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All Journal INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Buletin Udayana Mengabdi Jurnal Farmasi Udayana
I.N.K. Widjaja
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Chemistry Dentistry Education Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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SOSIALISASI DAN PELATIHAN REGENERASI MINYAK JELANTAH DENGAN JERAMI PADI (ORIZA SATIVA) KEPADA PEDAGANG GORENGAN DI PASAR MALAM BUKIT JIMBARAN, BADUNG, BALI A.A.R.P Dewi; M. Oka; D.A.F Sari; N.K.D Triastuti; A.A.M.A.M. Putra; I.N.K. Widjaja
Buletin Udayana Mengabdi Vol 15 No 3 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

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Abstract

Penggunaan minyak goreng yang berulang-ulang dapat menurunkan kualitas minyak goreng baik secarafisika maupun kimia. Jerami padi dapat digunakan sebagai adsorben dalam pemurnian minyak goreng bekaspakai. Dengan pemurnian minyak jelantah tentu sangat membantu pedagang gorengan kecil menekan biayaoperasional. Target khususnya adalah untuk meningkatkan wawasan dan ketrampilan pedagang gorengandalam pemurnian minyak jelantah, sehingga dalam jangka panjang dapat membantu memperbaiki keadaanperekonomian pedagang melalui penghematan yang cerdas. Kegiatan pemberdayaan ini diberikan kepadapedagang gorengan yang berjualan di areal Pasar Malam Bukit Jimbaran. Metode yang digunakan yaitusosialisasi mengenai bahaya penggunaan minyak jelantah dan pelatihan pemurnian minyak jelantah. Selainitu dilakukan pula upaya evaluasi dan monitoring terhadap pelaksanaan penjernihan mandiri. Melaluikegiatan pemberdayaan ini pedagang akan memperoleh pengetahuan arti penting menjaga kualitas produkdan terampil dalam hal regenerasi minyak jelantah. Dari kegiatan pemberdayaan ini terlihat antusiasme yangbesar dari peserta dalam mengikuti program dan secara umum peserta dapat melakukan penjernihan secaramandiri.
TINGKAT KEPUASAN PASIEN TERHADAP PENGGUNAAN OBAT GENERIK DAN OBAT GENERIK BERMEREK (BRANDED GENERIC) PADA PASIEN RAWAT JALAN DI BADAN RUMAH SAKIT UMUM TABANAN L.P.F. Larasanty,; I.N.K. Widjaja; N.K.W Prasminda; N.L.P.U Antari; N.L.P.D. Wulandari; R.A.D. Puspitasari; N.M.F Irmayanti; P.P. Andiani
Jurnal Farmasi Udayana Vol. 5, No. 1, Tahun 2016
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Perbedaan jumlah penggunaan obat generik dan obat generik bermerek salah satunya dapat disebabkan oleh adanya perbedaan kepuasan pasien. Kaptopril merupakan jenis obat antihipertensi lini pertama yang ada dipasaran dalam bentuk produk generik dan produk generik bermerek. Kaptopril digunakan secara luas dan digunakan dalam jangka waktu panjang oleh pasien hipertensi. Penelitian ini bertujuan untuk mengetahui tingkat kepuasan pasien hipertensi di Badan Rumah Sakit Umum Tabanan terhadap penggunaan obat kaptopril generik dan obat kaptopril generik bermerek. Kepuasan pasien diukur dengan menggunakan skor gap. Skor gap diperoleh dengan membandingkan antara harapan dan persepsi pasien terhadap penggunaan obat kaptopril generik dan kaptopri generik bermerek. Harapan dan persepsi pasien diukur menggunakan skala likert dalam kuisioner yang berisi pernyataan tentang core product, actual product dan augmented product. Data yang diperoleh dianalisis dengan uji statistik parametrik menggunakan uji t berpasangan dengan taraf kepercayaan 95%. Empat puluh sembilan orang responden ikut serta dalam penelitian. Hasil penelitian menunjukkan harapan pasien yang tinggi baik pada penggunaan kaptopril generik maupun kaptopril generik bermerek. Tingkat kepuasan pasien hipertensi di Badan Rumah Sakit Umum Tabanan terhadap penggunaan obat kaptopril generik dan kaptopril generik bermerek termasuk dalam kategori sedang dan tidak terdapat perbedaan yang signifikan antara kepuasan pasien terhadap penggunaan kedua jenis obat tersebut (p > 0,05).
STUDI PENDAHULUAN DERIVATISASI BEBERAPA SENYAWA DENGAN GUGUS AMIN MENGGUNAKAN DANSIL KLORIDA PADA KLT-SPEKTROFOTODENSITOMETER Dewi Puspita Apsari; Ni Putu Linda Laksmiani; I.N.K. Widjaja
Jurnal Farmasi Udayana Vol. 1, No. 1, Tahun 2012
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Advance derivatization study of several amines with dansyl chloride has been carried out. The aim of this study was to determine influence of molecul structures compound toward dansylation. Derivatization was done by reacting  4000 ng drugs which contain primary or secondary amine group with 100 ng dansyl chloride at a temperature 450 C and pH 9 for a hour. Interference was separated using stationary phase silica G60 and mobile phase  etyl acetat : methanol : ammonia (85:10:5), detection on spectrophotodensytometer ?eks 312 nm mode fluorescence with filter K400. Compounds that have a primary or secondary amine groups can be derivatized using  dansyl chloride though that most affects  of  the reaction is  rigidity of molecul structure. Differences fluorescence intensity between each derivatives influenced by the reactivity amine groups and steric hindrance of the compound.
PENGARUH VARIASI KEPOLARAN FASE GERAK ASETON-DIKLOROMETANA: METANOL-ASAM ASETAT TERHADAP % DISTRIBUSI (+)-KATEKIN DARI GAMBIR DENGAN METODE KROMATOGRAFI CAIR VAKUM Era S.Y.,; Eka L; I.N.K. Widjaja
Jurnal Farmasi Udayana Vol. 1, No. 1, Tahun 2012
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

