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All Journal e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK Jurnal Kedokteran Klinik
Frans Wantania
Medical Faculty Sam Ratulangi University Manado
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Perbandingan Pemulihan Laju Jantung antara Subjek Obes Sentral Terlatih dengan yang Non-obes Sentral Tak Terlatih Wowor, Ribka; Wantania, Frans; Pamolango, Fendy
e-CliniC Vol 5, No 2 (2017): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v5i2.16878

Abstract

Abstract: Heart rate recovery (HRR) is a predictor of cardiovascular mortality in adult as well as a risk factor of diabetes mellitus and cardiovascular diseases. Heart rate recovery is affected by autonomic nerve system and interestingly, athletes have more effective autonomic nerve system than the non-athletes. This was an observational descriptive study with a cross-sectional design. Subjects were 15 adult trained males with central obesity and 15 untrained males without central obesity. Central obesity was determined if abdominal circumferences was above 90 cm. The treadmill test with Bruce protocol was used to evaluate the HHR at the second minute of recovery which was abnormal if the HRR below 42 times per minute. The non-tailed T test was used to determine the comparison of HRR between trained central obese and non-trained non-central obese subjects. The results showed that the 15 trained males with central obesity had average age 31.7±3.7 years and mean abdominal circumference 98.6±5.66 cm meanwhile the 15 untrained males without central obesity had mean age 29.4±6.4 years and mean abdominal circumference 80.27±7.05 cm. Mean HRR of the trained subjects was 55.6±10.6 and of the untrained subjects was 47.8 ±1.8. The non-tailed T test showed significant result in comparing the HRR between trained subjects and untrained subjects (P < 0.025). Abnormal HRR was found in 6.6% of the trained subjects and in 20% of the untrained subjects. Conclusion: Trained males with central obesity had a better HRR significantly than untrained males without central obesity; therefore, physical exercise played an important role in HRR.Keywords: heart rate recovery (HRR), central obesity, trained Abstrak: Pemulihan laju jantung (PLJ) merupakan prediktor kematian kardiovaskular pada orang dewasa dan dipengaruhi oleh sistem saraf otonom. Uniknya, atlet atau individu yang terlatih memiliki sistem saraf otonom yang lebih efektif dibandingkan dengan yang tidak terlatih. Jenis penelitian ialah deskriptif observasional dengan desain potong lintang. Subjek penelitian terdiri dari15 pria dewasa dengan obesitas sentral yang terlatih dan 15 pria dewasa dengan non-obesitas sentral yang tidak terlatih. Subjek dinyatakan terlatih bila memenuhi rekomendasi latihan fisik menurut WHO. Obesitas sentral diukur dengan meteran pada lingkar perut bila lebih dari 90 cm. Uji latih jantung (ULJ) menggunakan treadmill dengan protokol Bruce. Pemulihan laju jantung dinilai pada menit ke-2 fase pemulihan dan dikatakan abnormal bila PLJ <42 x/menit. Perbandingan antara PLJ pada subjek obes sentral yang terlatih dengan subjek non-obes sentral yang tidak terlatih diuji dengan uji-T tidak berpasangan. Hasil penelitian mendapatkan 15 subjek pria obes sentral yang terlatih dengan rerata usia 31,7±3,7 tahun, rerata lingkar perut 98,6±5,66cm dan 15 subjek pria non-obes sentral yang tidak terlatih dengan rerata usia 29,4±6,4 tahun, rerata lingkar perut 0,27±7,05cm. Rerata PLJ pada subjek obes sentral yang terlatih 55,6±10,6, dan rerata PLJ pada non-obes sentral yang tidak terlatih 47,8±1,8. Uji-T tidak berpasangan mendapatkan hasil bermakna untuk perbandingan antara PLJ pada subjek obes sentral yang terlatih dengan subjek non-obes sentral yang tidak terlatih (p<0,025). Didapatkan nilai abnormal PLJ 6,6% pada kelompok subjek obes sentral terlatih dan 20,0% pada kelompok subjek non-obes sentral tak terlatih. Simpulan: Subjek obes sentral yang terlatih memiliki PLJ yang lebih baik dibandingkan dengan subjek non-obes sentral yang tidak terlatih secara bermakna yang menunjukkan faktor latihan fisik berperan penting terhadap PLJ.Kata kunci: pemulihan laju jantung (PLJ), obesitas sentral, terlatih
Hubungan Infeksi Hepatitis Virus C Kronik dengan Kualitas Hidup Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis Reguler Tjhie, Otto S.; Wantania, Frans; Palar, Stella
e-CliniC Vol 5, No 1 (2017): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v5i1.14699

