produced by the liquid-assisted grinding (LAG) method with the same molar ratio of the CAN and ARG mixture using ethanol as solvent. The co-amorphous formation of CAN-ARG was identified by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods. The solubility and dissolution test was performed to know the impact of the co-amorphous CAN-ARG formation. The PXRD pattern of CAN-ARG of LAG result showed a very low peak intensity compared to pure CAN and ARG. The DSC thermogram of the CAN-ARG LAG result does not show any sharp endothermic peaks. The PXRD and DSC results reveal that CAN and ARG can form co-amorphous. The solubility and dissolution rate of candesartan cilexetil in co-amorphous CAN-ARG was better than that of pure CAN. It can be concluded, liquid-assisted grinding of CAN-ARG mixture is identified to form co-amorphous which has an impact on increasing the solubility and dissolution rate of candesartan cilexetil.
PENGARUH PEMBENTUKAN KO-KRISTAL PIRIMETAMIN-ASAM FUMARAT TERHADAP KELARUTAN DAN LAJU DISOLUSINYA Riskia Putri Peratiwi; Fikri Alatas; Fani Wahyuni; Rani Sugandi; Hestiary Ratih; Faizal Hermanto
Kartika : Jurnal Ilmiah Farmasi Vol 4 No 1 (2016)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v4i1.55

Abstract

ABSTRAK Pirimetamin (PIR) adalah suatu obat antimalaria dengan kelarutan yang buruk di dalam air, sehingga ketersediaan hayatinya rendah. Pembentukan ko-kristal dapat mempengaruhi kelarutan dan laju disolusi bahan aktif farmasi tanpa mengubah aktivitas farmakologinya. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pembentukan ko-kristal pirimetamin (PIR) dengan asam fumarat(FUM) terhadap kelarutan dan laju disolusi pirimetamin. Ko-kristal PIR-FUM dibuat dalam perbandingan stoikiometri ekuimolar menggunakan metode penggilingan basah dengan menggunakan campuran pelarut aseton:air(1:1). Karakterisasi ko-kristal dilakukan dengan metode difraksi sinar-X serbuk, spektrofotometri infra merah, dan mikroskopik. Uji kelarutan dan uji laju disolusi dilakukan di dalam media air dan larutan dapar pH 1,2; 4,5; dan 6,8. Pola difraksi sinar-X serbuk hasil penggilingan basah berbeda dengan pola difraksi komponen-komponen murninya yang mengindikasikan terbentuknya ko-kristal PIR-FUM. Ko-kristal PIR-FUM mempunyai kelarutan dan laju disolusi lebih tinggi daripada pirimetamin murni. Kata kunci : Pirimetamin, asam fumarat, penggilingan basah, ko-kristal. ABSTRACT Pyrimethamine (PIR) is an antimalaria drug with poor solubility in water, so its bioavailability is low. Co-crystal formation can affects solubility and dissolution rate of  active pharmaceutical ingredient  without altering its pharmacological activity. The aim of this study was to investigate the influence of co-crystal formation between pyrimethamine (PIR) and fumaric acid (FUM) on the solubility and dissolution rate of pyrimethamine. PIR-FUM co-crystal was prepared in equimolar stoichiometric ratio by a solvent-drop grinding method. Characterization of co-crystal was conducted by  powder X-ray diffractometry, infrared spectroscopy, and microscopy methods. X-ray powder diffraction pattern of the solvent-drop grinding result was different from diffraction pattern of pure components that indicate the formation of PIR-FUM co-crystal. PIR-FUM co-crystal has solubility and dissolution rate higher than pure pyrimethamine. Keywords:       Pyrimethamine, fumaric acid, solvent drop grinding, co-crystal.
Co-Authors Abilyo Ramadan Akhirul Kahfi Syam Alisha Ramadhanty Ludin Bella Dewinta Saraswati Bintary, Dyan Dadan Suryasaputra Diamona Ayu Lestari Dini Tereslina Endah Wahyuni Erina Sifa Mutmainah Faizal Hermanto Fani Wahyuni Fani Wahyuni, Fani Farah Salsabilla Saidah Azhar Febrianti, Mia Fikri Alatas Gladdis Kamilah Pratiwi Gosepa, Oke Setiawan Hartyana Sutarna, Titta Hesti Kurnia Ine Rosmala Dewi Jessie Sofia Pamudji Maria Elvina Tresia Butar-Butar Meyra Pratami Dewilestari Mia Agustin Nabila Anis Nadira Cantika Putri Ananda Nasrul Wathoni Nira Purnamasari, Nira Pratiwi, Gladdis Kamilah Prianto, Ulla L. F. Purwoko, Agus Rani Sugandi Rani Sugandi, Rani Renata Ananda Marthasedana Rini Agustin Riskia Putri Peratiwi Riskia Putri Peratiwi, Riskia Putri Sheila Nur Hasanah Sri Restu Andriyani Sundani Nurono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Wulan Anggraeni Yoga Windhu Wardhana Yoga Windu Wardhana