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All Journal e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK Jurnal Kedokteran Klinik
Frans Wantania
Medical Faculty Sam Ratulangi University Manado
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Journal : JURNAL BIOMEDIK

 1 
Pengaruh Pemberian Alopurinol terhadap Tekanan Darah Pasien Gagal Jantung Wowor, Ribka; Wantania, Frans
Jurnal Biomedik : JBM Vol 10, No 1 (2018): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.10.1.2018.18997

Abstract

Abstract: Hyperuricemia is an independent risk factor of hypertension. Most of heart failure patients with uncontrolled hypertension had hyperuricemia. This study was aimed to determine the effect of allopurinol to blood pressure in heart failure patients. This was a clinical trial study with a control-non randomized design, performed on heart failure patients (40-74 years old). Wilcoxon Sign Rank was used to test the means of blood pressure difference between after and before the allopurinol treatment. The results showed that there were no significant differences in mean blood pressure between before and after allopurinol treatment (SBP, P=0.650; DBP, P=0.356). Conclusion: There was a decrease of blood pressure in heart failure patients after allopurinol treatment; albeit, it was not statistically significan.Keywords: allopurinol, blood pressure, heart failureAbstrak: Hiperurisemia merupakan salah satu faktor risiko independen terhadap timbulnya hipertensi. Pasien gagal jantung dengan tekanan darah tidak terkontrol sering mengalami hiperurisemia. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian alopurinol terhadap tekanan darah pada pasien gagal jantung. Penelitian ini merupakan uji klinis terbuka tanpa randomisasi untuk meneliti pengaruh pemberian alopurinol pada terapi standar congestive heart failure (CHF). Beda rerata tekanan darah pre dan post diuji menggunakan Wilcoxon Sign Rank. Hasil penelitian menunjukkan pada kelompok alopurinol didapatkan penurunan tekanan darah sesudah pemberian alopurinol walaupun perbedaan rerata pre-post TDS (P=0,650) dan perbedaan rerata pre-post TDD tidak bermakna (P=0,356). Simpulan: Pasien CHF yang diberikan alopurinol mengalami penurunan tekanan darah walaupun secara statistik tidak bermaknaKata kunci: alopurinol, tekanan darah, gagal jantung
HIPERURISEMIA DAN SINDROMA KORONER AKUT Wantania, Frans; Lefrandt, Reginald L.
JURNAL BIOMEDIK : JBM Vol 8, No 3 (2016): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.8.3.2016.14149

Abstract

Abstract: Recent studies show that hyperuricaemia plays an important role in endothelial dysfunction results in atherosclerotic plaque and myocardial infarction. Hyperuricemia can induce platelet aggregation in the vessel results in cardiovascular events. Meanwhile, inflammation plays a pivotal role in the development of atherosclerotic procces. Moreover, hyperuricemia produces reactive oxygen species that stimulate lipid peroxidation which could disrupt the biological membrane structure, therefore, triggers atherosclerotic plaque rupture and the occurence of acute coronary syndrome.Keywords: hyperuricemia, acute coronary syndromeAbstrak: Beberapa penelitian telah menunjukkan adanya peran signifikan hiperurisemia terhadap terjadinya disfungsi endotel vaskuler yang akan menyebabkan pembentukan plak ateroslerosis. Hubungan antara peningkatan kadar asam urat dengan aterosklerosis adalah disfungsi endotel dan proses inflamasi. Hiperurisemia menyebabkan terbentuknya agregasi platelet pada pembuluh darah, yang akhirnya mencetus penyakit kardiovaskuler. Bahkan, hiperurisemia menyediakan terbentuknya radikal bebas, reactive oxygen species (ROS) yang menginduksi peroksidasi lipid yang dapat menganggu struktur dan kekentalan membran biologik, sehingga memicu rupturnya plak dan terjadi sindroma koroner akut.Kata kunci: hiperurisemia, sindroma koroner akut
ADIPONECTIN AND TUMOR NECROSIS FACTOR ALPHA LEVELS, AND THEIR CORRELATIONS WITH ENDOTHELIAL DYSFUNCTION IN CENTRAL OBESITY Wantania, Frans; Lefrandt, Reginald L.; Pandelaki, Karel
Jurnal Biomedik : JBM Vol 3, No 3 (2011): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.3.3.2011.876