Abstract

Abstract: Chronic kidney disease (CKD) is a pathophysiologic process with diverse etiology, resulting in a progressive decline of renal function, and generally end up with kidney failure. CKD is a clinical condition characterized by the irreversible decline in kidney function requiring renal replacement therapy such as dialysis or kidney transplantation. This study was aimed to determine the relationship between chronic hepatitis C virus with the quality of life of patients with CKD who underwent regular hemodialysis. This was an observational analytical study with a cross sectional design. Samples were CKD patients undergoing hemodialysis who were infected with hepatitis C virus in chronic hemodialysis at Installation of Special Measures Section Prof. Dr. R. D. Kandou Hospital Manado from October to December 2015. The results showed that there were 82 people as samples. Thirty-one (36.6%) of them were patients with CKD who were infected with chronis hepatitis C. Most samples were male as many as 54 patients (65.9%) and 18 of them were infected with chronic hepatitis C virus. The age group 39-47 years was the largest age group as many as 10 patients (33.33%). The analysis of the relationship of anti-HCV and quality of life was tested with a correlation coefficient point biserial (p=0.327). Conclusion: There were no relationship between chronic hepatitis C virus infectionand the quality of life in patients with chronic kidney disease undergoing regular hemodialysis.Keywords: CKD, chronic hepatitis C virus infection, quality of life Abstrak:Penyakit ginjal kronik(PGK) adalah suatu proses patofisiologis dengan etiologi yang beragam, mengakibatkan penurunan fungsi ginjal yang progresif, dan pada umumnya berakhir dengan gagal ginjal. PGK adalah suatu keadaan klinis yang ditandai dengan penurunan fungsi ginjal yang ireversibel yang memerlukan terapi pengganti ginjal berupa dialisis atau transplantasi ginjal. Penelitian ini bertujuan untuk mengetahui hubungan hepatitis virus C kronik dengan kualitas hidup pasien PGK yang menjalani hemodialisis reguler. Jenis penelitian ialah observational analitik dengan desain potong lintang. Sampel penelitian ialah pasien PGK yang menjalani hemodialisis yang terinfeksi virus hepatitis C kronik di Instalasi Tindakan Khusus Hemodialisis Bagian/SMF Ilmu Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado periode Oktober-Desember 2015. Hasil penelitian mendapatkan jumlah sampel sebanyak 82 orang. Tiga puluh orang (36,6%) diantaranya ialah penderita PGK yang terinfeksi hepatitis C kronik. Jenis kelamin terbanyak ialah laki-laki sebanyak 54 penderita (65,9%) dan 18 diantaranya terinfeksi virus hepatitis C kronik. Kelompok usia 39-47 tahun merupakan kelompok usia terbanyak yaitu 10 orang (33,33%). Hasil analisis hubungan anti-HVC dan kualitas hidup yang diuji dengan koefisien korelasi point biserial mendapatkan niai p=0,327. Simpulan: Tidak terdapat hubungan antara infeksi virus hepatitis C kronik dan kualitas hidup pada pasien PGK yang menjalani hemodialisa regulerKata kunci: penyakit ginjal kronik, infeksi virus hepatitis C kronik, kualitas hidup
HUBUNGAN KADAR ASAM URAT DENGAN KEJADIAN GAGAL JANTUNG AKUT PADA PASIEN HIPERTENSI Pualillin, Rezuanto; Rampengan, Starry H.; Wantania, Frans
e-CliniC Vol 3, No 1 (2015): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.3.1.2015.7389

