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All Journal Majalah Kedokteran Bandung Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Nita Afriani
Fakultas Kedokteran Universitas Andalas
Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Ramipril Terhadap Gambaran Histopatologis Otak Tikus Wistar yang Mengalami Edema Otak Rizka Fitria Husni; Nita Afriani; Aswiyanti Asri
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1504.012 KB) | DOI: 10.25077/jikesi.v2i1.287

Abstract

Background. Brain edema is excessive accumulation of fluid in the intracranial or extracellular space of the brain. It can be caused by head trauma, brain tumors, hypoxia, metabolic disorders, or acute hypertension. Acute myocardial infraction is damage to the myocard that occurs due to lack oxygen. When acute myocardial infarction occurs, there will be disruption of blood flow in the form of stasis which allows emboli and decreased Cardiac Output which will cause a decrease in Cerebral Blood Flow. There will be a state of ischemia and hypoxia so that the hemostatic mechanism is disturbed which will trigger brain edema. Objective. This research was conducted to see the effect of giving ramipril to histopathological of the brain of wistar rat with brain edema. Methods. This research is an experimental study. We used 32 animals which were divided into 4 groups (K-, K +, P1, and P2). P1 was given 3 mg/kgBW ramipril for 7 consecutive days. P2 was given 4 mg/kgBW ramipril for 7 consecutive days. On days 8 and 9, P1, P2, and K+ induced isoproterenol 85 mg/kgBW for 2 consecutive days to induce brain edema through the mechanism of acute myocardial infarction. Data analysis was performed using One Way Anova test and Post Hoc Bonferroni test. Results. The mean area of ​​brain edema in the K-, K +, P1, and P2 groups respectively were 20.76%, 34.69%, 22.70%, and 21.90%. Conclusion. There was a significant effect of giving ramipril to histopathological of the brain of wistar rat with brain edema
Pengaruh Ramipril terhadap Gambaran Mikroskopis Sel Neuron Otak Tikus Wistar yang Mengalami Edema Otak Muhammad Arief Ansyar; Nita Afriani; Aisyah Ellyanti
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 2 (2021): Juni 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1757.08 KB) | DOI: 10.25077/jikesi.v2i2.318

Abstract

Background. Brain edema is swelling in the brain due to excessive accumulation of fluid in the brain. This condition is triggered by a decrease in cerebral blood flow (CBF) due to heart damage or isoproterenol administraion. A decrease in CBF results in brain edema which triggers damage to neuron cells. This study uses isoproterenol to induce brain edema. This damage is prevented by giving ramipril with the aim of improving cardiac and brain perfusion. Objective. To see the effect of giving ramipril to the microscopic assessment of mouses brain neuron cells with brain edema which was induced by isoproterenol. Methods. This research is an experimental study which was used 21 experimental animals which were divided into 3 groups (K-, K +, and P). The treatment group (P) was given ramipril at a dose of 3 mg/KgBW for 7 days. On the 8th and 9th day K+ and P groups were injected by isoproterenol 85 mg/KgBW to induce brain edema through AMI. Data analysis was performed using the Kruskal-Wallis Test and Mann Whitney U Test (MWUT). Results. The average number of neuron cell damage in the K -, K +, and P group, respectively, 6.2, 26.3 and 17.33. Significant differences were obtained for each group with a value of p = 0.001 (p <0.05). Conclusion. There is a significant effect of giving ramipril to the microscopic assessment of mouses brain neuron cells with brain edema which was induced by isoproterenol.
Gambaran Motivasi Belajar Mahasiswa Kedokteran Universitas Andalas selama Pandemi COVID-19 Muhamad Imamhamda Muttaqien; Y Yulistini; Nita Afriani
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 3 (2021): September 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v2i3.349

