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All Journal e-CliniC JURNAL BIOMEDIK The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Harlinda Haroen
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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GAMBARAN GANGGUAN HEMOSTASIS PADA PENDERITA SIROSIS HATI YANG DI RAWAT DI RSUP PROF.DR.R.D.KANDOU PERIODE AGUSTUS 2013 – AGUSTUS 2015 Saragih, Garry G.; Waleleng, Bradley J.; Haroen, Harlinda
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.1.2016.10945

Abstract

Abstract: Liver cirrhosis is a chronic disease characterized by changes in the structure and architecture of the liver parenchyma resulting in liver dysfunction. One of the liver dysfunction is changes in metabolism of proteins that play a role in blood clotting hemostasis). Therefore, one of the complications often found in liver cirrhosis is bleeding. This study aimed to obtain the profile of hemostatic disorder of cirrchosis patients treated in Prof. Dr. R. D. Kandou Hospital Manado from August 2013 toAugust 2015. This was a retrospective descriptive study using the secondary data of the Medical Record. The results showed that there were 75 patients with liver cirrhosis; 34 (45.7%) had impaired hemostasis. The highest proportion of cirrhotic patients with hemostasis disorder was male (67.6%); age group of 51-65 years (55.8%); the most common cause was HBV infection (35.3%); the most often bleeding manifestation was melena (61.7%); and the most common cause of bleeding was esophageal varices (44.1%), prolongation of PT (86.7%) and of APTT (46.7%). Low level of platelets count occured in 85,2% of patients. Conclusion: Almost half of the patients with liver cirrhosis had hemostasis disorders. Prolongation of PT occurred in most of the patients, however, no significant APTT prolongation was found. Thrombocytopenia frequently occured in patients with liver cirrhosis associated with hemostasis disorders. Keywords: hemostatic disorder, PT, thrombocytopenia, cirrchosis  Abstrak: Sirosis hati adalah penyakit hati kronis dimana terjadi perubahan struktur dan arsitektur dari parenkim hati sehingga hati tidak dapat berfungsi dengan baik. Salah satu fungsi hati yang terganggu ialah metabolisme protein yang berperan dalam mengatur fungsi pembekuan darah (hemostasis). Salah satu komplikasi yang sering dijumpai pada sirosis hati adalah perdarahan. Penelitian inin menggunakan metode retrospektif dengan mengambil data sekunder di Instalasi Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado. Dari hasil penelitian diperoleh pasien sirosis hati sebanyak 75 orang, dan 34 orang (45,7%) diantaranya mengalami gangguan hemostasis. Proporsi tertinggi pasien sirosis disertai gangguan hemostasis ialah laki-laki (67,6%); kelompok umur 51-65 tahun (55,8%); penyebab terbanyak infeksi HBV (35,3%); manifestasi perdarahan yang sering muncul ialah melena (61,7%) dengan penyebab perdarahan tersering adalah varises esofagus (44,1%); serta pemanjangan PT (86,7%) dan APTT (46,7%). Nilai trombosit dibawah normal (trombositopenia) terjadi pada 85,2% pasien. Simpulan: Hampir setengah pasien sirosis hati mengalami gangguan hemostasis. Pemanjangan PT terjadi pada sebagian besar pasien yang diperiksa sedangkan pemanjangan APTT tidak signifikan. Trombositopenia sering terjadi pada pasien sirosis hati disertai gangguan hemostasis. Kata kunci: Gangguan hemostasis, PT, trombositopenia, sirosis.
Profil keganasan saluran cerna di RSUP Prof. Dr. R. D. Kandou Manado tahun 2014-2015 Kabo, Def R.M.; Waleleng, Bradley J.; Haroen, Harlinda
e-CliniC Vol 4, No 2 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i2.14492