Abstract

Abstract: Long period of hypertension causes enlargement of the heart muscle, which leads to heart failure. Increased uric acid will causes endothelial dysfunction nas a result of the over production of reactive oxygen species (ROS), decrease the amount of nitric oxide (NO), increased rennin production, and the occurrence of inflammatory reactions. This speeds up the deterioration of the heart muscle, causing acute phase of heart failure. This study aimed to determine the relationship between uric acid levels and the incidence of acute heart failure in hypertensive patients in the emergency department and hypertension clinic of Prof. Dr R.D Kandou Hospital in Manado. This was an analytical observation by using the cross-sectional design. By using a non-probability sampling method we found 40 people as samples who had been diagnosed with heart failure due to hypertension. There were 15 samples that had experienced acute heart failure and 25 samples did not. Logistic Regression Test results stated that there was no significant effect of uric acid level with the incidence of acute heart failure (p = 0.188), with the value of the odds ratio of 1.198. Conclusion: There was no correlation between the levels of uric acid with the incidence of acute heart failure in patients with hypertension.Keywords: uricacid, hypertension, acute heart failureAbstrak: Hipertensi yang lama menyebabkan terjadinya pembesaran otot jantung sehingga berdampak pada terjadinya gagal jantung. Peningkatan asam urat juga menyebabkan disfungsi endotel akibat produksi reactive oxygen species (ROS) yang berlebihan, penurunan jumlah nitric oxide(NO), produksi renin meningkat, dan terjadinya reaksi inflamasi. Hal ini mempercepat perburukan otot jantung sehingga terjadi fase akut gagal jantung. Untuk mengetahui hubunganantara kadar asam urat dengan kejadian gagal jantung akut pada pasien hipertensidi instalasi rawat daruratdan poliklinik hipertensi RSUP Prof. Dr. R.D Kandou Manado. Jenis Penelitian ini adalah observasi analitik dengan menggunakan rancangan penelitian potong lintang. Dengan menggunakan metode non-probability sampling didapatkan 40 orang sebagai sampel yang telah didiagnosis menderita gagal jantung akibat hipertensi dimana 15 sampel yang mengalami episode akut dan 25 sampel yang tidak mengalami gagal jantung akut. Hasil Uji Regresi Logistik menyatakan bahwa tidak ada pengaruh yang signifikan antara kadar asam urat dengan kejadian gagal jantung akut (p=0,188), dengan nilai odds ratio sebesar 1,198. Simpulan: Tidak terdapat hubungan antara kadar asam urat dengan kejadian gagal jantung akut pada pasien hipertensi.Abstract: Long period of hypertension causes enlargement of the heart muscle, which leads to heart failure. Increased uric acid will causes endothelial dysfunction nas a result of the over production of reactive oxygen species (ROS), decrease the amount of nitric oxide (NO), increased rennin production, and the occurrence of inflammatory reactions. This speeds up the deterioration of the heart muscle, causing acute phase of heart failure. This study aimed to determine the relationship between uric acid levels and the incidence of acute heart failure in hypertensive patients in the emergency department and hypertension clinic of Prof. Dr R.D Kandou Hospital in Manado. This was an analytical observation by using the cross-sectional design. By using a non-probability sampling method we found 40 people as samples who had been diagnosed with heart failure due to hypertension. There were 15 samples that had experienced acute heart failure and 25 samples did not. Logistic Regression Test results stated that there was no significant effect of uric acid level with the incidence of acute heart failure (p = 0.188), with the value of the odds ratio of 1.198. Conclusion: There was no correlation between the levels of uric acid with the incidence of acute heart failure in patients with hypertension.Keywords: uricacid, hypertension, acute heart failureAbstrak: Hipertensi yang lama menyebabkan terjadinya pembesaran otot jantung sehingga berdampak pada terjadinya gagal jantung. Peningkatan asam urat juga menyebabkan disfungsi endotel akibat produksi reactive oxygen species (ROS) yang berlebihan, penurunan jumlah nitric oxide(NO), produksi renin meningkat, dan terjadinya reaksi inflamasi. Hal ini mempercepat perburukan otot jantung sehingga terjadi fase akut gagal jantung. Untuk mengetahui hubunganantara kadar asam urat dengan kejadian gagal jantung akut pada pasien hipertensidi instalasi rawat daruratdan poliklinik hipertensi RSUP Prof. Dr. R.D Kandou Manado. Jenis Penelitian ini adalah observasi analitik dengan menggunakan rancangan penelitian potong lintang. Dengan menggunakan metode non-probability sampling didapatkan 40 orang sebagai sampel yang telah didiagnosis menderita gagal jantung akibat hipertensi dimana 15 sampel yang mengalami episode akut dan 25 sampel yang tidak mengalami gagal jantung akut. Hasil Uji Regresi Logistik menyatakan bahwa tidak ada pengaruh yang signifikan antara kadar asam urat dengan kejadian gagal jantung akut (p=0,188), dengan nilai odds ratio sebesar 1,198. Simpulan: Tidak terdapat hubungan antara kadar asam urat dengan kejadian gagal jantung akut pada pasien hipertensi.Kata kunci: asam urat, hipertensi, gagal jantung akut: asam urat, hipertensi, gagal jantung akut
HUBUNGAN HIPERURISEMIA DENGAN KARDIOMEGALI PADA PASIEN GAGAL JANTUNG KONGESTIF Masengi, Keishi G. D.; Ongkowijaya, Jeffrey; Wantania, Frans
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.1.2016.10971

