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All Journal PHARMACON CHEMISTRY PROGRESS
Frenly Wehantouw
Jurusan Farmasi Fak MIPA UKIT Tomohon Hl Kampus Unsrat, Bahu Manado 95115
Chemistry Medicine & Pharmacology

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UJI FITOKIMA DAN AKTIVITAS ANALGESIK EKSTRAK ETANOL TANAMAN KUCING-KUCINGAN (Acalypha indica L.) PADA TIKUS PUTIH BETINA GALUR WISTAR (Rattus norvegicus L) Wemay, Miranti Aike; Fatimawali, Fatimawali; Wehantouw, Frenly
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2314

Abstract

ABSTRACTThis research aims to determine the phytochemical compounds and testing the analgesiceffects of ethanol extract of kucing-kucingan plant (Acalypha indica Linn.). Phytochemicaltesting conducted according to Harbone methods and analgesic activity of rats reaction timeis determined based on the thermal response after giving the ethanol extract of A indica L.This study used 20 female Wistar rats were divided into a treatment group was given 0,035mg / kg extract of leaves, stems and roots, negative control receive aquadest and positivecontrol using aspirin. Reaction time data were analyzed using One Way ANOVA followed byDuncan's test multipe Range Test. The results showed that the ethanol extract of A.indica L.contains alkaloids and saponins in the extract while the third type of flavonoid and tanninfound only in leaf extracts. Testing the analgesic activity of ethanol extract A. indica L.showed that the leaf extract gave the highest reaction time of 3.16 seconds, and stem and rootextracts followed by 1.72 seconds and 2.85 seconds. Reaction time in rats given leaf extractA.indica L. did not give significantly different with aspirin group (P> 0:05).Keywords : Phytochemical testing, analgesic, ethanol extract of kucing-kucingan (A.indicaL.).ABSTRAKPenelitian ini bertujuan untuk mengetahui senyawa fitokimia dan menguji efek analgetik
ANALISIS KANDUNGAN AKRILAMIDA DALAM UBI GORENG YANG DIJUAL DI KOTA MANADO MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI (KCKT) Sengke, Clara A.; Citraningtyas, Gayatri; Wehantouw, Frenly
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2388

Abstract

ABSTRACTAcrylamide is caused by a high temperature (more than 1200C) in the food that contains highcarbohydrate. Acrylamide was classified as senyawa that caused cancer or have highpotention as carcinogenic compound in the human body. Junk food which mostly eaten bypeople is fries. The aims of this research were to identify how much acrylamide was containsin sweet potato fries that has been sell at Manado City using High Performance LiquidChromatography (HPLC) method. The samples that has been identified is came from 7 storein 7 sub district at Manado City. In this research, the acrylamide were analysed with HighPerformance Liquid Chromatography using Shim-Pack VP-ODS (4,6 x 250 mm) column,comparison of mobile phase acetonitrile and phosphate acid 11,45 mM (20 : 80), flow rate 1ml/minute and at wave length 210 nm. The result shows acrylamide found in sweet potatofries with retention time ±3,311 minutes. Acrylamide that contains in sweet potato frieswhich has been sell in Manado City were 118,54-866,75 μg/kg. Acrylamide level that foundin sweet potato fries is still under lethal dose.Keywords : Acrylamide, sweet potato fries, HPLC, Manado
Analisis Kandungan Akrilamida Dalam Pisang Goreng Yang Beredar di Kota Manado Menggunakan Kromatografi Cair Kinerja Tinggi (KCKT) Tandi, Debora; Fatimawali, Fatimawali; Wehantouw, Frenly
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.490

Abstract

Acrylamide can be formed as a consequence of heating athigh temperature (more than1200C) in food contains high of carbohydrate. Acrylamide was classified as carcinogeniccompound to human being. Junk food which mostly eaten by people is fries. The objectiveof this research is to identify acrylamide in banana fries marketed in Manado city usingHigh Performance Liquid Chromatography (HPLC). Samples were taken from 12 places,by 6 sub district Manado City. Acrylamide were analyzed by HPLC using Shim-Pack VPODS(4,6 x 250 nm) column, comparison of mobile phase acetonitrile and phospate acid11,45 mM (5:95), flow rate 1 ml/minuteand at wave lenght 210 nm. The result shows thatAcrylamide contains in banana fries with retention time ±4,284 minutes. Acrylamidecontained in banana fries which marketed in Manado City were 39,65 – 1789,52 μg/kg.Acrylamide level in banana fries is at under lethal dose (LD50)Keywords : Acrylamide, banana fries, HPLC, Manado
PENGARUH FOTOOKSIDASI TERHADAP AKTIVITAS ANTIOKSIDAN VIRGIN COCONUT OIL Wehantouw, Frenly; Roreng, Matheda K
CHEMISTRY PROGRESS Vol 14, No 2 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.14.2.2021.37288

Abstract

ABSTRAK Virgin Coconut Oil (VCO) merupakan produk olahan kelapa tanpa pemanasan. VCO merupakan produk yang memiliki aktivitas antioksidan. Tujuan penelitian yaitu menguji aktivitas antioksidan Virgin Coconut Oil yang diberikan pencahayaan. Sistem fotooksidasi menggunakan kota cahaya yang dimodifikasi menggunakan lampu fluorescen. Fotooksidasi VCO menggunakan eritrosin sebagai sensitizer. Aktivitas antioksidan diuji menggunakan metode penangkalan radikal bebas DPPH, selanjutnya nilai IC50 ditentukan menggunakan analisis probit. Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi VCO maka aktivitas antioksidan akan semakin tinggi, nilai IC50 sebesar 12,02%. Aktivitas antioksidan Virgin Coconut Oil yang dicahaya selama 7 jam mengalami menurunan menjadi 96,13%. Larutan VCO yang mengandung eritrosin mengalami penurunan absorbansi sebesar 0,121 selama proses fotooksidasi. Kesimpulan penelitian ini ialah cahaya menyebabkan reaksi fotooksidasi sehingga menurunkan aktivitas antioksidan VCO.ABSTRACT Virgin Coconut Oil is a coconut processed product without heating. VCO is a product that has antioxidant activity. The research objective was to test the antioxidant activity of Virgin Coconut Oil under lighting. Photooxidation system using a modified light box of fluorescent light, while its antioxidant activity was tested using the DPPH free radical scavenging method, the IC50 value was determined using probit analysis. The results showed that the higher the VCO concentration, the higher the antioxidant activity. Antioxidan activity of Virgin Coconut Oil that is exposed to light decreased to 96.13%. The absorbance of VCO solution containing erythrosine as sensitizer decreased to 0.121 due to photooxidation. The conclusion of this study is that light will cause a photooxidation reaction, thereby reducing the antioxidant activity of VCO.
Co-Authors Clara A. Sengke Debora Tandi Dewa Gede Katja Edi Suryanto Edwin Paendong Fatimawali . Feti Fatimah Gabriela Clementine Ranti Gayatri Citraningtyas John Monintja Mamondol, Oktavianus Mercy Taroreh Miranti Aike Wemay Momuat, Lidya Novel Kojong Roreng, Matheda K Sherly Dawile