Abstract

Abstract: Gastrointestinal cancer refers to malignant condition of the gastrointestinal tract and accessory organ of digestion including esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum, and anus. In 2012, WHO reported that the incidence of colorectal cancer was 1.361, gastric cancer was 0.952, and esophageal cancer was 0.456 per 100,000 population. This study was aimed to identify the profile of gastrointestinal malignancy in Prof. Dr. R. D. Kandou Hospital Manado in 2014-2015. This was a retrospective descriptive study based on the data of the Installation of Medical Record of Prof. Dr. R. D. Kandou Hospital Manado of gastrointestinal malignancy cases. There were 39 patients as samples. The majority of cases were male (25 patients; 64.1%), age group 60-69 years (17 patients; 43.6%), had colorectal cancer (35 patients; 89.7%), and adenocarcinoma as the most common type (23 patients; 58.9%). The most common treatment was chemotherapy (14 patients; 35. 9%). Conclusion: In this study, most cases were males aged 60-69 years.Keywords: malignancy, cancer, gastrointestinal. Abstrak: Kanker saluran cerna mengacu pada kondisi keganasan pada saluran pencernaan dan organ aksesori pencernaan, termasuk esofagus, lambung, sistem empedu, pankreas, usus kecil, usus besar, rektum dan anus. Studi oleh WHO tahun 2012 melaoprkan insiden terjadinya kanker kolorektal 1,361, kanker perut/gaster 0,952, dan kanker esofagus 0,456 per 100.000 penduduk. Penelitian ini bertujuan untuk mengetahui profil keganasan saluran cerna di RSUP Prof. dr. R. D. Kandou Manado Tahun 2014-2015. Jenis penelitian ialah deskriptif retrospektif berdasarkan data di Bagian Instalasi Rekam Medik RSUP Prof. dr. R. D. Kandou Manado Tahun 2014-2015 yang menderita keganasan saluran cerna. Sampel penelitian berjumlah 39 kasus. Mayoritas kasus ialah jenis kelamin laki-laki yaitu 25 pasien (64,1%) dan kelompok usia 60-69 tahun yaitu 17 orang (43,6%), menderita kanker kolorektal yaitu 35 kasus (89,7%), adenokarsinoma merupakan jenis kanker tersering yaitu 23 pasien (58,9%). Tatalaksana yang sering dilakukan ialah kemoterapi sebanyak 14 pasien (35,9%). Simpulan: Pada penelitian ini terbanyak pada jenis kelamin laki-laki dan kelompok usia60-69 tahun. Kata kunci: keganasan, kaker, saluran cerna.
Gambaran komponen sindrom metabolik pada pasien kanker payudara di RSUP Prof. Dr. R. D. Kandou Manado tahun 2014 – 2015 Wowor, Kartika; Haroen, Harlinda; Pandelaki, Karel
e-CliniC Vol 4, No 2 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i2.14561

