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All Journal Jurnal Biologi Tropis Community Development Journal: Jurnal Pengabdian Masyarakat
Ilsa Hunaifi
Universitas Mataram
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Public Health

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Protein S Deficiency and The Mechanism of Protein S in Hemostasis and Atherosclerosis Nur Feby Febiana Agistany; Ananda Karunia Ramadhan; Dira Kurnia Rizki; Raditya Bayu Farizil Akhyar; Ilsa Hunaifi
Jurnal Biologi Tropis Vol. 23 No. 4 (2023): October - December
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4.5565

Abstract

Protein S (PS) is Vitamin K dependant protein which plays a role in regulating the blood clotting process in the body. Protein S deficiency is explained as a condition characterized by reduced levels of protein S in the serum so that it makes the blood clot too easily. The purpose of this literature review is to give an update of protein S defficiency and the mechanism of protein s in hemostasis and atherosclerosis based on publish literature reference from various database. Protein S plays important role in hemostasis by regulating blood cloth process in the initiation phase of the extrinsic pathway as a TFPI cofactor or in the propagation phase, namely as an APC cofactor and independent activity of TFPIα and APC. Protein S deficiency is known to be associated with the occurrence of atherosclerosis via the Tyro3-Axl-Mer (TAM) receptor. The main clinical manifestations of the majority of patients with heterozygous mutations in the protein S (PROS1) gene are deep vein thrombosis (DVT) and pulmonary embolism that precipitate by VTE. Administration of anticoagulant drugs such as heparin in the form of low-molecular-weight heparin (LMWH) or unfractionated heparin, vitamin K antagonists (VKA), namely warfarin, or direct oral anticoagulants (DOACs) can be selected as a management of protein S deficiency with VTE. Protein S has a central role in the coagulation prosses and its deficiency associated with atherosclerotic conditions.
The Role of Neutrophil in The Pathophysiology of Frailty Syndrome Muhammad Ghifari Rifanhsa; Ilsa Hunaifi; Ika Primayanti
Jurnal Biologi Tropis Vol. 23 No. 4 (2023): October - December
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4.5780

Abstract

Neutrophils, also known as polymorphonuclear leukocytes, play a significant role in fueling systemic inflammation and tissue damage within the context of frailty, a clinical syndrome associated with increased susceptibility to stressors and decreased functional performance typically linked to aging. This literature review delves into the interplay between neutrophils and frailty, shedding light on their contribution to age-related systemic inflammation. The investigation explored the correlation between heightened neutrophil levels, diminished physical activity, increased frailty, and elevated white blood cell counts. These findings underscore the substantial role of neutrophils in the development of frailty, necessitating further research to enhance comprehension of their involvement for more effective prevention and intervention strategies. The implications of this study emphasize the importance of tailored exercise regimens, promoting optimal nutrition practices, efficiently managing chronic inflammation, and improving the control of chronic diseases as essential approaches to address frailty among older individuals.
PENYULUHAN PEMANFAATAN TANAMAN KATANG-KATANG (IPOMOEA PES-CAPRAE) SEBAGAI ALTERNATIF PENGOBATAN TRADISIONAL DI MASYARAKAT DESA TAMAN AYU, GERUNG, LOMBOK BARAT Muhammad Naufal Farras Ananta; Varelia Angelina; Baiq Irzana Putri Alamanda; Muhammad Iqbal Farobbi; Imasayu Nuralyza; Ilsa Hunaifi; Raisya Hasin; Dewi Suryani; Nisa Isneni Hanifa
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 6 No. 1 (2025): Volume 6 No. 1 Tahun 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v6i1.40706

Abstract

Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman masyarakat Desa Taman Ayu, Gerung, Lombok Barat, mengenai manfaat Ipomoea pes-caprae sebagai alternatif pengobatan tradisional. Metode kegiatan meliputi pretest, ceramah, sesi tanya jawab, pembagian leaflet, dan posttest, yang dilakukan secara langsung kepada 30 peserta. Penyampaian materi mencakup pengenalan tanaman, manfaat tradisionalnya, dan cara pengolahannya. Hasil kegiatan menunjukkan peningkatan pengetahuan dan keterampilan masyarakat dalam memanfaatkan tanaman ini untuk pengobatan, seperti mengatasi nyeri perut, kram, dan sengatan ubur-ubur. Diskusi interaktif juga memperkuat pemahaman peserta. Kesimpulan dari kegiatan ini adalah bahwa penyuluhan efektif dalam membangun kesadaran masyarakat tentang pemanfaatan sumber daya lokal untuk kesehatan holistik, mendukung pengelolaan lingkungan berkelanjutan, serta meningkatkan kapasitas mereka dalam pengolahan obat tradisional.
Co-Authors Ananda Karunia Ramadhan Baiq Irzana Putri Alamanda Dewi Suryani Dira Kurnia Rizki Ika Primayanti Imasayu Nuralyza Muhammad Ghifari Rifanhsa Muhammad Iqbal Farobbi Muhammad Naufal Farras Ananta Nisa Isneni Hanifa Nur Feby Febiana Agistany Raditya Bayu Farizil Akhyar Raisya Hasin Varelia Angelina