Abstract

Latar Belakang: Pandemi COVID-19 telah merubah cara pembelajaran di semua perguruan tinggi, termasuk pendidikan kedokteran, yakni dengan menggunakan metode pembelajaran jarak jauh (PJJ). Penelitian ini bertujuan mengetahui gambaran motivasi belajar mahasiswa tahap sarjana di Fakultas Kedokteran Universitas Andalas selama pandemi COVID-19. Metode: Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional study. Pengambilan sampel dengan teknik simple random sampling, didapatkan sampel sebanyak 309 responden yang merupakan mahasiswa angkatan 2017, 2018, dan 2019. Motivasi belajar diukur dengan menggunakan kuesioner Motivated Strategies for Learning Questionnaire (MSLQ). Hasil pengukuran disajikan dengan skala kategorik, yaitu motivasi tinggi, sedang, dan rendah. Hasil: Analisis univariat menunjukkan bahwa 79% mahasiswa kedokteran Universitas Andalas memiliki tingkat motivasi belajar tinggi dan tidak ditemukan mahasiswa yang memiliki tingkat motivasi belajar rendah. Angkatan 2019 memiliki tingkat motivasi belajar tertinggi pada saat pandemi, yaitu sebesar 88,9% diantara angkatan mahasiswa aktif lainnya. Kesimpulan: Mahasiswa kedokteran Universitas Andalas memiliki tingkat motivasi belajar sedang dan tinggi selama pandemi COVID-19, serta mahasiswa angkatan 2019 memiliki tingkat motivasi tinggi terbesar, yakni sebesar 88,9%.
Effect of High Fat Diet on Histopathological Appearance of Pregnant Wistar Rat’s Liver Desmawati Desmawati; Ruhilmi Nisa; Nita Afriani
Majalah Kedokteran Bandung Vol 54, No 3 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n3.2650

Abstract

Indonesia is facing increased consumption of calorie-dense foods, such as fast food, among its society. Changes in diet and physical activities towards unhealthy ones can result in an imbalanced lifestyle, leading to various consequences, including hyperlipidemia. Pregnant women experience significant increases in plasma concentrations of lipids, lipoproteins, and apolipoproteins. Excessive cholesterol levels in pregnant women will result in the formation of fat in the liver. The purpose of this study was to determine the effect of a high-fat diet to pregnant Wistar rats (Rattus norvegicus) on the histopathological features of the liver. A true experimental with post test only control group design was applied in this study, which was conducted from August 2020 to November 2021. Fourteen (14) pregnant female rats were divided into two groups. The first group of rats was fed with a high-fat diet, while the second group, which was the control group, was given a standard diet. The high-fat diet used was 3 mL/rat/day beef brain. After the rats delivered their litters, the rats’ livers were retrieved, then examined histopathologically under a microscope. This research was conducted from No fatty liver was identified in the control group or the treatment group. Hence, a high-fat diet does not affect the liver histopathological features in pregnant Wistar rats.
Pengaruh Yodium terhadap Gambaran Histopatologi Kelenjar Tiroid Tikus yang Diinduksi Timbal Asetat Friska Marcelly; Miftah Irrahmah; Nita Afriani
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 1 (2023): Maret 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i1.886

Abstract

Latar Belakang: Timbal adalah logam berat beracun yang mudah ditemui di lingkungan. Timbal menyebabkan stres oksidatif pada berbagai jaringan dan organ tubuh, termasuk kelenjar tiroid. Kerusakan akibat stres oksidatif akan dikompensasi oleh tubuh dengan antioksidan, salah satunya adalah yodium. Objektif: Penelitian ini bertujuan untuk melihat pengaruh pemberian larutan yodium terhadap gambaran histopatologi kelenjar tiroid tikus yang diinduksi dengan timbal asetat. Metode: Penelitian ini merupakan penelitian eksperimental menggunakan 18 ekor tikus rattus norvegicus yang dibagi dalam 3 kelompok, yaitu kelompok kontrol negatif yang hanya diberi pakan standar, kontrol positif yang diberi pakan standar dan timbal asetat 100mg/L, serta kelompok perlakuan yang diberi pakar standar, timbal asetat 100mg/L, dan larutan yodium 12,5mg selama 19 hari. Pada hari ke 20 tikus dimatikan dan dilakukan pengambilan organ tiroid untuk dibuatkan preparat dengan pulasan hematoxylin eosin. Preparat dibaca menggunakan mikroskop, dilihat kerusakannya, dan dianalisis lebih lanjut. Hasil: Penelitian menunjukkan pada kelompok kontrol negatif sel-sel terlihat normal, pada kontrol positif sel mengalami kerusakan disertai infiltrasi sel radang, sedangkan pada kelompok perlakuan terjadi penurunan jumlah kerusakan dan sel radang secara signifikan. Pada hasil analisis data didapatkan perbedaan yang bermakna tiap kelompok penelitian dengan nilai p<0,05. Kesimpulan: Penelitian ini adalah terdapat pengaruh pemberian larutan yodium dalam mencegah kerusakan tiroid tikus yang diinduksi timbal asetat.
Co-Authors Aisyah Ellyanti Aswiyanti Asri Desmawati Desmawati Friska Marcelly Miftah Irrahmah Muhamad Imamhamda Muttaqien Muhammad Arief Ansyar Rizka Fitria Husni Ruhilmi Nisa Yulistini, Yulistini