The research was conducted to determine the influence of mobile phase polarity of acetone-dichloromethana : methanol-acetic acid on the percent distribution of (+)-catechin from gambier by vacuum liquid chromatography and to determine the polarity mobile phase required to obtain the largest amount of (+)-catechin percent distribution. Gambier extract was fractionated using vacuum liquid chromatography with several variations of polarity of acetone-dichloromethane : methanol-acetic acid mobile phase expressed by the dielectric constant value (?) of 13.74 to 17.51. Fractions were analyzed by TLC-spectrophotodensitometer to calculate the concentration and the percent distribution of (+)-catechin. To know the effect of variations in mobile phase polarity on the percent distribution of (+)-catechin performed statistical analysis using one-way ANOVA test (? = 0.05). The results show that the variation of polarity of acetone-dichloromethane : methanol-acetic acid mobile phase (? = 13.74 to 17.51) had a significant influence on percent distribution of (+)-catechin from gambier by vacuum liquid chromatography method (p <0.05). Fraction with a mobile phase of acetone-dichloromethane (4:6) 50% : methanol-acetic acid (3:4) 50%, which had a value of dielectric constant of 15.62 yield the largest amount of (+)-catechin percent distribution value (45.40%).
UJI AKTIVITAS PENANGKAPAN RADIKAL DPPH EKSTRAK PRODUK TEH HITAM (Camellia sinensis (L.) O.K.) DAN GAMBIR (Uncaria gambir (Hunter) Roxb) SERTA PROFIL KLT-DENSITOMETERNYA Jaya, I. G. N. I. P; Leliqia N. P. E; I.N.K. Widjaja
Jurnal Farmasi Udayana Vol. 1, No. 1, Tahun 2012
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