Abstract

Abstract: Hyperuricemia leads to left ventricular hypertrophy that affects the occurrence of congestive heart failure. Increased uric acid level causes increased production of reactive oxygen species (ROS). This ROS stimulates tumor necrosis factor-alpha (TNF-?) which binds to tumor necrosis factor receptor (TNFR) in the heart, causing a series of reactions of myocyte apoptosis and fibrosis with left ventricular hypertrophy as the final result. This study aimed to determine the relationship between hyperuricemia and cardiomegaly in patients with congestive heart failure. This was an analytical study with a cross sectional design. Samples were 30 patients with congestive heart failure hospitalized in Irina F and Cardio Vascular Brain Center Prof. Dr. R. D. Kandou Hospital in Manado. The result of independent T test stated that there was a significant association between hyperuricemia and cardiomegaly in patients with congestive heart failure with a p value 0,020 and an odds ratio of 3.571.Keywords: hyperuricemia, cardiomegaly, left ventricular hypertrophy, congestive heart failure Abstrak: Hiperurisemia menyebabkan terjadinya hipertrofi ventrikel kiri sehingga berdampak terjadinya gagal jantung kongestif. Peningkatan kadar asam urat menyebabkan peningkatan produksi reactive oxygen species (ROS). ROS akan menstimulasi tumour necrosis factor-alpha (TNF-?) yangs selanjutnya akan berikatan dengan tumour necrosis factor receptor (TNFR) di jantung sehingga menyebabkan serangkaian reaksi apoptosis miosit dan fibrosis dengan hasil akhir hipertrofi ventrikel kiri. Penelitian ini bertujuan untuk mengetahui hubungan hiperurisemia dengan kardiomegali pada pasien gagal jantung kongestif. Penelitian ini menggunakan metode analitik dengan desain potong lintang. Sampel penelitian ini ialah 30 pasien gagal jantung kongestif di rawat inap Irina F dan Cardio Vascular Brain Center RSUP Prof. Dr. R. D. Kandou Manado. Hasil Uji T Independent menyatakan bahwa ada hubungan bermakna antara hiperurisemia dan kardiomegali pada pasien gagal jantung kongestif (p=0,020), dengan nilai odds ratio sebesar 3,571.Kata kunci: hiperurisemia, kardiomegali, hipertrofi ventrikel kiri, gagal jantung kongestif
PREVALENSI VIRUS HEPATITIS PADA PASIEN PENYAKIT GINJAL KRONIK YANG MENJALANI HEMODIALISIS RUTIN BAGIAN ILMU PENYAKIT DALAM RSUP PROF. DR. R. D. KANDOU MANADO Belung, Alvisco; Moeis, E.; Wantania, Frans
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.1.2016.11027