Abstract

Abstract: Background: In obesity, macrophages that infiltrate into adipose tissues create an inflammatory condition.  Besides that, adipose tissues release proinflammatory cytokines such as TNF alpha. These cytokines promote LDL oxydation by ROS, and accelerate NO degradation resulting in endothelial dysfunction. Adiponectin which could prevent endothelial dysfunction is decreased secondarily to TNF alpha’s action. Objectives: To determine the serum levels of TNF alpha and adiponectin, and their correlations with the endothelial dysfunction. Methods: This was an observational, descriptive, and analytic study with cross sectional. Samples were students of senior high schools in Manado.  Sampling method was carried out consecutively until the required number was enough. Data consisted of age, blood pressure, waist circumference, body weight, lipid profile, creatinin, TNF alpha, adiponectin, and albumin creatinine ratio. We used the Spearman Correlation to analyze the data. Result: Over a 4-month period, there were 35 obese male subjects with ages of 16-18 years old. The average of body weights was 83.23 kg, and of waist circumferences was 103.94 cm.  Endothelial dysfunction was found in 5.72% of samples, high levels of TNF alpha in 68.57% of samples, and low levels of adiponectin in 62.8% of samples.  We found a significant positive correlation between TNF alpha and endothelial dysfunction (r=0.554, p<0.000), and an inverse correlation between adiponectin level and endothelial dysfunction (r = -0.349, p=0.020). Conclusion: There were high levels of TNF alpha in 68.57% of samples and low levels of adiponectin in 62.86% of samples. There was a significant correlation between TNF alpha level and endothelial dysfunction. There was an inverse correlation between adiponectin level and endothelial dysfunction. Key words: obesity, adiponectin TNF alpha, endothelial dysfunction.
Masalah Kesehatan pada Lansia: Sindroma Frailty Wowor, Ribka; Wantania, Frans
Jurnal Biomedik : JBM Vol 12, No 2 (2020): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.12.2.2020.29162

Abstract

Abstract: Frailty Syndrome is a geriatric syndrome with characteristics of reduced functional ability and adaptation functions that caused by the decline in various body systems and also increased susceptibility to various stress, which decreases a person’s functional performance. The prevalence of frailty syndrome ranges from 7% at the age above 65 years and 30% at ages above 80 years. Research on Caucasian races, women suffer more frailty than men (7:5), while in the African American group found twice that of Caucasians (14:7). Generally, to determine a frailty syndrome we used the Fried’s clinical criteria when there are three or more of the weaknesses such as, reduced road speed, complaints of fatigue, decreased activity, and weight loss. The clinical picture of frailty syndrome is based on weakness, reduced walking speed, fatigue, low physical activity, and weight loss. The diagnosis is based on clinical signs and symptoms and their comorbidities.Keywords: frailty syndrome, weakness Abstrak: Sindroma frailty adalah suatu sindroma geriatri dengan karakteristik berkurangnya kemampuan fungsional dan gangguan fungsi adaptasi yang diakibatkan oleh merosotnya berbagai sistem tubuh, serta meningkatnya kerentanan terhadap berbagai macam stressor, yang menurunkan performa fungsional seseorang. Prevalensi sindroma frailty berkisar 7% pada usia diatas 65 tahun dan 30% pada usia diatas 80 tahun. Penelitian terhadap ras Kaukasia, perempuan lebih banyak menderita frailty dibandingkan laki-laki (7:5), sedangkan pada kelompok Afrika-Amerika didapatkan dua kali lipat dibandingkan ras Kaukasia (14:7). Umumnya, untuk menentukan suatu sindroma frailty dipergunakan kriteria klinis dari Fried yaitu bila terdapat tiga atau lebih dari kelemahan, berkurangnya kecepatan jalan, keluhan cepat lelah, menurunnya aktivitas, dan berkurangnya berat badan. Gambaran klinis sindroma frailty berdasarkan adanya kelemahan, berkurangnya kecepatan jalan, rasa cepat lelah, aktivitas fisik yang rendah, dan hilangnya berat badan. Diagnosis didasarkan atas tanda dan gejala klinis serta penyakit komorbidnya.Kata kunci: sindrom frailty, kelemahan
Co-Authors Alvisco Belung, Alvisco Bagus Yuvi Setyo Ramadhani Bradley J. Waleleng E. Moeis, E. Emma Sy. Moeis Harlinda Haroen Israel A. Rondonuwu, Israel A. Jeffrey Ongkowijaya Karel Pandelaki Keishi G. D. Masengi, Keishi G. D. Linda Rotty Linda W.A Rotty Pamolango, Fendy Reginald L. Lefrandt Rezuanto Pualillin Savitri, Maghfirah Sedli, Bisuk P. Starry H. Rampengan Stella Palar Tamsil, Yordhan Tjhie, Otto S. Warouw, Finny Wowor, Ribka Yunellia Z. Patasik