The purpose of this research was to compare the DPPH scavenging activity of black tea (Camellia sinensis (L.) OK) and gambier (Uncaria gambir (Hunter) Roxb) product extract and to determine their TLC-densitometer profile. This research was conducted in two stages, first stage was to examine the DPPH scavenging activity of black tea and gambier product extract. This assay used some concentrations of black tea product extract, gambier product extract, and standard vitamin C (10, 20, 40, 80, 160, 200, and 320 µg/mL). The second stage was to determine the extracts profile by TLC-densitometer. The result of this research showed that the DPPH scavenging activity of gambier product extract was greater (IC50 = 88,57±0,64 µg/mL) than black tea product extract (IC50 = 311,54±2,79 µg/mL). The result of profile determination of black tea product extract at a mobile phase of MeOH:toluene (50:50) showed that no spot was supposed a volatile oil group; at mobile phase of ethyl acetate:formic acid:acetic acid:H2O (100:11:11:26) showed two spots that was supposed a flavonoid group, spot with Rf 0,41 (?max 365 nm) and spot with Rf 0,97 (?max 280 nm); at mobile phase of CHCl3:MeOH (90:10) showed that spot with Rf 0,87 (?max 275 nm) was supposed an alkaloid group; at mobile phase of acetic acid:diethyl ether:n-hexane:ethyl acetate (20:20:20:40) showed that spot with Rf 0,62 (?max 290 nm) was supposed a tannin group. While the result of profile determination of gambier product extract at mobile phase of ethyl acetate:formic acid:acetic acid:H2O (100:11:11:26) showed two spots that was supposed a flavonoid group, spot with Rf 0,81 (?max 280 nm) and spot with Rf 0,92 (?max 280 nm); at mobile phase of acetic acid:diethyl ether:n-hexane:ethyl acetate (20:20:20:40) showed that spot with Rf 0,42 (?max 285 nm) was supposed a tannin group.
DERIVATISASI MORFIN MENGGUNAKAN DANSIL KLORIDA UNTUK MENINGKATKAN KEPEKAAN DETEKSI MORFIN PADA METODE KLT- SPEKTROFOTODENSITOMETER L.P. Ari Chandrayan; N.P. Linda L.; I.N.K. Widjaja
Jurnal Farmasi Udayana Vol. 1, No. 1, Tahun 2012
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Fluorescence detection could be used for enhance  the  sensitivity of morphine  detection  by TLC-Spectrophotodensytometry. Morfin is a compound  that fluoresces intrinsically incapable. ence, morphine  was derivatized using dansyl chloride. Morphine was derivatized by two methods, derivatization in solution and overspotting method. The derivatization reaction was kept at pH 9 and 450  C for 20 minute. The ratio between dansyl chloride and analyte concentration was 6:1. The derivatization result was separated from the interference using TLC. The TLC method was using Al-TLC silica G60 plate as a stationary phase and etyl acetate : methanol : amonia (85:10:5) as the mobile phase. The dansyl derivative was detected at ?eks 365 nm and K540 filter for fluoresence. Derivatization  of  morphine-dansyl chloride capable  to  enhancing  the  sensitivity of  morphine detection using TLC-Spectrophotodensytometry. Derivatization in solution and overspotting method took the same time in procedure  but  they  gave  different sensitivity. Derivatization in solution method gave more quantity  than derivatization of overspotting.
OPTIMASI METODE EKSTRAKSI CAIR-CAIR SENYAWA-SENYAWA PADA TABLET EKSTASI DITENTUKAN DENGAN SPEKTROFOTODENSITOMETER Ida Bagus Gde Agung Raditya Eka Putra; Ni Putu Linda Laksmiani; I.N.K. Widjaja
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 5 (2015): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/IJLFS.2015.v05.i01.p01

Abstract

A research concerned on liquid-liquid extraction method optimation has been carried out. The optimation was held to choose the extraction solvent and variation of pH. The simulation solution which contained methylendioxy methampethamine, methampethamine, ketamine, and amitryptiline as the internal standard were analyzed by TLC-Spectrophotodensitometry. The extract was spotted on TLC Si 60 G F254 chromatography plate, then eluted by TB mobile phase (cyclohexhane : toluene : dietylamine = 75:15:10). The chromatography plate was scanned at 202 nm. The chromatogram was analyzed based on the ratio between the area under curve (AUC) of the analyte and the AUC of the internal standard. The concentration and the recovery of the extract was determined.The simulation solution was extracted into chloroform and toluene solvent, the best solvent was selected. The selected solvent (chloroform) was used to extract the sample in pH range 10-12. The pH 11.5 was the best condition to extract the sample.The result showed that the optimum liquid-liquid extraction of the compounds on ecstasy was chloroform as the solvent with pH 11.5. This optimum condition give recovery of MDMA (99.192%), MA (98.203%) and ketamine (88.114%).
Co-Authors A.A.M.A.M. Putra A.A.R.P Dewi D.A.F Sari Dewi Puspita Apsari Era S.Y., Ida Bagus Gde Agung Raditya Eka Putra Jaya, I. G. N. I. P L.P. Ari Chandrayan Luh Putu Febryana Larasanty M. Oka N.K.D Triastuti N.K.W Prasminda N.L.P.D. Wulandari N.L.P.U Antari N.M.F Irmayanti N.P. Linda L. Ni Putu Eka Leliqia Ni Putu Linda Laksmiani P.P. Andiani R.A.D. Puspitasari