Abstract

Abstract: Chronic Kidney Disease ( CKD ) is a pathophysiological process with diverse etiology resulting in a progressive decline in kidney function. Dialysis is a process of diffusion of solutes and water passively through a porous membrane of a liquid compartment towards other liquid compartments. Hepatitis is a systemic viral infection that attacks the liver. Transmission of Hepatitis B Virus and Hepatitis C Virus is a crucial problem in patients undergoing hemodialysis. This research was conducted by using a retrospective descriptive method. The samples were all positive CKD patients with hepatitis virus in the Hemodialysis Installation of Prof. Dr. R. D. Kandou Manado Hospital. Based on research conducted found that there were 87 patients undergoing hemodialysis with a diagnosis of Chronic Kidney Disease, a total of 25 patients were found positive for Hepatitis C virus and 14 patients with positive HbsAg.Keywords: Chronic Kidney Disease, Hepatitis Virus, HemodialysisAbstrak: Penyakit Ginjal Kronik (PGK) adalah suatu proses patofisiologis dengan etiologi yang beragam, mengakibatkan penurunan fungsi ginjal yang progresif. Dialisis adalah suatu proses difusi zat terlarut dan air secara pasif melalui suatu membran berpori dari satu kompartemen cair menuju kompartemen cair lainnya. Virus Hepatitis merupakan infeksi sistemik yang menyerang hati. Transmisi Virus Hepatitis B dan Virus Hepatitis C merupakan masalah sangat penting pada pasien yang menjalani hemodialisa. Penelitian ini dilakukan dengan menggunakan metode deskriptif retrospektif. Sampel penelitian adalah semua pasien PGK yang positif virus hepatitis di Instalasi Tindakan Hemodialisis RSUP Prof. Dr. R. D. Kandou Manado. Berdasarkan penelitian yang dilakukan didapatkan ada 87 pasien yang menjalani hemodialisis dengan diagnosis Penyakit Ginjal Kronik, sebanyak 25 pasien ditemukan positif Virus Hepatitis C dan 14 pasien dengan HbsAg positif.Kata Kunci: Penyakit Ginjal Kronik, Virus Hepatitis, Hemodialisis
PROFIL KANKER PAYUDARA RSUP PROF. DR. R. D. KANDOU MANADO TAHUN 2013 – 2014 Rondonuwu, Israel A.; Haroen, Harlinda; Wantania, Frans
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i1.10972

Abstract

Abstract: Breast cancer is becoming one health problem worldwide due to the increasing tendency of morbidity and mortality for years. The incidence of breast cancer is increasing in some countries due to the increasing life expectancy, urbanization, and adoption of lifestyle. This study aimed to obtain the profile of breast cancer patients in Prof. Dr. R. D. Kandou Hospital Manado during 2013-2014. This was a retrospective descriptive study using data from medical record in Prof. Dr. R. D. Kandou Hospital Manado. The results showed that there were 151 cases of breast cancer. Most of them were aged 40-49 (61 cases; 43%); senior high school as the highest education (92 cases; 61%). Family history with breast cancer was fouond in only 6 cases (4%). The most common histological type was invasive ductal carsinoma (147 cases; 97.6%). The most common clinical stage was stage IV (96 cases; 63.6%). Conclusion: Most of the breast cancer cases were aged 40-49 years, senior high school, no family history of breast cancer, invasive ductal carcinoma, and clinical stage IV,Keywords: breast cancer, age, education, family history, histopatology type, clinical stage  Abstrak: Kanker payudara masih menjadi salah satu masalah kesehatan yang ada di seluruh dunia karena meningkatnya morbiditas dan mortalitas selama bertahun-tahun. Insiden kanker payudara meningkat di beberapa negara karena meningkatnya harapan hidup, urbanisasi dan adopsi pola hidup. Penelitian ini bertujuan untuk mengetahui profil penderita kanker payudara di RSUP. Prof. Dr. R. D. Kandou Manado tahun 2013-2014. Penelitian ini menggunakan metode deskriptif retrospektif berdasarkan data rekam medik RSUP. Prof. Dr. R. D. Kandou Manado tahun 2013-2014. Hasil penelitian memperlihatkan dari 151 kasus kanker payudara, sebagian besar berusia 40-49 tahun sebanyak 61 kasus (43%) dengan tingkat pendidikan terbanyak SMA sebanyak 92 kasus (61%). Riwayat penyakit keluarga mengalami kanker payudara sebanyak 6 kasus (4%). Jenis histopatologik terbanyak karsinoma duktal invasif sebanyak 147 kasus (97,6%). Stadium klinis yang paling banyak ditemukan yaitu stadium IV sebanyak 96 kasus (63,6%). Simpulan: Pada penelitian ini kanker payudara terbanyak pada usia 40-49 tahun, tingkat pendidikan SMA, tanpa riwayat kanker payudara dalam keluarga, jenis histopatologik karsinoma duktal invasif, dan stadium klinis IV.Kata kunci: kanker payudara, usia, pendidikan, riwayat penyakit keluarga, tipe histopatologi, stadium sklinis.
GAMBARAN HEMATOLOGI PADA PASIEN SINDROM KORONER AKUT YANG DIRAWAT DI BLU RSUP PROF. Dr. R.D. KANDOU MANADO TAHUN 2010 Ramadhani, Bagus Yuvi Setyo; Rotty, Linda W.A; Wantania, Frans
e-Biomedik Vol 1, No 1 (2013): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v1i1.1154

