Muhammad Hasan
Department of Anatomy, Faculty of Medicine, University of Jember, Jember, Indonesia

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The Effect of Shallot Peel Ethanol Extract in Reducing Kidney MDA Levels in Diazinon-induced Wistar Rats Mukhammad Arif Hadi Khoiruddin; Dina Helianti; Muhammad Hasan; Rosita Dewi; Sheilla Rachmania
Journal of Agromedicine and Medical Sciences Vol 8 No 2 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i2.27424

Abstract

Diazinon is an organophosphate pesticide often used by farmer. The residue of diazinon may contaminate agricultural products and if accidentally consumed in a long term, may potentially led to health problems such as kidney disorders. Shallot (Allium cepa) peel was recently proposed to help recover the kidney damage due to its high flavonoid antioxidant content. This study aims to determine the antioxidant effect of shallot peel extract in reducing oxidative stress caused by diazinon with malondialdehyde (MDA) level indicator on the kidney of Wistar rats (Rattus norvegicus). This research was a true experimental with an in-vivo posttest-only control group design. The 28 rats were divided using a simple random sampling technique. The groups were the control group (K0), the diazinon group (K1), SPEE (Shallot Peel Ethanol Extract) groups which are P1 (300 mg/kg BW), P2 (600 mg/kg BW), P3 (900 mg/kg BW), P4 (1200 mg/kg BW) and P5 (2400 mg/kg BW). At the end of the study, the MDA kidney levels was analysed using the TBARS method. Effective doses were found in 600 mg/kg BW/day, 900 mg/kg BW/day, 1200 mg/kg BW/day, and 2400 mg/kg BW/day. The optimal dose of shallot peel extract in this study was 600 mg/kg BW/day. This study showed the effectiveness of shallot peel extract in reducing kidney MDA levels in diazinon-induced Wistar rats. Keywords: shallot peel, diazinon, kidney MDA level
Hubungan Antara Pola Makan dan Aktivitas Fisik Terhadap Tingkat Depresi di Masa Pandemi Pada Pelajar SMAN 1 Manyar Gresik, Indonesia: Correlation Between Dietary Patterns and Physical Activity Towards Depression Level During Pandemic Among Students of SMAN 1 Manyar Gresik, Indonesia Annisa Citra Herrastri Hertanto; Ancah Caesarina Novi Marchianti; Muhammad Hasan
Amerta Nutrition Vol. 7 No. 2 (2023): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v7i2.2023.283-294

Abstract

Background: Unhealthy dietary patterns and low physical activity during a pandemic can be risk factors for depression. Objectives: This study aimed to analyze the correlation between dietary patterns and physical activities toward depression levels during the pandemic among SMA N 1 Manyar Gresik students. Methods: This research used observational with a cross-sectional study design at SMA N 1 Manyar Gresik. The sample was 78 students from the 12th grade. The sampling technique used was simple random sampling. The data obtained were then analyzed using the Kendall Correlation test to determine the correlation between dietary patterns and physical activities on the depression level. Each variable was obtained by analyzing the Food Frequency Questionnaire, Food Recall 2x24 hours, International Physical Activity Questionnaire-Short Form, and Modified Beck Depression Inventory-II. Results: The results showed relationships between diet and depression levels. Diet was assessed from the frequency of the type of food that dominated in the last month and macronutrient intake. There were relationships between the frequency of food consumption that dominated in the last month and the depression level (p=0,003; r=0,319) and between macronutrient intake and depression level. Conclusions: The results showed the need to increase food consumption from the minimally processed foods group by paying attention to macronutrient intake and performing physical activity in moderate to high-intensity categories according to the recommendations of the adolescent age group to prevent depression.