Abstract

Abstract: Metabolic syndrome (MetS) is estimated to become an important factor for the development of certain types of cancer and their mortality inter alia breast cancer. This was a descriptive retrospective study based on secondary data of medical records of breast cancer patients at Prof. Dr. R. D. Kandou Manado Hospital in 2014-2015. The results showed that the most common components of MetS in breast cancer cases were low level of HDL in 67 cases (68%). One component of MetS was found in 46 cases (64%); 3components of MetS in 6 cases (8%); and 4 components of MetS in 8 cases (11%). Family history of cancer was found in 3 cases with breast cancer (1%). Family history of MetS was found in 3 cases; 1 case of hypertension (0.25%) and 2 cases of hypertension and diabetes (0.50%). The most common clinical stage that had MetS components was stage IV in 27 cases (46%). Conclusion: Most breast cancer patients with MetS components had low level of HDL, only had 1 MetS component, family history of breast cancer and some components of MetS, and in clinical stage IV.Keywords: breast cancer, metabolic syndrome Abstrak: Sindrom metabolik diperkirakan menjadi faktor penting perkembangan jenis kanker tertentu dan mortalitasnya, termasuk peningkatan risiko kanker payudara. Jenis penelitian ialah deskriptif retrospektif berdasarkan data sekunder dari catatan rekam medis pasien kanker payudara di RSUP Prof. Dr. R. D. Kandou Manado tahun 2014-2015. Hasil penelitian memperlihatkan komponen SM yang sering ditemukan ialah kadar HDL rendah berjumlah 67 kasus (68%). Kasus yang memiliki 1 komponen yang memenuhi kriteria SM berjumlah 46 data (64%), 3 komponen berjumlah 6 data (8%) dan 4 komponen berjumlah 8 data (11%). Riwayat penyakit keluarga yang menderita kanker didapatkan tiga kasus dengan kanker payudara (1%). Riwayat penyakit keluarga yang mengalami komponen sindrom metabolik pada tiga kasus; satu kasus dengan hipertensi (0,25%) dan dua kasus dengan hipertensi dan diabetes (0,50%). Stadium klinis yang paling sering memiliki komponen sindrom metabolik ialah stadium IV sebanyak 27 kasus (46%). Simpulan: pada sebagian besar pasien kanker payudara yang memiliki komponen SM ditemukan kadar HDL rendah, hanya memiliki 1 komponen SM, riwayat penyakit keluarga berupa kanker payudara dan beberapa komponen sindrom metabolik, serta stadium klinis IV. Kata kunci: kanker payudara, sindrom metabolik
PROFIL KANKER PAYUDARA RSUP PROF. DR. R. D. KANDOU MANADO TAHUN 2013 – 2014 Rondonuwu, Israel A.; Haroen, Harlinda; Wantania, Frans
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i1.10972

Abstract

Abstract: Breast cancer is becoming one health problem worldwide due to the increasing tendency of morbidity and mortality for years. The incidence of breast cancer is increasing in some countries due to the increasing life expectancy, urbanization, and adoption of lifestyle. This study aimed to obtain the profile of breast cancer patients in Prof. Dr. R. D. Kandou Hospital Manado during 2013-2014. This was a retrospective descriptive study using data from medical record in Prof. Dr. R. D. Kandou Hospital Manado. The results showed that there were 151 cases of breast cancer. Most of them were aged 40-49 (61 cases; 43%); senior high school as the highest education (92 cases; 61%). Family history with breast cancer was fouond in only 6 cases (4%). The most common histological type was invasive ductal carsinoma (147 cases; 97.6%). The most common clinical stage was stage IV (96 cases; 63.6%). Conclusion: Most of the breast cancer cases were aged 40-49 years, senior high school, no family history of breast cancer, invasive ductal carcinoma, and clinical stage IV,Keywords: breast cancer, age, education, family history, histopatology type, clinical stage  Abstrak: Kanker payudara masih menjadi salah satu masalah kesehatan yang ada di seluruh dunia karena meningkatnya morbiditas dan mortalitas selama bertahun-tahun. Insiden kanker payudara meningkat di beberapa negara karena meningkatnya harapan hidup, urbanisasi dan adopsi pola hidup. Penelitian ini bertujuan untuk mengetahui profil penderita kanker payudara di RSUP. Prof. Dr. R. D. Kandou Manado tahun 2013-2014. Penelitian ini menggunakan metode deskriptif retrospektif berdasarkan data rekam medik RSUP. Prof. Dr. R. D. Kandou Manado tahun 2013-2014. Hasil penelitian memperlihatkan dari 151 kasus kanker payudara, sebagian besar berusia 40-49 tahun sebanyak 61 kasus (43%) dengan tingkat pendidikan terbanyak SMA sebanyak 92 kasus (61%). Riwayat penyakit keluarga mengalami kanker payudara sebanyak 6 kasus (4%). Jenis histopatologik terbanyak karsinoma duktal invasif sebanyak 147 kasus (97,6%). Stadium klinis yang paling banyak ditemukan yaitu stadium IV sebanyak 96 kasus (63,6%). Simpulan: Pada penelitian ini kanker payudara terbanyak pada usia 40-49 tahun, tingkat pendidikan SMA, tanpa riwayat kanker payudara dalam keluarga, jenis histopatologik karsinoma duktal invasif, dan stadium klinis IV.Kata kunci: kanker payudara, usia, pendidikan, riwayat penyakit keluarga, tipe histopatologi, stadium sklinis.
Gambaran hematologi rutin dan hubungannya dengan rerata gula darah pada pasien diabetes melitus tipe 2 di Poliklinik Endokrin RSUP Prof. Dr. R. D. Kandou Manado Kekenusa, Gita C.; Pandelaki, Karel; Haroen, Harlinda
e-CliniC Vol 4, No 2 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i2.14769

