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All Journal Buletin Farmatera ACI (Acta Cardiologia Indonesiana)
Sheila Dhiene Putri
Department Of Cardiology, Faculty Of Medicine, Universitas Muhammadiyah Sumatera Utara
Medicine & Pharmacology

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Significance of Electrocardiographic QTc Interval on Assessment of Left Ventricular Diastolic Dysfunction in Hypertensive Patient: A Simple Screening Tool Sheila Dhiene Putri; Harris Hasan; Refli Hasan; A. Afif Siregar; Nizam Akbar; Cut Aryfa Andra
ACI (Acta Cardiologia Indonesiana) Vol 5, No 1 (2019)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (694.18 KB) | DOI: 10.22146/aci.44551

Abstract

Background: Diastolic dysfunction as part of heart failure with preserved ejection fraction (HFpEF) has gain interests, due to the increasing prevalence rate and poor prognosis. Besides the mechanism is not fully understood, there are some difficulties in detecting the presence of diastolic dysfunction. Previous studies have shown correlation between some electrocardiographic parameters and diastolic function. Furthermore, the aim of this study is to assess the diagnostic value of the QTc interval in detecting left ventricular diastolic dysfunction.Methods: A cross sectional study was conducted on patients with clinical suspicion of heart failure. Electrocardiographic examination was performed to obtain QTc interval (msec) using the Bazett formula. Left ventricular diastolic function was assessed using Tissue Doppler Imaging by echocardiography. Using correlation test and ROC method, the relationships between QTc interval and LV diastolic function were investigated.Results: Of 82 patients analyzed, there were 62 patients (75.9%) known to have diastolic dysfunction. The QTc interval was found to be longer in the group with diastolic dysfunction compared to the normal group (442.9±27 vs. 402.1±18.2, p <0.001). There was a strong negative correlation between the QTc interval and diastolic function (r = -0.619; p <0.001). Using ROC analysis, the cut off point for QTc interval was 410 ms with 91% sensitivity, 70% specificity, and 90% positive predictive value.Conclusion: The QTc interval is an accurate, simple and highly feasible electrocardiographic parameter as a screening tool to determine the presence of left ventricular diastolic dysfunction.
Work Shifts Affect Blood Pressure in Employees In Tegal Sari Mandala II Village Siti Nur Azizah; Sheila Dhiene Putri
Buletin Farmatera Vol 10, No 3 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract: Work shifts are a work system that is widely applied in various work sectors to increase productivity. However, the implementation of this system can hurt workers' health, especially in terms of blood pressure. Based on data from Tegal Sari Mandala II Village, Medan City, it was found that there was an increase in the prevalence of hypertension in workers who worked shifts compared to workers who had fixed working hours. Hypertension in shift workers can be caused by circadian rhythm disruptions, increased cortisol levels, irregular sleep patterns, and higher stress levels. This study aims to determine the effect of work shifts on blood pressure in employees in Tegal Sari Mandala II Village. This study uses an analytical design with a cross-sectional method. The sample consisted of 100 randomly selected employees. Data was collected through blood pressure measurements using a digital sphygmomanometer. Data analysis was carried out using the Chi-Square test with univariate and bivariate methods to measure the relationship between work shifts and hypertension. The results showed a significant relationship between work shifts and hypertension incidence (p=0.001). Shift workers are more prone to hypertension than non-shift workers, with the prevalence of grade 2 hypertension being 14 employees in the shift group. Shift workers have a higher risk of hypertension than non-shift workers. Therefore, structured occupational health interventions, good sleep patterns, and education about stress management are needed to reduce the risk of hypertension in shift workers.
HbA1c Levels Relate to the Severity of Atherosclerotic Lesions in Coronary Heart Disease Patients with Type 2 Diabetes Mellitus Faridah Zulfa Rambe; Sheila Dhiene Putri
Buletin Farmatera Vol 11, No 1 (2026)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract: Cardiovascular disease is one of the main causes of death in the world. In diabetes mellitus patients who experience hyperglycemia, the risk of coronary heart disease increases 2-4 times. Diabetes mellitus can be diagnosed using HbA1c examination. Coronary heart disease can be diagnosed using a coronary angiography examination, and the results are assessed using the vessel disease score. The design of this research is observational analytic with a cross-sectional approach. The research was conducted in October-December 2023 at RSU. Medan Hajj. The sample for this study was patients with coronary heart disease who had type 2 diabetes mellitus and underwent HbA1c examination and coronary angiography. Data analysis used the Mann-Whitney test. Based on data from RSU. Haji Medan obtained 23 samples, after 18 samples of multi-vessel disease were found with uncontrolled HbA1c levels, and then analysed with a result of 0.027 (p-value 0.05), which means there is a relationship between HbA1c levels and the severity of atherosclerotic lesions in disease patients. Coronary heart disease patients who have type 2 diabetes mellitus. There is a relationship between HbA1c levels and the severity of atherosclerotic lesions in coronary heart disease patients who have type 2 diabetes mellitus.
Co-Authors A. Afif Siregar Andra, Cut Aryfa Faridah Zulfa Rambe Harris Hasan Hasan, Refli Nizam Akbar Siti Nur Azizah