Abstract

Abstract: Acute coronary syndrome (ACS) is a series of clinical disorders caused by acute ischemic heart disease, including angina unstable, non-ST elevation myocardial infarction, and ST-elevation myocardial infarction. This study aimed to determine the relationship of routine hematological changes with the course of acute coronary syndromes. We used a descriptive method. Data were obtained from the secondary data of ACS patients in the ICCU RSUP Prof. Dr. R. D. Kandou Manado during 2010. The data were presented in distributive tables. The results showed that most patients did not experience decreases in hematological parameters such as hemoglobin, hematocrite, erythrocyte counts, and platelet counts. The leucocyte counts increased in 50% of cases. Conclusion: In general, there was no decrease in hematological parameters, except leukocyte counts, among the ACS patients in the ICCU RSUP Prof. Dr. R. D. Kandou Manado during 2010. Keywords: acute coronary syndrome, coronary heart disease, hematology, inflammation Abstrak: Sindrom koroner akut (SKA) merupakan rangkaian gangguan klinis yang disebabkan oleh penyakit akut iskemik jantung, termasuk angina tidak stabil, non-ST elevasi miocard infraction, dan ST-elevasi miocard infraction. Penelitian ini bertujuan untuk mengetahui hubungan perubahan hematologi rutin dengan perjalanan penyakit sindrom koroner akut. Penelitian ini memakai metode deskriptif dengan menggunakan data sekunder dari penderita SKA di ruang ICCU RSUP Prof. Dr. R. D. Kandou Manado selama tahun 2010. Data hasil penelitian disajikan dalam bentuk tabel distributif. Hasil penelitian  memperlihatkan bahwa sebagian besar pasien tidak memperlihatkan penurunan parameter hematologi. Jumlah leukosit meningkat pada 50% kasus. Simpulan: Umumnya tidak terdapat penurunan parameter hematologi, kecuali jumlah leukosit pada pasien SKA ruang ICCU RSUP Prof. Dr. R. D. Kandou Manado selama tahun 2010. Kata kunci: Sindrom koroner akut, penjakit jantung koroner, Hematologi, inflamasi
Pengaruh Pemberian Alopurinol terhadap Tekanan Darah Pasien Gagal Jantung Wowor, Ribka; Wantania, Frans
Jurnal Biomedik : JBM Vol 10, No 1 (2018): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.10.1.2018.18997

Abstract

Abstract: Hyperuricemia is an independent risk factor of hypertension. Most of heart failure patients with uncontrolled hypertension had hyperuricemia. This study was aimed to determine the effect of allopurinol to blood pressure in heart failure patients. This was a clinical trial study with a control-non randomized design, performed on heart failure patients (40-74 years old). Wilcoxon Sign Rank was used to test the means of blood pressure difference between after and before the allopurinol treatment. The results showed that there were no significant differences in mean blood pressure between before and after allopurinol treatment (SBP, P=0.650; DBP, P=0.356). Conclusion: There was a decrease of blood pressure in heart failure patients after allopurinol treatment; albeit, it was not statistically significan.Keywords: allopurinol, blood pressure, heart failureAbstrak: Hiperurisemia merupakan salah satu faktor risiko independen terhadap timbulnya hipertensi. Pasien gagal jantung dengan tekanan darah tidak terkontrol sering mengalami hiperurisemia. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian alopurinol terhadap tekanan darah pada pasien gagal jantung. Penelitian ini merupakan uji klinis terbuka tanpa randomisasi untuk meneliti pengaruh pemberian alopurinol pada terapi standar congestive heart failure (CHF). Beda rerata tekanan darah pre dan post diuji menggunakan Wilcoxon Sign Rank. Hasil penelitian menunjukkan pada kelompok alopurinol didapatkan penurunan tekanan darah sesudah pemberian alopurinol walaupun perbedaan rerata pre-post TDS (P=0,650) dan perbedaan rerata pre-post TDD tidak bermakna (P=0,356). Simpulan: Pasien CHF yang diberikan alopurinol mengalami penurunan tekanan darah walaupun secara statistik tidak bermaknaKata kunci: alopurinol, tekanan darah, gagal jantung
HIPERURISEMIA DAN SINDROMA KORONER AKUT Wantania, Frans; Lefrandt, Reginald L.
JURNAL BIOMEDIK : JBM Vol 8, No 3 (2016): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.8.3.2016.14149