Abstract

Abstract: Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia due to a defect in insulin action, insulin secretion by pancreatic beta cells or both. In patients with type 2 diabetes (T2DM), trombopoiesis acceleration and increased turnover and increased hematocrit occur resulting in impaired blood flow velocity. This increased blood viscosity causes vasoconstriction due to thickening of blood vessel walls.This study was aimed to obtain the profile of hematology and its correlation with average blood glucose in type 2 DM patients. This was a descriptive analytical study using patients’ medical record in the Endocrine Clinic of Prof. Dr. R. D. Kandou Hospital Manado from August to October 2016. The results of Spearman’s correlation test were as follows: correlation between average blood glucose and hemoglobin concentration with r = 0.083 and p = 0.272; correlation between average blood glucose and levels of hematocrit with r = 0.123 and p = 0.184; correlation between the average glucose blood and levels of erythrocyte with r = 0.121 and p = 0.187; correlation between average blood glucose and platelet with r = 0.052 and p = 0.353; and correlation between average blood glucose and levels of leukocytes with r = 0.247 and p = 0.033. Conclusion: Among type 2 DM patients, there were no significant correlations between average blood glucose level and hemoglobin, hematocrit, and erythrocyte levels, as well as platelet levels. However, there was a significant correlation between average blood glucose and leukocyte level.Keywords: T2 DM, average blood glucose, hemoglobin, hematocrit, platelets Abstrak: Diabetes Melitus (DM) merupakan suatu kelompok penyakit metabolik yang ditandai oleh hiperglikemia akibat defek pada kerja insulin, sekresi insulin oleh sel beta pancreas, atau keduanya. Pada pasien DM tipe 2 (DMT2) terjadi percepatan trombopoiesis serta peningkatan pergantian trombosit dan hematokrit yang dapat berakibat terhadap kecepatan aliran darah. Viskositas darah yang meningkat dapat menyebabkan terjadinya vasokonstriksi akibat penebalan dinding pembuluh darah. Penelitian ini bertujuan untuk mengetahui gambaran hematologi dan hubungannya dengan rerata gula darah pada pasien DM tipe 2. Jenis penelitian ini deskriptif analitik dengan menggunakan data rekam medik pasien di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado periode Agustus-Oktober 2016. Hasil uji korelasi Spearman memperlihatkan nilai hubungan antara rerata gula darah dan kadar hemoglobin r = 0,083 dan p = 0,272; nilai hubungan antara rata-rata gula darah dan kadar hematocrit r = 0,123 dan p = 0,184; nilai hubungan antara rata-rata gula darah dan kadar eritrosit r = 0,121 dan p = 0,187; nilai hubungan antara rata-rata gula darah dan trombosit r = 0,052 dan p = 0,353, serta nilai hubungan antara rata-rata gula darah dan kadar leukosit r = 0,247 dan p = 0,033. Simpulan: Pada pasien DMT 2 tidak dijumpai hubungan bermakna antara rerata gula darah dengan kadar hemoglobin, kadar hematokrit, kadar eritrosit, dan kadar trombosit namun terdapat hubungan bermakna antara rerata gula darah dan leukosit.Kata kunci: DMT2, rerata gula darah, hemoglobin, hematokrit, trombosit
Profil Tumor Solid pada Pasien Rawat Inap di Bagian KSM Ilmu Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado Periode Januari 2013-Desember 2014 Kandow, Krisye M.; Rotty, Linda W.A.; Haroen, Harlinda
e-CliniC Vol 5, No 1 (2017): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v5i1.15888

Abstract

Abstract: Solid tumor is an abnormal swelling in the human body caused by a number of diseases, such as malignancy (cancer). This was a descriptive retrospective study involving all medical record data of solid tumor patients treated in Prof. Dr. R. D. Kandou Hospital Manado from January 2013 through December 2014. The most frequently found tumor was breast cancer (181 people; 28.8%) and the least one was nasopharyngeal cancer (6 patients; 1%). The majority of patients were 50-59 years old (180 patients; 28.7%) and the least found were 20-29 years old (7 patients; 1.1%). Females (460 patients; 73.2%) were more commonly found than males (168 patients; 26.8%). The occupation of most patients was housewives (287 patients; 45.7%), and the least found was university/high school students (3 patients; 0.5%). The type of tumor according to gender was breast cancer in females (181 patients; 28.8%) and most of the patients were aged 40-49 years old and 50-59 years old (each of 61 patients; 9.7%). Conclusion: Solid tumor was most commonly found in females, aged 50-59 years old, and housewives; breast cancer had the highest percentage.Keywords: solid tumor, carcinoma, mortality Abstrak: Tumor solid adalah bentuk benjolan yang tidak normal dalam tubuh, yang disebabkan oleh berbagai macam penyakit, antara lain keganasan (kanker). Penelitian ini bertujuan untuk mendapatkan profil tumor solid pada pasien rawat inap di Bagian KSM Ilmu Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2013-Desember 2014. Jenis penelitian ialah deskriptif retrospektif dengan menggunakan seluruh data rekam medis status pasien tumor solid yang dirawat di RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2013-Desember 2014. Hasil penelitian memperlihatkan tumor terbanyak ialah karsinoma mammae (181 pasien; 28,8%) dan yang paling sedikit karsinoma nasofaring (6 orang; 1%). Sampel penelitian terbanyak berusia 50-59 tahun (180 pasien; 28,7%) dan yang paling sedikit berusia 20-29 tahun (7 pasien; 1,1%). Sampel berjenis kelamin perempuan sebanyak 460 pasien (73,2%) dan jenis kelamin laki-laki 168 pasien (26,8%). Pekerjaan pasien yang tersering ialah sebagai ibu rumah tangga (287 pasien; 45,7%) dan yang paling sedikit mahasiswa/pelajar (3 pasien; 0,5%). Jenis tumor berdasarkan jenis kelamin ditemukan sebagian besar pasien perempuan menderita karsinoma mammae (181 pasien; 28,8%), berusia 40-49 tahun dan 50-59 tahun (masing-masing 61 pasien; 9,7%). Simpulan: Tumor solid lebih sering ditemukan pada jenis kelamin perempuan, kelompok usia 50-59 tahun, pekerjaan sebagai ibu rumah tangga; karsinoma mammae dengan persentase tertinggi.Kata kunci: tumor solid, karsinoma, mortalitas
PROFILE OF ANEMIA FROM JANUARY TO DECEMBER 2010 AT PROF. Dr. R. D. KANDOU HOSPITAL MANADO Jim, Edwin; Haroen, Harlinda; Rotty, Linda W A
Jurnal Biomedik : JBM Vol 4, No 3 (2012): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.4.3.2012.797