Abstract

Abstract: Recent studies show that hyperuricaemia plays an important role in endothelial dysfunction results in atherosclerotic plaque and myocardial infarction. Hyperuricemia can induce platelet aggregation in the vessel results in cardiovascular events. Meanwhile, inflammation plays a pivotal role in the development of atherosclerotic procces. Moreover, hyperuricemia produces reactive oxygen species that stimulate lipid peroxidation which could disrupt the biological membrane structure, therefore, triggers atherosclerotic plaque rupture and the occurence of acute coronary syndrome.Keywords: hyperuricemia, acute coronary syndromeAbstrak: Beberapa penelitian telah menunjukkan adanya peran signifikan hiperurisemia terhadap terjadinya disfungsi endotel vaskuler yang akan menyebabkan pembentukan plak ateroslerosis. Hubungan antara peningkatan kadar asam urat dengan aterosklerosis adalah disfungsi endotel dan proses inflamasi. Hiperurisemia menyebabkan terbentuknya agregasi platelet pada pembuluh darah, yang akhirnya mencetus penyakit kardiovaskuler. Bahkan, hiperurisemia menyediakan terbentuknya radikal bebas, reactive oxygen species (ROS) yang menginduksi peroksidasi lipid yang dapat menganggu struktur dan kekentalan membran biologik, sehingga memicu rupturnya plak dan terjadi sindroma koroner akut.Kata kunci: hiperurisemia, sindroma koroner akut
ADIPONECTIN AND TUMOR NECROSIS FACTOR ALPHA LEVELS, AND THEIR CORRELATIONS WITH ENDOTHELIAL DYSFUNCTION IN CENTRAL OBESITY Wantania, Frans; Lefrandt, Reginald L.; Pandelaki, Karel
Jurnal Biomedik : JBM Vol 3, No 3 (2011): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.3.3.2011.876

Abstract

Abstract: Background: In obesity, macrophages that infiltrate into adipose tissues create an inflammatory condition.  Besides that, adipose tissues release proinflammatory cytokines such as TNF alpha. These cytokines promote LDL oxydation by ROS, and accelerate NO degradation resulting in endothelial dysfunction. Adiponectin which could prevent endothelial dysfunction is decreased secondarily to TNF alpha’s action. Objectives: To determine the serum levels of TNF alpha and adiponectin, and their correlations with the endothelial dysfunction. Methods: This was an observational, descriptive, and analytic study with cross sectional. Samples were students of senior high schools in Manado.  Sampling method was carried out consecutively until the required number was enough. Data consisted of age, blood pressure, waist circumference, body weight, lipid profile, creatinin, TNF alpha, adiponectin, and albumin creatinine ratio. We used the Spearman Correlation to analyze the data. Result: Over a 4-month period, there were 35 obese male subjects with ages of 16-18 years old. The average of body weights was 83.23 kg, and of waist circumferences was 103.94 cm.  Endothelial dysfunction was found in 5.72% of samples, high levels of TNF alpha in 68.57% of samples, and low levels of adiponectin in 62.8% of samples.  We found a significant positive correlation between TNF alpha and endothelial dysfunction (r=0.554, p<0.000), and an inverse correlation between adiponectin level and endothelial dysfunction (r = -0.349, p=0.020). Conclusion: There were high levels of TNF alpha in 68.57% of samples and low levels of adiponectin in 62.86% of samples. There was a significant correlation between TNF alpha level and endothelial dysfunction. There was an inverse correlation between adiponectin level and endothelial dysfunction. Key words: obesity, adiponectin TNF alpha, endothelial dysfunction.
Co-Authors Alvisco Belung, Alvisco Bagus Yuvi Setyo Ramadhani Bradley J. Waleleng E. Moeis, E. Emma Sy. Moeis Harlinda Haroen Israel A. Rondonuwu, Israel A. Jeffrey Ongkowijaya Karel Pandelaki Keishi G. D. Masengi, Keishi G. D. Linda Rotty Linda W.A Rotty Pamolango, Fendy Reginald L. Lefrandt Rezuanto Pualillin Savitri, Maghfirah Sedli, Bisuk P. Starry H. Rampengan Stella Palar Tamsil, Yordhan Tjhie, Otto S. Warouw, Finny Wowor, Ribka Yunellia Z. Patasik