Abstract

Abstrak: Anemia merupakan salah satu masalah kesehatan masyarakat yang paling tersebar, terutama di negara berkembang, dengan konsekuensi ekonomi, sosial, kesehatan, dan kesejahteraan yang penting. Anemia dapat disebabkan oleh penyebab terkait nutrisi, keganasan, penyakit infeksi/inflamasi dan juga kehilangan darah. Studi ini merupakan studi deskriptif retrospektif pada pasien rawat inap dengan anemia sejak Januari-Desember 2010 di ruang perawatan Penyakit Dalam RSUP. Prof. Dr. R.D. Kandou Manado. Diagnosis ditegakkan berdasarkan kriteria WHO untuk hemoglobin (Hb) (< 13 g% pada laki-laki dan < 12 g% pada perempuan yang tidak hamil). Data dikelompokkan berdasarkan gender, usia, dan penyakit terkait. Pasien rawat inap selama Januari - Desember 2010 sebanyak 1.457 laki-laki dan 1.142 perempuan. Anemia ditemukan sebanyak 251 kasus (17,22%) pada laki-laki dan 205 kasus (17,95%) pada perempuan. Pada kedua kelompok, anemia tersering pada usia > 60 tahun (pada laki-laki 40,63%, perempuan 43,41%). Jenis anemia sedang (Hb 6-10 g%) yang tersering ditemukan (pada laki-laki 57,76%, perempuan 58,04%). Penyakit ginjal kronik merupakan penyakit yang tersering ditemukan baik pada pasien anemia laki-laki (34,26%) maupun perempuan (49,75%). Simpulan: kejadian anemia pada kedua kelompok gender hampir sama banyak, dan yang paling sering ditemukan ialah anemia sedang pada usia > 60 tahun, dengan penyerta tersering penyakit ginjal kronik.Kata kunci: anemia, hemoglobin, penyakit ginjal kronik.Abstract: Anemia is one of the most widespread public health problems, especially in developing countries, and has important health, welfare, social, and economic consequences. Anemia can result from nutrition-related causes, malignancy, inflammatory/infectious diseases, as well as from blood loss. This was a retrospective descriptive study of anemic in-patients from January to December 2010 at the Internal Medicine ward of Prof. Dr. R. D. Kandou Hospital Manado. Diagnosis was based on WHO criteria for hemoglobin (< 13 g% for males, < 12 g% for non-pregnant females). Data was divided based on gender, age, and related-diseases. There were 1,457 male and 1,142 female in-patients. Anemia was found in 251 cases (17.22%) in male in-patients, and 205 cases (17.95%) in female in-patients. In both groups, the most frequent cases were found at age > 60 years. Moderate anemia (Hb 6-10 g%) was the most frequent anemia (males 57.76%, females 58.04%). Chronic kidney diseases were the most related diseases found in both groups. Conclusion: the occurrences of anemia in both genders were nearly the same. Besides that, the most frequent cases in both genders were moderate anemia at age > 60 years, and the most common related disease was chronic kidney disease.Keywords: anemia, hemoglobin, chronic kidney disease
Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia Adiwinata, Randy; Waleleng, Bradley Jimmy; Haroen, Harlinda; Rotty, Linda; Gosal, Fandy; Rotty, Luciana; Hendratta, Cecillia; Lasut, Pearla; Winarta, Jeanne; Waleleng, Andrew; Tendean, Michael
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202398-101

Abstract

L-Asparaginase is one of the main chemotherapy regiments for acute lymphocytic leukemia (ALL) management. Acute pancreatitis is one of the serious side effects of l-asparaginase administration and may lead to interruption of chemotherapy cycle. Long term complications may be devastating for patients which include of pseudocyst pancreas and chronic pancreatitis. Asparaginase induced pancreatitis is rare among adult due to the nature of ALL which commonly occurred in children population. The pathophysiology of asparaginase induced pancreatitis is still unclear. Here we present 18-year-old male with ALL and asparaginase induced acute necrotizing pancreatitis which complicated to chronic pancreatitis and pseudocyst. 
Co-Authors Bradley J. Waleleng Bradley Jimmy Waleleng Edwin Jim Fandy Gosal Frans Wantania Garry G. Saragih, Garry G. Hendratta, Cecillia Israel A. Rondonuwu, Israel A. Kabo, Def R.M. Kandow, Krisye M. Karel Pandelaki Kekenusa, Gita C. Linda Rotty Linda W A Rotty Luciana Rotty, Luciana Pearla Lasut Randy Adiwinata, Randy Rotty, Linda W.A. Tendean, Michael Waleleng, Andrew Winarta, Jeanne Wowor, Kartika